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tsh

Victor ID 2280
Gene Name tsh
Sequence Strain (Species/Organism) Escherichia coli APEC O1
NCBI Gene ID 5616581
NCBI Protein GI 157418156
Locus Tag APECO1_O1CoBM73
Genbank Accession DQ381420
Protein Accession YP_001481228
Other Database IDs UniProtKB-ID: Q27TE9_ECOK1
UniRef100: UniRef100_B1P7P2
UniRef90: UniRef90_O88093
UniRef50: UniRef50_Q47692
UniParc: UPI00006C9B8F
EMBL: DQ381420
EMBL-CDS: ABD51643.1
RefSeq_NT: NC_009837.1
EnsemblGenome: EBESCG00000038953.
EnsemblGenome_TRS: EBESCT00000039903
EnsemblGenome_PRO: EBESCP00000038254
GenomeReviews: DQ381420_GR
eggNOG: COG3468
HOGENOM: HBG467630
OMA: DIFNPAN
ProtClustDB: CLSK2393949
BioCyc: ECOL405955:APECO1_O1COBM73-MONOMER
Taxonomy ID 405955
Plasmid No pAPEC-O1-ColBM
Gene Starting Position 58774
Gene Ending Position 62907
Gene Strand (Orientation) +
Protein Name Tsh
Protein pI 5.66
Protein Weight 138374.69
Protein Length 1377
DNA Sequence 
>gi|157418083:58774-62907 Escherichia coli APEC O1 plasmid pAPEC-O1-ColBM, complete sequence
AATGAACAGAATTTATTCTCTTCGCTACAGCGCTGTGGCCCGGGGCTTTATTGCCGTATCTGAGTTTGCT
AGGAAATGTGTTCATAAGTCTGTCAGACGTCTGTGTTTCCCGGTTTTATTACTGATCCCGGTACTATTCT
CTGCAGGAAGTCTTGCGGGAACGGTCAATAATGAACTCGGGTATCAGTTATTTCGTGATTTTGCTGAAAA
TAAGGGGATGTTCCGCCCGGGGGCAACGAATATCGCTATTTATAATAAGCAGGGAGAATTTGTCGGTACG
CTGGATAAGGCAGCTATGCCTGATTTCAGTGCTGTGGATTCGGAAATCGGTGTGGCGACACTGATAAACC
CGCAGTATATCGCCAGCGTGAAACATAACGGGGGATATACAAACGTTAGCTTTGGTGATGGTGAAAACCG
TTACAATATCGTGGACCGGAATAATGCGCCGTCACTGGATTTTCATGCCCCCCGGCTGGGTAAACTGGTG
ACAGAGGTTGCCCCTACTGCGGTGACGGCGCAGGGGGCAGTGGCTGGCGCATATCTGGATAAGGAGCGCT
ATCCTGTTTTTTATCGTCTGGGGTCTGGTACTCAGTATATTAAGGACAGTAACGGACAGCTGACAAAAAT
GGGAGGTGCATATTCCTGGCTGACCGGCGGGACTGTCGGTAGCCTGTCATCCTATCAGAATGGAGAAATG
ATTAGCACCAGTTCAGGTCTGGTTTTTGATTACAAACTTAATGGTGCAATGCCCATTTATGGCGAGGCCG
GTGACAGCGGTTCGCCTTTATTTGCTTTTGATACTGTTCAGAATAAATGGGTGCTGGTCGGTGTTCTTAC
TGCGGGGAATGGCGCGGGGGGCAGGGGAAATAACTGGGCTGTTATTCCACTGGATTTTATCGGGCAGAAA
TTTAATGAAGACAATGATGCCCCGGTCACGTTCAGAACATCGGAAGGTGGTGCACTGGAGTGGAGCTTTA
ACAGCAGTACCGGAGCTGGTGCGCTGACACAGGGAACCACCACATATGCCATGCACGGGCAGCAGGGAAA
TGACCTGAATGCTGGTAAGAACCTGATATTTCAGGGGCAGAATGGTCAGATTAACCTTAAGGATTCGGTT
TCTCAGGGGGCGGGTTCCCTGACGTTCCGTGATAATTACACAGTAACAACCTCTAACGGAAGTACCTGGA
CCGGTGCCGGTATTGTTGTGGACAACGGGGTGTCCGTAAACTGGCAGGTTAATGGTGTTAAGGGCGATAA
CCTGCATAAAATTGGTGAAGGTACGCTGACGGTACAGGGTACAGGTATTAATGAAGGTGGCCTGAAGGTC
