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sat from Escherichia coli CFT073

Victor ID 2113
Gene Name sat from Escherichia coli CFT073
Sequence Strain (Species/Organism) Escherichia coli CFT073
NCBI Gene ID 1039573
NCBI Protein GI 26249454
Locus Tag c3619
Protein Accession NP_755494.1
Other Database IDs UniProtKB-ID: SAT_ECOL6
UniRef100: UniRef100_Q8FDW4
UniRef90: UniRef90_Q8FDW4
UniRef50: UniRef50_O32591
UniParc: UPI00000AF83F
EMBL: AF289092
EMBL: AJ586888
EMBL: AE014075
EMBL-CDS: AAG30168.1
EMBL-CDS: CAE55775.1
EMBL-CDS: AAN82067.1
RefSeq_NT: NC_004431.1
MEROPS: S06.004
TCDB: 1.B.12.4.6
EnsemblGenome: EBESCG00000040977
EnsemblGenome_TRS: EBESCT00000041927
EnsemblGenome_PRO: EBESCP00000040276
GenomeReviews: AE014075_GR
KEGG: ecc:c3619
NMPDR: fig|199310.1.peg.3537
HOGENOM: HBG467630
OMA: RDINGE
Taxonomy ID 199310
Gene Starting Position 3456361
Gene Ending Position 3460260
Gene Strand (Orientation) -
Protein Name Aecreted auto transpoter toxin
DNA Sequence 
>gi|26245917:3456361-3460260 Escherichia coli CFT073, complete genome
ATCAGAAAGAGTAACGGAAGTTGGCGTTGATCGCGTTATCCACGTTGTATTTACCAAATGCCGATTTCTC
AAACTCAAGACCGAAGCGAAGATTATCGCGAATTTCGGCGTTGAGACCAACATTCATGAGCATACGACCG
TCTTTTTCACCTTTGATACGTTTCTCACCGGACGCATCACGCAGTACGGTTTCACCGTTGGCAAACAGGT
CAAACTGGTAGCCAAGGCCGGCGCGGGCTGTGACTTTCCAGTCCTTACCGGAGAAGGATTTACCCACATC
AACACCGGTACGCCCAATCAGCGGATTAAAGTCCTTATCCTTCATGGTGAGGTTCATTCCCTGGTCCTTC
CAGGAGAACTGTTTCCCGGATACAGCACCGTAAACAAGTTCCGCCTGCGGCTCAATCCATGCAGAGTCAG
TTACATGGTAACGGTAACCGACTTCCGCACCGGCATACCAGGAGTGGGAGCTGTAGTCTCTGGTGCCAAG
GCCGGCGAAAGTTGCGGTATACTCGTTGTCATGGTGAACGTACTTACCGATGAGGTCGATATATGCTCCG
GACTCAAACATGGCAGAGGCATAGAGACCGGCACCCACAGACTTCGTTTCACCACTGAAGGCATCACTGC
CTGCATGGCTGTCGGTATAGGTCATGGTCACCCCGGTGAAGAGGTCAAGGCCATCGAGTTCATGTTTGTT
ATCCGCACCGACCTGAACGTGGGTGTAGTTGTCACTGAATCCACCGCCGGCAGACCCGGTTCCGCTAATG
ATTCGGGCCCATGCACCGGACTCACCGTTAATGTCACGCAGATCACCCATACGTTTGTTAAGGTTGTTGA
CCTCAGCAAGGAAGGCTTTATAGCCGCCTGACATCAGTAATGTTGCCTTTTTAGCCGCATCGGCGTTGGC
CACAGATTTATAGCCGATCAGAGTCCATGTTGCTTTGTCTGTATCGTTCTTTTGCTCGATAACCGGTGTT
ACATCACTGAAGCCAATACTCCGAGTCGTAGCTTTAAAGACATCTACTGCAGTTCCTTTTGGTGCGCTGA
CCAGATCGATATTCAGTCCGTTGCTGTTTCCATTTTTCTCAATGAAGTCGACTAACAGAAGGTTGTTTTT
ACCAGACAACGATTTATTGACAACAAGCTGATCTGCTTGGGCCAGATTTGCACGCAGCACAAATGCACTG
TCATCTATAGTAAGGTTGTTCACTGTAAGGGTTGTAAACTTCCCATTATCACCAGTAAAACGCACCATAC
