| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
traT from Escherichia coli (strain: A2363) |
Escherichia coli (strain: A2363) |
3244810
|
|
58000389
|
O2R_18 |
|
YP_190117.1 |
plays a role in APEC complement resistance; similar to protein family HMM PF05818 |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
traT from Escherichia coli EH41 |
Escherichia coli EH41 |
3654467
|
|
73853290
|
LH0131 |
|
YP_308786.1 |
Complement resistance protein |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
ehxA |
Escherichia coli |
3654480
|
|
73853298
|
LH0144 |
AY258503 |
YP_308794 |
hemolysin A |
Virulence factor |
TOXIN: Ehx demonstrated lysis of BL-3 cells (cells from a bovine lymphoma cell line), sheep and human erythrocytes [Ref6229:Bauer and Welch, 1996]. |
8557336
|
|
|
ehxC |
Escherichia coli |
3654481
|
|
73853299
|
LH0145 |
AY258503 |
YP_308795 |
hemolysin C |
Virulence factor |
TOXIN: Ehx demonstrated lysis of BL-3 cells (cells from a bovine lymphoma cell line), sheep and human erythrocytes [Ref6229:Bauer and Welch, 1996]. |
8557336
|
|
|
eatA from Escherichia coli (strain: JEF100) |
Escherichia coli (strain: JEF100) |
3829299
|
|
83404842
|
pCoo056 |
|
YP_424856.1 |
secreted autotransporter serine protease EatA |
Virulence factor |
MUTATION: interruption of the eatA gene retarded fluid accumulation in the rabbit ileal loop model, suggesting that this autotransporter contributes to the virulence of ETEC [Ref6230:Patel et al., 2004]. |
14977988
|
|
|
traT from Escherichia coli (strain: A2363) |
Escherichia coli (strain: A2363) |
3853397
|
|
84060756
|
O2ColV112 |
|
YP_443958.1 |
surface exclusion protein; similar to GenBank Accession Number AAW58918 |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
iroB from Escherichia coli (strain: A2363) |
Escherichia coli (strain: A2363) |
3853505
|
|
84060896
|
O2ColV53 |
|
YP_444106.1 |
iron-related glycotransferase; similar to NP_753168 |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroC from Escherichia coli (strain: A2363) |
Escherichia coli (strain: A2363) |
3853506
|
|
84060897
|
O2ColV54 |
|
YP_444107.1 |
iron-related ABC transporter protein; similar to GenBank Accession Number AAN76099 |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroD from Escherichia coli (strain: A2363) |
Escherichia coli (strain: A2363) |
3853507
|
|
84060898
|
O2ColV55 |
|
YP_444108.1 |
iron-related ferric enterochelin esterase; similar to GenBank Accession Number AAN76100 |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroN from Escherichia coli (strain: A2363) |
Escherichia coli (strain: A2363) |
3853509
|
|
84060900
|
O2ColV57 |
|
YP_444110.1 |
iron-related siderophore receptor; similar to GenBank Accession Number AAN76093 |
Virulence factor |
MUTATION: iroA gene cluster mutants were unable to resist Lcn2 in mouse serum [Ref6232:Fischbach et al., 2006]. |
17060628
|
|
|
iucA from Escherichia coli (strain: A2363) |
Escherichia coli (strain: A2363) |
3853516
|
|
84060856
|
O2ColV11 |
|
YP_444058.1 |
aerobactin biosynthesis protein; similar to GenBank Accession Number CAA53707 |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucB from Escherichia coli (strain: A2363) |
Escherichia coli (strain: A2363) |
3853517
|
|
84060857
|
O2ColV12 |
|
YP_444059.1 |
N-hydroxylysine acetylase; aerobactin biosynthesis protein; similar to GenBank Accession Number CAH64815 |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucC from Escherichia coli (strain: A2363) |
Escherichia coli (strain: A2363) |
3853518
|
|
84060858
|
O2ColV13 |
|
YP_444060.1 |
aerobactin biosynthesis protein; similar to GenBank Accession Number CAH64814 |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucD from Escherichia coli (strain: A2363) |
Escherichia coli (strain: A2363) |
3853519
|
|
84060859
|
O2ColV14 |
|
YP_444061.1 |
L-lysine 6-monooxigenase; similar to GenBank Accession Number CAE55773 |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iutA from Escherichia coli (strain: A2363) |
Escherichia coli (strain: A2363) |
3853520
|
|
84060860
|
O2ColV15 |
|
YP_444062.1 |
ferric aerobactin receptor; similar to GenBank Accession Number CAE55774 |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
traT from Escherichia coli (strain: DIJ1, serotype: O86:H-) |
Escherichia coli (strain: DIJ1, serotype: O86:H-) |
4364265
|
|
116006905
|
pO86A1_p122 |
|
YP_788088.1 |
TraT complement resistance protein precursor |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
bfpA from Escherichia coli (strain: E2348/69, serotype: O127:H6) |
Escherichia coli (strain: E2348/69, serotype: O127:H6) |
6382168
|
|
190014867
|
MAR003 |
|
YP_001965379.1 |
Major pilin structural unit bundlin |
Virulence factor |
MUTATION: bfpA deletion mutant of EPEC was less virulent in humans than the wild-type EPEC [Ref6235:Bieber et al., 1998]. |
9641917
|
|
|
bfpB from Escherichia coli (strain: E2348/69, serotype: O127:H6) |
Escherichia coli (strain: E2348/69, serotype: O127:H6) |
6382170
|
|
190014869
|
MAR005 |
|
YP_001965381.1 |
Lipoprotein |
Virulence factor |
MUTATION: bfpB mutant EPEC is unable to form BFP which is a major virulence factor of EPEC [Ref6236:Ramer et al., 1996]. |
8932312
|
|
|
bfpE from Escherichia coli (strain: E2348/69, serotype: O127:H6) |
Escherichia coli (strain: E2348/69, serotype: O127:H6) |
6382174
|
|
190014873
|
MAR009 |
|
YP_001965385.1 |
Transmembrane protein |
Virulence factor |
MUTATION: bfpE mutant strain of EPEC fails to form detectable BFP and fails to carry out autoaggregation and localized adherence to HEp-2 epithelial cells in tissue culture [Ref6237:Blank and Donnenberg, 2001]. |
11443077
|
|
|
bfpF from Escherichia coli (strain: E2348/69, serotype: O127:H6) |
Escherichia coli (strain: E2348/69, serotype: O127:H6) |
6382175
|
|
190014874
|
MAR010 |
|
YP_001965386.1 |
Nucleotide binding protein |
Virulence factor |
MUTATION: bfpF mutant colonized the human intestine but was about 200-fold less virulent than the wild-type EPEC [Ref6235:Bieber et al., 1998]. |
9641917
|
|
|
bfpP from Escherichia coli (strain: E2348/69, serotype: O127:H6) |
Escherichia coli (strain: E2348/69, serotype: O127:H6) |
6382176
|
|
190014875
|
MAR011 |
|
YP_001965387.1 |
Prepilin peptidase |
Virulence factor |
MUTATION: mutation in bfpP blocks BFP biogenesis and localized adherence to host cells by EPEC [Ref6238:Anantha et al., 2000]. |
10762251
|
|
|
perA |
Escherichia coli |
6382186
|
|
190014885
|
MAR020 |
|
YP_001965397.1 |
Transcriptional activator, bfp operon |
Virulence factor |
MUTATION: bfpT (perA) disruption mutant of EPEC was less virulent in humans than the wild-type EPEC [Ref6235:Bieber et al., 1998]. |
9641917
|
|
|
bfpA from Escherichia coli (strain: B171) |
Escherichia coli (strain: B171) |
1238603
|
|
10955353
|
pB171_003 |
|
NP_053065.1 |
Bundlin |
Virulence factor |
MUTATION: bfpA deletion mutant of EPEC was less virulent in humans than the wild-type EPEC [Ref6235:Bieber et al., 1998]. |
9641917
|
|
|
bfpB from Escherichia coli (strain: B171) |
Escherichia coli (strain: B171) |
1238604
|
|
10955355
|
pB171_005 |
|
NP_053067.1 |
BfpB |
Virulence factor |
MUTATION: bfpB mutant EPEC is unable to form BFP which is a major virulence factor of EPEC [Ref6236:Ramer et al., 1996]. |
8932312
|
|
|
bfpE from Escherichia coli (strain: B171) |
Escherichia coli (strain: B171) |
1238607
|
|
10955359
|
pB171_009 |
|
NP_053071.1 |
BfpE |
Virulence factor |
MUTATION: bfpE mutant strain of EPEC fails to form detectable BFP and fails to carry out autoaggregation and localized adherence to HEp-2 epithelial cells in tissue culture [Ref6237:Blank and Donnenberg, 2001]. |
11443077
|
|
|
bfpF from Escherichia coli (strain: B171) |
Escherichia coli (strain: B171) |
1238608
|
|
10955360
|
pB171_010 |
|
NP_053072.1 |
BfpF |
Virulence factor |
MUTATION: bfpF mutant colonized the human intestine but was about 200-fold less virulent than the wild-type EPEC [Ref6235:Bieber et al., 1998]. |
9641917
|
|
|
bfpP from Escherichia coli (strain: B171) |
Escherichia coli (strain: B171) |
1238616
|
|
10955361
|
pB171_011 |
|
NP_053073.1 |
prepilin peptidase |
Virulence factor |
MUTATION: mutation in bfpP blocks BFP biogenesis and localized adherence to host cells by EPEC [Ref6238:Anantha et al., 2000]. |
10762251
|
|
|
bfpT |
Escherichia coli |
1238617
|
|
10955374
|
pB171_024 |
EF011039 |
NP_053086 |
BfpT |
Virulence factor |
MUTATION: bfpT (perA) disruption mutant of EPEC was less virulent in humans than the wild-type EPEC [Ref6235:Bieber et al., 1998]. |
9641917
|
|
|
rfaH from Escherichia coli E24377A |
Escherichia coli E24377A |
5586647
|
|
157157494
|
EcE24377A_4360 |
|
YP_001465326.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
dppA from Escherichia coli E24377A |
Escherichia coli E24377A |
5586739
|
|
157159059
|
EcE24377A_4037 |
|
YP_001465018.1 |
dipeptide ABC transporter, periplasmic dipeptide-binding protein |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
fliC from Escherichia coli E24377A |
Escherichia coli E24377A |
5586916
|
|
157159035
|
EcE24377A_2158 |
|
YP_001463228.1 |
flagellin FliC |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
ompA from Escherichia coli E24377A |
Escherichia coli E24377A |
5589214
|
|
157159269
|
EcE24377A_1071 |
|
YP_001462189.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
fimH from Escherichia coli E24377A |
Escherichia coli E24377A |
5589412
|
|
157157381
|
EcE24377A_4917 |
|
YP_001465845.1 |
protein FimH |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
dsbA from Escherichia coli E24377A |
Escherichia coli E24377A |
5590815
|
|
157155214
|
EcE24377A_4378 |
|
YP_001465340.1 |
thiol:disulfide interchange protein DsbA |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
dsbA from Escherichia coli HS |
Escherichia coli HS |
5591486
|
|
157163329
|
EcHS_A4083 |
|
YP_001460647.1 |
thiol:disulfide interchange protein DsbA |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
fimH from Escherichia coli HS |
Escherichia coli HS |
5591791
|
|
157163764
|
EcHS_A4546 |
|
YP_001461082.1 |
protein FimH |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
ompA from Escherichia coli HS |
Escherichia coli HS |
5591810
|
|
157160478
|
EcHS_A1066 |
|
YP_001457796.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
tonB from Escherichia coli HS |
Escherichia coli HS |
5593249
|
|
157160757
|
EcHS_A1361 |
|
YP_001458075.1 |
outer membrane receptor-mediated transport energizer protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
dppA from Escherichia coli HS |
Escherichia coli HS |
5593889
|
|
157163019
|
EcHS_A3744 |
|
YP_001460337.1 |
dipeptide ABC transporter, periplasmic dipeptide-binding protein |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
rfaH from Escherichia coli HS |
Escherichia coli HS |
5594372
|
|
157163316
|
EcHS_A4064 |
|
YP_001460634.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
mppA |
Escherichia coli APEC O1 |
4491551
|
|
117623583
|
APECO1_483 |
CP000468 |
YP_852496 |
periplasmic murein peptide-binding protein precursor |
Virulence factor |
MUTATION: mppA mutant is attenuated in chickens [Ref6646:Li et al., 2005]. |
15845486
|
|
|
sbmA |
Escherichia coli APEC O1 |
4491947
|
|
117622640
|
APECO1_1631 |
CP000468 |
YP_851553 |
transport protein |
Virulence factor |
MUTATION: sbmA mutant is attenuated in chickens [Ref6646:Li et al., 2005]. |
15845486
|
|
|
fimH from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
4492146
|
|
117626628
|
APECO1_2110 |
|
YP_859951.1 |
type 1 fimbiral adhesin FimH |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
ychF |
Escherichia coli |
4492443
|
|
117623421
|
APECO1_319 |
|
YP_852334.1 |
translation-associated GTPase |
Virulence factor |
MUTATION: ychF mutant is attenuated in chickens [Ref6646:Li et al., 2005]. |
15845486
|
|
|
waaL |
Escherichia coli APEC O1 |
4492586
|
|
117625899
|
APECO1_2834 |
CP000468 |
YP_859222 |
lipid A-core, surface polymer ligase |
Virulence factor |
MUTATION: waaL mutant is attenuated in chickens [Ref6646:Li et al., 2005]. |
15845486
|
|
|
dppA from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
4492758
|
|
117625828
|
APECO1_2904 |
|
YP_859151.1 |
dipeptide transporter protein DppA |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
dsbA from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
4492849
|
|
117626134
|
APECO1_2601 |
|
YP_859457.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
ibeA from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
4493341
|
|
117626645
|
APECO1_2093 |
|
YP_859968.1 |
invasion protein IbeA |
Virulence factor |
MUTATION: deletion mutant was significantly less invasive in human brain microvascular endothelial cells (BMECs) than the parent strain (E. coli K1) [Ref6647:Huang et al., 2001]. |
11237832
|
|
|
papA from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
4493551
|
|
117625209
|
APECO1_3519 |
|
YP_854256.1 |
major fibrial protein |
Virulence factor |
MUTATION: mutant papA in wild-type smooth strains do not mediate Gal-Gal adherence [Ref6648:Johnson, 1991]. |
1672263
|
|
|
sitB |
Escherichia coli |
4493636
|
|
117623375
|
APECO1_273 |
|
YP_852288.1 |
ABC Mn+2/Fe+2 transporter, ATPase subunit SitB |
Virulence factor |
MUTATION: sitB mutant is attenuated in chickens [Ref6646:Li et al., 2005]. |
15845486
|
|
|
malX |
Escherichia coli APEC O1 |
4493654
|
|
117623807
|
APECO1_704 |
CP000468 |
YP_852720 |
bifunctional PTS system maltose and glucose-specific transporter subunits IICB |
Virulence factor |
MUTATION: malX mutant is attenuated in chickens [Ref6646:Li et al., 2005]. |
15845486
|
|
|
ompA from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
4493784
|
|
117623167
|
APECO1_62 |
|
YP_852080.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
tia from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
4493822
|
|
117625198
|
APECO1_3530 |
|
YP_854245.1 |
Tia invasion determinant |
Virulence factor |
MUTATION: tia deletion strains were noninvasive and lacked the ability to adhere to human ileocecal cells [Ref6649:Fleckenstein et al., 1996]. |
8675335
|
|
|
papG from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
4493827
|
|
117625201
|
APECO1_3527 |
|
YP_854248.1 |
allele II |
Virulence factor |
MUTATION: attenuated to human neutrophils in vitro [Ref6650:Tewari et al., 1994]. |
7960108
|
|
|
rfaH from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
4494179
|
|
117626120
|
APECO1_2615 |
|
YP_859443.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
kpsS |
Escherichia coli APEC O1 |
4494206
|
|
117625251
|
APECO1_3477 |
CP000468 |
YP_854344 |
polysialic acid capsule synthesis protein KpsS |
Virulence factor |
MUTATION: kpsS mutant is attenuated in chickens [Ref6646:Li et al., 2005]. |
15845486
|
|
|
wcaE |
Escherichia coli APEC O1 |
4494493
|
|
117624251
|
APECO1_1145 |
CP000468 |
YP_853164 |
putative glycosyl transferase |
Virulence factor |
MUTATION: wcaE mutant is attenuated in chickens [Ref6646:Li et al., 2005]. |
15845486
|
|
|
APECO1_3367 |
Escherichia coli APEC O1 |
4494532
|
|
117625360
|
APECO1_3367 |
CP000468 |
YP_855140 |
putative Yqi fimbrial adhesin |
Virulence factor |
MUTATION: yqi mutant is attenuated in chickens [Ref6651:Antão et al., 2009]. |
19907658
|
|
|
fliC from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
4494642
|
|
117624065
|
APECO1_964 |
|
YP_852978.1 |
flagellin |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
yjjQ |
Escherichia coli APEC O1 |
4494948
|
|
117626679
|
APECO1_2059 |
CP000468 |
YP_860002 |
hypothetical protein |
Virulence factor |
MUTATION: yjjQ mutant is attenuated in chickens [Ref6652:Li et al., 2008]. |
18375801
|
|
|
chuA from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
4495129
|
|
117625783
|
APECO1_2948 |
|
YP_859106.1 |
outer membrane heme/hemoglobin receptor ChuA |
Virulence factor |
MUTATION: chuA mutant unable to grow on iron-depleted medium containing heme [Ref6653:Torres and Payne, 1997]. |
9157252
|
|
|
tktA |
Escherichia coli APEC O1 |
4495170
|
|
117625164
|
APECO1_3594 |
CP000468 |
YP_854152 |
transketolase |
Virulence factor |
MUTATION: tktA mutant is attenuated in chickens [Ref6646:Li et al., 2005]. |
15845486
|
|
|
tonB from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
4495352
|
|
117623468
|
APECO1_368 |
|
YP_852381.1 |
membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
rfaH from Escherichia coli 536 |
Escherichia coli 536 |
4187921
|
|
110644186
|
ECP_4055 |
|
YP_671916.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
ECP_4655 |
Escherichia coli 536 |
4190232
|
|
110644762
|
ECP_4655 |
CP000247 |
YP_672492 |
FimH protein precursor |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
dppA from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3989640
|
|
91213056
|
UTI89_C4082 |
|
YP_543042.1 |
periplasmic dipeptide transport protein precursor |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
cnf1 |
Escherichia coli UTI89 |
3990770
|
|
91213869
|
UTI89_C4921 |
CP000243 |
YP_543855 |
cytotoxic necrotizing factor 1 |
Virulence factor |
MUTATION: attenuated in mice [Ref6654:Rippere-Lampe et al., 2001]. |
11349064
|
|
|
hlyA from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3990775
|
|
91213874
|
UTI89_C4926 |
|
YP_543860.1 |
hemolysin A |
Virulence factor |
MUTATION: attenuated in zebra fish [Ref6655:Wiles et al., 2009]. |
20019794
|
|
|
hlyC from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3990776
|
|
91213875
|
UTI89_C4927 |
|
YP_543861.1 |
hemolysin C |
Virulence factor |
MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells [Ref6656:Stanley et al., 1996]. |
8793877
|
|
|
chuA from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3991259
|
|
91213002
|
