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ibeA from Escherichia coli SMS-3-5

Victor ID 2251
Gene Name ibeA from Escherichia coli SMS-3-5
Sequence Strain (Species/Organism) Escherichia coli SMS-3-5
NCBI Gene ID 6146360
NCBI Protein GI 170682712
Locus Tag EcSMS35_4868
Protein Accession YP_001746779.1
Other Database IDs UniProtKB-ID: B1LDS7_ECOSM
UniRef100: UniRef100_B1LDS7
UniRef90: UniRef90_Q659Z2
UniRef50: UniRef50_Q9FCY5
UniParc: UPI00016A25A6
EMBL: CP000970
EMBL-CDS: ACB18608.1
RefSeq_NT: NC_010498.1
EnsemblGenome: EBESCG00000062580.
EnsemblGenome_TRS: EBESCT00000063533
EnsemblGenome_PRO: EBESCP00000061175
GenomeReviews: CP000970_GR
KEGG: ecm:EcSMS35_4868
HOGENOM: HBG583717
OMA: IPPCMAM
ProtClustDB: CLSK767238
BioCyc: ECOL439855:ECSMS35_4868-MONOMER
Taxonomy ID 439855
Gene Starting Position 4979542
Gene Ending Position 4980912
Gene Strand (Orientation) +
Protein Name invasion protein IbeA
DNA Sequence 
>gi|170679574:4979542-4980912 Escherichia coli SMS-3-5, complete genome
TATGGAATTTTATCTGGAACCCGCTCGTAATATACCTGTACTGGCAACCACGGAAGTGTTAGTTGTTGGT
GGTGGTCCATCGGGTATTGCCGCAGCAATGAGTGCCGCTCGTGAAGGCGCAGCTACTATGCTGATTGAAC
GTTTCGGTTGTTTTGGCGGAATGATGACAACGGCTGGCGTCGAGTCAATTGCCTGGTGGCGTCATGAAAA
TACGGTAGAGTCAGGTGGACTGGCACGCGAAATAGAAGAAACGGCAAAATCAATGGGGGCGTCCAGCCCT
GAGCCGCAATCGAATAGTCAGGCTATTAACGCCGAGCGTTTCAAACTGGTTGCGGATGCAATGCTTGAAC
AGGCAGGTGTGCGCCGCGTACTACACATTACCGCCGTTGATGTTATTAAGCAGGGCAATAATTTACTCGG
CGTAATAACAGAGAGTAAATCTGGTCGTCAGGCTATTTTGGCGAATGTCATTATTGACTGTACTGGCGAT
GCCGATATTGCATGGTTTGCCGGAGCACCATTTATTAAGCGTGAACGCGAAGAGCTAATGTGTATGACAA
CCGTTTTTAGTTGCGCAAATATAAATAAAAACGCGTTCATGCAAAATATTAAGAGCACGGAACCTAAATA
TGGAGACTGGGGGGCGGATGAAGAAAATAAAAACTGGTCTTATGATGTTCATGAATCTTGTCGCGATATG
TTTAGCCCTTATCTGGGTAAAGTCTTTGCGAAAGGAAAGTCGGCAGGAATTATTCCAAAAGATGTGACGT
TAGGCGGTTCCTGGAGTACGGTCACCGAGTATGGTGATGCGAATTACTTGAACGTTGTCAGCATCCCTGC
CGTCGATTGTACGGATGTTTTTGACCTGACGCGTGCAGAAATAGAAGGCCGCAAGCAAGCCATGCAGGCG
ATTGAAGCGTTGCGTCAATTCCAGCCAGGATTTGAACAGGCACAATTAAAAAATTTCGGTATGACGGTGG
GAACAAGAGAATCAAGACATATTATTGGGCGAGTCCAGCTTACGGAAAATGATATTTGTAATGAGGGACG
TCATGCGGATTCAATAGGGGTATTCCCTGAGTTTATAGATGGAAATGGTCATCTTAAATTACCTCTTGAA
GCGAACTATTTTCAAATCCCTTATGGCGTAATGATTCCGCAGCAAGTTGAAAACCTGTTGGTTTGCGGAC
GGGCAATCGATGCAGATAATTTCGCCTATGCGACAATCCGTAATATGGGGTGTTGTATTGTCACTGGAGA
AGGTGCAGGGACTGCCGCTGCTATTGCCATTAAAAATAACACTACCGTTTCACAGGTAGATATTCAGACG
GTACAGGAACGCTTACAGCAAAATGGCGTAAAAGTCTTTTA
Protein Sequence 
>gi|170682712|ref|YP_001746779.1| invasion protein IbeA [Escherichia coli SMS-3-5] MEFYLEPARNIPVLATTEVLVVGGGPSGIAAAMSAAREGAATMLIERFGCFGGMMTTAGVESIAWWRHENTVESGGLAREIEETAKSMGASSPEPQSNSQAINAERFKLVADAMLEQAGVRRVLHITAVDVIKQGNNLLGVITESKSGRQAILANVIIDCTGDADIAWFAGAPFIKREREELMCMTTVFSCANINKNAFMQNIKSTEPKYGDWGADEENKNWSYDVHESCRDMFSPYLGKVFAKGKSAGIIPKDVTLGGSWSTVTEYGDANYLNVVSIPAVDCTDVFDLTRAEIEGRKQAMQAIEALRQFQPGFEQAQLKNFGMTVGTRESRHIIGRVQLTENDICNEGRHADSIGVFPEFIDGNGHLKLPLEANYFQIPYGVMIPQQVENLLVCGRAIDADNFAYATIRNMGCCIVTGEGAGTAAAIAIKNNTTVSQVDIQTVQERLQQNGVKVF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: deletion mutant was significantly less invasive in human brain microvascular endothelial cells (BMECs) than the parent strain (E. coli K1) (Huang et al., 2001).
References
Huang et al., 2001: Huang SH, Wan ZS, Chen YH, Jong AY, Kim KS. Further characterization of Escherichia coli brain microvascular endothelial cell invasion gene ibeA by deletion, complementation, and protein expression. The Journal of infectious diseases. 2001; 183(7); 1071-1078. [PubMed: 11237832].