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espG from Escherichia coli O127:H6 str. E2348/69

Victor ID 3488
Gene Name espG from Escherichia coli O127:H6 str. E2348/69
Sequence Strain (Species/Organism) Escherichia coli O127:H6 str. E2348/69
NCBI Gene ID 7062692
NCBI Protein GI 215489001
Locus Tag E2348C_3970
Protein Accession YP_002331432.1
Other Database IDs UniProtKB-ID: B7UMC8_ECO27
UniRef100: UniRef100_O52121
UniRef90: UniRef90_O85646
UniRef50: UniRef50_Q8VNS6
UniParc: UPI00000BB833
EMBL: FM180568
EMBL-CDS: CAS11518.1
RefSeq_NT: NC_011601.1
EnsemblGenome: EBESCG00000110871.
EnsemblGenome_TRS: EBESCT00000115384
EnsemblGenome_PRO: EBESCP00000104347
GenomeReviews: FM180568_GR
KEGG: ecg:E2348C_3970
HOGENOM: HBG467957
OMA: AHANIDG
ProtClustDB: CLSK2393224
Taxonomy ID 574521
Gene Starting Position 4135192
Gene Ending Position 4136388
Gene Strand (Orientation) +
Protein Name LEE-encoded effector EspG
DNA Sequence 
>gi|215485161:4135192-4136388 Escherichia coli O127:H6 str. E2348/69, complete genome
TATGATACTTGTTGCCAAATTGTTCATTACAAACCAGATAGGAGAATCTCTCATGATAAATGGACTTAAT
AATGACTCCGCATCTTTAGTTTTAGATGCTGCAATGAAAGTTAATTCTGGGTTTAAAAAAAGCTGGGATG
AGATGTCATGCGCTGAAAAGTTACTTAAAGTACTTAGTTTTGGTTTATGGAATCCAACGTACAGTCGTAG
TGAAAGACAATCATTTCAAGAGTTGTTAACCGTTTTAGAGCCTGTATATCCACTTCCCAATGAATTAGGC
AGAGTATCTGCTCGTTTTTCAGATGGCTCATCCTTAAGAATTTCCGTCACTAACAGCGAAAGTATTGAAG
CCGAGATTCGCACACCAGATAATGAAAAGATTACTGTGCTCCTGGAGTCAAACGAACAAAATAGGTTATT
ACAATCTTTACCCATCGATCGCCACATGCCATACATTCAGGTTCATCGTGCCTTATCTGAGATGGACCTG
ACTGATACTACCTCAATGCGCAATCTACTTGGTTTTACGTCAAAACTATCAACAACCTTGATTCCTCATA
ATGCTCAAACAGATCCGCTTTCCGGGCCTACACCATTCAGCTCTATCTTTATGGATACATGTCGAGGACT
CGGCAATGCAAAGCTTTCACTCAATGGTGTTGATATACCTGCAAATGCACAAATGTTGCTTCGCGATGCA
CTAGGACTTAAAGACACACACTCATCACCTTCCCGGAATGTTATAGATCATGGTATTTCTCGCCATGATG
CAGAGCAAATAGCAAGAGAAAGCAGCGGCAGCGATAATCAGAAAGCTGAAGTTGTGGAATTTTTATGCCA
TCCAGAAGCAGCAACGGCCATATGCTCGGCTTTCTATCAATCTTTCAATGTGCCAGCCTTAACGTTGACA
CATGAAAGGATCTCTAAAGCCAGTGAATACAATGCGGAAAGATCGTTAGATACACCTAACGCTTGCATTA
ACATCAGTATCTCTCAATCATCAGATGGAAACATTTATGTTACCAGCCATACCGGGGTTCTGATAATGGC
GCCAGAAGACCGCCCCAACGAGATGGGCATGTTGACGAACAGGACTTCTTATGAAGTGCCGCAAGGTGTG
AAATGTACAATCGATGAAATGGTAAGAGCGCTACAACCAAGGTATGCCGCATCTGAAACGTACTTACAAA
ACACTTA
Protein Sequence 
>gi|215489001|ref|YP_002331432.1| LEE-encoded effector EspG [Escherichia coli O127:H6 str. E2348/69] MILVAKLFITNQIGESLMINGLNNDSASLVLDAAMKVNSGFKKSWDEMSCAEKLLKVLSFGLWNPTYSRSERQSFQELLTVLEPVYPLPNELGRVSARFSDGSSLRISVTNSESIEAEIRTPDNEKITVLLESNEQNRLLQSLPIDRHMPYIQVHRALSEMDLTDTTSMRNLLGFTSKLSTTLIPHNAQTDPLSGPTPFSSIFMDTCRGLGNAKLSLNGVDIPANAQMLLRDALGLKDTHSSPSRNVIDHGISRHDAEQIARESSGSDNQKAEVVEFLCHPEAATAICSAFYQSFNVPALTLTHERISKASEYNAERSLDTPNACINISISQSSDGNIYVTSHTGVLIMAPEDRPNEMGMLTNRTSYEVPQGVKCTIDEMVRALQPRYAASETYLQNT
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: the inhibitory effect of the espG mutant on Cl– uptake in Caco-2 monolayers was significantly attenuated as compared with wild-type EPEC (Gill et al., 2007).
References
Gill et al., 2007: Gill RK, Borthakur A, Hodges K, Turner JR, Clayburgh DR, Saksena S, Zaheer A, Ramaswamy K, Hecht G, Dudeja PK. Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli. The Journal of clinical investigation. 2007; 117(2); 428-437. [PubMed: 17256057].