UTI89_C4028 |
|
YP_542988.1 |
outer membrane hemin receptor ChuA |
Virulence factor |
MUTATION: chuA mutant unable to grow on iron-depleted medium containing heme [Ref6653:Torres and Payne, 1997]. |
9157252
|
|
|
iroN from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3991364
|
|
91210147
|
UTI89_C1118 |
|
YP_540133.1 |
IroN protein |
Virulence factor |
MUTATION: iroA gene cluster mutants were unable to resist Lcn2 in mouse serum [Ref6232:Fischbach et al., 2006]. |
17060628
|
|
|
iroD from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3991366
|
|
91210149
|
UTI89_C1120 |
|
YP_540135.1 |
IroD protein |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroC from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3991367
|
|
91210150
|
UTI89_C1121 |
|
YP_540136.1 |
IroC protein |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroB from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3991368
|
|
91210151
|
UTI89_C1122 |
|
YP_540137.1 |
putative glucosyltransferase |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
tonB from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3991369
|
|
91210476
|
UTI89_C1451 |
|
YP_540462.1 |
membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
papG from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3992036
|
|
91213835
|
UTI89_C4887 |
|
YP_543821.1 |
p pilus adhesin PapG protein |
Virulence factor |
MUTATION: attenuated to human neutrophils in vitro [Ref6650:Tewari et al., 1994]. |
7960108
|
|
|
papA from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3992044
|
|
91213843
|
UTI89_C4895 |
|
YP_543829.1 |
major pilin subunit PapA |
Virulence factor |
MUTATION: mutant papA in wild-type smooth strains do not mediate Gal-Gal adherence [Ref6648:Johnson, 1991]. |
1672263
|
|
|
fimH from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3992235
|
|
91213965
|
UTI89_C5017 |
|
YP_543951.1 |
type 1 fimbiral adhesin FimH |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
ibeA from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3992253
|
|
91213983
|
UTI89_C5035 |
|
YP_543969.1 |
invasion protein IbeA |
Virulence factor |
MUTATION: deletion mutant was significantly less invasive in human brain microvascular endothelial cells (BMECs) than the parent strain (E. coli K1) [Ref6647:Huang et al., 2001]. |
11237832
|
|
|
aslA from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3992515
|
|
91213321
|
UTI89_C4359 |
|
YP_543307.1 |
arylsulfatase |
Virulence factor |
MUTATION: disruption mutant was less invasive in an in vitro HBMEC invasion assay than the wild-type E. coli K1 [Ref6657:Hoffman et al., 2000]. |
10948126
|
|
|
dsbA from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3992605
|
|
91213404
|
UTI89_C4447 |
|
YP_543390.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
fliC from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3993212
|
|
91211142
|
UTI89_C2124 |
|
YP_541128.1 |
flagellin |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
rfaH from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3993833
|
|
91213389
|
UTI89_C4427 |
|
YP_543375.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
ompA from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3994721
|
|
91210052
|
UTI89_C1022 |
|
YP_540038.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
iroN from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1034931
|
|
26247124
|
c1250 |
|
NP_753164.1 |
Siderophore receptor IroN |
Virulence factor |
MUTATION: iroA gene cluster mutants were unable to resist Lcn2 in mouse serum [Ref6232:Fischbach et al., 2006]. |
17060628
|
|
|
iroD from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1034933
|
|
26247126
|
c1252 |
|
NP_753166.1 |
Ferric enterochelin esterase |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroC from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1034934
|
|
26247127
|
c1253 |
|
NP_753167.1 |
ATP binding cassette (ABC) transporter homolog |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroB from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1034935
|
|
26247128
|
c1254 |
|
NP_753168.1 |
Putative glucosyltransferase |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
tonB from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1035499
|
|
26247582
|
c1717 |
|
NP_753622.1 |
membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
ycjM |
Escherichia coli CFT073 |
1035566
|
|
26247644
|
c1780 |
AE014075 |
NP_753684 |
putative sucrose phosphorylase |
Virulence factor |
MUTATION: ycjM mutant is attenuated in chickens [Ref6646:Li et al., 2005]. |
15845486
|
|
|
rfaH from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1035846
|
|
26250608
|
c4789 |
|
NP_756648.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
wecE |
Escherichia coli CFT073 |
1036493
|
|
26250530
|
c4711 |
AE014075 |
NP_756570 |
TDP-4-oxo-6-deoxy-D-glucose transaminase |
Virulence factor |
MUTATION: wecE mutant is attenuated in mice [Ref6658:Bahrani-Mougeot et al., 2002]. |
12180926
|
|
|
dsbA from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1036525
|
|
26250621
|
c4804 |
|
NP_756661.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
focA |
Escherichia coli CFT073 |
1036891
|
|
26247113
|
c1239 |
AE014075 |
NP_753153 |
F1C major fimbrial subunit precursor |
Virulence factor |
MUTATION: focA deletion mutants were unable to bind to brain glycolipids [Ref6659:Prasadarao et al., 1993]. |
8098039
|
|
|
fliC from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1036977
|
|
26248190
|
c2338 |
|
NP_754230.1 |
flagellin |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
chuA from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1037196
|
|
26250130
|
c4308 |
|
NP_756170.1 |
Outer membrane heme/hemoglobin receptor |
Virulence factor |
MUTATION: chuA mutant unable to grow on iron-depleted medium containing heme [Ref6653:Torres and Payne, 1997]. |
9157252
|
|
|
fimH from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1037233
|
|
26251208
|
c5400 |
|
NP_757248.1 |
FimH protein precursor |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
fimF |
Escherichia coli CFT073 |
1037237
|
|
26251205
|
c5397 |
AE014075 |
NP_757245 |
FimF protein precursor |
Virulence factor |
MUTATION: fimF mutant is attenuated in mice [Ref6658:Bahrani-Mougeot et al., 2002]. |
12180926
|
|
|
fimD |
Escherichia coli CFT073 |
1037242
|
|
26251204
|
c5396 |
AE014075 |
NP_757244 |
Outer membrane usher protein fimD precursor |
Virulence factor |
MUTATION: fimD mutant is attenuated in mice [Ref6658:Bahrani-Mougeot et al., 2002]. |
12180926
|
|
|
fimC |
Escherichia coli CFT073 |
1037243
|
|
26251203
|
c5395 |
AE014075 |
NP_757243 |
chaperone protein fimC precursor |
Virulence factor |
MUTATION: fimC mutant is attenuated in mice [Ref6658:Bahrani-Mougeot et al., 2002]. |
12180926
|
|
|
fimI from E. coli CFT073 |
Escherichia coli CFT073 |
1037245
|
|
26251202
|
c5394 |
|
NP_757242.1 |
Fimbrin-like protein fimI precursor |
Virulence factor |
MUTATION: fimI mutant is attenuated in mice [Ref6658:Bahrani-Mougeot et al., 2002]. |
12180926
|
|
|
fimB |
Escherichia coli CFT073 |
1037250
|
|
26251199
|
c5391 |
AE014075 |
NP_757239 |
tyrosine recombinase |
Virulence factor |
MUTATION: fimB mutant is attenuated in mice [Ref6658:Bahrani-Mougeot et al., 2002]. |
12180926
|
|
|
dppA from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1037335
|
|
26250183
|
c4361 |
|
NP_756223.1 |
Periplasmic dipeptide transport protein precursor |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
manB from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1037835
|
|
26248405
|
c2557 |
|
NP_754445.1 |
Phosphomannomutase |
Virulence factor |
MUTATION: manB mutant is attenuated in mice [Ref6658:Bahrani-Mougeot et al., 2002]. |
12180926
|
|
|
waaW |
Escherichia coli CFT073 |
1038245
|
|
26250272
|
c4450 |
AE014075 |
NP_756312 |
UDP-galactose:(galactosyl) LPS alpha1,2-galactosyltransferase |
Virulence factor |
MUTATION: waaW mutant is attenuated in chickens [Ref6646:Li et al., 2005]. |
15845486
|
|
|
hlyC from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1039495
|
|
26249404
|
c3569 |
|
NP_755444.1 |
Hemolysin C |
Virulence factor |
MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells [Ref6656:Stanley et al., 1996]. |
8793877
|
|
|
hlyA from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1039496
|
|
26249405
|
c3570 |
|
NP_755445.1 |
Hemolysin A |
Virulence factor |
MUTATION: attenuated in zebra fish [Ref6655:Wiles et al., 2009]. |
20019794
|
|
|
papG from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1039518
|
|
26249418
|
c3583 |
|
NP_755458.1 |
PapG protein |
Virulence factor |
MUTATION: attenuated to human neutrophils in vitro [Ref6650:Tewari et al., 1994]. |
7960108
|
|
|
papA from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1039530
|
|
26249427
|
c3592 |
|
NP_755467.1 |
PapA protein |
Virulence factor |
MUTATION: mutant papA in wild-type smooth strains do not mediate Gal-Gal adherence [Ref6648:Johnson, 1991]. |
1672263
|
|
|
sat from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1039573
|
|
26249454
|
c3619 |
|
NP_755494.1 |
Aecreted auto transpoter toxin |
Virulence factor |
MUTATION: Sat elicits cytopathic activity that damages host tissue and may increase the ability of E. coli to propagate [Ref6660:Guyer et al., 2002]. |
12117966
|
|
|
iutA from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1039578
|
|
26249458
|
c3623 |
|
NP_755498.1 |
IutA protein |
Virulence factor |
MUTATION: mutant attenuated in mice competition assay [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
iucD from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1039579
|
|
26249459
|
c3624 |
|
NP_755499.1 |
IucD protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucC from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1039580
|
|
26249460
|
c3625 |
|
NP_755500.1 |
IucC protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucB from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1039581
|
|
26249461
|
c3626 |
|
NP_755501.1 |
IucB protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucA from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1039582
|
|
26249462
|
c3627 |
|
NP_755502.1 |
IucA protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
kpsC |
Escherichia coli CFT073 |
1039730
|
|
26249525
|
c3690 |
AE014075 |
NP_755565 |
KpsC protein |
Virulence factor |
MUTATION: kpsC mutant is attenuated in mice [Ref6658:Bahrani-Mougeot et al., 2002]. |
12180926
|
|
|
pyrD |
Escherichia coli CFT073 |
1039998
|
|
26246966
|
c1081 |
AE014075 |
NP_753006 |
dihydroorotate dehydrogenase 2 |
Virulence factor |
MUTATION: pyrD mutant is attenuated in mice [Ref6658:Bahrani-Mougeot et al., 2002]. |
12180926
|
|
|
ompA from Escherichia coli CFT073 |
Escherichia coli CFT073 |
1039999
|
|
26246978
|
c1093 |
|
NP_753018.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
phoU |
Escherichia coli CFT073 |
1040241
|
|
161486057
|
c4648 |
AE014075 |
NP_756506 |
transcriptional regulator PhoU |
Virulence factor |
MUTATION: phoU mutant is attenuated in mice [Ref6658:Bahrani-Mougeot et al., 2002]. |
12180926
|
|
|
rfaH from Escherichia coli O157:H7 str. Sakai |
Escherichia coli O157:H7 str. Sakai |
915134
|
|
15834024
|
ECs4770 |
|
NP_312797.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
stx1B |
Escherichia coli O157:H7 str. EDL933 |
956702
|
|
15802645
|
Z3343 |
AE005174 |
NP_288672 |
shiga-like toxin 1 subunit B encoded within prophage CP-933V |
Virulence factor |
TOXIN: Stx induces apoptosis in HeLa cells [Ref6661:Cherla et al., 2003]. |
14638419
|
|
|
map from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
956892
|
|
15799850
|
Z0178 |
|
NP_285862.1 |
methionine aminopeptidase |
Virulence factor |
MUTATION: map mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z3341 |
Escherichia coli O157:H7 str. EDL933 |
956966
|
|
15802643
|
Z3341 |
AE005174 |
NP_288670 |
hypothetical protein |
Virulence factor |
MUTATION: Z3341 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
stx1A |
Escherichia coli O157:H7 str. EDL933 |
956968
|
|
15802646
|
Z3344 |
AE005174 |
NP_288673 |
shiga-like toxin 1 subunit A encoded within prophage CP-933V |
Virulence factor |
TOXIN: Stx induces apoptosis in HeLa cells [Ref6661:Cherla et al., 2003]. |
14638419
|
|
|
Z0275 |
Escherichia coli O157:H7 str. EDL933 |
957027
|
|
15799923
|
Z0275 |
AE005174 |
NP_285935 |
hypothetical protein |
Virulence factor |
MUTATION: Z0275 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
sanA |
Escherichia coli O157:H7 str. EDL933 |
957084
|
|
15802700
|
Z3399 |
AE005174 |
NP_288727 |
hypothetical protein |
Virulence factor |
MUTATION: sanA mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
mglA |
Escherichia coli O157:H7 str. EDL933 |
957113
|
|
15802705
|
Z3404 |
AE005174 |
NP_288732 |
galactose/methyl galaxtoside transporter ATP-binding protein |
Virulence factor |
MUTATION: mglA mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z0390 |
Escherichia coli O157:H7 str. EDL933 |
957204
|
|
15800026
|
Z0390 |
AE005174 |
NP_286038 |
hypothetical protein |
Virulence factor |
MUTATION: Z0390 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z3496 |
Escherichia coli O157:H7 str. EDL933 |
957222
|
|
15802787
|
Z3496 |
AE005174 |
NP_288814 |
hypothetical protein |
Virulence factor |
MUTATION: Z3496 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z0469 |
Escherichia coli |
957315
|
|
15800100
|
Z0469 |
|
NP_286112.1 |
putative structural protein (partial) |
Virulence factor |
MUTATION: Z0469 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
rdgC |
Escherichia coli O157:H7 str. EDL933 |
957342
|
|
15800120
|
Z0492 |
AE005174 |
NP_286132 |
recombination associated protein |
Virulence factor |
MUTATION: rdgC mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z0609 |
Escherichia coli O157:H7 str. EDL933 |
957466
|
|
15800217
|
Z0609 |
AE005174 |
NP_286229 |
hypothetical protein |
Virulence factor |
MUTATION: Z0609 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
evgS |
Escherichia coli O157:H7 str. EDL933 |
957555
|
|
15802913
|
Z3632 |
AE005174 |
NP_288940 |
hybrid sensory histidine kinase in two-component regulatory system with EvgA |
Virulence factor |
MUTATION: evgS mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
yfhH |
Escherichia coli |
957907
|
|
161367545
|
Z3841 |
|
NP_289117.2 |
putative DNA-binding transcriptional regulator |
Virulence factor |
MUTATION: yfhH mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
trxC |
Escherichia coli O157:H7 str. EDL933 |
957981
|
|
15803110
|
Z3867 |
AE005174 |
NP_289141 |
thioredoxin 2 |
Virulence factor |
MUTATION: trxC mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z0990 |
Escherichia coli O157:H7 str. EDL933 |
957986
|
|
15800523
|
Z0990 |
AE005174 |
NP_286535 |
hypothetical protein |
Virulence factor |
MUTATION: Z0990 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z3950 |
Escherichia coli O157:H7 str. EDL933 |
958085
|
|
15803172
|
Z3950 |
AE005174 |
NP_289204 |
hypothetical protein |
Virulence factor |
MUTATION: Z3950 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
recD |
Escherichia coli O157:H7 str. EDL933 |
958288
|
|
15803338
|
Z4136 |
AE005174 |
NP_289371 |
exonuclease V subunit alpha |
Virulence factor |
MUTATION: recD mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
kduI |
Escherichia coli O157:H7 str. EDL933 |
958313
|
|
15803363
|
Z4163 |
AE005174 |
NP_289396 |
5-keto-4-deoxyuronate isomerase |
Virulence factor |
MUTATION: kduI mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z4200 |
Escherichia coli O157:H7 str. EDL933 |
958343
|
|
15803400
|
Z4200 |
AE005174 |
NP_289433 |
hypothetical protein |
Virulence factor |
MUTATION: z4200 (pkgA) mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z3635 |
Escherichia coli O157:H7 str. EDL933 |
958378
|
|
15802914
|
Z3635 |
AE005174 |
NP_288942 |
putative transporter YfdV |
Virulence factor |
MUTATION: z3635 (yfdV) mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z4282 |
Escherichia coli O157:H7 str. EDL933 |
958414
|
|
15803476
|
Z4282 |
AE005174 |
NP_289509 |
hypothetical protein |
Virulence factor |
MUTATION: z4282 mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
speA |
Escherichia coli |
958416
|
|
15803477
|
Z4283 |
|
NP_289510.1 |
arginine decarboxylase |
Virulence factor |
MUTATION: speA mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z4318 |
Escherichia coli O157:H7 str. EDL933 |
958457
|
|
15803511
|
Z4318 |
AE005174 |
NP_289544 |
hypothetical protein |
Virulence factor |
MUTATION: Z4318 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
pitB |
Escherichia coli O157:H7 str. EDL933 |
958466
|
|
15803532
|
Z4341 |
AE005174 |
NP_289565 |
partial putative transport protein |
Virulence factor |
MUTATION: pitB mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z1126 |
Escherichia coli O157:H7 str. EDL933 |
958522
|
|
15800647
|
Z1126 |
AE005174 |
NP_286661 |
hypothetical protein |
Virulence factor |
MUTATION: Z1126 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z1129 |
Escherichia coli O157:H7 str. EDL933 |
958525
|
|
15800650
|
Z1129 |
AE005174 |
NP_286664 |
putative helicase |
Virulence factor |
MUTATION: z1129 mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
tdcE |
Escherichia coli O157:H7 str. EDL933 |
958549
|
|
15803653
|
Z4466 |
AE005174 |
NP_289686 |
formate acetyltransferase 3 |
Virulence factor |
MUTATION: tdcE mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z1182 |
Escherichia coli O157:H7 str. EDL933 |
958755
|
|
15800703
|
Z1182 |
AE005174 |
NP_286717 |
hypothetical protein |
Virulence factor |
