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tktA

Victor ID 2065
Gene Name tktA
Sequence Strain (Species/Organism) Escherichia coli APEC O1
NCBI Gene ID 4495170
NCBI Protein GI 117625164
Locus Tag APECO1_3594
Genbank Accession CP000468
Protein Accession YP_854152
Other Database IDs UniProtKB-ID: A1AFC3_ECOK1
UniRef100: UniRef100_Q1R793
UniRef90: UniRef90_P27302
UniRef50: UniRef50_P21726
UniParc: UPI0000E45163
EMBL: CP000468
EMBL-CDS: ABJ02363.1
RefSeq_NT: NC_008563.1
EnsemblGenome: EBESCG00000038194.
EnsemblGenome_TRS: EBESCT00000039144
EnsemblGenome_PRO: EBESCP00000037661
GenomeReviews: CP000468_GR
KEGG: ecv:APECO1_3594
eggNOG: COG0021
HOGENOM: HBG565885
OMA: MAVWRPC
ProtClustDB: PRK12754
BioCyc: ECOL405955:APECO1_3594-MONOMER
Taxonomy ID 405955
Gene Starting Position 3273504
Gene Ending Position 3275495
Gene Strand (Orientation) -
Protein Name transketolase
Protein pI 5.5
Protein Weight 68623.43
Protein Length 663
Protein Note catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
DNA Sequence 
>gi|117622295:3273504-3275495 Escherichia coli APEC O1, complete genome
ATTACAGCAGCGCTTTTGCTTTCGCAACAACGTTGTCAACGGTGAAGCCGAACTCTTCAAACAGCTGCTC
TGCCGGAGCAGATTCACCGAAGGTGGTCATGCCGACGATAGCGCCGTTCAGGCCAACATACTTGTACCAG
TAGTCAGCAATGCCAGCTTCCACCGCAACACGAGCGGTAACCGCTTTCGGCAGTACGGATTCACGGTAAG
CCGCGTCCTGCTTGTCGAATGCGTCGGTAGACGGCATGGAAACCACGCGCGCTTTCACGCCTTCGGCAGT
CAGTTTTTCGTAGGCGGCAACAGCCAGTTCAACTTCAGAACCGGTCGCGATGAAGATCAGTTCCGGCTGA
CCAGCACAGTCTTTCAGCACATAACCACCGCGCGCGATGTTTGCCAGCTGCTCTTCAGTACGTTCCTGCT
GCGCCAGGTTCTGACGGGAGAGGATAAGCGCAGTCGGGCCGTCCTGACGCTCAACGCCGTATTTCCACGC
TACTGCGGATTCAACCTGGTCACACGGACGCCATGTAGACATGTTCGGGGTCACGCGCAGAGAAGCGATC
TGTTCTACCGGCTGGTGAGTCGGGCCATCTTCGCCCAGACCGATGGAGTCGTGGGTGTAAACCATCACCT
GACGCTGTTTCATCAGCGCAGCCATACGTACGGCATTACGTGCGTATTCCACGAACATCAGGAAGGTTGA
GGTATACGGCAGGAAACCACCGTGCAGGGAGATACCGTTAGCAATCGCGGTCATACCGAACTCGCGAACA
CCGTAGTGGATGTAGTTACCTGCAGCATCTTCGTTGATTGCTTTAGAACCAGACCACAGGGTCAGGTTAG
ACGGAGCAAGGTCAGCGGAGCCGCCGAGGAATTCCGGCAACAGCGGACCGAACGCTTCGATAGCATTCTG
AGACGCTTTACGGCTGGCGATTTTCGCCGGATTAGCCTGAAGTTTAGCAATGAACTCTTTCGCTTTCGCG
TCGAAGTCAGACGGCATTTCGCCTTTCATACGGCGGGTAAATTCAGCGGCTTCCTGCGGATAAGCTTTCG
