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focA

Victor ID 2097
Gene Name focA
Sequence Strain (Species/Organism) Escherichia coli CFT073
NCBI Gene ID 1036891
NCBI Protein GI 26247113
Locus Tag c1239
Genbank Accession AE014075
Protein Accession NP_753153
Other Database IDs UniProtKB-ID: FIM1C_ECOL6
UniRef100: UniRef100_P62605
UniRef90: UniRef90_P62605
UniRef50: UniRef50_Q47223
UniParc: UPI000012AA53
EMBL: AE014075
EMBL-CDS: AAN79696.1
RefSeq_NT: NC_004431.1
EnsemblGenome: EBESCG00000043926
EnsemblGenome_TRS: EBESCT00000044876
EnsemblGenome_PRO: EBESCP00000043225
GenomeReviews: AE014075_GR
KEGG: ecc:c1239
NMPDR: fig|199310.1.peg.1196
HOGENOM: HBG701898
OMA: ISMAVFS
ProtClustDB: CLSK2393955
Taxonomy ID 199310
Gene Starting Position 1188212
Gene Ending Position 1188754
Gene Strand (Orientation) +
Protein Name F1C major fimbrial subunit precursor
Protein pI 6.51
Protein Weight 16145.41
Protein Length 180
Protein Note Escherichia coli K-12 ortholog: b4314; Escherichia coli O157:H7 ortholog: z5912
DNA Sequence 
>gi|26245917:1188212-1188754 Escherichia coli CFT073, complete genome
TATGAAGTTAAAATTCATCTCCATGGCTGTATTTTCAGCTCTGACCCTGGGTGTTGCGACAAATGCGTCT
GCTGTCACCACGGTTAATGGTGGTACAGTTCATTTTAAGGGTGAAGTGGTTAATGCTGCATGTGCTGTAA
ACACTAACTCATTCGATCAGACGGTTAATCTTGGACAGGTTCGTTCCGAAAGATTGAAAGTAGATGGAGC
TAAAAGCAATCCAGTTGGATTTACAATTGAATTAAATGATTGTGACTCGCAGGTGTCTGCTGGTGCAGGA
ATTGTCTTTTCAGGCCCAGCAGTTACTGGTAAAACAGATGTTCTTGCTTTACAAAGTTCTGCAGCGGGTT
CTGCAACAAACGTCGGCGTTCAGATTACTGACCATACCGGCAAGGTTGTACCTTTAGATGGAACTGCAAG
CTCAACGTTTACATTAACTGACGGAACCAACAAAATTCCATTTCAGGCGGTTTACTACGCAACTGGACAG
GCCACTGCTGGTATTGCCAACGCCGACGCCACCTTTAAAGTTCAGTACCAGTA
Protein Sequence 
>gi|26247113|ref|NP_753153.1| F1C major fimbrial subunit precursor [Escherichia coli CFT073]
MKLKFISMAVFSALTLGVATNASAVTTVNGGTVHFKGEVVNAACAVNTNSFDQTVNLGQVRSERLKVDGA
KSNPVGFTIELNDCDSQVSAGAGIVFSGPAVTGKTDVLALQSSAAGSATNVGVQITDHTGKVVPLDGTAS
STFTLTDGTNKIPFQAVYYATGQATAGIANADATFKVQYQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: focA deletion mutants were unable to bind to brain glycolipids (Prasadarao et al., 1993).
COG COG3539NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport
References
Prasadarao et al., 1993: Prasadarao NV, Wass CA, Hacker J, Jann K, Kim KS. Adhesion of S-fimbriated Escherichia coli to brain glycolipids mediated by sfaA gene-encoded protein of S-fimbriae. The Journal of biological chemistry. 1993; 268(14); 10356-10363. [PubMed: 8098039].