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eatA from Escherichia coli (strain: JEF100)

Victor ID 6
Gene Name eatA from Escherichia coli (strain: JEF100)
Sequence Strain (Species/Organism) Escherichia coli (strain: JEF100)
NCBI Gene ID 3829299
NCBI Protein GI 83404842
Locus Tag pCoo056
Protein Accession YP_424856.1
Other Database IDs UniProtKB-ID: Q2VP03_ECOLX
UniRef100: UniRef100_Q2VP03
UniRef90: UniRef90_Q84GK0
UniRef50: UniRef50_Q84GK0
UniParc: UPI000065C6CB
EMBL: CR942285
EMBL-CDS: CAI79539.1
RefSeq_NT: NC_007635.1
ProtClustDB: CLSK2392806
Taxonomy ID 562
Plasmid No pCoo
Gene Starting Position 42071
Gene Ending Position 46165
Gene Strand (Orientation) -
Protein Name secreted autotransporter serine protease EatA
DNA Sequence 
>gi|83404799:42071-46165 Escherichia coli plasmid pCoo, complete sequence
ATCAGAAATAATAACGGAAGTTAGCATTTATAGAGTTGTCTATATTATATCTCCCAAACGCCGACTTCTC
CAACTCCAGACCAAAACGCATATTGTCTTTAACTTCCACATTCGTTCCCACGTTCATTAGCATCCTGCTG
TCTTTTTCACCTTTGAAGTGTTTTTTACCAGAAGCATCCTGTAAAACAGTTTCTCCATTTGCCAGCAAAT
CGAACTGGTAACTCAGTCCTGCACGTGCTGTTACTTTCCAGGTATCTCCAGAGAACACTCTACCTACATC
CACGCCTGTTCGACCAATTAGTGGGTGATAGTCTTTGTCTTTCATACTCAATTGCATTCCCTGGTCTTTC
CAGTTAAATGACTTTCCTGATACCGAACCATAAACCAGTTCCATCTGTGGTTCCACCCATGTATTTTCTG
ACATGTGATAACGATACCCGATTTCAGCTCCAGCATACAAAGAATGGGTGGTATAGCTTCTTTCCCCCAG
GGAGGCAAAATTCAACGTATACCGATTATCATGATGGAGATATTTACCAATCAGGTCAAAATAAGCTCCA
GACTCAAAGAGACCTGATGCATACACCCCTCCCCCTAGCGATTTTGTTTTACCGCTGAAAGCCTGGCTGC
TGGCATTGCTGTCTGTATAGGTCAGTAATGCACCGGTGAATAAATTTAGACCGTTCAGCTCATGCTTTCT
GTCTGCACCAATCTGAACGTGGGTATAGTTATCTCTGTAACCACTCTCACCTGAACCGGTACCATTCATG
ATACGCGCCCACCCTCCAGCATCTCCCTGACTATCCCGTAAATCCCCCATACGTTTGTTCAGATTATTGA
CTTCCGTCAGGAAGGATTTATAACCTGAATCCATAAAGTCCGTTGCGATTTTCGAGGCTCTGGCATCAGC
GACAGACTGATATCCAGTCAGCACCCACTTTGTGGCTGTATCCGTATTTTCTGTCCTGATTTCTGGCGTG
ATATTACTGAATCCAATCTGCTGGGTTCCGGCCTTGAATGTATTTTCATCACTGCCTTTTGGTGCAGTGA
TTAACGTCACATTTGTACCATTGGCTGCTTTGTTAAAAAAGTTAACAAGAATAGTATTATTGCTGCCCTG
CAGTTTGCCGGTAACATTCAACTGGTCAGCCTGGCCATTGTTTACATGTACAAGAAACACTGAGTTAGAC
GCAATAAGCTCTTTTACCCGCAGTTTTGCAAAATGCCCTCTTCCACCTAACTCTATTTGGGAGTCGTTGG
CTTTCAGCTCTTTGATTTCCGAATTTCTATCAGAGTGCCACAGAGCATTGTTCATATTCACTGAGCTCTG
TGGCCCCATAATATTGCCCTGCAAAACAGCATTATATCCCCTCATTAAGGTATTGAATAATGGAGAGTCC
GTCTTCCCGATAGTTGCATTACTGTCTCCCAGATTAATAATTGCTGCAGAGTCCTCTGCTATAATATTTG
