Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

espF from Escherichia coli O157:H7 str. TW14359

Victor ID 3702
Gene Name espF from Escherichia coli O157:H7 str. TW14359
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. TW14359
NCBI Gene ID 8219231
NCBI Protein GI 254795625
Locus Tag ECSP_4665
Protein Accession YP_003080462.1
Other Database IDs UniProtKB-ID: C6UYK7_ECO5T
UniRef100: UniRef100_O85622
UniRef90: UniRef90_O85622
UniRef50: UniRef50_Q5K5R0
UniParc: UPI00000D00B7
EMBL: CP001368
EMBL-CDS: ACT74386.1
RefSeq_NT: NC_013008.1
EnsemblGenome: EBESCG00000166692.
EnsemblGenome_TRS: EBESCT00000169222
EnsemblGenome_PRO: EBESCP00000155889
GenomeReviews: CP001368_GR
KEGG: etw:ECSP_4665
ProtClustDB: CLSK2393223
Taxonomy ID 544404
Gene Starting Position 4648401
Gene Ending Position 4649147
Gene Strand (Orientation) -
Protein Name LEE-encoded type III secreted effector
DNA Sequence 
>gi|254791136:4648401-4649147 Escherichia coli O157:H7 str. TW14359, complete genome
GTTACCCTTTCTTCGATTGCTCATAGGCAGCTAAATGATCTTTTAATGCCTGTGCAAGGGGCGGTAGTCC
ACTAGGCCCTGTCGGTGGCGGTGGTGCCTGACGGGCGGGCTTAAAACCTAAAGCCTCAGGACCTTTCGAT
TTTTCATAGGCAGCCAAGTGCTCTTTTAATGCCTGTGCAATGGGCGGTAAAGGTCGGGATGCCCCGGATG
CCTGTCCACTTGTCGGTGGCGGCGGTGCCTGACGGGCGGGCTTAAAACCTAAAGCCTCAGGACCTTTCGA
TTTTTCATAGGCAGCCAAGTGCTCTTTTAATGCCTGTGCAATGGGCGGTAAAGGTCGGGATGCCCCGGAT
GCCTGTCCACTTGTCGGTGGCGGCGGTGCCTGACGGGCGGGCTTAAAACCTAAAGCCTCAGGACCTTTCG
ATTTTTCATAGGCAGCCAAGTGCTCTTTTAATGCCTGTGCAATGGGCGGTAAAGGTCGGGATGCCCCGGA
TGCCTGTCCACTTGTCGGTGGCGGCGGTGCCGGACGAGAGGGAGTAAATGAAGTCACCTGGCTGCTCACA
TTAAAAATCGTTCTCGCATTAACATTCGACGAGCCTGGAGAAAAAGGGGAATGAACTTTCACCGGAGTAA
GACGCACGGCCTGAGGGGCTACAGAAAATCCAGTTCCCCCCGCAGAGCTCACTCGACTTGCGATACCTAC
AAGCTGCCGCCCTAGTGTAGAAGCAGCGTTACTAATTCCATTAAGCA
Protein Sequence 
>gi|254795625|ref|YP_003080462.1| LEE-encoded type III effector [Escherichia coli O157:H7 str. TW14359] MLNGISNAASTLGRQLVGIASRVSSAGGTGFSVAPQAVRLTPVKVHSPFSPGSSNVNARTIFNVSSQVTSFTPSRPAPPPPTSGQASGASRPLPPIAQALKEHLAAYEKSKGPEALGFKPARQAPPPPTSGQASGASRPLPPIAQALKEHLAAYEKSKGPEALGFKPARQAPPPPTSGQASGASRPLPPIAQALKEHLAAYEKSKGPEALGFKPARQAPPPPTGPSGLPPLAQALKDHLAAYEQSKKG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: espF mutant of EPEC is deficient in its ability to disrupt electrical resistance across a polarized monolayer of intestinal epithelial cells, suggesting that EspF is an effector molecule required for disrupting intestinal epithelial barrier function (McNamara et al., 2001).
References
McNamara et al., 2001: McNamara BP, Koutsouris A, O'Connell CB, Nougayréde JP, Donnenberg MS, Hecht G. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. The Journal of clinical investigation. 2001; 107(5); 621-629. [PubMed: 11238563].