MUTATION: Z1182 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z1202 |
Escherichia coli O157:H7 str. EDL933 |
958789
|
|
15800723
|
Z1202 |
AE005174 |
NP_286737 |
hypothetical protein |
Virulence factor |
MUTATION: Z1202 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
trxB |
Escherichia coli |
958846
|
|
15800751
|
Z1232 |
|
NP_286765.1 |
thioredoxin reductase |
Virulence factor |
MUTATION: trxB mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
ompA from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
958948
|
|
15800816
|
Z1307 |
|
NP_286832.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
Z1328 |
Escherichia coli O157:H7 str. EDL933 |
958973
|
|
15800834
|
Z1328 |
AE005174 |
NP_286850 |
hypothetical protein |
Virulence factor |
MUTATION: Z1328 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
yqeJ |
Escherichia coli O157:H7 str. EDL933 |
958999
|
|
15803368
|
Z4168 |
AE005174 |
NP_289401 |
hypothetical protein |
Virulence factor |
MUTATION: ygeJ mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
ymcC |
Escherichia coli O157:H7 str. EDL933 |
959050
|
|
15800907
|
Z1403 |
AE005174 |
NP_286923 |
putative regulator |
Virulence factor |
MUTATION: ymcC mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
stx2B from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
959107
|
|
15800961
|
Z1465 |
AE005174 |
NP_286977 |
shiga-like toxin II B subunit encoded by bacteriophage BP-933W |
Virulence factor |
TOXIN: Stx induces apoptosis in HeLa cells [Ref6661:Cherla et al., 2003]. |
14638419
|
|
|
pgaA |
Escherichia coli O157:H7 str. EDL933 |
959162
|
|
15801015
|
Z1526 |
AE005174 |
NP_287031 |
outer membrane protein PgaA |
Virulence factor |
MUTATION: ycdS mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
agaB |
Escherichia coli O157:H7 str. EDL933 |
959220
|
|
15803678
|
Z4492 |
AE005174 |
NP_289711 |
PTS system N-acetylgalactosamine-specific transporter subunit IIB |
Virulence factor |
MUTATION: agaB mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
mdoC |
Escherichia coli O157:H7 str. EDL933 |
959379
|
|
15801164
|
Z1681 |
AE005174 |
NP_287181 |
glucans biosynthesis protein |
Virulence factor |
MUTATION: mdoC (ymdD) mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
ypjA |
Escherichia coli O157:H7 str. EDL933 |
959506
|
|
15803170
|
Z3948 |
AE005174 |
NP_289202 |
putative ATP-binding component of a transport system |
Virulence factor |
MUTATION: ypjA mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
serA |
Escherichia coli O157:H7 str. EDL933 |
959584
|
|
15803448
|
Z4251 |
AE005174 |
NP_289481 |
D-3-phosphoglycerate dehydrogenase |
Virulence factor |
MUTATION: serA mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z1829 |
Escherichia coli O157:H7 str. EDL933 |
959588
|
|
15801299
|
Z1829 |
AE005174 |
NP_287316 |
hypothetical protein |
Virulence factor |
MUTATION: z1829 mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z5946 |
Escherichia coli O157:H7 str. EDL933 |
959707
|
|
15804920
|
Z5946 |
AE005174 |
NP_290962 |
putative restriction modification enzyme S subunit |
Virulence factor |
MUTATION: Z5946 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
fimH from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
959733
|
|
15804895
|
Z5918 |
|
NP_290936.1 |
minor fimbrial subunit, D-mannose specific adhesin |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
fimE |
Escherichia coli O157:H7 str. EDL933 |
959740
|
|
15804888
|
Z5911 |
AE005174 |
NP_290929 |
tyrosine recombinase |
Virulence factor |
MUTATION: fimE mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
yjhS |
Escherichia coli O157:H7 str. EDL933 |
959744
|
|
15804884
|
Z5905 |
AE005174 |
NP_290925 |
hypothetical protein |
Virulence factor |
MUTATION: yjhS mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z5886 |
Escherichia coli O157:H7 str. EDL933 |
959763
|
|
15804865
|
Z5886 |
AE005174 |
NP_290906 |
hypothetical protein |
Virulence factor |
MUTATION: Z5886 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
nrdD |
Escherichia coli O157:H7 str. EDL933 |
959802
|
|
15804828
|
Z5848 |
AE005174 |
NP_290869 |
anaerobic ribonucleoside triphosphate reductase |
Virulence factor |
MUTATION: nrdD mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z1930 |
Escherichia coli O157:H7 str. EDL933 |
959880
|
|
15801390
|
Z1930 |
AE005174 |
NP_287407 |
putative protease encoded within prophage CP-933X |
Virulence factor |
MUTATION: Z1930 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
yjeJ |
Escherichia coli O157:H7 str. EDL933 |
959978
|
|
15804737
|
Z5750 |
AE005174 |
NP_290778 |
hypothetical protein |
Virulence factor |
MUTATION: yjeJ mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
yjcF |
Escherichia coli O157:H7 str. EDL933 |
960058
|
|
15804658
|
Z5665 |
AE005174 |
NP_290699 |
hypothetical protein |
Virulence factor |
MUTATION: yjcF mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
arp |
Escherichia coli O157:H7 str. EDL933 |
960113
|
|
15804603
|
Z5608 |
AE005174 |
NP_290644 |
regulator of acetyl CoA synthetase |
Virulence factor |
MUTATION: arp mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z5444 |
Escherichia coli O157:H7 str. EDL933 |
960248
|
|
15804490
|
Z5444 |
AE005174 |
NP_290530 |
putative glycoporin |
Virulence factor |
MUTATION: Z5444 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
dsbA from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
960300
|
|
15804445
|
Z5392 |
|
NP_290485.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
rfaH from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
960318
|
|
15804432
|
Z5362 |
|
NP_290472.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
ilvG |
Escherichia coli O157:H7 str. EDL933 |
960401
|
|
15804359
|
Z5279 |
AE005174 |
NP_290399 |
acetolactate synthase 2 catalytic subunit |
Virulence factor |
MUTATION: ilvG mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
narG |
Escherichia coli O157:H7 str. EDL933 |
960477
|
|
15801455
|
Z2001 |
AE005174 |
NP_287472 |
nitrate reductase 1, alpha subunit |
Virulence factor |
MUTATION: narG mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
tonB from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
960504
|
|
15801478
|
Z2030 |
|
NP_287495.1 |
membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
Z2056 |
Escherichia coli O157:H7 str. EDL933 |
960527
|
|
15801501
|
Z2056 |
AE005174 |
NP_287518 |
hypothetical protein |
Virulence factor |
MUTATION: z2056 mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z2142 |
Escherichia coli O157:H7 str. EDL933 |
960608
|
|
15801579
|
Z2142 |
AE005174 |
NP_287596 |
putative tail component of prophage CP-933O |
Virulence factor |
MUTATION: z2142 mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z2144 |
Escherichia coli O157:H7 str. EDL933 |
960610
|
|
15801581
|
Z2144 |
AE005174 |
NP_287598 |
putative tail component of prophage CP-933O |
Virulence factor |
MUTATION: Z2144 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z2149 |
Escherichia coli |
960615
|
|
15801586
|
Z2149 |
|
NP_287603.1 |
hypothetical protein |
Virulence factor |
MUTATION: Z2149 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z2176 |
Escherichia coli O157:H7 str. EDL933 |
960638
|
|
15801609
|
Z2176 |
AE005174 |
NP_287626 |
hypothetical protein |
Virulence factor |
MUTATION: z2176 mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
ydeK |
Escherichia coli O157:H7 str. EDL933 |
960656
|
|
15801627
|
Z2195 |
AE005174 |
NP_287644 |
putative lipoprotein |
Virulence factor |
MUTATION: ydeK mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z2203 |
Escherichia coli O157:H7 str. EDL933 |
960662
|
|
15801633
|
Z2203 |
AE005174 |
NP_287650 |
putative fimbrial usher protein |
Virulence factor |
MUTATION: Z2203 mutation is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z2205 |
Escherichia coli O157:H7 str. EDL933 |
960664
|
|
15801635
|
Z2205 |
AE005174 |
NP_287652 |
putative fimbrial-like protein |
Virulence factor |
MUTATION: z2205 mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z2207 |
Escherichia coli O157:H7 str. EDL933 |
960666
|
|
15801637
|
Z2207 |
AE005174 |
NP_287654 |
putative oxidoreductase |
Virulence factor |
MUTATION: z2207 mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
yddA |
Escherichia coli O157:H7 str. EDL933 |
960672
|
|
15801642
|
Z2212 |
AE005174 |
NP_287659 |
putative ATP-binding component of a transport system |
Virulence factor |
MUTATION: yddA mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z5214 |
Escherichia coli O157:H7 str. EDL933 |
960719
|
|
15804316
|
Z5214 |
AE005174 |
NP_290355 |
hypothetical protein |
Virulence factor |
MUTATION: Z5214 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z5212 |
Escherichia coli O157:H7 str. EDL933 |
960725
|
|
15804314
|
Z5212 |
AE005174 |
NP_290353 |
hypothetical protein |
Virulence factor |
MUTATION: Z5212 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z5131 |
Escherichia coli O157:H7 str. EDL933 |
960841
|
|
15804240
|
Z5131 |
AE005174 |
NP_290279 |
hypothetical protein |
Virulence factor |
MUTATION: Z5131 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
escC |
Escherichia coli O157:H7 str. EDL933 |
960846
|
|
15804236
|
Z5126 |
AE005174 |
NP_290275 |
hypothetical protein |
Virulence factor |
MUTATION: escC mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z5121 |
Escherichia coli O157:H7 str. EDL933 |
960851
|
|
15804231
|
Z5121 |
AE005174 |
NP_290270 |
hypothetical protein |
Virulence factor |
MUTATION: z5121(st22) mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
escV |
Escherichia coli O157:H7 str. EDL933 |
960852
|
|
15804230
|
Z5120 |
AE005174 |
NP_290269 |
hypothetical protein |
Virulence factor |
MUTATION: escV mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
escN from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
960853
|
|
15804229
|
Z5119 |
|
NP_290268.1 |
escN |
Virulence factor |
MUTATION: deletion of escN abolished pathogenicity in infant rabbits compared to wild-type EHEC [Ref6664:Ritchie and Waldor, 2005]. |
15731044
|
|
|
sepQ |
Escherichia coli O157:H7 str. EDL933 |
960856
|
|
15804226
|
Z5116 |
AE005174 |
NP_290265 |
hypothetical protein |
Virulence factor |
MUTATION: sepQ mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z5114 |
Escherichia coli O157:H7 str. EDL933 |
960858
|
|
15804224
|
Z5114 |
AE005174 |
NP_290263 |
hypothetical protein |
Virulence factor |
MUTATION: Z5114 (cesF) mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
tir from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
960860
|
|
15804222
|
Z5112 |
|
NP_290261.1 |
putative translocated intimin receptor protein |
Virulence factor |
MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture [Ref6665:Schüller et al., 2007]. |
17474908
|
|
|
eae from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
960862
|
|
15804220
|
Z5110 |
|
NP_290259.1 |
intimin adherence protein |
Virulence factor |
MUTATION: attenuated in humans [Ref6666:Donnenberg et al., 1993]. |
8376594
|
|
|
espA from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
960865
|
|
15804217
|
Z5107 |
|
NP_290256.1 |
secreted protein EspA |
Virulence factor |
MUTATION: deletion of espA in STEC abolished ability to attach to HeLa cells and induce actin rearrangements [Ref6667:Ebel et al., 1998]. |
9786192
|
|
|
espD from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
960866
|
|
15804216
|
Z5106 |
|
NP_290255.1 |
secreted protein EspD |
Virulence factor |
MUTATION: espD deletion mutant of the enterohemorrhagic E. coli (EHEC) strain EDL933 had impaired attachment to HeLa cells [Ref6668:Kresse et al., 1999]. |
10456938
|
|
|
espB from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
960867
|
|
15804215
|
Z5105 |
|
NP_290254.1 |
secreted protein EspB |
Virulence factor |
MUTATION: deletion mutant attenuated in humans compared to wild-type EPEC [Ref6669:Tacket et al., 2000]. |
10816529
|
|
|
espF from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
960871
|
|
15804211
|
Z5100 |
|
NP_290250.1 |
espF |
Virulence factor |
MUTATION: espF EPEC mutant is deficient in its ability to disrupt electrical resistance across a polarized monolayer of intestinal epithelial cells, suggesting that EspF is an effector molecule required for disrupting intestinal epithelial barrier function [Ref6670:McNamara et al., 2001]. |
11238563
|
|
|
yibD |
Escherichia coli |
960931
|
|
15804159
|
Z5042 |
|
NP_290198.1 |
predicted glycosyl transferase |
Virulence factor |
MUTATION: yibD mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
rhsA |
Escherichia coli O157:H7 str. EDL933 |
960959
|
|
15804134
|
Z5014 |
AE005174 |
NP_290173 |
rhsA protein in rhs element |
Virulence factor |
MUTATION: rhsA mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
hrpA |
Escherichia coli O157:H7 str. EDL933 |
961000
|
|
15801734
|
Z2313 |
AE005174 |
NP_287752 |
ATP-dependent RNA helicase HrpA |
Virulence factor |
MUTATION: hrpA mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z2318 |
Escherichia coli O157:H7 str. EDL933 |
961004
|
|
15801738
|
Z2318 |
AE005174 |
NP_287756 |
putative phosphatidate cytidiltransferase |
Virulence factor |
MUTATION: Z2318 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
dppA from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
961074
|
|
15804087
|
Z4961 |
|
NP_290125.1 |
dipeptide transport protein |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
dctA |
Escherichia coli O157:H7 str. EDL933 |
961092
|
|
15804072
|
Z4942 |
AE005174 |
NP_290108 |
C4-dicarboxylate transporter DctA |
Virulence factor |
MUTATION: dctA mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z2368 |
Escherichia coli O157:H7 str. EDL933 |
961108
|
|
15801782
|
Z2368 |
AE005174 |
NP_287800 |
hypothetical protein |
Virulence factor |
MUTATION: Z2368 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
chuA from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
961176
|
|
15804044
|
Z4911 |
|
NP_290080.1 |
outer membrane heme/hemoglobin receptor |
Virulence factor |
MUTATION: chuA mutant unable to grow on iron-depleted medium containing heme [Ref6653:Torres and Payne, 1997]. |
9157252
|
|
|
yhiJ |
Escherichia coli |
961212
|
|
15804024
|
Z4887 |
|
NP_290060.1 |
hypothetical protein |
Virulence factor |
MUTATION: yhiJ mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z3620 |
Escherichia coli O157:H7 str. EDL933 |
961230
|
|
15802901
|
Z3620 |
AE005174 |
NP_288928 |
hypothetical protein |
Virulence factor |
MUTATION: Z3620 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
ycjV |
Escherichia coli O157:H7 str. EDL933 |
961311
|
|
15801852
|
Z2463 |
AE005174 |
NP_287870 |
putative ATP-binding component of a transport system |
Virulence factor |
MUTATION: ycjV mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
acnA |
Escherichia coli O157:H7 str. EDL933 |
961382
|
|
15801901
|
Z2532 |
AE005174 |
NP_287921 |
aconitate hydratase |
Virulence factor |
MUTATION: acnA mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
trpB |
Escherichia coli O157:H7 str. EDL933 |
961399
|
|
15801917
|
Z2550 |
AE005174 |
NP_287938 |
tryptophan synthase subunit beta |
Virulence factor |
MUTATION: trpB mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z6010 |
Escherichia coli O157:H7 str. EDL933 |
961413
|
|
15801929
|
Z6010 |
AE005174 |
NP_287950 |
hypothetical protein |
Virulence factor |
MUTATION: Z6010 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
trkA |
Escherichia coli O157:H7 str. EDL933 |
961474
|
|
15803817
|
Z4660 |
AE005174 |
NP_289851 |
potassium transporter peripheral membrane component |
Virulence factor |
MUTATION: trkA mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z2702 |
Escherichia coli O157:H7 str. EDL933 |
961645
|
|
15802086
|
Z2702 |
AE005174 |
NP_288108 |
hypothetical protein |
Virulence factor |
MUTATION: Z2702 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z2749 |
Escherichia coli O157:H7 str. EDL933 |
961691
|
|
15802132
|
Z2749 |
AE005174 |
NP_288154 |
hypothetical protein |
Virulence factor |
MUTATION: z2749 mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
Z2751 |
Escherichia coli O157:H7 str. EDL933 |
961692
|
|
15802133
|
Z2751 |
AE005174 |
NP_288155 |
hypothetical protein |
Virulence factor |
MUTATION: z2751 mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
celF |
Escherichia coli O157:H7 str. EDL933 |
961704
|
|
15802145
|
Z2764 |
AE005174 |
NP_288167 |
6-phospho-beta-glucosidase |
Virulence factor |
MUTATION: celF mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
cspC |
Escherichia coli O157:H7 str. EDL933 |
961796
|
|
15802236
|
Z2868 |
AE005174 |
NP_288259 |
cold shock-like protein CspC |
Virulence factor |
MUTATION: cspC mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z2984 |
Escherichia coli O157:H7 str. EDL933 |
961896
|
|
15802336
|
Z2984 |
AE005174 |
NP_288362 |
putative serine acetlyltransferase of prophage CP-933T |
Virulence factor |
MUTATION: Z2984 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
sdiA |
Escherichia coli O157:H7 str. EDL933 |
961914
|
|
15802351
|
Z3004 |
AE005174 |
NP_288377 |
DNA-binding transcriptional activator SdiA |
Virulence factor |
MUTATION: sidA mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
fliC from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
961921
|
|
15802358
|
Z3013 |
|
NP_288384.1 |
flagellin |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
yedL |
Escherichia coli |
961931
|
|
15802367
|
Z3022 |
|
NP_288393.1 |
hypothetical protein |
Virulence factor |
MUTAITON: yedL mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z3023 |
Escherichia coli O157:H7 str. EDL933 |
961932
|
|
15802368
|
Z3023 |
AE005174 |
NP_288394 |
putative secreted protein |
