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hlyC from Escherichia coli O157:H7 str. Sakai

Victor ID 2276
Gene Name hlyC from Escherichia coli O157:H7 str. Sakai
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. Sakai
NCBI Gene ID 1789689
NCBI Protein GI 10955282
Locus Tag pO157p17
Protein Accession NP_052623.1
Other Database IDs UniProtKB-ID: O82885_ECO57
UniRef100: UniRef100_Q5K5Z5
UniRef90: UniRef90_Q5K5Z5
UniRef50: UniRef50_P09985
UniParc: UPI00000BA353
EMBL: EF079672
EMBL: AB011549
EMBL-CDS: ABK79666.1
EMBL-CDS: BAA31773.1
RefSeq_NT: NC_002128.1
EnsemblGenome: EBESCG00000059793.
EnsemblGenome_TRS: EBESCT00000060746
EnsemblGenome_PRO: EBESCP00000058390
GenomeReviews: AB011549_GR
HOGENOM: HBG296557
ProtClustDB: CLSK862057
Taxonomy ID 386585
Plasmid No pO157
Gene Starting Position 16118
Gene Ending Position 16609
Gene Strand (Orientation) +
Protein Name hemolysin C
DNA Sequence 
>gi|10955266:16118-16609 Escherichia coli O157:H7 str. Sakai plasmid pO157, complete sequence
CATGGGGAAGGTTGCATGGCTATGGGCCTGTTCTCCTCTGCATAAAAAATGGCCATTATCTGTTTTTGCT
ATTAATGTCATACCTGCTATTCAGACAAATCAATTTGCTCTCTTAATAAAGGATGAGCTTCCTGTAGCTT
TTTGTAGCTGGGCCAGTTTAGATCTGGAATGTGAGGTAAAATATATAAATGATGTAACATCTTTGTATGC
AAAAGACTGGATGTCGGGAGAAAGAAAGTGGTTTATTGACTGGATAGCTCCATTTGGACACAACATGGAG
TTATATAAATACATGAGGAAAAAGTATCCTTATGAGTTATTCAGAGCAATAAGGTTAGATGAGAGCAGTA
AAACAGGAAAAATAGCTGAATTTCATGGAGGGGGGATAGATAAAAAACTGGCATCAAAAATATTCAGGCA
ATACCATCATGAACTTATGTCTGAAGTAAAAAACAGACAAGATTTTAATTTTAATATTGAGAAAGAAAAC
TA
Protein Sequence 
>gi|10955282|ref|NP_052623.1| hemolysin C [Escherichia coli O157:H7 str. Sakai] MGKVAWLWACSPLHKKWPLSVFAINVIPAIQTNQFALLIKDELPVAFCSWASLDLECEVKYINDVTSLYAKDWMSGERKWFIDWIAPFGHNMELYKYMRKKYPYELFRAIRLDESSKTGKIAEFHGGGIDKKLASKIFRQYHHELMSEVKNRQDFNFNIEKEN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells (Stanley et al., 1996).
COG COG2994O, under O: Posttranslational modification, protein turnover, chaperones
References
Stanley et al., 1996: Stanley P, Koronakis V, Hardie K, Hughes C. Independent interaction of the acyltransferase HlyC with two maturation domains of the Escherichia coli toxin HlyA. Molecular microbiology. 1996; 20(4); 813-822. [PubMed: 8793877].