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tir from Escherichia coli O127:H6 str. E2348/69

Victor ID 3498
Gene Name tir from Escherichia coli O127:H6 str. E2348/69
Sequence Strain (Species/Organism) Escherichia coli O127:H6 str. E2348/69
NCBI Gene ID 7064348
NCBI Protein GI 215488972
Locus Tag E2348C_3941
Protein Accession YP_002331403.1
Other Database IDs UniProtKB-ID: B7UM99_ECO27
UniRef100: UniRef100_O52147
UniRef90: UniRef90_Q9KWH9
UniRef50: UniRef50_Q58I88
UniParc: UPI00000BCCB0
EMBL: FM180568
EMBL-CDS: CAS11489.1
RefSeq_NT: NC_011601.1
EnsemblGenome: EBESCG00000113285.
EnsemblGenome_TRS: EBESCT00000114714
EnsemblGenome_PRO: EBESCP00000105204
GenomeReviews: FM180568_GR
KEGG: ecg:E2348C_3941
HOGENOM: HBG468013
OMA: SETHTST
ProtClustDB: CLSK334862
Taxonomy ID 574521
Gene Starting Position 4113829
Gene Ending Position 4115481
Gene Strand (Orientation) -
Protein Name translocated intimin receptor Tir
DNA Sequence 
>gi|215485161:4113829-4115481 Escherichia coli O127:H6 str. E2348/69, complete genome
TTTAAACGAAACGTACTGGTCCCGGCGTTGGTGCGGCATTTACAGAACTTACTGCGCTCTCGCCACCACT
CGTTAATCCTCCCATACCTAAACGCAATCCGCCGCTGTTTGCCAGAAGCGCATAAGTACTTTGGATACCT
TGCCCTGGAGTTCCTATTAACCTTCCGGTAACTGGGCCGCTCCCTGAAAAATTCTGAATAACGCTATAAC
CAGGATCTGCAGCGACCTCATCATAAATATGCTCTTCTGGCTGATGAGCCGATAGACTATTCCGAGCCCC
CCCAACTTCAGCATATGGATTAACCACTTCGCTAGAGGAATCTGACCAGTGTGTCGATGCAACACTCCCC
TGCGAATCACGTCTATTCAGAGAAGCGTCTTCTGCTCTTGTGGCATCAGTGCCACCTTGTGCTGGGGTAT
TCCCTCCGGTCTGTTGCTGCACTACCGTATGTGTTGTTGTAGTAGTTGTCTGTTCTGCCGGCTGATTTCG
TCTATGGAGCGCAGTCGTTACACCAGCACCAATTCCCCCAGCAACAATCAATGCACTGCTGAGGCCGTAA
CCAATACCCGATGAAAGCTGTAATTCCTCCTGACGTCTGGCATGCTGATCCTCATATCGCTGCTGCGCCT
GTGCATTGCTTTCAACAGCCTGCTGTCTGGCCACCTCACCAGCCTCTTTAGCTTGTTGTGCTATTTGCTC
AACAATATCATCTTTTAATTCCCCAGACGGAATAGCATTTCCGTTCGCATCGATGTTAACTTTCTGGTTC
TCAGGGTTCTTGAATGCTTCTTGCGTTAACTGATCTTTTGTTGCACTTTCTGCAGCATTTGCGGCCTGAT
CAGGATCGGTGGTTGTAGGATCATCCGGTTCCGGTGTCAAAGCCAACGCCTGTGCAATACCAGTTGCCGC
CAGTCCCGCTAAACCAGCAGCAATTGCGCCGACAGAAACCCAGAATTTAGGATCTGAGCGAACGCTGGAA
TTTGTTGTTGAAGTATGGGTTTCGCTAACAACGCCATCATCTATTCCCGAAGCGCTGCCAACACCAACAG
AACGCGTATCAACGTCCTTGGGTTGACGTCCTCCATGATTGTCTGGGTCTAATTTGGCCAGTATTTTCGT
ACGAGCTTCCGCGATATCTGATGCGACAGTGACCATCGGATGCCCACTACCGCCACGTCCCCCGGTAAAA
ACAAATCTGTTTTTACCCTCAGTATCAATAGATTGCAAGCTGCTCCATTCTTGAGGACTTAATGTAACGC
TAACCTCCAAACCATTTTTTTCTCCAATAGCGGCATGAGTACCATCTGCCTGCACTTCAACACGAAATGC
AGAGGGTCCAATTTGCGTATTGAGAATATCAAGTGGCCCCTTATCATGGAGAACTTCAAATCCTCCAAGC
AAGCATGTCTCAGATGTAGCTGCAGCAAGCCTCGATGGGTTTGTAGGAAGTCCTGGAATATCTCTGGAAT
CGACAGAATCAGCCATAGAATTTCTCAGGGGAGAAAACAATGAACGAGATCCTAATGCTCCTGTAGAGCT
AATTAGATGACCAGTTCCTCCCCGTGCCGCGCCGTCTGTTTGTGAAGGTAGTGGCGGCGCAGGGGGAATT
AAATGATTGCCATTTACATTATTACCAAGGTTACCAATAGGCA
Protein Sequence 
>gi|215488972|ref|YP_002331403.1| translocated intimin receptor Tir [Escherichia coli O127:H6 str. E2348/69] MPIGNLGNNVNGNHLIPPAPPLPSQTDGAARGGTGHLISSTGALGSRSLFSPLRNSMADSVDSRDIPGLPTNPSRLAAATSETCLLGGFEVLHDKGPLDILNTQIGPSAFRVEVQADGTHAAIGEKNGLEVSVTLSPQEWSSLQSIDTEGKNRFVFTGGRGGSGHPMVTVASDIAEARTKILAKLDPDNHGGRQPKDVDTRSVGVGSASGIDDGVVSETHTSTTNSSVRSDPKFWVSVGAIAAGLAGLAATGIAQALALTPEPDDPTTTDPDQAANAAESATKDQLTQEAFKNPENQKVNIDANGNAIPSGELKDDIVEQIAQQAKEAGEVARQQAVESNAQAQQRYEDQHARRQEELQLSSGIGYGLSSALIVAGGIGAGVTTALHRRNQPAEQTTTTTTHTVVQQQTGGNTPAQGGTDATRAEDASLNRRDSQGSVASTHWSDSSSEVVNPYAEVGGARNSLSAHQPEEHIYDEVAADPGYSVIQNFSGSGPVTGRLIGTPGQGIQSTYALLANSGGLRLGMGGLTSGGESAVSSVNAAPTPGPVRFV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture (Schüller et al., 2007).
References
Schüller et al., 2007: Schüller S, Chong Y, Lewin J, Kenny B, Frankel G, Phillips AD. Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture models. Cellular microbiology. 2007; 9(5); 1352-1364. [PubMed: 17474908].