Virulence factor |
MUTATION: Z3023 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z3026 |
Escherichia coli O157:H7 str. EDL933 |
961934
|
|
15802370
|
Z3026 |
GN097348 |
NP_288396 |
putative secreted protein |
Virulence factor |
MUTATION: Z3026 mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
Z3062 |
Escherichia coli O157:H7 str. EDL933 |
961974
|
|
15802403
|
Z3062 |
AE005174 |
NP_288429 |
hypothetical protein |
Virulence factor |
MUTATION: z3062 mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
manB from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
962089
|
|
15802510
|
Z3194 |
|
NP_288536.1 |
phosphomannomutase |
Virulence factor |
MUTATION: manB mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
manC |
Escherichia coli O157:H7 str. EDL933 |
962090
|
|
15802511
|
Z3195 |
AE005174 |
NP_288537 |
mannose-1-P guanosyltransferase |
Virulence factor |
MUTATION: manC mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
fcI |
Escherichia coli O157:H7 str. EDL933 |
962092
|
|
15802513
|
Z3197 |
AE005174 |
NP_288539 |
fucose synthetase |
Virulence factor |
MUTATION: fcl mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
wbdP |
Escherichia coli O157:H7 str. EDL933 |
962094
|
|
15802515
|
Z3199 |
AE005174 |
NP_288541 |
glycosyl transferase |
Virulence factor |
MUTATION: wbdP mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
per |
Escherichia coli O157:H7 str. EDL933 |
962095
|
|
15802516
|
Z3200 |
AE005174 |
NP_288542 |
perosamine synthetase |
Virulence factor |
MUTATION: per mutant is attenuated in calves [Ref6662:Dziva et al., 2004]. |
15528651
|
|
|
iutA from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6143094
|
|
170680936
|
EcSMS35_3178 |
|
YP_001745168.1 |
ferric aerobactin receptor IutA |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
rfaH from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6143458
|
|
170682425
|
EcSMS35_4222 |
|
YP_001746174.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
iucB from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6144084
|
|
170681805
|
EcSMS35_3181 |
|
YP_001745171.1 |
aerobactin siderophore biosynthesis protein IucB |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
dsbA from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6144184
|
|
170681207
|
EcSMS35_4241 |
|
YP_001746187.1 |
thiol:disulfide interchange protein DsbA |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
dppA from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6144283
|
|
170679624
|
EcSMS35_3863 |
|
YP_001745830.1 |
dipeptide ABC transporter, periplasmic dipeptide-binding protein |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
fliC from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6144795
|
|
170682489
|
EcSMS35_1258 |
|
YP_001743319.1 |
flagellin FliC |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
tonB from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6145010
|
|
170681605
|
EcSMS35_1880 |
|
YP_001743934.1 |
outer membrane receptor-mediated transport energizer protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
iucD from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6145117
|
|
170682870
|
EcSMS35_3179 |
|
YP_001745169.1 |
L-lysine 6-monooxygenase IucD |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
fimH from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6145732
|
|
170681950
|
EcSMS35_4847 |
|
YP_001746758.1 |
protein FimH |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
iucA from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6145998
|
|
170683655
|
EcSMS35_3182 |
|
YP_001745172.1 |
aerobactin siderophore biosynthesis protein IucA |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
aslA from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6146022
|
|
170681296
|
EcSMS35_4166 |
|
YP_001746117.1 |
arylsulfatase |
Virulence factor |
MUTATION: disruption mutant was less invasive in an in vitro HBMEC invasion assay than the wild-type E. coli K1 [Ref6657:Hoffman et al., 2000]. |
10948126
|
|
|
ompA from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6146246
|
|
170681860
|
EcSMS35_2163 |
|
YP_001744213.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
ibeA from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6146360
|
|
170682712
|
EcSMS35_4868 |
|
YP_001746779.1 |
invasion protein IbeA |
Virulence factor |
MUTATION: deletion mutant was significantly less invasive in human brain microvascular endothelial cells (BMECs) than the parent strain (E. coli K1) [Ref6647:Huang et al., 2001]. |
11237832
|
|
|
chuA from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6146648
|
|
170681293
|
EcSMS35_3802 |
|
YP_001745768.1 |
outer membrane heme/hemoglobin receptor ChuA |
Virulence factor |
MUTATION: chuA mutant unable to grow on iron-depleted medium containing heme [Ref6653:Torres and Payne, 1997]. |
9157252
|
|
|
iucC from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6147083
|
|
170679922
|
EcSMS35_3180 |
|
YP_001745170.1 |
aerobactin siderophore biosynthesis protein IucC |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
traJ from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6106483
|
|
170650783
|
EcSMS35_A0041 |
|
YP_001739929.1 |
type IV secretion-like conjugative transfer system regulator TraJ |
Virulence factor |
MUTATION: traJ mutants of E. coli K1 are attenuated in rat pups and macrophages [Ref6671:Hill et al., 2004]. |
14688129
|
|
|
traT from Escherichia coli SMS-3-5 |
Escherichia coli SMS-3-5 |
6106527
|
|
170650825
|
EcSMS35_A0012 |
|
YP_001739900.1 |
type IV secretion-like conjugative transfer system complement resistance protein TraT |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
ompA from Escherichia coli str. K-12 substr. MG1655 |
Escherichia coli str. K-12 substr. MG1655 |
945571
|
|
16128924
|
b0957 |
|
NP_415477.1 |
outer membrane protein A (3a;II*;G;d) |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
tonB from Escherichia coli str. K-12 substr. MG1655 |
Escherichia coli str. K-12 substr. MG1655 |
945843
|
|
16129213
|
b1252 |
|
NP_415768.1 |
membrane spanning protein in TonB-ExbB-ExbD complex |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
cusC |
Escherichia coli str. K-12 substr. MG1655 |
946288
|
|
16128555
|
b0572 |
U00096 |
NP_415104 |
copper/silver efflux system, outer membrane component |
Virulence factor |
MUTATION: ibeB mutant is unable to invade BMEC and was attenuated in a newborn rat model [Ref6672:Huang et al., 1999]. |
10225861
|
|
|
dppA from Escherichia coli str. K-12 substr. MG1655 |
Escherichia coli str. K-12 substr. MG1655 |
948062
|
|
16131416
|
b3544 |
|
NP_418001.1 |
dipeptide transporter |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
rfaL |
Escherichia coli str. K-12 substr. MG1655 |
948148
|
|
16131493
|
b3622 |
U00096 |
NP_418079 |
O-antigen ligase |
Virulence factor |
MUTATION: rfaL mutant is attenuated in rats [Ref6673:Gonzalez et al., 2001]. |
11430402
|
|
|
setC |
Escherichia coli str. K-12 substr. MG1655 |
948177
|
|
16131529
|
b3659 |
U00096 |
NP_418115 |
predicted sugar efflux system |
Virulence factor |
MUTATION: yicK mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
rfaH from Escherichia coli str. K-12 substr. MG1655 |
Escherichia coli str. K-12 substr. MG1655 |
948327
|
|
16131688
|
b3842 |
|
NP_418284.1 |
DNA-binding transcriptional antiterminator |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
dsbA from Escherichia coli str. K-12 substr. MG1655 |
Escherichia coli str. K-12 substr. MG1655 |
948353
|
|
16131701
|
b3860 |
|
NP_418297.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
yijP |
Escherichia coli str. K-12 substr. MG1655 |
948458
|
|
16131793
|
b3955 |
U00096 |
NP_418390 |
conserved inner membrane protein |
Virulence factor |
MUTATION: yijP mutant had reduced invasion of BMEC [Ref6674:Wang et al., 1999]. |
10456927
|
|
|
fimH from Escherichia coli str. K-12 substr. MG1655 |
Escherichia coli str. K-12 substr. MG1655 |
948847
|
|
16132141
|
b4320 |
|
NP_418740.1 |
minor component of type 1 fimbriae |
Virulence factor |
MUTATION: attenuated in humans and mice [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
aslA from Escherichia coli str. K-12 substr. MG1655 |
Escherichia coli str. K-12 substr. MG1655 |
949015
|
|
16131653
|
b3801 |
|
NP_418245.1 |
acrylsulfatase-like enzyme |
Virulence factor |
MUTATION: disruption mutant was less invasive in an in vitro HBMEC invasion assay than the wild-type E. coli K1 [Ref6657:Hoffman et al., 2000]. |
10948126
|
|
|
fliC from Escherichia coli str. K-12 substr. MG1655 |
Escherichia coli str. K-12 substr. MG1655 |
949101
|
|
16129870
|
b1923 |
|
NP_416433.1 |
flagellar filament structural protein (flagellin) |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
dsbA from Escherichia coli str. K-12 substr. DH10B |
Escherichia coli str. K-12 substr. DH10B |
6058256
|
|
170083333
|
ECDH10B_4049 |
|
YP_001732653.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
tonB from Escherichia coli str. K-12 substr. DH10B |
Escherichia coli str. K-12 substr. DH10B |
6058282
|
|
170080929
|
ECDH10B_1367 |
|
YP_001730249.1 |
membrane spanning protein in TonB-ExbB-ExbD complex |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
dppA from Escherichia coli str. K-12 substr. DH10B |
Escherichia coli str. K-12 substr. DH10B |
6058698
|
|
170083053
|
ECDH10B_3723 |
|
YP_001732373.1 |
dipeptide transporter; periplasmic-binding component of ABC superfamily |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
rfaH from Escherichia coli str. K-12 substr. DH10B |
Escherichia coli str. K-12 substr. DH10B |
6058984
|
|
170083320
|
ECDH10B_4031 |
|
YP_001732640.1 |
DNA-binding transcriptional antiterminator |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
ompA from Escherichia coli str. K-12 substr. DH10B |
Escherichia coli str. K-12 substr. DH10B |
6060328
|
|
170080615
|
ECDH10B_1027 |
|
YP_001729935.1 |
outer membrane protein A (3a;II*;G;d) |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
aslA from Escherichia coli str. K-12 substr. DH10B |
Escherichia coli str. K-12 substr. DH10B |
6061059
|
|
170083285
|
ECDH10B_3991 |
|
YP_001732605.1 |
acrylsulfatase-like enzyme |
Virulence factor |
MUTATION: disruption mutant was less invasive in an in vitro HBMEC invasion assay than the wild-type E. coli K1 [Ref6657:Hoffman et al., 2000]. |
10948126
|
|
|
toxB from Escherichia coli O157:H7 str. Sakai |
Escherichia coli O157:H7 str. Sakai |
1789667
|
|
10955324
|
pO157p58 |
|
NP_052665.1 |
toxin B |
Virulence factor |
MUTATION: toxB mutants had attenuated adherence to Caco-2 cells [Ref6675:Tatsuno et al., 2001]. |
11598035
|
|
|
hlyA from Escherichia coli O157:H7 str. Sakai |
Escherichia coli O157:H7 str. Sakai |
1789686
|
|
10955283
|
pO157p18 |
|
NP_052624.1 |
hemolysin A |
Virulence factor |
MUTATION: attenuated in zebra fish [Ref6655:Wiles et al., 2009]. |
20019794
|
|
|
hlyC from Escherichia coli O157:H7 str. Sakai |
Escherichia coli O157:H7 str. Sakai |
1789689
|
|
10955282
|
pO157p17 |
|
NP_052623.1 |
hemolysin C |
Virulence factor |
MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells [Ref6656:Stanley et al., 1996]. |
8793877
|
|
|
espP from Escherichia coli O157:H7 str. Sakai |
Escherichia coli O157:H7 str. Sakai |
1789732
|
|
10955344
|
pO157p78 |
|
NP_052685.1 |
EspP |
Virulence factor |
MUTATION: espP mutant is attenuated in calves [Ref6676:Dziva et al., 2007]. |
17451446
|
|
|
traJ from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
5616535
|
|
157418110
|
APECO1_O1CoBM27 |
|
YP_001481182.1 |
positive regulator of conjugative transfer; similar to AAO49515 |
Virulence factor |
MUTATION: traJ mutants of E. coli K1 are attenuated in rat pups and macrophages [Ref6671:Hill et al., 2004]. |
14688129
|
|
|
traT from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
5616563
|
|
157418138
|
APECO1_O1CoBM55 |
|
YP_001481210.1 |
surface exclusion and complement resistance protein; similar to AAT85681; identified by match to protein family HMM PF05818 |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
tsh |
Escherichia coli APEC O1 |
5616581
|
|
157418156
|
APECO1_O1CoBM73 |
DQ381420 |
YP_001481228 |
Tsh |
Virulence factor |
MUTATION: tsh mutant is attenuated in chickens [Ref6677:Chen et al., 2008]. |
18589815
|
|
|
iroN from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
5616645
|
|
157418221
|
APECO1_O1CoBM137 |
|
YP_001481293.1 |
salmochelin siderophore system, salmochelin receptor; similar to AAS80269; identified by match to protein family HMM PF00593 |
Virulence factor |
MUTATION: iroA gene cluster mutants were unable to resist Lcn2 in mouse serum [Ref6232:Fischbach et al., 2006]. |
17060628
|
|
|
iroD from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
5616647
|
|
157418223
|
APECO1_O1CoBM139 |
|
YP_001481295.1 |
salmochelin siderophore system, ferric enterochelin esterase; similar to AAS80267; identified by match to protein family HMM PF |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroC from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
5616648
|
|
157418224
|
APECO1_O1CoBM140 |
|
YP_001481296.1 |
salmochelin siderophore system, ATP-binding cassette; similar to AAP41471; identified by match to protein family HMM PF00005 |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroB from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
5616649
|
|
157418225
|
APECO1_O1CoBM141 |
|
YP_001481297.1 |
salmochelin siderophore system, glycosyltransferase; similar to AAS80265; identified by match to protein family HMM PF06722 |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iutA from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
5616676
|
|
157418252
|
APECO1_O1CoBM168 |
|
YP_001481324.1 |
aerobactin siderophore system, ferric aerobactin receptor protein; similar to ABA54744; identified by match to protein family HMM PF00593 |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
iucD from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
5616677
|
|
157418253
|
APECO1_O1CoBM169 |
|
YP_001481325.1 |
aerobactin siderophore system, L-lysine 6-monooxygenase; similar to CAE55774 |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucC from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
5616678
|
|
157418254
|
APECO1_O1CoBM170 |
|
YP_001481326.1 |
aerobactin siderophore system, aerobactin biosynthesis protein; similar to ABA54742; identified by match to protein family HMMPFO4183 |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucA from Escherichia coli APEC O1 |
Escherichia coli APEC O1 |
5616680
|
|
157418256
|
APECO1_O1CoBM172 |
|
YP_001481328.1 |
aerobactin siderophore system, aerobactin synthetase; similar to ABA54740; identified by match to protein family HMM PF04183 |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
eatA from Escherichia coli E24377A |
Escherichia coli E24377A |
5585855
|
|
157149562
|
EcE24377A_E0051 |
|
YP_001451588.1 |
secreted serine peptidase EatA |
Virulence factor |
MUTATION: interruption of the eatA gene retarded fluid accumulation in the rabbit ileal loop model, suggesting that this autotransporter contributes to the virulence of ETEC [Ref6230:Patel et al., 2004]. |
14977988
|
|
|
traJ from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3996471
|
|
91206349
|
UTI89_P104 |
|
YP_538703.1 |
functional relaxosome complex initiator |
Virulence factor |
MUTATION: traJ mutants of E. coli K1 are attenuated in rat pups and macrophages [Ref6671:Hill et al., 2004]. |
14688129
|
|
|
traT from Escherichia coli UTI89 |
Escherichia coli UTI89 |
3996502
|
|
91206380
|
UTI89_P135 |
|
YP_538734.1 |
surface exclusion outer membrane protein |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
espP from Escherichia coli O157:H7 str. EDL933 |
Escherichia coli O157:H7 str. EDL933 |
3683719
|
|
75994466
|
L7020 |
|
YP_325580.1 |
putative exoprotein-precursor |
Virulence factor |
MUTATION: espP mutant is attenuated in calves [Ref6676:Dziva et al., 2007]. |
17451446
|
|
|
EHEC-hlyC |
Escherichia coli O157:H7 str. EDL933 |
3683746
|
|
75994493
|
L7047 |
AF074613 |
YP_325607 |
hemolysin transport protein |
Virulence factor |
MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells [Ref6656:Stanley et al., 1996]. |
8793877
|
|
|
EHEC-hlyA |
Escherichia coli O157:H7 str. EDL933 |
3683747
|
|
75994494
|
L7048 |
AF074613 |
YP_325608 |
hemolysin toxin protein |
Virulence factor |
MUTATION: hlyA mutant is attenuated in calves [Ref6663:van et al., 2005]. |
15731074
|
|
|
traT |
Escherichia coli |
2716459
|
|
41057009
|
pC15-1a_084 |
FJ449539 |
NP_957629 |
conjugal transfer surface exclusion protein TraT |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
tir |
Escherichia coli |
2716469
|
|
41057025
|
pC15-1a_100 |
AF550679 |
NP_957645 |
hypothetical protein |
Virulence factor |
MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture [Ref6665:Schüller et al., 2007]. |
17474908
|
|
|
traT |
Escherichia coli |
1446509
|
|
32470006
|
p165897_034 |
|
NP_862946.1 |
TraT |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
tir |
Escherichia coli |
1446522
|
|
32470019
|
p165897_049 |
|
NP_862961.1 |
Tir |
Virulence factor |
MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture [Ref6665:Schüller et al., 2007]. |
17474908
|
|
|
traT from Escherichia coli E24377A |
Escherichia coli E24377A |
5585733
|
|
157149414
|
EcE24377A_C0002 |
|
YP_001451443.1 |
TraT complement resistance protein |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
eltA from Escherichia coli E24377A |
Escherichia coli E24377A |
5585630
|
|
157149353
|
EcE24377A_F0020 |
|
YP_001451390.1 |
heat-labile enterotoxin A |
Virulence factor |