AACTCAGATAGCCCATATTTTTCACTGAAAGGCTGGCCCGCTCACCGAGATGAATTCCTTCTGTAGTCGA
GATTACAGGTGAATAATACCCCGGCTTTCCTACAGAAGGGATCCCTGTCAGAGTCAGAGAGGCGTTTTCT
TTTATTTCCATAGTGTTATTTGTGAAAATACCACTCTGTGCAGTCAGTTTTGCTCCTTTTTCGAGAAGCA
GACTACTATTAATAAAGCTACCAACATGGTCAAGAATAGCATTCTGAGAGGTCACACTAACAGAACTGTC
ATAAGCCTCAATACCACCAGTAAAATTCTCCCTGACCTCCAGAGACGAATGGTTTTCGAGCAGCACATTA
CCACTGTAATAACTTTGGTCAGCAGCTGTTGTTGCAGTGGAACTCCCTTCAACAGAAGATACTGCATTAC
CGGTTCCATCATTCTTGTCAGTAAAGACCCGAGAACTTCCCAGAATGACGGTACTTCCGTTGGCAGCACT
AATATCTCCTTGCATACGAGTATTTCTGGAGAGATGGAATGTTGCTGCATCAAGCTTCAGTTTATCCATT
GTAAACTGACGGTTTTCCCAATCACTCTGGCCGGCTGAGGTTGTCATTCCAGCATGAATCACCGGATGCC
CCTGGAATATCAGAGTACCTGACTTTTTCGTTATCACCCCTTCAGGCAGATTAACAGAACCATCAAGAGT
CAGCACATCCTTACCAGAGAGTGGATGTATATTTACATCCATATAACCATTAAGTTGTCCATGAAACATA
TAAGGTTGAGAGCTTTCCTCAATCTTCTGCTGTTTCACGATTTGAATCGCTTTATCACGATCGTGACCAA
CATTTTGCCAGACATTGGTATTATCTAAATCACTGAAAAATGGACCGTACGCCTTTGATTTCAGGATAAA
GTAAGTATTTGATGCAGAAACATAATATAAGTCACCTGGACTACCACGCCCCCCAAAAACTTCATATGTC
TTCACATCAACACTAATGTCATTTTCATTTAGTGTTTGTAATTTAAGTGTTAATTCAGATTTGTTTTTGT
TATTGTTAGAAATAATAGCACCATAATCTGCAGCCTGAAGACGAGTAAAGGTTACATTATTTCCATTTAA
ATCAAGAGTGCCGCCTCTATATCCCCATGATATTTTATCTGGGTTAACTTGATTAGCATCTGAAAGTATA
ACTGTTGCACGACCACTGGAAATGTTAATAGAGCTAAAGGCTTGCTTGTGTCCATTATCATCAGGGCGTT
GATTCAGAATTACGGTTCCATCACCGACTTTCAGTCCTCCATTATTAACCCCTTTTCCATTAACAGTTAA
TGTGCCTTCACCAACTTTATGTAAGTTATCATTATTAACACCATTAACCTGCCAAAGCACATTTACACCT
TTTTCAGTAATGATACCACCTCCGGTCCATGTTTGGTCAGTTAAGGATGTAACTGTGTAGTTGTTAAAAA
ACTGCAGATAGCCAGCCCCTTGATCTATAGAGTCGTGTAAAATAACCTCTCCATTATTTCCTGTAAATTG
AAGATTTTTACCTGCATTTAGGTCTTCCCCTTTTTTTCCATGCATGTCCCACACAACTCCCTCTTGACTT
AATGTTCCCACTCCTGCGTCTTTATCATATCTCCATTGTAAGCTCCCCTTTTTAGAGTCATATGATATTG
TTTTATCAAAATCATGCTTTTGTTGCTGATTAAGAAAATCTTGAGTTGTGACAACCCAGTTATTACCATA
CTCACTTCCTGATGAAAGAACGCCAATTAAAACCCATTTTTTTTCCAGAGAGTCATACGCAAATAAAGGA
GAGCCACTATCACCTTTATTTAGATAGTTTGCAAGAGGCCCATTAGCAGGATTAAAAATATCTCCTGTAG
GTGCAGTAATCATTTGCCCATTGTTATATGAGCTTAAAGCACTGATAGTTCCTCCAGTTAGGAAACCACC
ATTTGTATATACCGGTGTAAGATTTCCATTTTTATCCTTTATATATTGCAATCCACCTCCAAGCCTATAA
AAGGCTGTAAAACGCCCCCCTTCTTGATAAGCGCCATTTACAGCTCCAACACTGGAGACTTCTGCAGGGG
CGACCTCCGTGACAATCTTATTTAAACGTCGTGTTTTAATATCAAGGCTATTATGGTTGTTCTCTCCTAC
TACAGTATAATTATTTTGAATATGTCCAAAACTCATTATATCTGATCCATTAACATGCTTTGCTGTGACA
ACATATTGAGGTGAGTACAGTGTATGGTCTCCTGGTGGTAATGTCCCTGTATTCATCGTGGCACTACTAA
