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ibeA from Escherichia coli APEC O1

Victor ID 2051
Gene Name ibeA from Escherichia coli APEC O1
Sequence Strain (Species/Organism) Escherichia coli APEC O1
NCBI Gene ID 4493341
NCBI Protein GI 117626645
Locus Tag APECO1_2093
Protein Accession YP_859968.1
Other Database IDs UniProtKB-ID: A1AJK4_ECOK1
UniRef100: UniRef100_Q6X972
UniRef90: UniRef90_Q659Z2
UniRef50: UniRef50_Q9FCY5
UniParc: UPI000035D6B7
EMBL: CP000468
EMBL-CDS: ABJ03844.1
RefSeq_NT: NC_008563.1
EnsemblGenome: EBESCG00000036105.
EnsemblGenome_TRS: EBESCT00000037055
EnsemblGenome_PRO: EBESCP00000035572
GenomeReviews: CP000468_GR
KEGG: ecv:APECO1_2093
eggNOG: NOG27896
HOGENOM: HBG583717
OMA: IPPCMAM
ProtClustDB: CLSK767238
BioCyc: ECOL405955:APECO1_2093-MONOMER
Taxonomy ID 405955
Gene Starting Position 4953359
Gene Ending Position 4954729
Gene Strand (Orientation) +
Protein Name invasion protein IbeA
DNA Sequence 
>gi|117622295:4953359-4954729 Escherichia coli APEC O1, complete genome
TATGGAATTTTATCTGGAACCCGCTCGTAATATACCTGTACTGGCAACCACGGAAGTGTTAGTTGTTGGT
GGTGGTCCATCGGGTATTGCCGCAGCAATGAGTGCCGCTCGTGAAGGCGCAGCTACTATGCTGATTGAAC
GTTTCGGTTGTTTTGGCGGAATGATGACAACGGCTGGCGTCGAGTCAATTGCCTGGTGGCGTCATGAAAA
TACGGTAGAGTCAGGTGGACTGGCACGCGAAATAGAAGAAACGGCAAAATCAATGGGGGCGTCCAGCCCT
GAGCCGCAATCGAATAGTCAGGCTATTAACGCCGAGCGTTTCAAACTGGTTGCGGATGCAATGCTTGAAC
AGGCAGGTGTGCGCCGCGTACTACACATTACCGCCGTTGATGTTATCAAGCAGGGCAATAATTTACTCGG
CGTAATAACAGAGAGTAAATCTGGTCGTCAGGCTATTTTGGCAAATGTCATTATTGACTGTACTGGTGAT
GCTGATATTGCATGGTTTGCCGGAGCACCATTTATTAAGCGTGAACGCGAAGAGCTAATGTGTATGACAA
CCGTTTTTAGTTGCGCAAATATAAATAAAAACGCGTTCATGCAAAATATTAATAGCACGGAACCTAAATA
TGGAGACTGGGGGGCGGATGAAGAAAATAAAAACTGGTCTTATGATGTTCATGAATCTTGTCGCGATATG
TTTAGCCCTTATCTGGGTAAAGTCTTTGCGAAAGGAAAGTCGGCAGGAATTATTCCAAAAGATGTGACGT
TAGGCGGTTCCTGGAGTACGGTCACCGAGTATGGTGATGCGAATTACTTGAACGTTGTCAGCATCCCTGC
CGTCGATTGTACGGATGTTTTTGACCTGACGCGTGCAGAAATAGAAGGCCGCAAGCAAGCCATGCAGGCG
ATTGAAGCGTTGCGTCAATTCCAGCCAGGATTTGAACAGGCACAATTAAAAAATTTCGGTATGACGGTGG
GAACAAGAGAATCAAGACATATTATTGGGCGAGTCCAGCTTACGGAAAATGATATTTGTAATGAGGGACG
TCATGCGGATTCAATAGGGGTATTCCCTGAGTTTATAGATGGAAATGGTCATCTTAAATTACCTCTTGAA
GCGAACTATTTTCAAATCCCTTATGGCGTAATGATTCCGCAGCAAGTTGAAAACCTGTTGGTTTGCGGAC
GGGCAATCGATGCAGATAATTTCGCCTATGCGACAATCCGTAATATGGGGTGTTGTATTGTCACTGGAGA
AGGTGCAGGGACTGCCGCTGCTATTGCCATTAAAAATAACACTACCGTTTCACAGGTAGATATTCAGACG
GTACAGGAACGCTTACAGCAAAATGGCGTAAAAGTCTTTTA
Protein Sequence 
>gi|117626645|ref|YP_859968.1| invasion protein IbeA [Escherichia coli APEC O1] MEFYLEPARNIPVLATTEVLVVGGGPSGIAAAMSAAREGAATMLIERFGCFGGMMTTAGVESIAWWRHENTVESGGLAREIEETAKSMGASSPEPQSNSQAINAERFKLVADAMLEQAGVRRVLHITAVDVIKQGNNLLGVITESKSGRQAILANVIIDCTGDADIAWFAGAPFIKREREELMCMTTVFSCANINKNAFMQNINSTEPKYGDWGADEENKNWSYDVHESCRDMFSPYLGKVFAKGKSAGIIPKDVTLGGSWSTVTEYGDANYLNVVSIPAVDCTDVFDLTRAEIEGRKQAMQAIEALRQFQPGFEQAQLKNFGMTVGTRESRHIIGRVQLTENDICNEGRHADSIGVFPEFIDGNGHLKLPLEANYFQIPYGVMIPQQVENLLVCGRAIDADNFAYATIRNMGCCIVTGEGAGTAAAIAIKNNTTVSQVDIQTVQERLQQNGVKVF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: deletion mutant was significantly less invasive in human brain microvascular endothelial cells (BMECs) than the parent strain (E. coli K1) (Huang et al., 2001).
References
Huang et al., 2001: Huang SH, Wan ZS, Chen YH, Jong AY, Kim KS. Further characterization of Escherichia coli brain microvascular endothelial cell invasion gene ibeA by deletion, complementation, and protein expression. The Journal of infectious diseases. 2001; 183(7); 1071-1078. [PubMed: 11237832].