MUTATION: Deletion mutants of eltA and eltB had decreased levels of inducing cAMP secretion in an in vitro culture system, and had less adherence to IPEC-J2 and Caco-2 cells than the wild-type ETEC [Ref6678:Johnson et al., 2009]. |
18978047
|
|
|
rfaH from Escherichia coli SE11 |
Escherichia coli SE11 |
7002513
|
|
209921319
|
ECSE_4128 |
|
YP_002295403.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
tonB from Escherichia coli O157:H7 str. EC4115 |
Escherichia coli O157:H7 str. EC4115 |
6967035
|
|
209396499
|
ECH74115_1739 |
|
YP_002270184.1 |
transport protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001] |
11553558
|
|
|
dsbA from Escherichia coli O157:H7 str. EC4115 |
Escherichia coli O157:H7 str. EC4115 |
6967123
|
|
209400816
|
ECH74115_5300 |
|
YP_002273372.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
dppA from Escherichia coli O157:H7 str. EC4115 |
Escherichia coli O157:H7 str. EC4115 |
6967851
|
|
209396782
|
ECH74115_4912 |
|
YP_002273027.1 |
dipeptide ABC transporter, periplasmic dipeptide-binding protein |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
chuA from Escherichia coli O157:H7 str. EC4115 |
Escherichia coli O157:H7 str. EC4115 |
6967853
|
|
209396568
|
ECH74115_4857 |
|
YP_002272975.1 |
outer membrane heme/hemoglobin receptor ChuA |
Virulence factor |
MUTATION: chuA mutant unable to grow on iron-depleted medium containing heme [Ref6653:Torres and Payne, 1997]. |
9157252
|
|
|
rfaH from Escherichia coli O157:H7 str. EC4115 |
Escherichia coli O157:H7 str. EC4115 |
6968671
|
|
209396563
|
ECH74115_5280 |
|
YP_002273359.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
ompA from Escherichia coli O157:H7 str. EC4115 |
Escherichia coli O157:H7 str. EC4115 |
6969157
|
|
209397392
|
ECH74115_1121 |
|
YP_002269625.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
fimH from Escherichia coli O157:H7 str. EC4115 |
Escherichia coli O157:H7 str. EC4115 |
6969617
|
|
209399868
|
ECH74115_5826 |
|
YP_002273845.1 |
protein FimH |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
iroN from Escherichia coli (strain: chi7122, serotype: O78:K80:H9, group: ExPEC, subgroup: APEC) |
Escherichia coli (strain: chi7122, serotype: O78:K80:H9, group: ExPEC, subgroup: APEC) |
7379404
|
|
222104801
|
MM1_0014 |
|
YP_002539290.1 |
IroN, siderophore receptor |
Virulence factor |
MUTATION: iroA gene cluster mutants were unable to resist Lcn2 in mouse serum [Ref6232:Fischbach et al., 2006]. |
17060628
|
|
|
iroD from Escherichia coli (strain: chi7122, serotype: O78:K80:H9, group: ExPEC, subgroup: APEC) |
Escherichia coli (strain: chi7122, serotype: O78:K80:H9, group: ExPEC, subgroup: APEC) |
7379484
|
|
222104799
|
MM1_0011 |
|
YP_002539288.1 |
IroD, ferric enterochelin esterase |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iutA from Escherichia coli (strain: chi7122, serotype: O78:K80:H9, group: ExPEC, subgroup: APEC) |
Escherichia coli (strain: chi7122, serotype: O78:K80:H9, group: ExPEC, subgroup: APEC) |
7379559
|
|
222104883
|
MM1_0096 |
|
YP_002539372.1 |
ferric aerobactin receptor precursor |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
iucC from Escherichia coli (strain: chi7122, serotype: O78:K80:H9, group: ExPEC, subgroup: APEC) |
Escherichia coli (strain: chi7122, serotype: O78:K80:H9, group: ExPEC, subgroup: APEC) |
7379561
|
|
222104885
|
MM1_0098 |
|
YP_002539374.1 |
aerobactin siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucB from Escherichia coli (strain: chi7122, serotype: O78:K80:H9, group: ExPEC, subgroup: APEC) |
Escherichia coli (strain: chi7122, serotype: O78:K80:H9, group: ExPEC, subgroup: APEC) |
7379562
|
|
222104886
|
MM1_0099 |
|
YP_002539375.1 |
IucB |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucA from Escherichia coli (strain: chi7122, serotype: O78:K80:H9, group: ExPEC, subgroup: APEC) |
Escherichia coli (strain: chi7122, serotype: O78:K80:H9, group: ExPEC, subgroup: APEC) |
7379563
|
|
222104887
|
MM1_0100 |
|
YP_002539376.1 |
aerobactin siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucA from Escherichia coli (strain: APEC O103) |
Escherichia coli (strain: APEC O103) |
7324506
|
|
221218526
|
pO103_24 |
|
YP_002527484.1 |
Aerobactin siderophore biosynthesis protein IucA |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucB from Escherichia coli (strain: APEC O103) |
Escherichia coli (strain: APEC O103) |
7324507
|
|
221218527
|
pO103_25 |
|
YP_002527485.1 |
Aerobactin siderophore biosynthesis protein IucB |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucC from Escherichia coli (strain: APEC O103) |
Escherichia coli (strain: APEC O103) |
7324508
|
|
221218528
|
pO103_26 |
|
YP_002527486.1 |
Aerobactin siderophore biosynthesis protein IucC |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucD from Escherichia coli (strain: APEC O103) |
Escherichia coli (strain: APEC O103) |
7324509
|
|
221218529
|
pO103_27 |
|
YP_002527487.1 |
Aerobactin siderophore L-lysine 6-monooxygenase IucD |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iutA from Escherichia coli (strain: APEC O103) |
Escherichia coli (strain: APEC O103) |
7324510
|
|
221218530
|
pO103_28 |
|
YP_002527488.1 |
Aerobactin siderophore ferric receptor protein IutA |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
iroB from Escherichia coli (strain: APEC O103) |
Escherichia coli (strain: APEC O103) |
7324522
|
|
221218540
|
pO103_42 |
|
YP_002527498.1 |
Salmochelin siderophore glycosyltransferase IroB |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroC from Escherichia coli (strain: APEC O103) |
Escherichia coli (strain: APEC O103) |
7324523
|
|
221218541
|
pO103_43 |
|
YP_002527499.1 |
Salmochelin siderophore ATP-binding cassette IroC |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroD from Escherichia coli (strain: APEC O103) |
Escherichia coli (strain: APEC O103) |
7324524
|
|
221218542
|
pO103_44 |
|
YP_002527500.1 |
Salmochelin siderophore ferric enterochelin esterase IroD |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroN from Escherichia coli (strain: APEC O103) |
Escherichia coli (strain: APEC O103) |
7324526
|
|
221218544
|
pO103_46 |
|
YP_002527502.1 |
Salmochelin siderophore receptor protein IroN |
Virulence factor |
MUTATION: iroA gene cluster mutants were unable to resist Lcn2 in mouse serum [Ref6232:Fischbach et al., 2006]. |
17060628
|
|
|
traT from Escherichia coli (strain: APEC O103) |
Escherichia coli (strain: APEC O103) |
7324607
|
|
221218625
|
pO103_127 |
|
YP_002527583.1 |
conjugal transfer surface exclusion protein TraT |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
traT from Escherichia coli (strain: H30, serovar: O26:H11) |
Escherichia coli (strain: H30, serovar: O26:H11) |
7256873
|
|
219586125
|
pO26I_p078 |
|
YP_002456219.1 |
conjugal transfer surface exclusion protein TraT |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
espF from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7061130
|
|
215488961
|
E2348C_3930 |
|
YP_002331392.1 |
LEE-encoded effector EspF |
Virulence factor |
MUTATION: espF mutant of EPEC is deficient in its ability to disrupt electrical resistance across a polarized monolayer of intestinal epithelial cells, suggesting that EspF is an effector molecule required for disrupting intestinal epithelial barrier function [Ref6670:McNamara et al., 2001]. |
11238563
|
|
|
tonB from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7061491
|
|
215486487
|
E2348C_1379 |
|
YP_002328918.1 |
transport protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
rfaH from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7061758
|
|
215489181
|
E2348C_4154 |
|
YP_002331612.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
map from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7061805
|
|
215488973
|
E2348C_3942 |
|
YP_002331404.1 |
LEE-encoded effector Map |
Virulence factor |
MUTATION: map EPEC mutants have significantly reduced levels of invasion of HeLa cells [Ref6817:Jepson et al., 2003]. |
14531893
|
|
|
fliC from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7061913
|
|
215487128
|
E2348C_2041 |
|
YP_002329559.1 |
flagellin |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
fimH from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7062125
|
|
215489644
|
E2348C_4627 |
|
YP_002332075.1 |
minor component of type 1 fimbriae |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
escN from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7062686
|
|
215488979
|
E2348C_3948 |
|
YP_002331410.1 |
translocator EscN |
Virulence factor |
MUTATION: deletion of escN abolished pathogenicity in infant rabbits compared to wild-type EHEC [Ref6664:Ritchie and Waldor, 2005]. |
15731044
|
|
|
ler from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7062691
|
|
215488999
|
E2348C_3968 |
|
YP_002331430.1 |
transcription regulator Ler |
Virulence factor |
MUTATION: ler mutants had less adhesion to HeLa cells, ler is a regulator of many virulence genes in the LEE PAI which are needed for adherence [Ref6818:Torres et al., 2008]. |
18794291
|
|
|
espG from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7062692
|
|
215489001
|
E2348C_3970 |
|
YP_002331432.1 |
LEE-encoded effector EspG |
Virulence factor |
MUTATION: the inhibitory effect of the espG mutant on Cl– uptake in Caco-2 monolayers was significantly attenuated as compared with wild-type EPEC [Ref6819:Gill et al., 2007]. |
17256057
|
|
|
chuA from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7062790
|
|
215488778
|
E2348C_3743 |
|
YP_002331209.1 |
outer membrane heme/hemoglobin receptor |
Virulence factor |
MUTATION: chuA mutant unable to grow on iron-depleted medium containing heme [Ref6653:Torres and Payne, 1997]. |
9157252
|
|
|
ompA from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7063342
|
|
215486075
|
E2348C_0943 |
|
YP_002328506.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
ecpA from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7063831
|
|
215485400
|
E2348C_0249 |
|
YP_002327831.1 |
fimbrillin precursor |
Virulence factor |
MUTATION: ecpA mutant had attenuated adherence to HEp-2 cells compared to the parental EHEC strain [Ref6820:Rendón et al., 2007]. |
17563352
|
|
|
eaeA |
Escherichia coli O127:H6 str. E2348/69 |
7063868
|
|
215488970
|
E2348C_3939 |
|
YP_002331401.1 |
intimin EaeA |
Virulence factor |
MUTATION: attenuated in humans [Ref6666:Donnenberg et al., 1993]. |
8376594
|
|
|
espD from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7063878
|
|
215488966
|
E2348C_3935 |
|
YP_002331397.1 |
translocon EspD |
Virulence factor |
MUTATION: espD deletion mutant of the enterohemorrhagic E. coli (EHEC) strain EDL933 had impaired attachment to HeLa cells [Ref6668:Kresse et al., 1999]. |
10456938
|
|
|
espA from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7063880
|
|
215488967
|
E2348C_3936 |
|
YP_002331398.1 |
translocon EspA |
Virulence factor |
MUTATION: deletion of espA in STEC abolished ability to attach to HeLa cells and induce actin rearrangements [Ref6667:Ebel et al., 1998]. |
9786192
|
|
|
dsbA from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7063974
|
|
215489194
|
E2348C_4167 |
|
YP_002331625.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
espB from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7064346
|
|
215488965
|
E2348C_3934 |
|
YP_002331396.1 |
translocon EspB |
Virulence factor |
MUTATION: deletion mutant attenuated in humans compared to wild-type EPEC [Ref6669:Tacket et al., 2000]. |
10816529
|
|
|
espH from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7064347
|
|
215488975
|
E2348C_3944 |
|
YP_002331406.1 |
LEE-encoded effector EspH |
Virulence factor |
MUTATION: deletion mutant is attenuated in infant rabbits [Ref6664:Ritchie and Waldor, 2005]. |
15731044
|
|
|
tir from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7064348
|
|
215488972
|
E2348C_3941 |
|
YP_002331403.1 |
translocated intimin receptor Tir |
Virulence factor |
MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture [Ref6665:Schüller et al., 2007]. |
17474908
|
|
|
dppA from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7065057
|
|
215488827
|
E2348C_3792 |
|
YP_002331258.1 |
dipeptide transporter |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
papG from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7155270
|
|
218706490
|
ECUMN_3331 |
|
YP_002414009.1 |
Fimbrial PapG protein (P pilus class II adhesin) (PapGII) |
Virulence factor |
MUTATION: attenuated to human neutrophils in vitro [Ref6650:Tewari et al., 1994]. |
7960108
|
|
|
sat from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7155292
|
|
218706521
|
ECUMN_3367 |
|
YP_002414040.1 |
Serine protease precursor (Secreted autotransporter toxin) |
Virulence factor |
MUTATION: Sat elicits cytopathic activity that damages host tissue and may increase the ability of E. coli to propagate [Ref6660:Guyer et al., 2002]. |
12117966
|
|
|
iutA from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7155293
|
|
218706523
|
ECUMN_3371 |
|
YP_002414042.1 |
Ferric aerobactin receptor precursor |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
dppA from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7155420
|
|
218707178
|
ECUMN_4055 |
|
YP_002414697.1 |
dipeptide transporter ; periplasmic-binding component of ABC superfamily |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
aslA from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7155811
|
|
218707435
|
ECUMN_4324 |
|
YP_002414954.1 |
arylsulfatase-like enzyme |
Virulence factor |
MUTATION: disruption mutant was less invasive in an in vitro HBMEC invasion assay than the wild-type E. coli K1 [Ref6657:Hoffman et al., 2000]. |
10948126
|
|
|
chuA from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7155958
|
|
218707130
|
ECUMN_4000 |
|
YP_002414649.1 |
outer membrane hemin receptor |
Virulence factor |
MUTATION: chuA mutant unable to grow on iron-depleted medium containing heme [Ref6653:Torres and Payne, 1997]. |
9157252
|
|
|
fimH from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7156362
|
|
218707987
|
ECUMN_4927 |
|
YP_002415506.1 |
minor component of type 1 fimbriae |
Virulence factor |
MUTATION: attenuated in mice in humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
iucA from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7156875
|
|
218706527
|
ECUMN_3375 |
|
YP_002414046.1 |
aerobactin siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucB from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7156876
|
|
218706526
|
ECUMN_3374 |
|
YP_002414045.1 |
aerobactin siderophore biosynthesis protein, N(6)-hydroxylysine acetylase |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucC from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7156877
|
|
218706525
|
ECUMN_3373 |
|
YP_002414044.1 |
Aerobactin siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucD from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7156878
|
|
218706524
|
ECUMN_3372 |
|
YP_002414043.1 |
L-lysine 6-monooxygenase (Lysine N(6)-hydroxylase) |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
papA from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7157388
|
|
218706498
|
ECUMN_3339 |
|
YP_002414017.1 |
P-fimbriae major subunit precursor |
Virulence factor |
MUTATION: mutant papA in wild-type smooth strains do not mediate Gal-Gal adherence [Ref6648:Johnson, 1991]. |
1672263
|
|
|
rfaH from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7158028
|
|
218707473
|
ECUMN_4366 |
|
YP_002414992.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice |
|
|
|
ecpA from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7158311
|
|
218703573
|
ECUMN_0327 |
|
YP_002411092.1 |
E. coli common pilus (ECP) |
Virulence factor |
MUTATION: ecpA mutant had attenuated adherence to HEp-2 cells compared to the parental EHEC strain [Ref6820:Rendón et al., 2007]. |
17563352
|
|
|
ompA from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7158500
|
|
218704380
|
ECUMN_1146 |
|
YP_002411899.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
tonB from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7158576
|
|
218704775
|
ECUMN_1551 |
|
YP_002412294.1 |
transport protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
dsbA from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7159290
|
|
218707486
|
ECUMN_4384 |
|
YP_002415005.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
ompA from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7149956
|
|
218700524
|
ECIAI39_2190 |
|
YP_002408153.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
tia from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7150281
|
|
218702439
|
ECIAI39_4192 |
|
YP_002410068.1 |
Tia invasion determinant |
Virulence factor |
MUTATION: tia deletion strains were noninvasive and lacked the ability to adhere to human ileocecal cells [Ref6649:Fleckenstein et al., 1996]. |
8675335
|
|
|
chuA from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7150945
|
|
218702265
|
ECIAI39_4002 |
|
YP_002409894.1 |
outer membrane hemin receptor |
Virulence factor |
MUTATION: chuA mutant unable to grow on iron-depleted medium containing heme [Ref6653:Torres and Payne, 1997]. |
9157252
|
|
|
dppA from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7151167
|
|
218702310
|
ECIAI39_4053 |
|
YP_002409939.1 |
dipeptide transporter ; periplasmic-binding component of ABC superfamily |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
fimH from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7151334
|
|
218703019
|
ECIAI39_4793 |
|
YP_002410648.1 |
minor component of type 1 fimbriae |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
