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espG from Escherichia coli O157:H7 str. TW14359

Victor ID 3711
Gene Name espG from Escherichia coli O157:H7 str. TW14359
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. TW14359
NCBI Gene ID 8219270
NCBI Protein GI 254795664
Locus Tag ECSP_4704
Protein Accession YP_003080501.1
Other Database IDs UniProtKB-ID: C6UYP6_ECO5T
UniRef100: UniRef100_O85646
UniRef90: UniRef90_O85646
UniRef50: UniRef50_Q8VNS6
UniParc: UPI00000D00E6
EMBL: CP001368
EMBL-CDS: ACT74425.1
RefSeq_NT: NC_013008.1
EnsemblGenome: EBESCG00000166688.
EnsemblGenome_TRS: EBESCT00000169886
EnsemblGenome_PRO: EBESCP00000157715
GenomeReviews: CP001368_GR
KEGG: etw:ECSP_4704
ProtClustDB: CLSK2393224
Taxonomy ID 544404
Gene Starting Position 4680564
Gene Ending Position 4681760
Gene Strand (Orientation) +
Protein Name LEE-encoded type III secreted effector
DNA Sequence 
>gi|254791136:4680564-4681760 Escherichia coli O157:H7 str. TW14359, complete genome
TATGATACTTGTTGCCAAATTGTTCATTACAAACCAGATAGGAGAATCTCTCATGATAAATGGACTTAAT
AATGACTCCGCATCTTTAGTTTTAGATGCTGCAATGAAAGTTAATTCTGGGTTTAAAAAAAGCTGGGATG
AGATGTCATGCGCTGAAAAGTTATTTAAAGTACTTAGTTTTGGTTTATGGAATCCAACGTACAGTCGTAG
TGAAAGACAATCATTTCAAGAGTTGTTAACCGTTTTAGAGCCTGTATATCCACTTCCCAATGAATTAGGC
AGAGTATCTGCTCGTTTTTCAGATGGTTCATCCTTAAGAATTTCCGTCACTAACAGCGAACTTGTTGAAG
CCGAGATTCGCACAGCAAATAATGAAAAGATTACTGTGCTCCTGGAGTCAAACGAACAAAATAGGTTATT
ACAATCTTTACCCATCGATCGCCACATGCCATACATTCAGGTTCATCGTGCCTTATCTGAGATGGACCTG
ACTGATACTACCTCAATGCGCAATCTACTTGGTTTTACGTCAAAACTATCAACAACCTTGATTCCTCATA
ATGCTCAAACAGATCCGCTTTCCGGGCCTACACCATTCAGCTCTATCTTTATGGATACATGTCGAGGACT
CGGCAATGCAAAGCTTTCACTCAATGGTGTTGATATACCTGCAAATGCACAAAAATTGCTTCGCGATGCA
CTAGGACTTAAAGACACACATTCATCACCAACCCGGAATGTTATAGATCATGGTATTTCTCGCCATGATG
CAGAGCAAATAGCAAGAGAAAGCAGCGGCAGTGATAAACAGAAAGCTGAAGTTGTGGAATTTTTATGCCA
TCCAGAAGCAGCAACGGCCATATGCTCGGCTTTCTATCAATCTTTCAATGTGCCAGCCTTAACGTTGACA
CATGAAAGGATCTCTAAAGCCAGTGAATACAATGCGGAAAGATCATTAGATACACCTAACGCTTGCATTA
ACATCAGTATCTCTCAATCATCAGATGGAAACATTTATGTTACCAGCCATACTGGGGTTCTGATAATGGC
GCCAGAAGACCGCCCCAACGAGATGGGCATGTTGACGAACAGGACTTCTTATGAAGTGCCGCAAGGTGTG
AAATGTATAATCGATGAAATGGTAAGTGCGCTACAACCAAGGTATGCCGCATCTGAAACGTACTTACAAA
ACACTTA
Protein Sequence 
>gi|254795664|ref|YP_003080501.1| LEE-encoded type III effector [Escherichia coli O157:H7 str. TW14359] MILVAKLFITNQIGESLMINGLNNDSASLVLDAAMKVNSGFKKSWDEMSCAEKLFKVLSFGLWNPTYSRSERQSFQELLTVLEPVYPLPNELGRVSARFSDGSSLRISVTNSELVEAEIRTANNEKITVLLESNEQNRLLQSLPIDRHMPYIQVHRALSEMDLTDTTSMRNLLGFTSKLSTTLIPHNAQTDPLSGPTPFSSIFMDTCRGLGNAKLSLNGVDIPANAQKLLRDALGLKDTHSSPTRNVIDHGISRHDAEQIARESSGSDKQKAEVVEFLCHPEAATAICSAFYQSFNVPALTLTHERISKASEYNAERSLDTPNACINISISQSSDGNIYVTSHTGVLIMAPEDRPNEMGMLTNRTSYEVPQGVKCIIDEMVSALQPRYAASETYLQNT
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: the inhibitory effect of the espG mutant on Cl– uptake in Caco-2 monolayers was significantly attenuated as compared with wild-type EPEC (Gill et al., 2007).
References
Gill et al., 2007: Gill RK, Borthakur A, Hodges K, Turner JR, Clayburgh DR, Saksena S, Zaheer A, Ramaswamy K, Hecht G, Dudeja PK. Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli. The Journal of clinical investigation. 2007; 117(2); 428-437. [PubMed: 17256057].