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hlyC from Escherichia coli O111:H- str. 11128

Victor ID 3787
Gene Name hlyC from Escherichia coli O111:H- str. 11128
Sequence Strain (Species/Organism) Escherichia coli O111:H- str. 11128
NCBI Gene ID 8470734
NCBI Protein GI 260751836
Locus Tag ECO111_p3-01
Protein Accession YP_003237750.1
Other Database IDs UniProtKB-ID: C8URB8_ECO1A
UniRef100: UniRef100_Q5K5Z5
UniRef90: UniRef90_Q5K5Z5
UniRef50: UniRef50_P09985
UniParc: UPI00000B3039
EMBL: AP010963
EMBL-CDS: BAI39320.1
RefSeq_NT: NC_013366.1
EnsemblGenome: EBESCG00000195641.
EnsemblGenome_TRS: EBESCT00000196959
EnsemblGenome_PRO: EBESCP00000183939
GenomeReviews: AP010963_GR
KEGG: eoi:ECO111_p3-01
ProtClustDB: CLSK862057
Taxonomy ID 585396
Plasmid No pO111_3
Gene Starting Position 0
Gene Ending Position 515
Gene Strand (Orientation) +
Protein Name hemolysin C
DNA Sequence 
>gi|260751835:1-515 Escherichia coli O111:H- str. 11128 plasmid pO111_3, complete sequence
ATGAAATCTAATGCTTTTGACGTCATGGGGAAGGTTGCATGGCTATGGGCCTGTTCTCCTCTGCATAAAA
AATGGCCATTATCTGTTTTTGCTATTAATGTCATACCTGCTATTCAGACAAATCAATTTGCTCTCTTAAT
AAAGGATGAGCTTCCTGTAGCTTTTTGTAGCTGGGCCAGTTTAGATCTGGAATGTGAGGTAAAATATATA
AATGATGTAACATCTTTGTATGCAAAAGACTGGATGTCGGGAGAAAGAAAGTGGTTTATTGACTGGATAG
CTCCATTTGGACACAACATGGAGTTATATAAATACATGAGGAAAAAGTATCCTTATGAGTTATTCAGAGC
AATAAGGTTAGATGAGAGCAGTAAAACAGGAAAAATAGCTGAATTTCATGGAGGGGGGATAGATAAAAAA
CTGGCATCAAAAATATTCAGGCAATACCATCATGAACTTATGTCTGAAGTAAAAAACAGACAAGATTTTA
ATTTTAATATTGAGAAAGAAAACTA
Protein Sequence 
>gi|260751836|ref|YP_003237750.1| hemolysin C [Escherichia coli O111:H- str. 11128] MKSNAFDVMGKVAWLWACSPLHKKWPLSVFAINVIPAIQTNQFALLIKDELPVAFCSWASLDLECEVKYINDVTSLYAKDWMSGERKWFIDWIAPFGHNMELYKYMRKKYPYELFRAIRLDESSKTGKIAEFHGGGIDKKLASKIFRQYHHELMSEVKNRQDFNFNIEKEN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells (Stanley et al., 1996).
COG COG2994O, under O: Posttranslational modification, protein turnover, chaperones
References
Stanley et al., 1996: Stanley P, Koronakis V, Hardie K, Hughes C. Independent interaction of the acyltransferase HlyC with two maturation domains of the Escherichia coli toxin HlyA. Molecular microbiology. 1996; 20(4); 813-822. [PubMed: 8793877].