fliC from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7151372
|
|
218699513
|
ECIAI39_1132 |
|
YP_002407142.1 |
flagellin |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
papA from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7151788
|
|
0
|
ECIAI39_3404 |
|
- |
pseudo |
Virulence factor |
MUTATION: mutant papA in wild-type smooth strains do not mediate Gal-Gal adherence [Ref6648:Johnson, 1991]. |
1672263
|
|
|
iucB from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7151862
|
|
218701707
|
ECIAI39_3424 |
|
YP_002409336.1 |
aerobactin siderophore biosynthesis protein, N(6)-hydroxylysine acetylase |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucC from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7151863
|
|
218701708
|
ECIAI39_3425 |
|
YP_002409337.1 |
Aerobactin siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucD from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7151864
|
|
218701709
|
ECIAI39_3426 |
|
YP_002409338.1 |
L-lysine 6-monooxygenase (Lysine N(6)-hydroxylase) |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iutA from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7151865
|
|
218701710
|
ECIAI39_3427 |
|
YP_002409339.1 |
Ferric aerobactin receptor precursor |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
papA from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7152332
|
|
218702822
|
ECIAI39_4587 |
|
YP_002410451.1 |
major pilin protein PapA |
Virulence factor |
MUTATION: mutant papA in wild-type smooth strains do not mediate Gal-Gal adherence [Ref6648:Johnson, 1991]. |
1672263
|
|
|
papG from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7152338
|
|
218702830
|
ECIAI39_4595 |
|
YP_002410459.1 |
Fimbrial PapG protein (P pilus class II adhesin) (PapGII) |
Virulence factor |
MUTATION: attenuated to human neutrophils in vitro [Ref6650:Tewari et al., 1994]. |
7960108
|
|
|
tia from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7152341
|
|
218702831
|
ECIAI39_4596 |
|
YP_002410460.1 |
Tia invasion determinant |
Virulence factor |
MUTATION: tia deletion strains were noninvasive and lacked the ability to adhere to human ileocecal cells [Ref6649:Fleckenstein et al., 1996]. |
8675335
|
|
|
aslA from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7152793
|
|
218701288
|
ECIAI39_2989 |
|
YP_002408917.1 |
arylsulfatase-like enzyme |
Virulence factor |
MUTATION: disruption mutant was less invasive in an in vitro HBMEC invasion assay than the wild-type E. coli K1 [Ref6657:Hoffman et al., 2000]. |
10948126
|
|
|
iucA from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7152851
|
|
218701706
|
ECIAI39_3423 |
|
YP_002409335.1 |
aerobactin siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
rfaH from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7153071
|
|
218701455
|
ECIAI39_3155 |
|
YP_002409084.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
tonB from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7153490
|
|
218699959
|
ECIAI39_1589 |
|
YP_002407588.1 |
transport protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
dsbA from Escherichia coli IAI39 |
Escherichia coli IAI39 |
7154218
|
|
218701440
|
ECIAI39_3140 |
|
YP_002409069.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
traJ from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7144273
|
|
218692900
|
p1ECUMN_0115 |
|
YP_002406012.1 |
co,jugation transfer regulator protein |
Virulence factor |
MUTATION: traJ mutants of E. coli K1 are attenuated in rat pups and macrophages [Ref6671:Hill et al., 2004]. |
14688129
|
|
|
traT from Escherichia coli UMN026 |
Escherichia coli UMN026 |
7144350
|
|
218692867
|
p1ECUMN_0081 |
|
YP_002405979.1 |
conjugal transfer surface exclusion protein TraT |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
dppA from Escherichia coli 55989 |
Escherichia coli 55989 |
7145054
|
|
218697257
|
EC55989_3996 |
|
YP_002404924.1 |
dipeptide transporter ; periplasmic-binding component of ABC superfamily |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
iutA from Escherichia coli 55989 |
Escherichia coli 55989 |
7145114
|
|
218697849
|
EC55989_4641 |
|
YP_002405516.1 |
Ferric aerobactin receptor precursor |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
iucA from Escherichia coli 55989 |
Escherichia coli 55989 |
7146638
|
|
218697853
|
EC55989_4645 |
|
YP_002405520.1 |
aerobactin siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucB from Escherichia coli 55989 |
Escherichia coli 55989 |
7146639
|
|
218697852
|
EC55989_4644 |
|
YP_002405519.1 |
aerobactin siderophore biosynthesis protein, N(6)-hydroxylysine acetylase |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucC from Escherichia coli 55989 |
Escherichia coli 55989 |
7146640
|
|
218697851
|
EC55989_4643 |
|
YP_002405518.1 |
Aerobactin siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucD from Escherichia coli 55989 |
Escherichia coli 55989 |
7146641
|
|
218697850
|
EC55989_4642 |
|
YP_002405517.1 |
L-lysine 6-monooxygenase (Lysine N(6)-hydroxylase) |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
rfaH from Escherichia coli 55989 |
Escherichia coli 55989 |
7147756
|
|
218697561
|
EC55989_4317 |
|
YP_002405228.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
ecpA from Escherichia coli 55989 |
Escherichia coli 55989 |
7148058
|
|
218693755
|
EC55989_0297 |
|
YP_002401422.1 |
E. coli common pilus (ECP) |
Virulence factor |
MUTATION: ecpA mutant had attenuated adherence to HEp-2 cells compared to the parental EHEC strain [Ref6820:Rendón et al., 2007]. |
17563352
|
|
|
ompA from Escherichia coli 55989 |
Escherichia coli 55989 |
7148255
|
|
218694432
|
EC55989_1006 |
|
YP_002402099.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
tonB from Escherichia coli 55989 |
Escherichia coli 55989 |
7148346
|
|
218694767
|
EC55989_1350 |
|
YP_002402434.1 |
transport protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
dsbA from Escherichia coli 55989 |
Escherichia coli 55989 |
7149102
|
|
218697574
|
EC55989_4336 |
|
YP_002405241.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
dppA from Escherichia coli ED1a |
Escherichia coli ED1a |
7140515
|
|
218691829
|
ECED1_4223 |
|
YP_002400041.1 |
dipeptide transporter ; periplasmic-binding component of ABC superfamily |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
ecpA from Escherichia coli ED1a |
Escherichia coli ED1a |
7141136
|
|
218688179
|
ECED1_0335 |
|
YP_002396391.1 |
E. coli common pilus (ECP) |
Virulence factor |
MUTATION: ecpA mutant had attenuated adherence to HEp-2 cells compared to the parental EHEC strain [Ref6820:Rendón et al., 2007]. |
17563352
|
|
|
rfaH from Escherichia coli ED1a |
Escherichia coli ED1a |
7141515
|
|
218692134
|
ECED1_4544 |
|
YP_002400346.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
tonB from Escherichia coli ED1a |
Escherichia coli ED1a |
7141983
|
|
218689198
|
ECED1_1406 |
|
YP_002397410.1 |
transport protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
fliC from Escherichia coli ED1a |
Escherichia coli ED1a |
7142129
|
|
218689916
|
ECED1_2188 |
|
YP_002398128.1 |
Flagellin (Phase 1-C flagellin) |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
iucA from Escherichia coli ED1a |
Escherichia coli ED1a |
7142472
|
|
218692458
|
ECED1_4905 |
|
YP_002400670.1 |
aerobactin siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucB from Escherichia coli ED1a |
Escherichia coli ED1a |
7142473
|
|
218692457
|
ECED1_4904 |
|
YP_002400669.1 |
aerobactin siderophore biosynthesis protein, N(6)-hydroxylysine acetylase |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucC from Escherichia coli ED1a |
Escherichia coli ED1a |
7142474
|
|
218692456
|
ECED1_4903 |
|
YP_002400668.1 |
Aerobactin siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucD from Escherichia coli ED1a |
Escherichia coli ED1a |
7142475
|
|
218692455
|
ECED1_4902 |
|
YP_002400667.1 |
L-lysine 6-monooxygenase (Lysine N(6)-hydroxylase) |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
ompA from Escherichia coli ED1a |
Escherichia coli ED1a |
7142711
|
|
218688793
|
ECED1_0980 |
|
YP_002397005.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
dsbA from Escherichia coli ED1a |
Escherichia coli ED1a |
7142882
|
|
218692147
|
ECED1_4561 |
|
YP_002400359.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
iutA from Escherichia coli ED1a |
Escherichia coli ED1a |
7143612
|
|
218692454
|
ECED1_4901 |
|
YP_002400666.1 |
Ferric aerobactin receptor precursor |
Virulence factor |
MUTATION: attenuated in mice. [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
iutA from Escherichia coli S88 |
Escherichia coli S88 |
7119366
|
|
218534486
|
pECS88_0009 |
|
YP_002401016.1 |
Ferric aerobactin receptor precusor IutA |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
iroN from Escherichia coli S88 |
Escherichia coli S88 |
7119392
|
|
218534588
|
pECS88_0124 |
|
YP_002401118.1 |
outer membrane receptor FepA |
Virulence factor |
MUTATION: iroA gene cluster mutants were unable to resist Lcn2 in mouse serum [Ref6232:Fischbach et al., 2006]. |
17060628
|
|
|
iroB from Escherichia coli S88 |
Escherichia coli S88 |
7119430
|
|
218534592
|
pECS88_0128 |
|
YP_002401122.1 |
IroB, putative glucosyltransferase |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroC from Escherichia coli S88 |
Escherichia coli S88 |
7119431
|
|
218534591
|
pECS88_0127 |
|
YP_002401121.1 |
IroC, ATP binding cassette (ABC) transporter homolog |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iroD from Escherichia coli S88 |
Escherichia coli S88 |
7119432
|
|
218534590
|
pECS88_0126 |
|
YP_002401120.1 |
IroD, putative ferric enterochelin esterase |
Virulence factor |
MUTATION: attenuated in chicks [Ref6231:Caza et al., 2008]. |
18541653
|
|
|
iucA from Escherichia coli S88 |
Escherichia coli S88 |
7119436
|
|
218534490
|
pECS88_0013 |
|
YP_002401020.1 |
Aerobactin siderophore biosynthesis protein IucA |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucB from Escherichia coli S88 |
Escherichia coli S88 |
7119437
|
|
218534489
|
pECS88_0012 |
|
YP_002401019.1 |
N(6)-hydroxylysine acetylase IucB |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucC from Escherichia coli S88 |
Escherichia coli S88 |
7119438
|
|
218534488
|
pECS88_0011 |
|
YP_002401018.1 |
Aerobactin siderophore biosynthesis protein IucC |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucD from Escherichia coli S88 |
Escherichia coli S88 |
7119439
|
|
218534487
|
pECS88_0010 |
|
YP_002401017.1 |
L-lysine 6-monooxigenase IucD |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
traJ from Escherichia coli S88 |
Escherichia coli S88 |
7119465
|
|
218534534
|
pECS88_0064 |
|
YP_002401064.1 |
conjugal transfer transcriptional regulator TraJ |
Virulence factor |
MUTATION: traJ mutants of E. coli K1 are attenuated in rat pups and macrophages [Ref6671:Hill et al., 2004]. |
14688129
|
|
|
traT from Escherichia coli S88 |
Escherichia coli S88 |
7119470
|
|
218534560
|
pECS88_0092 |
|
YP_002401090.1 |
conjugal transfer surface exclusion protein TraT |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
fimH from Escherichia coli S88 |
Escherichia coli S88 |
7129499
|
|
218561496
|
ECS88_4938 |
|
YP_002394409.1 |
minor component of type 1 fimbriae |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
aslA from Escherichia coli S88 |
Escherichia coli S88 |
7129944
|
|
218560864
|
ECS88_4222 |
|
YP_002393777.1 |
arylsulfatase-like enzyme |
Virulence factor |
MUTATION: disruption mutant was less invasive in an in vitro HBMEC invasion assay than the wild-type E. coli K1 [Ref6657:Hoffman et al., 2000]. |
10948126
|
|
|
ompA from Escherichia coli S88 |
Escherichia coli S88 |
7130155
|
|
218557855
|
ECS88_0978 |
|
YP_002390768.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
dppA from Escherichia coli S88 |
Escherichia coli S88 |
7130233
|
|
218560622
|
ECS88_3964 |
|
YP_002393535.1 |
dipeptide transporter ; periplasmic-binding component of ABC superfamily |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
ecpA from Escherichia coli S88 |
Escherichia coli S88 |
7130299
|
|
218557210
|
ECS88_0290 |
|
YP_002390123.1 |
E. coli common pilus (ECP) |
Virulence factor |
MUTATION: ecpA mutant had attenuated adherence to HEp-2 cells compared to the parental EHEC strain [Ref6820:Rendón et al., 2007]. |
17563352
|
|
|
dsbA from Escherichia coli S88 |
Escherichia coli S88 |
7130870
|
|
218560936
|
ECS88_4310 |
|
YP_002393849.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
rfaH from Escherichia coli S88 |
Escherichia coli S88 |
7131265
|
|
218560923
|
ECS88_4290 |
|
YP_002393836.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
tonB from Escherichia coli S88 |
Escherichia coli S88 |
7131480
|
|
218558181
|
ECS88_1322 |
|
YP_002391094.1 |
transport protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
chuA from Escherichia coli S88 |
Escherichia coli S88 |
7131907
|
|
218560576
|
ECS88_3913 |
|
YP_002393489.1 |
outer membrane hemin receptor |
Virulence factor |
MUTATION: chuA mutant unable to grow on iron-depleted medium containing heme [Ref6653:Torres and Payne, 1997]. |
9157252
|
|
|
FliC from Escherichia coli S88 |
Escherichia coli S88 |
7132788
|
|
218558781
|
ECS88_1977 |
|
YP_002391694.1 |
flagellin |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
papA from Escherichia coli S88 |
Escherichia coli S88 |
7133169
|
|
218559971
|
ECS88_3265 |
|
YP_002392884.1 |
major pilin protein PapA |
Virulence factor |
MUTATION: mutant papA in wild-type smooth strains do not mediate Gal-Gal adherence [Ref6648:Johnson, 1991]. |
1672263
|
|
|
tia from Escherichia coli S88 |
Escherichia coli S88 |
7133342
|
|
218559962
|
ECS88_3256 |
|
YP_002392875.1 |
Tia invasion determinant |
Virulence factor |
MUTATION: tia deletion strains were noninvasive and lacked the ability to adhere to human ileocecal cells [Ref6649:Fleckenstein et al., 1996]. |
8675335
|
|
|
papG from Escherichia coli S88 |
Escherichia coli S88 |
7133471
|
|
218559963
|
ECS88_3257 |
|
YP_002392876.1 |
Fimbrial PapG protein (P pilus class II adhesin) (PapGII) |
Virulence factor |
MUTATION: attenuated to human neutrophils in vitro [Ref6650:Tewari et al., 1994]. |
7960108
|
|
|
ompA from Escherichia coli IAI1 |
Escherichia coli IAI1 |
7124740
|
|
218553544
|
ECIAI1_0998 |
|
YP_002386457.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
dppA from Escherichia coli IAI1 |
Escherichia coli IAI1 |
7125629
|
|
218556099
|
ECIAI1_3703 |
|
YP_002389012.1 |
dipeptide transporter ; periplasmic-binding component of ABC superfamily |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
rfaH from Escherichia coli IAI1 |
Escherichia coli IAI1 |
7126217
|
|
218556406
|
ECIAI1_4035 |
|
YP_002389320.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
ecpA from Escherichia coli IAI1 |
Escherichia coli IAI1 |
7126700
|
|
218552859
|
ECIAI1_0294 |
|
YP_002385772.1 |
E. coli common pilus (ECP) |
Virulence factor |
MUTATION: ecpA mutant had attenuated adherence to HEp-2 cells compared to the parental EHEC strain [Ref6820:Rendón et al., 2007]. |
17563352
|
|
|
fliC from Escherichia coli IAI1 |
Escherichia coli IAI1 |
7126825
|
|
218554508
|
ECIAI1_2009 |
|
YP_002387421.1 |
flagellin |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
fimH from Escherichia coli IAI1 |
Escherichia coli IAI1 |
7127116
|
|
218556851
|
ECIAI1_4536 |
|
YP_002389765.1 |
minor component of type 1 fimbriae |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
tonB from Escherichia coli IAI1 |
Escherichia coli IAI1 |
7127821
|
|
218553804
|
ECIAI1_1272 |
|
YP_002386717.1 |
transport protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
dsbA from Escherichia coli IAI1 |
Escherichia coli IAI1 |
7128194
|
|
218556419
|
ECIAI1_4059 |
|
YP_002389333.1 |
periplasmic protein disulfide isomerase I |
Virulence factor, Protective antigen |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
bfpE from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7056322
|
|
215276200
|
E2348_P1_009 |
|
YP_002332163.1 |
transmembrane protein |
Virulence factor |
MUTATION: bfpE mutant strain of EPEC fails to form detectable BFP and fails to carry out autoaggregation and localized adherence to HEp-2 epithelial cells in tissue culture [Ref6237:Blank and Donnenberg, 2001]. |
11443077
|
|
|
bfpF from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7056323
|
|
215276201
|
E2348_P1_010 |
|
YP_002332164.1 |
nucleotide binding protein |
Virulence factor |
MUTATION: bfpF mutant colonized the human intestine but was about 200-fold less virulent than the wild-type EPEC [Ref6235:Bieber et al., 1998]. |
9641917
|
|
|
bfpP from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7056324
|
|
215276202
|
E2348_P1_011 |
|
YP_002332165.1 |
prepilin peptidase |
Virulence factor |
MUTATION: mutation in bfpP blocks BFP biogenesis and localized adherence to host cells by EPEC [Ref6238:Anantha et al., 2000]. |
10762251
|
|
|
bfpB from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7056325
|
|
215276196
|
E2348_P1_005 |
|
YP_002332159.1 |
lipoprotein |
Virulence factor |
MUTATION: bfpB mutant EPEC is unable to form BFP which is a major virulence factor of EPEC [Ref6236:Ramer et al., 1996]. |
8932312
|
|
|
bfpA from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7056343
|
|
215276194
|
E2348_P1_003 |
|
YP_002332157.1 |
major pilin structural unit bundlin |
Virulence factor |
MUTATION: bfpA deletion mutant of EPEC was less virulent in humans than the wild-type EPEC [Ref6235:Bieber et al., 1998]. |
9641917
|
|
|
traT from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7056350
|
|
215276226
|
E2348_P1_046 |
|
YP_002332189.1 |
