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acnA

Victor ID 2218
Gene Name acnA
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. EDL933
NCBI Gene ID 961382
NCBI Protein GI 15801901
Locus Tag Z2532
Genbank Accession AE005174
Protein Accession NP_287921
Other Database IDs UniProtKB-ID: Q8X7C7_ECO57
UniRef100: UniRef100_C3TC47
UniRef90: UniRef90_P25516
UniRef50: UniRef50_P25516
UniParc: UPI00000D0A85
EMBL: AE005174
EMBL: BA000007
EMBL-CDS: AAG56537.1
EMBL-CDS: BAB35272.1
RefSeq_NT: NC_002655.2
RefSeq_NT: NC_002695.1
EnsemblGenome: EBESCG00000028191.
EnsemblGenome_TRS: EBESCT00000029141
EnsemblGenome_PRO: EBESCP00000028034
EnsemblGenome: EBESCG00000058708.
EnsemblGenome_TRS: EBESCT00000059661
EnsemblGenome_PRO: EBESCP00000057489
GenomeReviews: AE005174_GR
GenomeRev
Taxonomy ID 155864
Gene Starting Position 2247962
Gene Ending Position 2250637
Gene Strand (Orientation) -
Protein Name aconitate hydratase
Protein pI 5.58
Protein Weight 90515.59
Protein Length 891
Protein Note Catalyzes the conversion of citrate to isocitrate
DNA Sequence 
>gi|16445223:2247962-2250637 Escherichia coli O157:H7 str. EDL933 chromosome, complete genome
GTTACTTCAACATATTACGAATGACATAATGCAAAATGCCGTCGTTCTGGTAGTAAGTCAACTCCGTCGC
GGTGTCGATACGACAACGGCAGGGTACGACTTCCTGGCTACCATCCGCGCGCGTAAGCGTCACCGGAACC
GTCGCGCCGGGTTGTAGATTTTGCAGATCGCCAATATCAATCTTCTCTTCCCCGGTTAGCCCTAACGTTT
TACGCGTTACGCCTTGCGGAAATTCCAGCGGCAGGATGCCCATGCCAATTAAATTCGAACGGTGAATTCG
TTCAAACGATTCGGCAATCACCACACGAATACCAAGCAGACGCGGACCTTTTGCCGCCCAGTCACGGCTG
GAGCCTGATCCATACTCTTTCCCGGCAATCACCGCCAGCGGCGTTTGCTCCTGCTTATAGCGCATCGCAG
CATCATAAATAGAGACTACGTCGCTGTCAGGTAAATGCCGCGTCATCCCCCCTTCAACGCCAGGCACCAT
TTCATTACGGATGCGAATATTGGCGAAGGTGCCGCGCATCATCACTTCATGGTTACCACGCCGCGAACCG
TAGGAGTTAAAGTCTTTTCGCTCAACACCCCGACCTTGTAGGTATCGACCCGCTGGGCTGTCGGGCTTAA
TACTGCCCGCCGGAGAGATATGGTCAGTGGTGACTGAATCCCCCAGCATTGCGAGGATCCGCGCACCGTG
AATATCTTCCACAGGTGCTGGCGTTGCCTGCATTTCATCAAAGAAAGGCGATAAACGAATATAGGTTGAA
TCCTCCTGCCATCCGTAGGTATCGGATCGTGCGACGTTAATTTCTTTCCACTCTGCAGTGCCTTCAAAGA
CTTCTGCGTACTCTTTGCGGAACATTTCTGTGGAGACTTGTTCTACCGCACGGGCAATTTCTTGTGCCGA
TGGCCAGATATCTTTCAGATATATTGGATCGCCTTTACGATCATGACCAATAGGCTCAGAAGCCAGGTTG
ATATTCATATTTCCCGCCAGCGCATAGGCAACCACCAGCGGCGGCGAGGCCAGCCAGTTAGTTTTAACCA
GCGGATGGATACGGCCTTCAAAGTTACGGTTGCCGGACAGCACTGCACCGACGGTTAAATCGCCTTTTTT
GATTGCCGTTTCGATAGGATCGGGCAGCGGCCCAGAGTTACCAATACAGGTGGTACAACCGTATCCCACA
AGGTTAAACCCCAGTTCGTCGAGATACGGTGTCAGTTTCGCTTTTGCCAGATAGTCAGAAACGACTTTCG
AACCCGGTGCCAGCGACGCTTTGACCCACGGTTGCCGCTTGAGGCCAAGAGTTACGGCTTTTTTCGCCAG
CAAGCCTGCGGCCATCAGCACACTTGGGTTAGAAGTGTTGGTGCACGAGGTTATCGCAGCAATGACCACA
GCGCCATCAGGTAACTGATACTGATGTCCGTTCATAACATAATCGACCGGCTGGCGATCTTTATGCGTGG
