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nrdD

Victor ID 2171
Gene Name nrdD
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. EDL933
NCBI Gene ID 959802
NCBI Protein GI 15804828
Locus Tag Z5848
Genbank Accession AE005174
Protein Accession NP_290869
Other Database IDs UniProtKB-ID: Q8XCE2_ECO57
UniRef100: UniRef100_C3SF87
UniRef90: UniRef90_Q9L646
UniRef50: UniRef50_Q9L646
UniParc: UPI00000D04AB
EMBL: AE005174
EMBL: BA000007
EMBL-CDS: AAG59435.1
EMBL-CDS: BAB38638.1
RefSeq_NT: NC_002655.2
RefSeq_NT: NC_002695.1
HSSP: P07071
EnsemblGenome: EBESCG00000023653.
EnsemblGenome_TRS: EBESCT00000024599
EnsemblGenome_PRO: EBESCP00000023492
EnsemblGenome: EBESCG00000057059.
EnsemblGenome_TRS: EBESCT00000058011
EnsemblGenome_PRO: EBESCP00000055839
GenomeReviews: AE005174
Taxonomy ID 155864
Gene Starting Position 5346045
Gene Ending Position 5348183
Gene Strand (Orientation) -
Protein Name anaerobic ribonucleoside triphosphate reductase
Protein pI 6.81
Protein Weight 75570.22
Protein Length 712
Protein Note Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates
DNA Sequence 
>gi|16445223:5346045-5348183 Escherichia coli O157:H7 str. EDL933 chromosome, complete genome
ATCAACCTATCTGCCCATTTCCCAAATGTTTAACGCGGCGCTTAACTTCTTCCTGCTTGCCGGCGTTAAA
CGGACGTGCATCCGGGCTACCTAAATATCCGCACACGCGGCGAGTTACCGACACACGGGAGGCGTCATGG
TTACCACATTTCGGGCAGGTGAAGCCTTTGCTGGTGCACTCGAACTCACCGGTAAAGCCACACTCGTAGC
ACTCATCAATCGGTGTATTGGTGCCGTAATACGGTACATGCTGATAGCTGTAATCCCAGACATCTTCCAG
CGCCTTCAGGTTGTGCTGAATGTTTGGATACTCGCCGTAGCAAATGAAACCACCGTTCGCCAGCGGCGGG
TAAGGCGCTTCAAAGTCGATCTTGTCGTACGGGTTCACCTTCTTCTCCACATCGAGGTGGAAACTGTTGG
TGTAGTAACCTTTATCGGTCACGCCCGGCACCACGCCAAACTCAGCAGTATCGAGACGGCAGAAGCGGTC
GCACAGGTTTTCACTCGGCGTGCTGTAGAGACTGAAACCATAACCCGTTTCTTCTTTCCACTGATCCACT
GCCTGACGCAGACGTTCAACAATGGCGATACCTTTCGCGCGGAGCTGCTCGTTGTCGTAAACATGTTCGC
CGCCGAACAGCGCGTTAATGGTTTCGTGGATGCCGATGTAACCCAGCGAAATAGACGCACGACCGTTTTT
GAAGATTTCAGAAATATCATCGTCAGCATTGAGACGCACGCCACAAGCACCTTCCATATAGAGGATCGGG
GCCACGCGCGCTTTCACGCCTTCGAGACGAGCGATACGGGTCATCAGAGCCTTACGTGCCAGCACCAGAC
GTTCATCCAGCAGCTTCCAGAAGGTGGCTTCATCGCCTTTTGCTTCCAGAGCAATACGCGGCAGGTTCAG
GCTGATCACGCCGAGGTTGTTACGACCATCGTGGATCTGCTCGCCGTTTTCATTTTCCCACACGCCGAGG
AAGCTGCGGCAGCCCATCGGGGTTTTAAACGAACCGGTGACTTTCACTACCTGATCGTAGTTCAGGATAT
CCGGATACATGCGCTTGCTTGCGCACTCCAGCGCCAGCTGTTTGATGTCGTAGTTCGGATCGCCTTTTTT