conjugal transfer surface exclusion protein TraT |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
traJ from Escherichia coli O127:H6 str. E2348/69 |
Escherichia coli O127:H6 str. E2348/69 |
7056370
|
|
215276255
|
E2348_P1_075 |
|
YP_002332218.1 |
transcriptional activator |
Virulence factor |
MUTATION: traJ mutants of E. coli K1 are attenuated in rat pups and macrophages [Ref6671:Hill et al., 2004]. |
14688129
|
|
|
toxB from Escherichia coli O26:H- |
Escherichia coli O26:H- |
8715786
|
|
284000161
|
pO26CRL_0032 |
|
YP_003377848.1 |
toxin B |
Virulence factor |
MUTATION: toxB mutants had attenuated adherence to Caco-2 cells [Ref6675:Tatsuno et al., 2001]. |
11598035
|
|
|
hlyC from Escherichia coli O26:H- |
Escherichia coli O26:H- |
8715862
|
|
284000229
|
pO26CRL_0108 |
|
YP_003377916.1 |
hemolysin C |
Virulence factor |
MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells [Ref6656:Stanley et al., 1996]. |
8793877
|
|
|
hlyA from Escherichia coli O26:H- |
Escherichia coli O26:H- |
8715863
|
|
284000230
|
pO26CRL_0109 |
|
YP_003377917.1 |
hemolysin A |
Virulence factor |
MUTATION: attenuated in zebra fish [Ref6655:Wiles et al., 2009]. |
20019794
|
|
|
ompA from Escherichia coli B str. REL606 |
Escherichia coli B str. REL606 |
8175755
|
|
254161071
|
ECB_00961 |
|
YP_003044179.1 |
outer membrane protein A (3a;II*;G;d) |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
dppA from Escherichia coli B str. REL606 |
Escherichia coli B str. REL606 |
8177616
|
|
254163468
|
ECB_03395 |
|
YP_003046576.1 |
dipeptide transporter |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
rfaH from Escherichia coli B str. REL606 |
Escherichia coli B str. REL606 |
8177876
|
|
254163799
|
ECB_03733 |
|
YP_003046907.1 |
transcriptional activator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
dsbA from Escherichia coli B str. REL606 |
Escherichia coli B str. REL606 |
8177889
|
|
254163812
|
ECB_03746 |
|
YP_003046920.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
fimH from Escherichia coli B str. REL606 |
Escherichia coli B str. REL606 |
8178231
|
|
254164241
|
ECB_04189 |
|
YP_003047351.1 |
minor component of type 1 fimbriae |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
tonB from Escherichia coli B str. REL606 |
Escherichia coli B str. REL606 |
8178456
|
|
254161331
|
ECB_01226 |
|
YP_003044439.1 |
membrane spanning protein in TonB-ExbB-ExbD complex |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
traT from Escherichia coli (strain: EC14, pathovar: UPEC, nat-host: Homo sapiens) |
Escherichia coli (strain: EC14, pathovar: UPEC, nat-host: Homo sapiens) |
8381950
|
|
256855359
|
pEC14_110 |
|
YP_003162603.1 |
IncF plasmid conjugative transfer surface exclusion protein TraT |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
tir from Escherichia coli (strain: A, other: UK epidemic CTX-M-producing strain (PFGE-defined); MLST-defined ST131 linea |
Escherichia coli (strain: A, other: UK epidemic CTX-M-producing strain (PFGE-defined); MLST-defined |
8319255
|
|
256367770
|
pEK499_p062 |
|
YP_003108327.1 |
inner membrane protein |
Virulence factor |
MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture [Ref6665:Schüller et al., 2007]. |
17474908
|
|
|
tir from Escherichia coli (strain: D, other: UK epidemic CTX-M-producing strain (PFGE-defined); MLST-defined ST131 linea |
Escherichia coli (strain: D, other: UK epidemic CTX-M-producing strain (PFGE-defined); MLST-defined |
8319157
|
|
256367694
|
pEK516_p77 |
|
YP_003108263.1 |
Tir |
Virulence factor |
MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture [Ref6665:Schüller et al., 2007]. |
17474908
|
|
|
eltA from Escherichia coli ETEC H10407 |
Escherichia coli ETEC H10407 |
8571459
|
|
268507198
|
pEntH10407_p39 |
|
YP_003293997.1 |
heat-labile enterotoxin A subunit |
Virulence factor |
MUTATION: Deletion mutants of eltA and eltB had decreased levels of inducing cAMP secretion in an in vitro culture system, and had less adherence to IPEC-J2 and Caco-2 cells than the wild-type ETEC [Ref6678:Johnson et al., 2009]. |
18978047
|
|
|
eltB |
Escherichia coli ETEC H10407 |
8571464
|
|
268507197
|
pEntH10407_p38 |
AP010910 |
YP_003293996 |
heat-labile enterotoxin B subunit |
Virulence factor |
MUTATION: Deletion mutants of eltA and eltB had decreased levels of inducing cAMP secretion in an in vitro culture system, and had less adherence to IPEC-J2 and Caco-2 cells than the wild-type ETEC [Ref6678:Johnson et al., 2009]. |
18978047
|
|
|
hcpA |
Escherichia coli O157:H7 str. TW14359 |
8214675
|
|
254791243
|
ECSP_0109 |
CP001368 |
YP_003076080 |
putative major pilin subunit |
Virulence factor |
MUTATION: hcpA deletion mutant had attenuated invasion of cultured epithelial cells compared to wild-type EHEC [Ref6836:Xicohtencatl-Cortes et al., 2009]. |
18952791
|
|
|
ecpA from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8214896
|
|
254791452
|
ECSP_0330 |
|
YP_003076289.1 |
Mat fimbrillin |
Virulence factor |
MUTATION: ecpA mutant had attenuated adherence to HEp-2 cells compared to the parental EHEC strain [Ref6820:Rendón et al., 2007]. |
17563352
|
|
|
ompA from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8215629
|
|
254792157
|
ECSP_1063 |
|
YP_003076994.1 |
outer membrane protein A (3a;II*;G;d) |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
espK |
Escherichia coli O157:H7 str. TW14359 |
8216050
|
|
254792564
|
ECSP_1484 |
CP001368 |
YP_003077401 |
non-LEE-encoded type III secreted effector |
Virulence factor |
MUTATION: espK mutant attenuated in calves [Ref6837:Vlisidou et al., 2006]. |
16958848
|
|
|
tonB from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8216210
|
|
254792722
|
ECSP_1644 |
|
YP_003077559.1 |
TonB protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
nleA |
Escherichia coli O157:H7 str. TW14359 |
8216268
|
|
254792777
|
ECSP_1702 |
CP001368 |
YP_003077614 |
non-LEE-encoded type III secreted effector |
Virulence factor |
MUTATION: nelA deletion mutant attenuated in mice [Ref6838:Gruenheid et al., 2004]. |
14982621
|
|
|
fliC from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8217094
|
|
254793574
|
ECSP_2528 |
|
YP_003078411.1 |
flagellar filament structural protein (flagellin) |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
stx2B from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8217818
|
|
254794270
|
ECSP_3252 |
CP001368 |
YP_003079107 |
shiga toxin II subunit B |
Virulence factor |
TOXIN: Stx induces apoptosis in HeLa cells [Ref6661:Cherla et al., 2003]. |
14638419
|
|
|
chuA from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219055
|
|
254795452
|
ECSP_4489 |
|
YP_003080289.1 |
outer membrane heme/hemoglobin receptor |
Virulence factor |
MUTATION: chuA mutant unable to grow on iron-depleted medium containing heme [Ref6653:Torres and Payne, 1997]. |
9157252
|
|
|
dppA from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219101
|
|
254795498
|
ECSP_4535 |
|
YP_003080335.1 |
dipeptide transporter, periplasmic-binding component of ABC superfamily |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
espF from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219231
|
|
254795625
|
ECSP_4665 |
|
YP_003080462.1 |
LEE-encoded type III secreted effector |
Virulence factor |
MUTATION: espF mutant of EPEC is deficient in its ability to disrupt electrical resistance across a polarized monolayer of intestinal epithelial cells, suggesting that EspF is an effector molecule required for disrupting intestinal epithelial barrier function [Ref6670:McNamara et al., 2001]. |
11238563
|
|
|
espB from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219235
|
|
254795629
|
ECSP_4669 |
|
YP_003080466.1 |
secreted protein EspB |
Virulence factor |
MUTATION: deletion mutant attenuated in humans compared to wild-type EPEC [Ref6669:Tacket et al., 2000]. |
10816529
|
|
|
espD from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219236
|
|
254795630
|
ECSP_4670 |
|
YP_003080467.1 |
secreted protein EspD |
Virulence factor |
MUTATION: espD deletion mutant of the enterohemorrhagic E. coli (EHEC) strain EDL933 had impaired attachment to HeLa cells [Ref6668:Kresse et al., 1999]. |
10456938
|
|
|
espA from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219237
|
|
254795631
|
ECSP_4671 |
|
YP_003080468.1 |
secreted protein EspA |
Virulence factor |
MUTATION: deletion of espA in STEC abolished ability to attach to HeLa cells and induce actin rearrangements [Ref6667:Ebel et al., 1998]. |
9786192
|
|
|
eae from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219240
|
|
254795634
|
ECSP_4674 |
|
YP_003080471.1 |
intimin adherence protein |
Virulence factor |
MUTATION: attenuated in humans [Ref6666:Donnenberg et al., 1993]. |
8376594
|
|
|
tir from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219242
|
|
254795636
|
ECSP_4676 |
|
YP_003080473.1 |
translocated intimin receptor protein |
Virulence factor |
MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture [Ref6665:Schüller et al., 2007]. |
17474908
|
|
|
espH from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219245
|
|
254795639
|
ECSP_4679 |
|
YP_003080476.1 |
LEE-encoded type III secreted effector |
Virulence factor |
MUTATION: deletion mutant is attenuated in infant rabbits [Ref6664:Ritchie and Waldor, 2005]. |
15731044
|
|
|
escN from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219249
|
|
254795643
|
ECSP_4683 |
|
YP_003080480.1 |
LEE-encoded type III secretion system factor |
Virulence factor |
MUTATION: deletion of escN abolished pathogenicity in infant rabbits compared to wild-type EHEC [Ref6664:Ritchie and Waldor, 2005]. |
15731044
|
|
|
ler from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219269
|
|
254795663
|
ECSP_4703 |
|
YP_003080500.1 |
locus of enterocyte effacement (LEE)-encoded regulator |
Virulence factor |
MUTATION: ler mutants had less adhesion to HeLa cells, ler is a regulator of many virulence genes in the LEE PAI which are needed for adherence [Ref6818:Torres et al., 2008]. |
18794291
|
|
|
espG from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219270
|
|
254795664
|
ECSP_4704 |
|
YP_003080501.1 |
LEE-encoded type III secreted effector |
Virulence factor |
MUTATION: the inhibitory effect of the espG mutant on Cl– uptake in Caco-2 monolayers was significantly attenuated as compared with wild-type EPEC [Ref6819:Gill et al., 2007]. |
17256057
|
|
|
rfaH from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219461
|
|
254795838
|
ECSP_4895 |
|
YP_003080675.1 |
DNA-binding transcriptional antiterminator |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
dsbA from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219479
|
|
254795851
|
ECSP_4913 |
|
YP_003080688.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
fimH from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8219970
|
|
254796322
|
ECSP_5404 |
|
YP_003081159.1 |
minor fimbrial subunit, D-mannose specific adhesin |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
iucA from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8484733
|
|
260867380
|
ECO111_1293 |
|
YP_003233782.1 |
siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
espG from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8485562
|
|
260869665
|
ECO111_3731 |
|
YP_003236067.1 |
T3SS secreted effector EspG |
Virulence factor |
MUTATION: the inhibitory effect of the espG mutant on Cl– uptake in Caco-2 monolayers was significantly attenuated in as compared with wild-type EPEC |
|
|
|
espF from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8485564
|
|
260869668
|
ECO111_3734 |
|
YP_003236070.1 |
T3SS secreted effector EspF |
Virulence factor |
MUTATION: espF mutant of EPEC is deficient in its ability to disrupt electrical resistance across a polarized monolayer of intestinal epithelial cells, suggesting that EspF is an effector molecule required for disrupting intestinal epithelial barrier function [Ref6670:McNamara et al., 2001]. |
11238563
|
|
|
escN from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8485567
|
|
260869686
|
ECO111_3752 |
|
YP_003236088.1 |
translocator EscN |
Virulence factor |
MUTATION: deletion of escN abolished pathogenicity in infant rabbits compared to wild-type EHEC [Ref6664:Ritchie and Waldor, 2005]. |
15731044
|
|
|
ler from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8485572
|
|
260869706
|
ECO111_3772 |
|
YP_003236108.1 |
transcription regulator Ler |
Virulence factor |
MUTATION: ler mutants had less adhesion to HeLa cells, ler is a regulator of many virulence genes in the LEE PAI which are needed for adherence [Ref6818:Torres et al., 2008]. |
18794291
|
|
|
efa1/lifA from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8485768
|
|
260870884
|
ECO111_5002 |
|
YP_003237286.1 |
Efa1/LifA-like protein |
Virulence factor |
MUTATION: deletion mutant lacks the ability to inhibit lymphokine production and lymphocyte proliferation compared to wild type EPEC [Ref6839:Klapproth et al., 2000]. |
10722613
|
|
|
espB from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8486116
|
|
260869672
|
ECO111_3738 |
|
YP_003236074.1 |
translocon EspB |
Virulence factor |
MUTATION: deletion mutant attenuated in humans compared to wild-type EPEC [Ref6669:Tacket et al., 2000]. |
10816529
|
|
|
espH from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8486117
|
|
260869682
|
ECO111_3748 |
|
YP_003236084.1 |
T3SS secreted effector EspH |
Virulence factor |
MUTATION: deletion mutant is attenuated in infant rabbits [Ref6664:Ritchie and Waldor, 2005]. |
15731044
|
|
|
tir from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8486118
|
|
260869679
|
ECO111_3745 |
|
YP_003236081.1 |
putative translocated intimin receptor Tir |
Virulence factor |
MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture [Ref6665:Schüller et al., 2007]. |
17474908
|
|
|
dppA from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8486355
|
|
260870271
|
ECO111_4360 |
|
YP_003236673.1 |
dipeptide transport protein |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
eae from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8486421
|
|
260869677
|
ECO111_3743 |
|
YP_003236079.1 |
theta intimin |
Virulence factor |
MUTATION: attenuated in humans [Ref6666:Donnenberg et al., 1993]. |
8376594
|
|
|
espD from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8486431
|
|
260869673
|
ECO111_3739 |
|
YP_003236075.1 |
translocon EspD |
Virulence factor |
MUTATION: espD deletion mutant of the enterohemorrhagic E. coli (EHEC) strain EDL933 had impaired attachment to HeLa cells [Ref6668:Kresse et al., 1999]. |
10456938
|
|
|
espA from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8486432
|
|
260869674
|
ECO111_3740 |
|
YP_003236076.1 |
translocon EspA |
Virulence factor |
MUTATION: deletion of espA in STEC abolished ability to attach to HeLa cells and induce actin rearrangements [Ref6667:Ebel et al., 1998]. |
9786192
|
|
|
fimH from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8486516
|
|
260871042
|
ECO111_5176 |
|
YP_003237444.1 |
minor component FimH of type 1 fimbriae |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
fliC from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8486550
|
|
260868515
|
ECO111_2503 |
|
YP_003234917.1 |
flagellin |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
iucB from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8487016
|
|
260867381
|
ECO111_1294 |
|
YP_003233783.1 |
siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucC from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8487017
|
|
260867382
|
ECO111_1295 |
|
YP_003233784.1 |
siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucD from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8487018
|
|
260867383
|
ECO111_1296 |
|
YP_003233785.1 |
siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iutA from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8487019
|
|
260867384
|
ECO111_1297 |
|
YP_003233786.1 |
putative ferric siderophore receptor |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
rfaH from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8488159
|
|
260870564
|
ECO111_4668 |
|
YP_003236966.1 |
DNA-binding transcriptional antiterminator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
map from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8488207
|
|
260869680
|
ECO111_3746 |
|
YP_003236082.1 |
T3SS secreted effector Map |
Virulence factor |
MUTATION: map EPEC mutants have significantly reduced levels of invasion of HeLa cells [Ref6817:Jepson et al., 2003]. |
14531893
|
|
|
ompA from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8488643
|
|
260867129
|
ECO111_1025 |
|
YP_003233531.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
tonB from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8488732
|
|
260868022
|
ECO111_1986 |
|
YP_003234424.1 |
membrane spanning protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
dsbA from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8489430
|
|
260870577
|
ECO111_4681 |
|
YP_003236979.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
iucA from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8479008
|
|
260854496
|
ECO26_1345 |
|
YP_003228387.1 |
siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
espG from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8480236
|
|
260858241
|
ECO26_5250 |
|
YP_003232132.1 |
T3SS secreted effector EspG |
Virulence factor |
MUTATION: the inhibitory effect of the espG mutant on Cl– uptake in Caco-2 monolayers was significantly attenuated as compared with wild-type EPEC [Ref6819:Gill et al., 2007]. |
17256057
|
|
|
espF from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8480244