GGGGACGGAAAGGTTGTACTGAACCAGCAGGCGGACAATAAAGGACAGGTGCAGGCGTTCAGCAGTGTTA
ATATTGCCAGTGGCCGGCCGACCGTGGTACTGACTGATGAGCGGCAGGTAAATCCGGATACCGTCTCATG
GGGATATCGTGGGGGCACACTGGATGTTAATGGTAACAGTCTGACGTTTCATCAGTTGAAGGCGGCAGAT
TATGGTGCCGTGCTGGCGAATAACGTTGATAAACGGGCCACTATCACGCTGGACTATGCCCTGCGGGCTG
ACAAAGTAGCACTGAATGGCTGGTCGGAATCAGGTAAAGGAACTGCCGGAAATTTATATAAATACAATAA
CCCGTACACAAATACGACGGATTACTTCATCCTGAAGCAGAGCACCTATGGTTATTTCCCCACGGACCAG
AGCAGCAACGCCACCTGGGAGTTTGTGGGGCACAGTCAGGGGGATGCACAGAAACTGGTAGCTGACCGTT
TCAATACTGCAGGGTATCTGTTTCACGGACAACTGAAAGGCAATCTGAATGTGGACAATCGCCTGCCTGA
AGGCGTTACCGGTGCTCTGGTGATGGACGGAGCTGCGGATATCTCCGGTACATTCACCCAGGAAAACGGG
CGTCTGACGCTGCAGGGGCATCCGGTTATCCATGCATACAATACTCAGTCTGTGGCTGACAAACTGGCTG
CCAGTGGAGACCATTCGGTTCTGACTCAGCCTACGTCATTCAGTCAGGAGGACTGGGAGAACCGCAGTTT
TACCTTTGACAGGCTGTCACTGAAGAACACTGATTTTGGTCTTGGTCGCAATGCCACACTGAACACAACC
ATCCAGGCAGATAACTCCAGCGTCACGCTGGGCGACAGCCGGGTATTTATCGACAAAAACGATGGCCAGG
GAACAGCCTTTACCCTTGAAGAAGGCACATCTGTTGCAACTAAAGATGCAGATAAAAGTGTCTTCAACGG
CACCGTCAACCTGGATAATCAGTCAGTGCTGAATATCAATGATATATTCAATGGCGGAATACAGGCGAAC
AACAGTACCGTGAATATCTCCTCAGACAGTGCCGTTCTGGGGAACTCAACACTGACCAGTACCGCCCTGA
ATCTGAACAAGGGAGCAAATGCTCTGGCCAGTCAGAGTTTTGTTTCTGACGGTCCAGTGAATATTTCTGA
TGCCACCCTGAGTCTGAACAGCCGTCCTGATGAGGTATCTCACACACTTTTACCTGTATACGATTATGCC
GGTTCATGGAACCTGAAGGGAGACGATGCCCGCCTGAACGTGGGGCCGTACAGTATGTTGTCAGGTAATA
TCAATGTTCAGGATAAAGGGACTGTCACCCTCGGAGGGGAAGGGGAACTGAGTCCTGACCTGACTCTTCA
GAATCAGATGTTGTACAGCCTGTTTAACGGGTACCGCAATATCTGGAGCGGGAGCCTGAATGCACCGGAT
GCCACCGTCAGCATGACAGACACCCAGTGGTCGATGAACGGAAACTCCACGGCAGGAAATATGAAACTTA
ACCGGACAATAGTCGGTTTTAACGGGGGAACATCACCGTTCACGACACTGACAACAGATAATCTGGACGC
GGTTCAGTCAGCATTTGTCATGCGTACAGACCTTAACAAGGCAGACAAACTGGTGATAAACAAGTCGGCA
ACAGGTCATGACAACAGCATCTGGGTTAACTTCCTGAAAAAACCTTCTAACAAGGACACGCTTGATATTC
CACTGGTCAGCGCACCTGAAGCGACAGCTGATAATCTGTTCAGGGCATCAACACGGGTTGTGGGATTCAG
TGATGTCACCCCCATCCTTAGTGTCAGAAAAGAGGACGGGAAAAAAGAGTGGGTCCTCGATGGTTACCAG
GTTGCACGTAACGACGGCCAGGGTAAGGCTGCCGCCACATTCATGCACATCAGCTATAACAACTTCATCA
CTGAAGTTAACAACCTGAACAAACGCATGGGCGATTTGAGGGATATTAATGGCGAAGCCGGTACGTGGGT
GCGTCTGCTGAACGGTTCCGGCTCTGCTGATGGCGGTTTCACTGACCACTATACCCTGCTGCAGATGGGG
GCTGACCGTAAGCACGAACTGGGAAGTATGGACCTGTTTACCGGCGTGATGGCCACCTACACTGACACAG
ATGCGTCAGCAGACCTGTACAGCGGTAAAACAAAATCATGGGGTGGTGGTTTCTATGCCAGTGGTCTGTT
CCGGTCCGGCGCTTACTTTGATGTGATTGCCAAATATATTCACAATGAAAACAAATATGACCTGAACTTT
GCCGGAGCTGGTAAACAGAACTTCCGCAGCCATTCACTGTATGCAGGTGCAGAAGTCGGATACCGTTATC
