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cnf1

Victor ID 2070
Gene Name cnf1
Sequence Strain (Species/Organism) Escherichia coli UTI89
NCBI Gene ID 3990770
NCBI Protein GI 91213869
Locus Tag UTI89_C4921
Genbank Accession CP000243
Protein Accession YP_543855
Other Database IDs UniProtKB-ID: Q1R2U0_ECOUT
UniRef100: UniRef100_Q1R2U0
UniRef90: UniRef90_Q46962
UniRef50: UniRef50_Q46962
UniParc: UPI00003E5B7B
EMBL: CP000243
EMBL-CDS: ABE10324.1
RefSeq_NT: NC_007946.1
EnsemblGenome: EBESCG00000068392.
EnsemblGenome_TRS: EBESCT00000069345
EnsemblGenome_PRO: EBESCP00000066823
GenomeReviews: CP000243_GR
KEGG: eci:UTI89_C4921
eggNOG: NOG43420
HOGENOM: HBG758748
OMA: NSARGAN
ProtClustDB: CLSK722764
BioCyc: ECOL364106:UTI89_C4921-MONOMER
Taxonomy ID 364106
Gene Starting Position 4817382
Gene Ending Position 4820426
Gene Strand (Orientation) -
Protein Name cytotoxic necrotizing factor 1
Protein pI 5.01
Protein Weight 107322.6
Protein Length 1014
DNA Sequence 
>gi|91209055:4817382-4820426 Escherichia coli UTI89 chromosome, complete genome
ATCAAAATTTTTTTGAAAATACCTTCAATACCGATATTTCGGAGGCATCTGCATTCAGAGAATAACTCTC
AGACAGAGACCTTACGACAACATTGCCGTCCACTCTCACCAGTACAGTCGCCGATGTACCAAAGCCATGT
TCAGGTATATTATCAAGGAAGTAAGGGAAAACAGAAACATTATCACGAATAATAGTGATTTGACTATCTG
GTTTTTTTTCAGATGATGAGTAAGTTATTAATGAATCTTCAAAATTTTCCGACAGATAATCGACTAAGAA
ATCATTGCTCATTATTCCCTCCACGCGAGGTATTGGTTCTTTTGTAAGTAGCTCAAGTACTTCAACTGCT
TTTTTCACCCCGGTAGTACTGGTAAATCCAGCCAAAGATTTTGTTGTACCAGTATGTACCTTATAAATAT
ATCCTTCTTTTCGGGCAACAATTGTCGTACAACCACTTAGATTTCCGCTTGTAATGATTACTGGTTTACC
CTCCTGGACTTCCTCAAGTGCTATTTTAATACCATTCGCCCCACGAGCAGAATTTGACACACGAATTATG
CTTGTTTCATTAGTAAGATTATACTTCTTCCAATAAGTTGAGCCGAGTGAAGATGAGTCTGATGGAATTT
CCCCAGTATAGGTGTTCAATGTTGGAATACCATTTAGCCCCACTGTATTATCATAGAAATACTGATCATA
GCCATGGTTATCAAAGCGATCTTTTTTGATGTAGAAAAAGAGAGGTTGTTGCTCATCAGCATTAGCGGCT
TCAAAATACGGATAGATTGCACGCTGACGTGTCGATGAAATACTTCCCCGTCCTTTAAGCACATCAATAT
TACCGCGACTTAATTTCTGAAAGTTAGATTTGGAGGTGCTTTCGATACTTTCTTTAAAATATCGTAGAGA
TAACAATTTACGTATGGTTGATATATCAGGAGGCGTTGATGGCTCAGGAAAATTAAATCTCCTGTCAACC
ACAGCCAGTACTTCAACCGGGGCTTCATCAGGAATTGCCCAATGATTAACATATGAAACATTATTATTGG
TGATATATTTTACGTGCACTTTTATAACTACCAGAAAGTGTCGTCTGCTTGCTGCATCTGCACTGTTAAC
ATTTGAGGTATATTCAGTAAAACCTAAGCTTGACTGTGGGCCCTGACCTAACAAAATTTCGTGTAATTCT
TCTGTACTTCCCCCAGCCGTATGATAAGAGGCAATATTCCATGCTTCTTCCTCAGTAGCTCCTCTCATCA
AAGTTACAAATCTATCCCCAAAGCTTCCAGAACCCTTAACATAATTAACAATATCCATTTCTGACGTTGG
TTGCGGTAATTTTGGGTTTGTATCAGGATATAAAAGTGAGCTGTCATCATTAATAAATGATAACGGAGAT
CCGGTCACTGCAGAATAGGGTTCATCTTTAAAAAATACAGGAATATTGAGACTTTCAAAATCAAATGGCT
GCCCCCCTTTTAGACCACCACCTCGAGTCCAGAGAATTTCATTATTATATTCGGTACGATAAATTCTTCG
GGATAAAATCTCATATCCTGTTTCAATGTCCACTTCATAGTAGATGCCGCTCAGAGAACTCCCTTTTACA
GCGACAATTTGATTATCTTCATCACTAAGCTTTACAATATTGACATGCTGCCCGGAACTTTTAAGCTTAA
CGTCTAACAAATTAGTTGAGGATATACTATCTTCAGCAATTCCATATTCCTTCAAAAATATATCGATATT