TGTCTTTTGTTTCTAGACGATTAATTGATGACTGGCTATTTAGATGCCAGATCGCATTATTCATGCTAAC
TGTAGCTTTGGGGGCTGTTATTGCGCCTCGATAAGCGGTATCAAAGCCATACAAAAGAGTCTCTGCCCAT
GCCTGATAAGCAGACGATATAGTCGGTGTTTCAGTTTCAGGCTGTCCCAGAGTAATGGTTGCTGCATCAT
CAGCATAAATATTTCCGGTGACAGATGCCATATTTCTGGCAATGAAATTTGCATTTCCACCACTCAGCCT
GAATCCATCAGCAGCGTAGTGGAGACCCGGCGTTACAGTTTTACTATTCTGTTCAGGGATTCCCATCATA
GTCAGTTCACCGGAGATATCAATACCTTTTGTTGTGAACATGGAATTTTGTGCTATAACTTTTGCTCCTT
TATCTATACTTATAGGAGTATTATCCAGAAAGGTTGCACCATTAAGTGTAACTACAGCTTGATCACCTAT
GGCTATTTGGCTGTTATGTGCAGTGATGCCACCTGTAAATTTAGTTTCTCCTATGGATAGATTAGTACTG
ATAGTTTGTTTGAAGTCAAAACCATTATTAGTAATATTTTTCCCTGCAAGATTATCAATGTAAACATTTT
TATCGCCGATTGTGATAGCTGATTTATTTGCTGATATATTTCCTTCAACATTGGCATTGCGTGATATTGA
AAAGTCAGCATTGTTCAGGTGTAATGTATCAAATTTAAACACCCCGGTTTTCCAGTCAGGCTGATCAAAT
GAGGTCTGCTGATTATTACTTTTGTAATCAGAATTGAATTTTTTATTATATGAACTCTCTGTTTCTTTCA
AAACGGTGACCCAGTCCGTTCCACAAAGAAATACCAGGGAGCAATGATTCGCTGAGCTTCTGAATATTGC
ATGCTCTGTTGCATGGCCTTGCATGGTAAGACTGGCATTACTGACTTCAACATCATTTTTTGTGTTGACA
CTACCATCCAGAATTAATTTTGCATTAGTTTTCTTATCCTGAGAATTAATATTGTGCGTTAGTTTTATAT
TGCCATTTATGTTCCCATGATATATGTAGGAGTCTTCGTTATTGATTGCCAGAACGGCTTCTTTCGTTGT
ATCTGAGTTAGTTATTGTTGTTCCATCGTCAGTGGCGGCAATTCTAGTAAAAGTCTGATTGTGTCCATTT
AAATCTAGCGTACCACCACGTTTAGTAAAAAATATCCCCGCATATTGATCATTGCCAAGGGAATTATCTT
TATTTAGTATTACCTTACCATTTCCGCTTGCAAGGTATATATTGTTAAATGTTCCTTCTTCATTAAGAAT
AACATTTCCTTCACCTATCTTTATATTTGCCCCCTGTTTTTTTTGAACATTCAGAGTACCGGGGCCTATT
TTGTGTAAAACATCATCACTGGAATACAATGCATTCCAGTTTACAATGCTTTCTTTTCCGATATCAATTC
CTGCTCCTTTAAATGTAAATCCCTGACCGTTTATGTTATATTCATGGCCTTCGTCAAAGATAATACCACC
GCTACCAAAATCCAAATTATCCTTAAACAGGACATCTCCCCCATTTGTGAACACAATATCTTTGTCTTTA
GTTATTTTTTCTTGAGTACCAGTGGTATCTGCATTGTTTTGGTGTAATGTTATATCTGTGTTTTTAATGG
TTACATTATTGCCATTCAGATTTATTTTATGACTATAGGTATCTTTTAACTCACTAACCAGTTTATCATT
GTATTTTGTTATCCATGTCAGTTGGTCACCATTAACGCTGGCAATACCATGGGTTGTTCCGACTAATACC
CATTTTTCTAGTTTGTTATCATATAAGTATGCTCCAGAGCCGCTGTCTCCGAATATTTCAAGATTACGAA
ATGTTTTATCATTTTTATAAATCATCATGCCGTATGAGTCCCATTGGGTGACCTCAAATAGACTAGCACT
TAACAGATCATGGCTATATGCTGAATTTGTTGAGATTTTGGATTCACCATTAATAAATGATGTTCCTCCA
GAGCCAGCACGAAAACCTATGATTTTTTTTGAACCGTCAGAAGTGACTATACCGTAGCGTTCTAATGCAT
CAGAATATGTTGTAGGGTTGGTCTCTGCCGGGGTGGCACCTACTGTTTCCACAACAAATTTATTTAACCT
CTGAATCTCAAAATCATTGGAATTTCTTCTGTCAACAACCCTGTAAGAAGACTGAGCGTAAACCTGGGTT
