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tir

Victor ID 2298
Gene Name tir
Sequence Strain (Species/Organism) Escherichia coli
NCBI Gene ID 1446522
NCBI Protein GI 32470019
Locus Tag p165897_049
Protein Accession NP_862961.1
Other Database IDs UniProtKB-ID: Q7B3U8_ECOLX
UniRef100: UniRef100_P13974
UniRef90: UniRef90_P13974
UniRef50: UniRef50_P13974
UniParc: UPI0000000F55
EMBL: AF550679
EMBL: AY458016
EMBL: DQ364638
EMBL: CP001232
EMBL: EU935739
EMBL: GU371928
EMBL: GU371929
EMBL: AM886293
EMBL-CDS: AAO49556.1
EMBL-CDS: AAR25126.1
EMBL-CDS: ABD60060.1
EMBL-CDS: ACJ63598.1
EMBL-CDS: ACQ42034.1
EMBL-CDS: ADL14068.1
EMBL-CDS: ADL14178.1
EMBL-CDS: CAP07761.1
RefSeq_NT: NC_004998.1
RefSeq_NT: NC_005327.1
RefSeq_NT: NC_009133.1
RefSeq_NT: NC
Taxonomy ID 562
Plasmid No p1658/97
Gene Starting Position 39810
Gene Ending Position 40473
Gene Strand (Orientation) +
Protein Name Tir
DNA Sequence 
>gi|32469973:39810-40473 Escherichia coli plasmid p1658/97, complete sequence
CAGGCGATGCAATGATTCAAACACGTAATCAATATCTGCAGTTTATGCTGGTTATGCTGGCTGCATGGGG
CATTAGTTGGGGAGCCAGATTTGTCATGGAGCAGGCCGTTCTGCTTTATGGATCAGGAAAAAACTATTTG
TTCTTCAGTCATGGTACTGTTCTGATGTACCTGCTGTGTGTTTTCCTGGTATACCGCCGTTGGATAGCTC
CGCTACCGGTCGTTGGTCAGCTGCGCAACGTTGGCGTACCGTGGCTGGTCGGTGCGATGGCCGTGGTGTA
TGTCGGTGTATTTCTGCTCGGTAAGGCGCTGGCTCTGCCTGCTGAGCCATTTATGACGAAACTTTTTGCC
GATAAGTCCATACCTGACGTGATCCTGACGTTGCTGACCATCTTTATCCTTGCCCCGTTGAATGAGGAAA
CGCTGTTCCGGGGGATTATGCTGAACGTCTTCCGTTCACGGTACTGCTGGACGATGTGGCTGGGGGCGCT
GATAACGTCGTTGTTGTTCGTCGCCGCGCACAGCCAGTATCAGAACCTGCTGACACTGGCAGAACTGTTC
CTGGTGGGGTTGATTACATCAGTGGCCAGGATCAGAAGTGGTGGCCTGCTGCTGCCGGTATTGCTGCATA
TGGAAGCAACCACGCTGGGTTTACTGTTTGGTTG
Protein Sequence 
>gi|32470019|ref|NP_862961.1| hypothetical protein p165897_049 [Escherichia coli] MIQTRNQYLQFMLVMLAAWGISWGARFVMEQAVLLYGSGKNYLFFSHGTVLMYLLCVFLVYRRWIAPLPVVGQLRNVGVPWLVGAMAVVYVGVFLLGKALALPAEPFMTKLFADKSIPDVILTLLTIFILAPLNEETLFRGIMLNVFRSRYCWTMWLGALITSLLFVAAHSQYQNLLTLAELFLVGLITSVARIRSGGLLLPVLLHMEATTLGLLFG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture (Schüller et al., 2007).
References
Schüller et al., 2007: Schüller S, Chong Y, Lewin J, Kenny B, Frankel G, Phillips AD. Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture models. Cellular microbiology. 2007; 9(5); 1352-1364. [PubMed: 17474908].