TGTTTCATTCAGAGTCCTGCCCTCATTATTTATAACGCTGCTAAGTACCTCCTGGTTTATTCCTGCCTTA
CTAATCAAGAGTGGAATTGCAAAAGACAGACCAAGCAATACTGCATTTGTCGCCAAACCAGGTATAGCAG
AACGACGTTCTTCATAAGTATCACCATTAATCAGTTGATCAAAACTGATCCCCATACTGGAAGTAATAAT
CCCCAGTCCAAGCGGAACAGATACCTCCGGGACTACGATATCAAATATAGGGGTCATTGATAAAATCGTC
TGGAGTATAGTCAGAGCATAGTCTCGTTGAGCTTCACTGTTTGATTTTATAACGATATCACCATCACTGA
AACTGCGTTTCTTAACAGAAATAGCTATAGCATCAAAAACATCTTTATTGCTAAGTGTCTTATTGGAATA
CAGAAAGTAAGACTCATTAAAATTACCATCATTTTCTATTGCATGTAGAACAGAATTTACTCCTGCATAG
GAAACTCCATCTTGACGACTATATAATGAAAAATGTTGGGAAAGTAATTGTTTGTTGTCACTATCCTTAA
TAAGTTCTTTAAGGGTAAGCCGCAAATCAGCGATATTCTTCTTGAATAAAAAAGGTTTTTTTGCACCAGG
AATGAAAAGCATTACCTTATCATTATTTTTGGCTACAAAAATATCAGATGCGTAATATCCATAAATATCA
AAGAATAATAGTGATATATTATCACTGCGATTTAAGGCGTTCATGGAGAAATTATATTCACGCTCATCAA
GCTCTCCATTTTTATAAAGATACAAAGCAGAGGAAATATAATAATTTTTTAGTAAAAGCTTAAATTTATC
ATAGTATTTCGACCAGTAATCTGACAGAGTTTTTCCATAAACACCTGCAAAATCACACTTTTGTAAAAAA
TGCAGGTATTCCGACGGGAGCATTTTTTCTTCATTTTCTTCGTTAAACACATCTGCACTCTTTGTTTTAT
AAATTCCTGTGCTTGAATTTGCATCATCAAAAACATCAAAACGATAACCAATATTAATAAGAGCGGCTTG
AGTGAGTGTCAGTACTTCTGTTTTATATTTCCCAAGATGATCCCATCCAGTATAAGATCTGCTATTACTC
CGGTTTTGAGAAAAGCAGATGAAATAAGCATTATCAGGATCAATCCGACTAAACCACGGCAAGTCAGTTT
TAAAACAATTCTTAATGTAATCGCTGACAACTCTTTCAGGTGAAGGGAAATTTGATACCAACTCATTGTA
CTCAAGAAGATATTTTTGTTGCCATTGGTTACCCA
Protein Sequence 
>gi|91213869|ref|YP_543855.1| cytotoxic necrotizing factor 1 [Escherichia coli UTI89]
MGNQWQQKYLLEYNELVSNFPSPERVVSDYIKNCFKTDLPWFSRIDPDNAYFICFSQNRSNSRSYTGWDH
LGKYKTEVLTLTQAALINIGYRFDVFDDANSSTGIYKTKSADVFNEENEEKMLPSEYLHFLQKCDFAGVY
GKTLSDYWSKYYDKFKLLLKNYYISSALYLYKNGELDEREYNFSMNALNRSDNISLLFFDIYGYYASDIF
VAKNNDKVMLFIPGAKKPFLFKKNIADLRLTLKELIKDSDNKQLLSQHFSLYSRQDGVSYAGVNSVLHAI
ENDGNFNESYFLYSNKTLSNKDVFDAIAISVKKRSFSDGDIVIKSNSEAQRDYALTILQTILSMTPIFDI
VVPEVSVPLGLGIITSSMGISFDQLINGDTYEERRSAIPGLATNAVLLGLSFAIPLLISKAGINQEVLSS
VINNEGRTLNETNIDIFLKEYGIAEDSISSTNLLDVKLKSSGQHVNIVKLSDEDNQIVAVKGSSLSGIYY
EVDIETGYEILSRRIYRTEYNNEILWTRGGGLKGGQPFDFESLNIPVFFKDEPYSAVTGSPLSFINDDSS
LLYPDTNPKLPQPTSEMDIVNYVKGSGSFGDRFVTLMRGATEEEAWNIASYHTAGGSTEELHEILLGQGP
QSSLGFTEYTSNVNSADAASRRHFLVVIKVHVKYITNNNVSYVNHWAIPDEAPVEVLAVVDRRFNFPEPS
TPPDISTIRKLLSLRYFKESIESTSKSNFQKLSRGNIDVLKGRGSISSTRQRAIYPYFEAANADEQQPLF
FYIKKDRFDNHGYDQYFYDNTVGLNGIPTLNTYTGEIPSDSSSLGSTYWKKYNLTNETSIIRVSNSARGA
NGIKIALEEVQEGKPVIITSGNLSGCTTIVARKEGYIYKVHTGTTKSLAGFTSTTGVKKAVEVLELLTKE
PIPRVEGIMSNDFLVDYLSENFEDSLITYSSSEKKPDSQITIIRDNVSVFPYFLDNIPEHGFGTSATVLV
RVDGNVVVRSLSESYSLNADASEISVLKVFSKKF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in mice (Rippere-Lampe et al., 2001).
References
Rippere-Lampe et al., 2001: Rippere-Lampe KE, O'Brien AD, Conran R, Lockman HA. Mutation of the gene encoding cytotoxic necrotizing factor type 1 (cnf(1)) attenuates the virulence of uropathogenic Escherichia coli. Infection and immunity. 2001; 69(6); 3954-3964. [PubMed: 11349064].