TCTGCGGCCTGAGGGTTCTTTTTGTTATGTGCAACAGTAACACTATAAGAACCTCCTATTGCGGTAGCTG
CGCCACTCGCTGCTGCACCAGAAAAATCCGGAATTGAGAGATTATGGAAAGAGAATTTATCTCCGTTTTT
TAAAGTGATTGTTACGTCTGTTGCTCCGGGCTGGAAAATACCTTTATTTTGTGCAAGATCAAGATAGTCT
CTCGCCCATACATTTGATATATCAATATTTGCTGCATTTACTGTACCGGCAACAGCCAGAGACAACATTG
TTGCTACAAGTTTTCGGTTTGTTTTACCAGAAACTCTTTTCGCTAATTCAGAAACAGCAATGAGTCCGCC
AGTGGCAGCACTATATTTAAGGGAGTATATTTTATTCATATATTCTCTCA
Protein Sequence 
>gi|26249454|ref|NP_755494.1| secreted auto transporter toxin [Escherichia coli CFT073] MREYMNKIYSLKYSAATGGLIAVSELAKRVSGKTNRKLVATMLSLAVAGTVNAANIDISNVWARDYLDLAQNKGIFQPGATDVTITLKNGDKFSFHNLSIPDFSGAAASGAATAIGGSYSVTVAHNKKNPQAAETQVYAQSSYRVVDRRNSNDFEIQRLNKFVVETVGATPAETNPTTYSDALERYGIVTSDGSKKIIGFRAGSGGTSFINGESKISTNSAYSHDLLSASLFEVTQWDSYGMMIYKNDKTFRNLEIFGDSGSGAYLYDNKLEKWVLVGTTHGIASVNGDQLTWITKYNDKLVSELKDTYSHKINLNGNNVTIKNTDITLHQNNADTTGTQEKITKDKDIVFTNGGDVLFKDNLDFGSGGIIFDEGHEYNINGQGFTFKGAGIDIGKESIVNWNALYSSDDVLHKIGPGTLNVQKKQGANIKIGEGNVILNEEGTFNNIYLASGNGKVILNKDNSLGNDQYAGIFFTKRGGTLDLNGHNQTFTRIAATDDGTTITNSDTTKEAVLAINNEDSYIYHGNINGNIKLTHNINSQDKKTNAKLILDGSVNTKNDVEVSNASLTMQGHATEHAIFRSSANHCSLVFLCGTDWVTVLKETESSYNKKFNSDYKSNNQQTSFDQPDWKTGVFKFDTLHLNNADFSISRNANVEGNISANKSAITIGDKNVYIDNLAGKNITNNGFDFKQTISTNLSIGETKFTGGITAHNSQIAIGDQAVVTLNGATFLDNTPISIDKGAKVIAQNSMFTTKGIDISGELTMMGIPEQNSKTVTPGLHYAADGFRLSGGNANFIARNMASVTGNIYADDAATITLGQPETETPTISSAYQAWAETLLYGFDTAYRGAITAPKATVSMNNAIWHLNSQSSINRLETKDSMVRFTGDNGKFTTLTVNNLTIDDSAFVLRANLAQADQLVVNKSLSGKNNLLLVDFIEKNGNSNGLNIDLVSAPKGTAVDVFKATTRSIGFSDVTPVIEQKNDTDKATWTLIGYKSVANADAAKKATLLMSGGYKAFLAEVNNLNKRMGDLRDINGESGAWARIISGTGSAGGGFSDNYTHVQVGADNKHELDGLDLFTGVTMTYTDSHAGSDAFSGETKSVGAGLYASAMFESGAYIDLIGKYVHHDNEYTATFAGLGTRDYSSHSWYAGAEVGYRYHVTDSAWIEPQAELVYGAVSGKQFSWKDQGMNLTMKDKDFNPLIGRTGVDVGKSFSGKDWKVTARAGLGYQFDLFANGETVLRDASGEKRIKGEKDGRMLMNVGLNAEIRDNLRFGLEFEKSAFGKYNVDNAINANFRYSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Sat elicits cytopathic activity that damages host tissue and may increase the ability of E. coli to propagate (Guyer et al., 2002).
COG COG4625S, under S: Function unknown
References
Guyer et al., 2002: Guyer DM, Radulovic S, Jones FE, Mobley HL. Sat, the secreted autotransporter toxin of uropathogenic Escherichia coli, is a vacuolating cytotoxin for bladder and kidney epithelial cells. Infection and immunity. 2002; 70(8); 4539-4546. [PubMed: 12117966].