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espF from Escherichia coli O157:H7 str. EDL933

Victor ID 2206
Gene Name espF from Escherichia coli O157:H7 str. EDL933
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. EDL933
NCBI Gene ID 960871
NCBI Protein GI 15804211
Locus Tag Z5100
Protein Accession NP_290250.1
Other Database IDs UniProtKB-ID: Q7DB85_ECO57
UniRef100: UniRef100_O85622
UniRef90: UniRef90_O85622
UniRef50: UniRef50_Q5K5R0
UniParc: UPI00000D00B7
EMBL: AE005174
EMBL: EU871626
EMBL: BA000007
EMBL-CDS: AAG58814.1
EMBL-CDS: ACG59612.1
EMBL-CDS: BAB37973.1
RefSeq_NT: NC_002655.2
RefSeq_NT: NC_002695.1
EnsemblGenome: EBESCG00000026840.
EnsemblGenome_TRS: EBESCT00000027788
EnsemblGenome_PRO: EBESCP00000026681
EnsemblGenome: EBESCG00000054552.
EnsemblGenome_TRS: EBESCT00000055504
EnsemblGenome_PRO: EBESCP00000053332
Taxonomy ID 155864
Gene Starting Position 4658239
Gene Ending Position 4658985
Gene Strand (Orientation) -
Protein Name espF
DNA Sequence 
>gi|16445223:4658239-4658985 Escherichia coli O157:H7 str. EDL933 chromosome, complete genome
GTTACCCTTTCTTCGATTGCTCATAGGCAGCTAAATGATCTTTTAATGCCTGTGCAAGGGGCGGTAGTCC
ACTAGGCCCTGTCGGTGGCGGTGGTGCCTGACGGGCGGGCTTAAAACCTAAAGCCTCAGGACCTTTCGAT
TTTTCATAGGCAGCCAAGTGCTCTTTTAATGCCTGTGCAATGGGCGGTAAAGGTCGGGATGCCCCGGATG
CCTGTCCACTTGTCGGTGGCGGCGGTGCCTGACGGGCGGGCTTAAAACCTAAAGCCTCAGGACCTTTCGA
TTTTTCATAGGCAGCCAAGTGCTCTTTTAATGCCTGTGCAATGGGCGGTAAAGGTCGGGATGCCCCGGAT
GCCTGTCCACTTGTCGGTGGCGGCGGTGCCTGACGGGCGGGCTTAAAACCTAAAGCCTCAGGACCTTTCG
ATTTTTCATAGGCAGCCAAGTGCTCTTTTAATGCCTGTGCAATGGGCGGTAAAGGTCGGGATGCCCCGGA
TGCCTGTCCACTTGTCGGTGGCGGCGGTGCCGGACGAGAGGGAGTAAATGAAGTCACCTGGCTGCTCACA
TTAAAAATCGTTCTCGCATTAACATTCGACGAGCCTGGAGAAAAAGGGGAATGAACTTTCACCGGAGTAA
GACGCACGGCCTGAGGGGCTACAGAAAATCCAGTTCCCCCCGCAGAGCTCACTCGACTTGCGATACCTAC
AAGCTGCCGCCCTAGTGTAGAAGCAGCGTTACTAATTCCATTAAGCA
Protein Sequence 
>gi|15804211|ref|NP_290250.1| hypothetical protein Z5100 [Escherichia coli O157:H7 str. EDL933] MLNGISNAASTLGRQLVGIASRVSSAGGTGFSVAPQAVRLTPVKVHSPFSPGSSNVNARTIFNVSSQVTSFTPSRPAPPPPTSGQASGASRPLPPIAQALKEHLAAYEKSKGPEALGFKPARQAPPPPTSGQASGASRPLPPIAQALKEHLAAYEKSKGPEALGFKPARQAPPPPTSGQASGASRPLPPIAQALKEHLAAYEKSKGPEALGFKPARQAPPPPTGPSGLPPLAQALKDHLAAYEQSKKG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: espF EPEC mutant is deficient in its ability to disrupt electrical resistance across a polarized monolayer of intestinal epithelial cells, suggesting that EspF is an effector molecule required for disrupting intestinal epithelial barrier function (McNamara et al., 2001).
References
McNamara et al., 2001: McNamara BP, Koutsouris A, O'Connell CB, Nougayréde JP, Donnenberg MS, Hecht G. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. The Journal of clinical investigation. 2001; 107(5); 621-629. [PubMed: 11238563].