|
|
260858280
|
ECO26_5289 |
|
YP_003232171.1 |
T3SS secreted effector EspF |
Virulence factor |
MUTATION: espF mutant of EPEC is deficient in its ability to disrupt electrical resistance across a polarized monolayer of intestinal epithelial cells, suggesting that EspF is an effector molecule required for disrupting intestinal epithelial barrier function [Ref6670:McNamara et al., 2001]. |
11238563
|
|
|
efa1/lifA fromEscherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8480245
|
|
260858281
|
ECO26_5291 |
|
YP_003232172.1 |
Efa1/LifA-like protein |
Virulence factor |
MUTATION: deletion mutant lacks the ability to inhibit lymphokine production and lymphocyte proliferation compared to wild type EPEC [Ref6839:Klapproth et al., 2000]. |
10722613
|
|
|
map from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8480654
|
|
260858268
|
ECO26_5277 |
|
YP_003232159.1 |
T3SS secreted effector Map |
Virulence factor |
MUTATION: map EPEC mutants have significantly reduced levels of invasion of HeLa cells [Ref6817:Jepson et al., 2003]. |
14531893
|
|
|
eae from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8480655
|
|
260858271
|
ECO26_5280 |
|
YP_003232162.1 |
intimin |
Virulence factor |
MUTATION: attenuated in humans [Ref6666:Donnenberg et al., 1993]. |
8376594
|
|
|
dppA from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8480894
|
|
260857652
|
ECO26_4638 |
|
YP_003231543.1 |
dipeptide transport protein |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
matB/ecpA from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8480920
|
|
260853523
|
ECO26_0328 |
|
YP_003227414.1 |
putative fimbrillin precursor |
Virulence factor |
MUTATION: ecpA mutant had attenuated adherence to HEp-2 cells compared to the parental EHEC strain [Ref6820:Rendón et al., 2007]. |
17563352
|
|
|
escN from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8480968
|
|
260858262
|
ECO26_5271 |
|
YP_003232153.1 |
T3SS structure protein EscN |
Virulence factor |
MUTATION: deletion of escN abolished pathogenicity in infant rabbits compared to wild-type EHEC [Ref6664:Ritchie and Waldor, 2005]. |
15731044
|
|
|
espD from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8480969
|
|
260858275
|
ECO26_5284 |
|
YP_003232166.1 |
translocator EspD |
Virulence factor |
MUTATION: espD deletion mutant of the enterohemorrhagic E. coli (EHEC) strain EDL933 had impaired attachment to HeLa cells [Ref6668:Kresse et al., 1999]. |
10456938
|
|
|
espB from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8480971
|
|
260858276
|
ECO26_5285 |
|
YP_003232167.1 |
translocator EspB |
Virulence factor |
MUTATION: deletion mutant attenuated in humans compared to wild-type EPEC [Ref6669:Tacket et al., 2000]. |
10816529
|
|
|
ler from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8480973
|
|
260858242
|
ECO26_5251 |
|
YP_003232133.1 |
transcription regulator Ler |
Virulence factor |
MUTATION: ler mutants had less adhesion to HeLa cells, ler is a regulator of many virulence genes in the LEE PAI which are needed for adherence [Ref6818:Torres et al., 2008]. |
18794291
|
|
|
fimH from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8481056
|
|
260858488
|
ECO26_5517 |
|
YP_003232379.1 |
minor component FimH of type 1 fimbriae |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
fliC from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8481090
|
|
260855903
|
ECO26_2815 |
|
YP_003229794.1 |
flagellin |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
iucB from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8481558
|
|
260854497
|
ECO26_1346 |
|
YP_003228388.1 |
siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucC from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8481559
|
|
260854498
|
ECO26_1347 |
|
YP_003228389.1 |
siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iucD from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8481560
|
|
260854499
|
ECO26_1348 |
|
YP_003228390.1 |
siderophore biosynthesis protein |
Virulence factor |
MUTATION: attenuated in mice [Ref6233:de and Martinez, 1988]. |
2973985
|
|
|
iutA from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8481561
|
|
260854500
|
ECO26_1349 |
|
YP_003228391.1 |
putative ferric siderophore receptor |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
tir from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8481750
|
|
260858269
|
ECO26_5278 |
|
YP_003232160.1 |
translocated intimin receptor Tir |
Virulence factor |
MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture [Ref6665:Schüller et al., 2007]. |
17474908
|
|
|
espA from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8482581
|
|
260858274
|
ECO26_5283 |
|
YP_003232165.1 |
translocator EspA |
Virulence factor |
MUTATION: deletion of espA in STEC abolished ability to attach to HeLa cells and induce actin rearrangements [Ref6667:Ebel et al., 1998]. |
9786192
|
|
|
espH from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8482582
|
|
260858266
|
ECO26_5275 |
|
YP_003232157.1 |
T3SS secreted effector EspH |
Virulence factor |
MUTATION: deletion mutant is attenuated in infant rabbits [Ref6664:Ritchie and Waldor, 2005]. |
15731044
|
|
|
rfaH from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8482829
|
|
260857754
|
ECO26_4745 |
|
YP_003231645.1 |
DNA-binding transcriptional antiterminator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
ompA from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8483180
|
|
260854249
|
ECO26_1084 |
|
YP_003228140.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
tonB from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8483275
|
|
260854911
|
ECO26_1764 |
|
YP_003228802.1 |
membrane spanning protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
dsbA from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8483965
|
|
260857741
|
ECO26_4732 |
|
YP_003231632.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
efa1/lifA from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8474155
|
|
260845650
|
ECO103_3564 |
|
YP_003223428.1 |
Efa1/LifA-like protein |
Virulence factor |
MUTATION: deletion mutant lacks the ability to inhibit lymphokine production and lymphocyte proliferation compared to wild type EPEC [Ref6839:Klapproth et al., 2000]. |
10722613
|
|
|
espF from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8474190
|
|
260845679
|
ECO103_3600 |
|
YP_003223457.1 |
T3SS secreted effector EspF |
Virulence factor |
MUTATION: espF mutant of EPEC is deficient in its ability to disrupt electrical resistance across a polarized monolayer of intestinal epithelial cells, suggesting that EspF is an effector molecule required for disrupting intestinal epithelial barrier function [Ref6670:McNamara et al., 2001]. |
11238563
|
|
|
escN from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8474193
|
|
260845697
|
ECO103_3618 |
|
YP_003223475.1 |
translocator EscN |
Virulence factor |
MUTATION: deletion of escN abolished pathogenicity in infant rabbits compared to wild-type EHEC [Ref6664:Ritchie and Waldor, 2005]. |
15731044
|
|
|
ler from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8474199
|
|
260845717
|
ECO103_3638 |
|
YP_003223495.1 |
transcription regulator Ler |
Virulence factor |
MUTATION: ler mutants had less adhesion to HeLa cells, ler is a regulator of many virulence genes in the LEE PAI which are needed for adherence [Ref6818:Torres et al., 2008]. |
18794291
|
|
|
espB from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8474872
|
|
260845683
|
ECO103_3604 |
|
YP_003223461.1 |
translocon EspB |
Virulence factor |
MUTATION: deletion mutant attenuated in humans compared to wild-type EPEC [Ref6669:Tacket et al., 2000]. |
10816529
|
|
|
espH from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8474873
|
|
260845693
|
ECO103_3614 |
|
YP_003223471.1 |
T3SS secreted effector EspH |
Virulence factor |
MUTATION: deletion mutant is attenuated in infant rabbits [Ref6664:Ritchie and Waldor, 2005]. |
15731044
|
|
|
tir from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8474874
|
|
260845690
|
ECO103_3611 |
|
YP_003223468.1 |
translocated intimin receptor Tir |
Virulence factor |
MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture [Ref6665:Schüller et al., 2007]. |
17474908
|
|
|
dppA from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8475113
|
|
260846337
|
ECO103_4276 |
|
YP_003224115.1 |
dipeptide transport protein |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
matB/ecpA from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8475139
|
|
260842499
|
ECO103_0270 |
|
YP_003220277.1 |
putative fimbrillin precursor |
Virulence factor |
MUTATION: ecpA mutant had attenuated adherence to HEp-2 cells compared to the parental EHEC strain [Ref6820:Rendón et al., 2007]. |
17563352
|
|
|
eae from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8475178
|
|
260845688
|
ECO103_3609 |
|
YP_003223466.1 |
intimin epsilon |
Virulence factor |
MUTATION: attenuated in humans [Ref6666:Donnenberg et al., 1993]. |
8376594
|
|
|
espD from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8475188
|
|
260845684
|
ECO103_3605 |
|
YP_003223462.1 |
translocon EspD |
Virulence factor |
MUTATION: espD deletion mutant of the enterohemorrhagic E. coli (EHEC) strain EDL933 had impaired attachment to HeLa cells [Ref6668:Kresse et al., 1999]. |
10456938
|
|
|
espA from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8475189
|
|
260845685
|
ECO103_3606 |
|
YP_003223463.1 |
translocon EspA |
Virulence factor |
MUTATION: deletion of espA in STEC abolished ability to attach to HeLa cells and induce actin rearrangements [Ref6667:Ebel et al., 1998]. |
9786192
|
|
|
fimH from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8475277
|
|
260847136
|
ECO103_5101 |
|
YP_003224914.1 |
minor component FimH of type 1 fimbriae |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
fliC from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8475311
|
|
260844327
|
ECO103_2179 |
|
YP_003222105.1 |
flagellin |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
espG from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8475820
|
|
260845718
|
ECO103_3639 |
|
YP_003223496.1 |
T3SS secreted effector EspG |
Virulence factor |
MUTATION: the inhibitory effect of the espG mutant on Cl– uptake in Caco-2 monolayers was significantly attenuated as compared with wild-type EPEC [Ref6819:Gill et al., 2007]. |
17256057
|
|
|
map from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8476939
|
|
260845691
|
ECO103_3612 |
|
YP_003223469.1 |
T3SS secreted effector Map |
Virulence factor |
MUTATION: map EPEC mutants have significantly reduced levels of invasion of HeLa cells [Ref6817:Jepson et al., 2003]. |
14531893
|
|
|
rfaH from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8477018
|
|
260846384
|
ECO103_4323 |
|
YP_003224162.1 |
DNA-binding transcriptional antiterminator RfaH |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
ompA from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8477375
|
|
260843206
|
ECO103_1003 |
|
YP_003220984.1 |
outer membrane protein A |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
tonB from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8477474
|
|
260843543
|
ECO103_1353 |
|
YP_003221321.1 |
membrane spanning protein TonB |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
dsbA from Escherichia coli O103:H2 str. 12009 |
Escherichia coli O103:H2 str. 12009 |
8478162
|
|
260846371
|
ECO103_4310 |
|
YP_003224149.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
hlyA from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8473051
|
|
260763804
|
ECO26_p1-02 |
|
YP_003237843.1 |
hemolysin A |
Virulence factor |
MUTATION: attenuated in zebra fish [Ref6655:Wiles et al., 2009]. |
20019794
|
|
|
hlyC from Escherichia coli O26:H11 str. 11368 |
Escherichia coli O26:H11 str. 11368 |
8473053
|
|
260763803
|
ECO26_p1-01 |
|
YP_003237842.1 |
hemolysin C |
Virulence factor |
MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells [Ref6656:Stanley et al., 1996]. |
8793877
|
|
|
hlyA from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8470732
|
|
260751837
|
ECO111_p3-02 |
|
YP_003237751.1 |
hemolysin A |
Virulence factor |
MUTATION: attenuated in zebra fish [Ref6655:Wiles et al., 2009]. |
20019794
|
|
|
hlyC from Escherichia coli O111:H- str. 11128 |
Escherichia coli O111:H- str. 11128 |
8470734
|
|
260751836
|
ECO111_p3-01 |
|
YP_003237750.1 |
hemolysin C |
Virulence factor |
MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells [Ref6656:Stanley et al., 1996]. |
8793877
|
|
|
hylC |
Escherichia coli O103:H2 str. 12009 |
8470589
|
|
260718958
|
ECO103_p32 |
AP010959 |
YP_003225099 |
hemolysin C |
Virulence factor |
MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells [Ref6656:Stanley et al., 1996]. |
8793877
|
|
|
hlyC from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8206889
|
|
254667465
|
ECSP_6017 |
|
YP_003082151.1 |
hemolysin transport protein |
Virulence factor |
MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells [Ref6656:Stanley et al., 1996]. |
8793877
|
|
|
hlyA from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8206890
|
|
254667466
|
ECSP_6018 |
|
YP_003082152.1 |
hemolysin toxin protein |
Virulence factor |
MUTATION: attenuated in zebra fish [Ref6655:Wiles et al., 2009]. |
20019794
|
|
|
espP from Escherichia coli O157:H7 str. TW14359 |
Escherichia coli O157:H7 str. TW14359 |
8206968
|
|
254667544
|
ECSP_6096 |
|
YP_003082230.1 |
putative exoprotein-precursor |
Virulence factor |
MUTATION: espP mutant is attenuated in calves [Ref6676:Dziva et al., 2007]. |
17451446
|
|
|
traT from Escherichia coli Vir68 |
Escherichia coli Vir68 |
8164705
|
|
253801054
|
pVir_80 |
|
YP_003034055.1 |
conjugal transfer surface exclusion protein TraT |
Virulence factor |
MUTATION: traT mutants have altered membrane permeability and are sensitive to hydrophobic antibiotics [Ref6228:Sukupolvi and O'Connor, 1987]. |
3323837
|
|
|
hlyC from Escherichia coli Vir68 |
Escherichia coli Vir68 |
8164736
|
|
253801086
|
pVir_111 |
|
YP_003034087.1 |
hemolysin activating protein HlyC |
Virulence factor |
MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells [Ref6656:Stanley et al., 1996]. |
8793877
|
|
|
ompA from Escherichia coli BW2952 |
Escherichia coli BW2952 |
7952946
|
|
238900215
|
BWG_0809 |
|
YP_002926011.1 |
outer membrane protein A (3a;II*;G;d) |
Virulence factor |
MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells [Ref6643:Prasadarao et al., 1999]. |
10531228
|
|
|
dppA from Escherichia coli BW2952 |
Escherichia coli BW2952 |
7953267
|
|
238902633
|
BWG_3233 |
|
YP_002928429.1 |
dipeptide transporter |
Virulence factor |
MUTATION: dppA mutant was attenuated 10- to 50-fold compared to the wild type for colonization of the bladders and kidneys of mice [Ref6641:Haugen et al., 2007]. |
17074858
|
|
|
rfaH from Escherichia coli BW2952 |
Escherichia coli BW2952 |
7953491
|
|
238902915
|
BWG_3518 |
|
YP_002928711.1 |
DNA-binding transcriptional antiterminator |
Virulence factor |
MUTATION: attenuated in mice [Ref6640:Nagy et al., 2002]. |
12117951
|
|
|
fimH from Escherichia coli BW2952 |
Escherichia coli BW2952 |
7954265
|
|
238903413
|
BWG_4018 |
|
YP_002929209.1 |
minor component of type 1 fimbriae |
Virulence factor |
MUTATION: attenuated in mice and humans [Ref6644:Wiles et al., 2008]. |
18482721
|
|
|
tonB from Escherichia coli BW2952 |
Escherichia coli BW2952 |
7954839
|
|
238900485
|
BWG_1081 |
|
YP_002926281.1 |
membrane spanning protein in TonB-ExbB-ExbD complex |
Virulence factor |
MUTATION: attenuated in mice [Ref6234:Torres et al., 2001]. |
11553558
|
|
|
fliC from Escherichia coli BW2952 |
Escherichia coli BW2952 |
7955988
|
|
238901132
|
BWG_1732 |
|
YP_002926928.1 |
flagellar filament structural protein (flagellin) |
Virulence factor |
MUTATION: fliC deletion mutants had reduced adherence in bovine tissue compared to the wild type EHEC and EPEC strains [Ref6642:Erdem et al., 2007]. |
17693516
|
|
|
dsbA from Escherichia coli BW2952 |
Escherichia coli BW2952 |
7956141
|
|
238902928
|
BWG_3531 |
|
YP_002928724.1 |
periplasmic protein disulfide isomerase I |
Virulence factor |
MUTATION: mutation of dsbA led to degradation of bundilin and an absence of localized adherence to host cells in EPEC [Ref6645:Donnenberg et al., 1997]. |
9224871
|
|
|
K1 Capsule |
Escherichia coli |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: K1 mutants were unable to cause meningitis in rats compared to wild type E. coli with a K1 capsule [Ref7302:Kim et al., 1992]. |
1326000
|
|
|
O75 O antigen |
Escherichia coli |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: O75 antigen mutant were were more sensitive to killing by both polymorphonuclear leukocytes (PMNs) and monocytes than the wild type [Ref7304:Burns and Hull, 1999]. |
10417134
|
|
|
K5 capsular antigen |
Escherichia coli |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: K5 deficient mutant is more sensitive to killing by polymorphonuclear leukocytes (PMNs) and monocytes than the wild type [Ref7304:Burns and Hull, 1999]. |
10417134
|
|
|
carA |
Escherichia coli str. K-12 substr. MG1655 |
949025
|
|
16128026
|
b0032 |
U00096 |
NP_414573 |
carbamoyl phosphate synthetase small subunit, glutamine amidotransferase |
Virulence factor |
MUTATION: A carAB mutant is attenuated in turkeys [Ref7338:Kwaga et al., 1994]. |
8063392
|
|
|
carB |
Escherichia coli str. K-12 substr. MG1655 |
944775
|
|
16128027
|
b0033 |
U00096 |
NP_414574 |
carbamoyl-phosphate synthase large subunit |
Virulence factor |
MUTATION: A carAB mutant is attenuated in turkeys [Ref7338:Kwaga et al., 1994]. |
8063392
|