ATGGTTCAGACCATCGCGAATCGCAAACACCAGTTTCGGGAACACCGCAGTTTTACGGTTTTTACCGAGG
CCTGCGATACGGTTACGCAGGATAGATTCCTGAATCAGGCGCGACTCCCAGCTGGTGCCCAGACCAAAAC
CAAAGGTTACAAACGGCGTCTGACCGTTGGCGGTGTGCAGGGTGTTTACTTCGTACTCCAGCGACTGGAA
GGCATCGTAGCACTCTTTAATGGTACGAGAGTTAGCGTAGCCTTCGGCGTCCGGGATGTTCCACTCTTCT
GCGGTCTTGCGATGTTTGTTGTAGCTGGCGGTGACAAACGGTGCCAGCACTTCATCGATACGGTTAATGG
TGGTGCCGCCATAAATATGGCTGGCAACCTGAGCAATAATCTGCGCAGTTACCGCGGTTGCCGTAGAGAT
CGACTTCGGCGGTTCAATCTCGGCGTTCCCCATCTTAAAGCCCTGGGTCAGCATGCCTTTCAGGTCGATC
AACATGCAGTTGAACATCGGGAAAAACGGTGAGTAATCGAGATCGTGATAGTGAATATCGCCACGCTCAT
GTGCCTGCACCACGTCACGCGGCAGCAGGTGCTGACGTGCATAGTGTTTAGCCACGATCCCGGCCAGCAG
GTCGCGCTGGGTTGGAATCACCTTGCTGTCTTTGTTGGCGTTTTCGTTGAGTAACGAGGCGTTGGTCTGC
TCGACCAGACCACGGATCTCCTGATTCAGGCGACCGCGTTTTTCACGTTCAATGTCGCGATCGTGACGGT
ACTCGATGTAAGCACGAGCCAGTTGTTTGTATGGACCTGACATCAGCTGGTTTTCAACAGCGGTCTGGAT
CTCATTGATATCCACCTGGTTGCGGCCCTGCATCTGCTCGCTGACAACTGCAGCAACAGTGGCGCAATAA
TCGGCATCATCGACTTCCGCTGCTTTAGCTGCACGCAGAATCGCTTCTTTGATGCGCTCTGATTTAAACG
GCACTTTGCAGCCGTCTCGTTTCATCACATGCGGTGTCA
Protein Sequence 
>gi|15804828|ref|NP_290869.1| anaerobic ribonucleoside triphosphate reductase [Escherichia coli O157:H7 str. EDL933]
MTPHVMKRDGCKVPFKSERIKEAILRAAKAAEVDDADYCATVAAVVSEQMQGRNQVDINEIQTAVENQLM
SGPYKQLARAYIEYRHDRDIEREKRGRLNQEIRGLVEQTNASLLNENANKDSKVIPTQRDLLAGIVAKHY
ARQHLLPRDVVQAHERGDIHYHDLDYSPFFPMFNCMLIDLKGMLTQGFKMGNAEIEPPKSISTATAVTAQ
IIAQVASHIYGGTTINRIDEVLAPFVTASYNKHRKTAEEWNIPDAEGYANSRTIKECYDAFQSLEYEVNT
LHTANGQTPFVTFGFGLGTSWESRLIQESILRNRIAGLGKNRKTAVFPKLVFAIRDGLNHKKGDPNYDIK
QLALECASKRMYPDILNYDQVVKVTGSFKTPMGCRSFLGVWENENGEQIHDGRNNLGVISLNLPRIALEA
KGDEATFWKLLDERLVLARKALMTRIARLEGVKARVAPILYMEGACGVRLNADDDISEIFKNGRASISLG
YIGIHETINALFGGEHVYDNEQLRAKGIAIVERLRQAVDQWKEETGYGFSLYSTPSENLCDRFCRLDTAE
FGVVPGVTDKGYYTNSFHLDVEKKVNPYDKIDFEAPYPPLANGGFICYGEYPNIQHNLKALEDVWDYSYQ
HVPYYGTNTPIDECYECGFTGEFECTSKGFTCPKCGNHDASRVSVTRRVCGYLGSPDARPFNAGKQEEVK
RRVKHLGNGQIG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: nrdD mutant is attenuated in calves (van et al., 2005).
COG COG1328F, under F: Nucleotide transport and metabolism
References
van et al., 2005: van Diemen PM, Dziva F, Stevens MP, Wallis TS. Identification of enterohemorrhagic Escherichia coli O26:H- genes required for intestinal colonization in calves. Infection and immunity. 2005; 73(3); 1735-1743. [PubMed: 15731074].