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espA from Escherichia coli O157:H7 str. EDL933

Victor ID 2203
Gene Name espA from Escherichia coli O157:H7 str. EDL933
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. EDL933
NCBI Gene ID 960865
NCBI Protein GI 15804217
Locus Tag Z5107
Protein Accession NP_290256.1
Other Database IDs UniProtKB-ID: Q7DB80_ECO57
UniRef100: UniRef100_O69412
UniRef90: UniRef90_O69412
UniRef50: UniRef50_O87743
UniParc: UPI00000D5DCD
EMBL: AE005174
EMBL: EU871626
EMBL: BA000007
EMBL-CDS: AAG58820.1
EMBL-CDS: ACG59618.1
EMBL-CDS: BAB37979.1
RefSeq_NT: NC_002655.2
RefSeq_NT: NC_002695.1
EnsemblGenome: EBESCG00000027267.
EnsemblGenome_TRS: EBESCT00000028215
EnsemblGenome_PRO: EBESCP00000027108
EnsemblGenome: EBESCG00000057004.
EnsemblGenome_TRS: EBESCT00000057956
EnsemblGenome_PRO: EBESCP00000055784
Taxonomy ID 155864
Gene Starting Position 4662121
Gene Ending Position 4662699
Gene Strand (Orientation) -
Protein Name secreted protein EspA
DNA Sequence 
>gi|16445223:4662121-4662699 Escherichia coli O157:H7 str. EDL933 chromosome, complete genome
GTTATTTACCAAGGGATATTGCTGAAATAGTTCTATATTGTAGAGATTGCACATCAGAACGTGCACTCGT
TAAGAGATTTAATGTATTCGACATTTGCTGAATTTCGAGCTGGCTATTATTCACTACCGTTGTCAGGTTA
TTCGCTTTAGCTGAAATAGCCGCCTTCACTGTTTGCAGATCACCAGCGCTTAAATCACCACTAAGATCAC
GAATACCAGTTACACTTATGTCATTACGTGGATCGTTTATATAGTCAATCACGTCTTGAGGAAGTTTGGC
TTTCGCATTCTTATCAGTGCTACTCTGAACATCAGCAATTTTGGCATCCACAAGATTAGCCATCTTTTGT
GCCGTGGTTGACGCTTTAGATGCCTCATTCATATCAGCAAACTTTGCAATCGACAGATTACTTTGTGCCT
GATACATATAAGAAAACATGAGAATCGCAGCCTGAAAAACACCGAGTTCCTCAAATAGCTTAACCACCTC
ATCCTTCGACATATTACCTAAGTCATAGATCGTCGATGTCGAAGAACTCGCACTCACATTAACAACGGAT
GTTGCATTTGATGTATCCA
Protein Sequence 
>gi|15804217|ref|NP_290256.1| hypothetical protein Z5107 [Escherichia coli O157:H7 str. EDL933] MDTSNATSVVNVSASSSTSTIYDLGNMSKDEVVKLFEELGVFQAAILMFSYMYQAQSNLSIAKFADMNEASKASTTAQKMANLVDAKIADVQSSTDKNAKAKLPQDVIDYINDPRNDISVTGIRDLSGDLSAGDLQTVKAAISAKANNLTTVVNNSQLEIQQMSNTLNLLTSARSDVQSLQYRTISAISLGK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: deletion of espA in STEC abolished ability to attach to HeLa cells and induce actin rearrangements (Ebel et al., 1998).
References
Ebel et al., 1998: Ebel F, Podzadel T, Rohde M, Kresse AU, Krämer S, Deibel C, Guzmán CA, Chakraborty T. Initial binding of Shiga toxin-producing Escherichia coli to host cells and subsequent induction of actin rearrangements depend on filamentous EspA-containing surface appendages. Molecular microbiology. 1998; 30(1); 147-161. [PubMed: 9786192].