CGTAAGCAGCGAATTTCTCGTTCCATGCGGACTCTTTCGCCTGGCCTGCTTCTTTCGCATCCCACTGAGC
ATAGATTTCAGACGGGATTTCGAACGGCGCGTATTTCCAGCCCAGCTGTTCGCGGGTCAGGGCAATTTCA
GCGTCGCCCAGCGGCGCACCGTGGGAGTCGTGGGTACCGGCTTTGTTCGGGGAACCGAAACCGATGATGG
TTTTGCACATCAGCAGGGACGGTTTGTCGGTCACTGCGCGCGCTTCTTCTATTGCGCGTTTGATGGATGC
CGCGTCATGACCGTCGATGTCGCGAATAACGTGCCAACCGTAAGCTTCGAAACGCATTGCGGTGTCGTCG
GTAAACCAGCCTTCAACGTGACCATCGATAGAAATACCGTTGTCATCGTAGAACGCAATCAGTTTACCCA
GCTTCAACGTACCCGCCAGAGAGCAAACTTCGTGGGAGATGCCTTCCATCATGCAGCCGTCGCCCATGAA
GGCGTAGGTGTAGTGGTCGACGATGTCGTGGCCCGGACGGTTAAACTGCGCCGCCAGCGTTTTTTCTGCA
ATCGCCATACCGACTGCGTTGGCAATACCCTGACCCAGCGGACCGGTGGTGGTTTCTACACCTGCGGTGT
AACCCACTTCCGGGTGACCCGGAGTTTTCGAGTGCAGCTGACGGAAGTTTTTCAGTTCTTCCATCGGCAG
ATCGTAACCGGTGAGGTGCAGCAGGCTGTAGATCAACATGGAGCCGTGGCCGTTGGACAGCACGAAGCGG
TCACGGTCAGCCCAGGACGGATTCTGCGGGTTGTGTTTCAGGAAATCACGCCACAGGACTTCGGCAATGT
CAGCCATACCCATAGGGGCACCCGGGTGACCGGATTTGGCTTTCTGTACTGCGTCCATGCTCAGCGCACG
AATAGCATTGGCAAGCTCTTTACGTGAGGACA
Protein Sequence 
>gi|117625164|ref|YP_854152.1| transketolase [Escherichia coli APEC O1]
MSSRKELANAIRALSMDAVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPQNPSWADRDRFVLSNGHGSML
IYSLLHLTGYDLPMEELKNFRQLHSKTPGHPEVGYTAGVETTTGPLGQGIANAVGMAIAEKTLAAQFNRP
GHDIVDHYTYAFMGDGCMMEGISHEVCSLAGTLKLGKLIAFYDDNGISIDGHVEGWFTDDTAMRFEAYGW
HVIRDIDGHDAASIKRAIEEARAVTDKPSLLMCKTIIGFGSPNKAGTHDSHGAPLGDAEIALTREQLGWK
YAPFEIPSEIYAQWDAKEAGQAKESAWNEKFAAYAKAYPQEAAEFTRRMKGEMPSDFDAKAKEFIAKLQA
NPAKIASRKASQNAIEAFGPLLPEFLGGSADLAPSNLTLWSGSKAINEDAAGNYIHYGVREFGMTAIANG
ISLHGGFLPYTSTFLMFVEYARNAVRMAALMKQRQVMVYTHDSIGLGEDGPTHQPVEQIASLRVTPNMST
WRPCDQVESAVAWKYGVERQDGPTALILSRQNLAQQERTEEQLANIARGGYVLKDCAGQPELIFIATGSE
VELAVAAYEKLTAEGVKARVVSMPSTDAFDKQDAAYRESVLPKAVTARVAVEAGIADYWYKYVGLNGAIV
GMTTFGESAPAEQLFEEFGFTVDNVVAKAKALL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tktA mutant is attenuated in chickens (Li et al., 2005).
COG COG0021G, under G: Carbohydrate transport and metabolism
References
Li et al., 2005: Li G, Laturnus C, Ewers C, Wieler LH. Identification of genes required for avian Escherichia coli septicemia by signature-tagged mutagenesis. Infection and immunity. 2005; 73(5); 2818-2827. [PubMed: 15845486].