ATCTGACAGATACGACGTTTGTTGAACCTCAGGCGGAACTGGTCTGGGGAAGACTGCAGGGCCAAACATT
TAACTGGAACGACAGTGGAATGGATGTCTCAATGCGTCGTAACAGCGTTAATCCTCTGGTAGGCAGAACC
GGCGTTGTTTCCGGTAAAACCTTCAGTGGTAAGGACTGGAGTCTGACAGCCCGTGCCGGCCTGCATTATG
AGTTCGATCTGACGGACAGTGCTGACGTTCATCTGAAGGATGCAGCGGGAGAACATCAGATTAATGGCAG
AAAAGACAGTCGTATGCTTTACGGTGTGGGGTTAAATGCCCGGTTTGGCGACAATACGCGTCTGGGGCTG
GAAGTTGAACGCTCTGCATTTGGTAAATACAACACAGATGATGCGATAAACGCTAATATTCGTTATTCAT
TCTG
Protein Sequence 
>gi|157418156|ref|YP_001481228.1| Tsh [Escherichia coli APEC O1]
MNRIYSLRYSAVARGFIAVSEFARKCVHKSVRRLCFPVLLLIPVLFSAGSLAGTVNNELGYQLFRDFAEN
KGMFRPGATNIAIYNKQGEFVGTLDKAAMPDFSAVDSEIGVATLINPQYIASVKHNGGYTNVSFGDGENR
YNIVDRNNAPSLDFHAPRLGKLVTEVAPTAVTAQGAVAGAYLDKERYPVFYRLGSGTQYIKDSNGQLTKM
GGAYSWLTGGTVGSLSSYQNGEMISTSSGLVFDYKLNGAMPIYGEAGDSGSPLFAFDTVQNKWVLVGVLT
AGNGAGGRGNNWAVIPLDFIGQKFNEDNDAPVTFRTSEGGALEWSFNSSTGAGALTQGTTTYAMHGQQGN
DLNAGKNLIFQGQNGQINLKDSVSQGAGSLTFRDNYTVTTSNGSTWTGAGIVVDNGVSVNWQVNGVKGDN
LHKIGEGTLTVQGTGINEGGLKVGDGKVVLNQQADNKGQVQAFSSVNIASGRPTVVLTDERQVNPDTVSW
GYRGGTLDVNGNSLTFHQLKAADYGAVLANNVDKRATITLDYALRADKVALNGWSESGKGTAGNLYKYNN
PYTNTTDYFILKQSTYGYFPTDQSSNATWEFVGHSQGDAQKLVADRFNTAGYLFHGQLKGNLNVDNRLPE
GVTGALVMDGAADISGTFTQENGRLTLQGHPVIHAYNTQSVADKLAASGDHSVLTQPTSFSQEDWENRSF
TFDRLSLKNTDFGLGRNATLNTTIQADNSSVTLGDSRVFIDKNDGQGTAFTLEEGTSVATKDADKSVFNG
TVNLDNQSVLNINDIFNGGIQANNSTVNISSDSAVLGNSTLTSTALNLNKGANALASQSFVSDGPVNISD
ATLSLNSRPDEVSHTLLPVYDYAGSWNLKGDDARLNVGPYSMLSGNINVQDKGTVTLGGEGELSPDLTLQ
NQMLYSLFNGYRNIWSGSLNAPDATVSMTDTQWSMNGNSTAGNMKLNRTIVGFNGGTSPFTTLTTDNLDA
VQSAFVMRTDLNKADKLVINKSATGHDNSIWVNFLKKPSNKDTLDIPLVSAPEATADNLFRASTRVVGFS
DVTPILSVRKEDGKKEWVLDGYQVARNDGQGKAAATFMHISYNNFITEVNNLNKRMGDLRDINGEAGTWV
RLLNGSGSADGGFTDHYTLLQMGADRKHELGSMDLFTGVMATYTDTDASADLYSGKTKSWGGGFYASGLF
RSGAYFDVIAKYIHNENKYDLNFAGAGKQNFRSHSLYAGAEVGYRYHLTDTTFVEPQAELVWGRLQGQTF
NWNDSGMDVSMRRNSVNPLVGRTGVVSGKTFSGKDWSLTARAGLHYEFDLTDSADVHLKDAAGEHQINGR
KDSRMLYGVGLNARFGDNTRLGLEVERSAFGKYNTDDAINANIRYSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tsh mutant is attenuated in chickens (Chen et al., 2008).
COG COG3468MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Chen et al., 2008: Chen X, Liu J, Gao S, Pan Z, Jiao X, Liu X. [Construction and characterization of avian pathogenic Escherichia coli mutants with iro and/or tsh gene mutation]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2008; 24(3); 401-408. [PubMed: 18589815].