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espF from Escherichia coli O26:H11 str. 11368

Victor ID 3741
Gene Name espF from Escherichia coli O26:H11 str. 11368
Sequence Strain (Species/Organism) Escherichia coli O26:H11 str. 11368
NCBI Gene ID 8480244
NCBI Protein GI 260858280
Locus Tag ECO26_5289
Protein Accession YP_003232171.1
Other Database IDs UniProtKB-ID: C8TNU8_ECO26
UniRef100: UniRef100_Q9RQE1
UniRef90: UniRef90_Q9RQE1
UniRef50: UniRef50_Q5K5R0
UniParc: UPI000005D2A6
EMBL: AP010953
EMBL-CDS: BAI28431.1
RefSeq_NT: NC_013361.1
EnsemblGenome: EBESCG00000173440.
EnsemblGenome_TRS: EBESCT00000172429
EnsemblGenome_PRO: EBESCP00000164357
GenomeReviews: AP010953_GR
KEGG: eoj:ECO26_5289
ProtClustDB: CLSK2393223
Taxonomy ID 573235
Gene Starting Position 5364044
Gene Ending Position 5364667
Gene Strand (Orientation) +
Protein Name T3SS secreted effector EspF
DNA Sequence 
>gi|260853213:5364044-5364667 Escherichia coli O26:H11 str. 11368, complete genome
TATGCTTAATGGAATTAGTCAAGCTGTTTCTACACTAGGACGGCATATTACTAGTGCGGCAAGCCGGGTA
AGCTCTGCGGGGTTATCTGGCTTTTCAGTGTCCCCTCAGGCTGTTCGTCTGAATCCGATTAGGGCTCAAT
CTCCTTTTTCTCCCGGTACGTCGAATATCAATGCGAGAACGACTTTTAATGTGAGTAGCCCGGCGACTTC
ATTTACTCCCTCTCGTCCGGCCCCACCGCCGCCGACAAGTGGACAGGCTTCCGGGGCATCCCGCCCTTTA
CCGCCCATTGCTCAGGCATTAAAAGATCATTTAGCTGCCTATGAAAAGTCGAAAAGTCTTGATACTTCAA
GCCTTAAGCCAAGCCGCCCGGCACCGCCGCCGCCGACAAGCGGGTTGGTATCTGGGTCATCCCGGTCTTT
ACCGCCCATTGCTCAGGCGCTAAAAGATCATTTGGCTGCCTATGAAAAATCGAAAAGTCTTGATACTTCA
GGTCTTAAGCCAAGCCGCCCGGCACCGCCGCCACCGACAAGTGGACAGGCATCCGAGGCATCCCGGCCAT
TACCGCCTATTGCTCAGGCATTAAAAGATCATTTAGCTGCCTATGAACTGTCGAAAAAGGCATA
Protein Sequence 
>gi|260858280|ref|YP_003232171.1| T3SS effector EspF [Escherichia coli O26:H11 str. 11368] MLNGISQAVSTLGRHITSAASRVSSAGLSGFSVSPQAVRLNPIRAQSPFSPGTSNINARTTFNVSSPATSFTPSRPAPPPPTSGQASGASRPLPPIAQALKDHLAAYEKSKSLDTSSLKPSRPAPPPPTSGLVSGSSRSLPPIAQALKDHLAAYEKSKSLDTSGLKPSRPAPPPPTSGQASEASRPLPPIAQALKDHLAAYELSKKA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: espF mutant of EPEC is deficient in its ability to disrupt electrical resistance across a polarized monolayer of intestinal epithelial cells, suggesting that EspF is an effector molecule required for disrupting intestinal epithelial barrier function (McNamara et al., 2001).
References
McNamara et al., 2001: McNamara BP, Koutsouris A, O'Connell CB, Nougayréde JP, Donnenberg MS, Hecht G. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. The Journal of clinical investigation. 2001; 107(5); 621-629. [PubMed: 11238563].