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nleA

Victor ID 3697
Gene Name nleA
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. TW14359
NCBI Gene ID 8216268
NCBI Protein GI 254792777
Locus Tag ECSP_1702
Genbank Accession CP001368
Protein Accession YP_003077614
Other Database IDs UniProtKB-ID: C6USQ1_ECO5T
UniRef100: UniRef100_B5YYL6
UniRef90: UniRef90_A1KWQ4
UniRef50: UniRef50_E0X6R7
UniParc: UPI00000D06D2
EMBL: CP001368
EMBL-CDS: ACT71538.1
RefSeq_NT: NC_013008.1
EnsemblGenome: EBESCG00000164063.
EnsemblGenome_TRS: EBESCT00000165612
EnsemblGenome_PRO: EBESCP00000158493
GenomeReviews: CP001368_GR
KEGG: etw:ECSP_1702
ProtClustDB: CLSK334746
Taxonomy ID 544404
Gene Starting Position 1722106
Gene Ending Position 1723431
Gene Strand (Orientation) -
Protein Name non-LEE-encoded type III secreted effector
Protein pI 4.85
Protein Weight 45353.35
Protein Length 441
DNA Sequence 
>gi|254791136:1722106-1723431 Escherichia coli O157:H7 str. TW14359 chromosome, complete genome
CTTAGACTCTTGTTTCTTGGATTATATCAAAGATATCAACATGATTTGATGGATTATGATGTGGTAAGCC
ATTGCTTTCGATATCGATTACCACATCCTCTGGATTTGGATGCCGCTGTCCAACAGGGATACCTTCTTCC
ATTGCGCGTATATCAGCACCTGTGGCATGTTCAATATCTGCTTTATTGGGGAAAATAGCTCCTTCTCTTG
CGTGCCACCATATACGAGGATAGTCAGTGAATCTAGCTACTTCAAACTCGGCCTTGTTTAAATCGGCAGC
CCCCAGTGTCGCACCAGCCCACCATAAAATAGTGTCTGGCTTTAATCCAGGGGTATTATACTGTATAGCA
TGCCCTGCTGCTTGCCCAACCATTGCACCGATATGAGGACTTAACATTGGATCTGTACTAGCAAATCTGG
ATACTGCAAATCCCCCTAAAGCACCAAGCGCATTTGCGGCAGCATTGGTAAGAACGGCATATTTAGTATT
AGGGTTATCTAAATCCCACTTGAAATGTGCGCCAAACTCCAGCCCTAGAGTTGCCTGTAATGGAGATGCA
CCATATTTAAAATCTGCTTCTCCCGGTCTGATAACCCACTCCTCCGTGTAATTTGCTTTCGGCCCATCAG
GAGTAAGTGGTGTTTCTCCAACAAGCTTCCATCCATTTTCAGTTTTGACTATAGGAAGTTCTACACCATG
ATTACGAACCACTTGAGCTGTTAATCCAAACCATGGTATTGGGTCTTTTGGCTCGGTGGTTACCGTCGAA
GTAGTGGCTGATGTTCCAGTCGATGCAATAGTCGACACTGCAGTGGTTGATATATTACTGTTGCTTAATG
CATTTTTTAACGGGCCAGGAAGGTCTTTAAAATTAAAACCTATTTCATCATGCAGAGGGAATATCTGTAA
AAAATAATTACCTGATGTAGGATGAATATCTGGTTTTACAATGTTTAGCTGGACACCATATTTACCAGAG
ATGCCTGAAACGGAACTAGGTATCTCTAATGCCATTTGGGTAACATTGAATAAACCAAACATATCCAATG
TTTTTTTTCCTATGGATCCTTCTTCAAGGTGAGGAGCTATATATTCGTCTAGCCCTGAGAGCAGACCTTT
ATCTTTTATCAAGCTCAGTAGAGCTGTTGTTTCACCGCATTCCGGTGCATGTTGCTGTATATCATCTGGA
ATATTAACAACAAATCCAGCTTGGCATCCTAGAGGTAATTCGGATTGCGGTATTTGTGTAGAGGGTATTT
GTTCTGTTTGATGATGTTGATTGTTTTGTGAGGTGATTCCAGATTGTATGGTCGGTTGAATGTTCA
Protein Sequence 
>gi|254792777|ref|YP_003077614.1| non-LEE-encoded type III secreted effector [Escherichia coli O157:H7 str. TW14359]
MNIQPTIQSGITSQNNQHHQTEQIPSTQIPQSELPLGCQAGFVVNIPDDIQQHAPECGETTALLSLIKDK
GLLSGLDEYIAPHLEEGSIGKKTLDMFGLFNVTQMALEIPSSVSGISGKYGVQLNIVKPDIHPTSGNYFL
QIFPLHDEIGFNFKDLPGPLKNALSNSNISTTAVSTIASTGTSATTSTVTTEPKDPIPWFGLTAQVVRNH
GVELPIVKTENGWKLVGETPLTPDGPKANYTEEWVIRPGEADFKYGASPLQATLGLEFGAHFKWDLDNPN
TKYAVLTNAAANALGALGGFAVSRFASTDPMLSPHIGAMVGQAAGHAIQYNTPGLKPDTILWWAGATLGA
ADLNKAEFEVARFTDYPRIWWHAREGAIFPNKADIEHATGADIRAMEEGIPVGQRHPNPEDVVIDIESNG
LPHHNPSNHVDIFDIIQETRV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: nelA deletion mutant attenuated in mice (Gruenheid et al., 2004).
References
Gruenheid et al., 2004: Gruenheid S, Sekirov I, Thomas NA, Deng W, O'Donnell P, Goode D, Li Y, Frey EA, Brown NF, Metalnikov P, Pawson T, Ashman K, Finlay BB. Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7. Molecular microbiology. 2004; 51(5); 1233-1249. [PubMed: 14982621].