CATTCACTTCCAGTTCGTTACTGGCGGCAAATGCTTTTGGTACATCGGGCAGTGCAACGCGATCCTGTGG
GCGTTTAGGCCCTGCCAGGCTCGCTTCAACGTCATTCATATCCAGATCTAACGTACTGGTAAAAATCGGT
TCATCGCCCGGGTTACGCCACATGCCCTGCGCTTTGGCATATTTTTCGACCAACTCGACCTGATCTTCGC
TGCGCCCGCTTAAACGCATGTAATCGAGGGTTACAGCATCGATTGGGAAGAAGCCACAGGTGGCACCATA
TTCTGGCGACATATTGGCAATGGTGGCGCGATCCGCCAACGGTAGTGAATCCAGACCATCACCATAAAAT
TCGACGAATTTCCCCACCACGCCATGTTTGCGCAGCATTTGGGTAACAGTGAGAACCAGGTCTGTGGCGG
TAATACCTTCACGTAATTTTCCGGTAAGTTTAAAGCCCACTACGTCCGGGATAAGCATGGAAACCGGCTG
GCCTAACATTGCGGCTTCTGCTTCGATGCCACCCACGCCCCACCCCAGCACGCCAAGGCCGTTGATCATA
GTGGTGTGCGAGTCAGTACCAACGAGTGTATCCGGATAAGCAATCCATTCACCGTCCTGCAATTCGCTCC
ACACTGCTTTGCCGAGATATTCGAGGTTAACCTGATGGCAAATGCCTGTGCCTGGCGGCACGACGCTAAA
CCGACTGAACGCTTGCTTTCCCCATTTCAGGAACACATAACGTTCGTGGTTGCGCTCCATTTCCAGGCGT
ACGTTTTCTTCAAATGCCTCATCATCACCAAAACGATCGACGGTCACCGAGTGGTCAATGACCAGGTCGA
CCGGTGAGAGCGGGTTAACCTTTGCAGTATCGCCACCGAGGCGTTTAACCGCTTCGCGCATTGCCGCCAG
ATCAACAACGGCAGGTACGCCGGTAAAGTCCTGCATCAGCACCCTTGCCGGGCGGTAGGCAATTTCACGG
TCAGCATGGGCATTTTTCAGCCATCCCGCCAGCGCGTGGATATCCTCTTCGGTAACCGAGTTACCATCCT
GCCAGCGCAGCAGATTTTCGAGCAAAACTTTGAGTGACTTGGGTAGACGGGTGATATCGCCCAGTGATTT
GGCAGCAAGCGGCAGGCTGTAGTAGTGGTAAGTTTTATCTTTGGCCTGCAACGCGTCCTTACTGGCTTCT
CGTAGGGTTGACGACA
Protein Sequence 
>gi|15801901|ref|NP_287921.1| aconitate hydratase [Escherichia coli O157:H7 str. EDL933]
MSSTLREASKDALQAKDKTYHYYSLPLAAKSLGDITRLPKSLKVLLENLLRWQDGNSVTEEDIHALAGWL
KNAHADREIAYRPARVLMQDFTGVPAVVDLAAMREAVKRLGGDTAKVNPLSPVDLVIDHSVTVDRFGDDE
AFEENVRLEMERNHERYVFLKWGKQAFSRFSVVPPGTGICHQVNLEYLGKAVWSELQDGEWIAYPDTLVG
TDSHTTMINGLGVLGWGVGGIEAEAAMLGQPVSMLIPDVVGFKLTGKLREGITATDLVLTVTQMLRKHGV
VGKFVEFYGDGLDSLPLADRATIANMSPEYGATCGFFPIDAVTLDYMRLSGRSEDQVELVEKYAKAQGMW
RNPGDEPIFTSTLDLDMNDVEASLAGPKRPQDRVALPDVPKAFAASNELEVNATHKDRQPVDYVMNGHQY
QLPDGAVVIAAITSCTNTSNPSVLMAAGLLAKKAVTLGLKRQPWVKASLAPGSKVVSDYLAKAKLTPYLD
ELGFNLVGYGCTTCIGNSGPLPDPIETAIKKGDLTVGAVLSGNRNFEGRIHPLVKTNWLASPPLVVAYAL
AGNMNINLASEPIGHDRKGDPIYLKDIWPSAQEIARAVEQVSTEMFRKEYAEVFEGTAEWKEINVARSDT
YGWQEDSTYIRLSPFFDEMQATPAPVEDIHGARILAMLGDSVTTDHISPAGSIKPDSPAGRYLQGRGVER
KDFNSYGSRRGNHEVMMRGTFANIRIRNEMVPGVEGGMTRHLPDSDVVSIYDAAMRYKQEQTPLAVIAGK
EYGSGSSRDWAAKGPRLLGIRVVIAESFERIHRSNLIGMGILPLEFPQGVTRKTLGLTGEEKIDIGDLQN
LQPGATVPVTLTRADGSQEVVPCRCRIDTATELTYYQNDGILHYVIRNMLK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: acnA mutant is attenuated in calves (van et al., 2005).
COG COG1048C, under C: Energy production and conversion
References
van et al., 2005: van Diemen PM, Dziva F, Stevens MP, Wallis TS. Identification of enterohemorrhagic Escherichia coli O26:H- genes required for intestinal colonization in calves. Infection and immunity. 2005; 73(3); 1735-1743. [PubMed: 15731074].