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hcpA

Victor ID 3692
Gene Name hcpA
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. TW14359
NCBI Gene ID 8214675
NCBI Protein GI 254791243
Locus Tag ECSP_0109
Genbank Accession CP001368
Protein Accession YP_003076080
Other Database IDs UniProtKB-ID: C6UVU2_ECO5T
UniRef100: UniRef100_C3TQE2
UniRef90: UniRef90_P36647
UniRef50: UniRef50_P36647
UniParc: UPI00000D0862
EMBL: CP001368
EMBL-CDS: ACT70004.1
RefSeq_NT: NC_013008.1
EnsemblGenome: EBESCG00000168020.
EnsemblGenome_TRS: EBESCT00000164963
EnsemblGenome_PRO: EBESCP00000158431
GenomeReviews: CP001368_GR
KEGG: etw:ECSP_0109
ProtClustDB: PRK10574
Taxonomy ID 544404
Gene Starting Position 121578
Gene Ending Position 122018
Gene Strand (Orientation) -
Protein Name putative major pilin subunit
Protein pI 4.39
Protein Weight 14401.01
Protein Length 146
DNA Sequence 
>gi|254791136:121578-122018 Escherichia coli O157:H7 str. TW14359 chromosome, complete genome
CTTAGTTGGCGTCATCAAAGCGGAAGACATCTTCGCAGGCTTGCTGCAATGCGCTGTCACTTTGAATATT
GCAGTTGCGCGCCCAGCCGGTGACGCCGTTTGCGTTATCCCAACCTGGCGTCATGACGACGCTTAGCCCA
TTGAGACTTTCTTGCCCGGTCAGCGACACCACGCCCTTTGCCACACTCATGGCTGAAACATAGCGGGTGG
TGGTAGGCGAGGGAATGCCATTGCTGCCACCGTCGCAGGTATCTAATCCACCATGTTCCAGCGCGCACAA
CTCTACGGCGGTACGGTAAGGCACAAAGGTTTGTAGCATGTCGGTGAGTGCGGCTTTGCGCAGGTAGTTT
TGATAAGCGGGAATACCAATGGCGCTTAAAATGGCAATGATGCCAATAACCACCATCAGTTCGATAAGTG
TAAAACCGCGTTGCTTGTCCA
Protein Sequence 
>gi|254791243|ref|YP_003076080.1| putative major pilin subunit [Escherichia coli O157:H7 str. TW14359]
MDKQRGFTLIELMVVIGIIAILSAIGIPAYQNYLRKAALTDMLQTFVPYRTAVELCALEHGGLDTCDGGS
NGIPSPTTTRYVSAMSVAKGVVSLTGQESLNGLSVVMTPGWDNANGVTGWARNCNIQSDSALQQACEDVF
RFDDAN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hcpA deletion mutant had attenuated invasion of cultured epithelial cells compared to wild-type EHEC (Xicohtencatl-Cortes et al., 2009).
COG COG4969NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport
References
Xicohtencatl-Cortes et al., 2009: Xicohtencatl-Cortes J, Monteiro-Neto V, Saldaña Z, Ledesma MA, Puente JL, Girón JA. The type 4 pili of enterohemorrhagic Escherichia coli O157:H7 are multipurpose structures with pathogenic attributes. Journal of bacteriology. 2009; 191(1); 411-421. [PubMed: 18952791].