AATCAGGCATTGGAGCTTTATCAAGCACTCCAACTAACACTCCATTCTTATCGTAGATATTTATATTTGA
TGCGCCAACTATAAAAGCTCCTTTATTTTCGGCAAAATCCCGAAATGTTTGATACGATATATCTGCATTA
ACTGTTGCAGCAAGAGATGGGGGGGCATAAGAAACAATAGCAATTGTTATTGGTGAAATAATTATTGATG
AAGCACTCTTCAGTTTCCCTTTAACAGAAACGCGACGGGCAAGTTCAGAAACAGCAATAAAACCTTTGGC
TAAAAAACTATACTTAAGAGAGAACACTTTATTCA
Protein Sequence 
>gi|83404842|ref|YP_424856.1| secreted autotransporter serine protease EatA [Escherichia coli] MNKVFSLKYSFLAKGFIAVSELARRVSVKGKLKSASSIIISPITIAIVSYAPPSLAATVNADISYQTFRDFAENKGAFIVGASNINIYDKNGVLVGVLDKAPMPDFSSATMNTGTLPPGDHTLYSPQYVVTAKHVNGSDIMSFGHIQNNYTVVGENNHNSLDIKTRRLNKIVTEVAPAEVSSVGAVNGAYQEGGRFTAFYRLGGGLQYIKDKNGNLTPVYTNGGFLTGGTISALSSYNNGQMITAPTGDIFNPANGPLANYLNKGDSGSPLFAYDSLEKKWVLIGVLSSGSEYGNNWVVTTQDFLNQQQKHDFDKTISYDSKKGSLQWRYDKDAGVGTLSQEGVVWDMHGKKGEDLNAGKNLQFTGNNGEVILHDSIDQGAGYLQFFNNYTVTSLTDQTWTGGGIITEKGVNVLWQVNGVNNDNLHKVGEGTLTVNGKGVNNGGLKVGDGTVILNQRPDDNGHKQAFSSINISSGRATVILSDANQVNPDKISWGYRGGTLDLNGNNVTFTRLQAADYGAIISNNNKNKSELTLKLQTLNENDISVDVKTYEVFGGRGSPGDLYYVSASNTYFILKSKAYGPFFSDLDNTNVWQNVGHDRDKAIQIVKQQKIEESSQPYMFHGQLNGYMDVNIHPLSGKDVLTLDGSVNLPEGVITKKSGTLIFQGHPVIHAGMTTSAGQSDWENRQFTMDKLKLDAATFHLSRNTRMQGDISAANGSTVILGSSRVFTDKNDGTGNAVSSVEGSSTATTAADQSYYSGNVLLENHSSLEVRENFTGGIEAYDSSVSVTSQNAILDHVGSFINSSLLLEKGAKLTAQSGIFTNNTMEIKENASLTLTGIPSVGKPGYYSPVISTTEGIHLGERASLSVKNMGYLSSNIIAEDSAAIINLGDSNATIGKTDSPLFNTLMRGYNAVLQGNIMGPQSSVNMNNALWHSDRNSEIKELKANDSQIELGGRGHFAKLRVKELIASNSVFLVHVNNGQADQLNVTGKLQGSNNTILVNFFNKAANGTNVTLITAPKGSDENTFKAGTQQIGFSNITPEIRTENTDTATKWVLTGYQSVADARASKIATDFMDSGYKSFLTEVNNLNKRMGDLRDSQGDAGGWARIMNGTGSGESGYRDNYTHVQIGADRKHELNGLNLFTGALLTYTDSNASSQAFSGKTKSLGGGVYASGLFESGAYFDLIGKYLHHDNRYTLNFASLGERSYTTHSLYAGAEIGYRYHMSENTWVEPQMELVYGSVSGKSFNWKDQGMQLSMKDKDYHPLIGRTGVDVGRVFSGDTWKVTARAGLSYQFDLLANGETVLQDASGKKHFKGEKDSRMLMNVGTNVEVKDNMRFGLELEKSAFGRYNIDNSINANFRYYF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: interruption of the eatA gene retarded fluid accumulation in the rabbit ileal loop model, suggesting that this autotransporter contributes to the virulence of ETEC (Patel et al., 2004).
References
Patel et al., 2004: Patel SK, Dotson J, Allen KP, Fleckenstein JM. Identification and molecular characterization of EatA, an autotransporter protein of enterotoxigenic Escherichia coli. Infection and immunity. 2004; 72(3); 1786-1794. [PubMed: 14977988].