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tir from Escherichia coli O157:H7 str. EDL933

Victor ID 2201
Gene Name tir from Escherichia coli O157:H7 str. EDL933
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. EDL933
NCBI Gene ID 960860
NCBI Protein GI 15804222
Locus Tag Z5112
Protein Accession NP_290261.1
Other Database IDs UniProtKB-ID: Q7DB77_ECO57
UniRef100: UniRef100_Q9R396
UniRef90: UniRef90_Q58I88
UniRef50: UniRef50_Q58I88
UniParc: UPI00000D00CA
EMBL: AE005174
EMBL: BA000007
EMBL-CDS: AAG58825.1
EMBL-CDS: BAB37984.1
RefSeq_NT: NC_002655.2
RefSeq_NT: NC_002695.1
PDB: 2ZQK
PDB: 2ZWK
EnsemblGenome: EBESCG00000024998.
EnsemblGenome_TRS: EBESCT00000025945
EnsemblGenome_PRO: EBESCP00000024838
EnsemblGenome: EBESCG00000056351.
EnsemblGenome_TRS: EBESCT00000057303
EnsemblGenome_PRO: EBESCP00000055131
GenomeReviews: A
Taxonomy ID 155864
Gene Starting Position 4668912
Gene Ending Position 4670588
Gene Strand (Orientation) -
Protein Name putative translocated intimin receptor protein
DNA Sequence 
>gi|16445223:4668912-4670588 Escherichia coli O157:H7 str. EDL933 chromosome, complete genome
TTTAGACGAAACGATGGGATCCCGGCGCTGGTGGGTTATTCGAAGTATTCACAGCGCTATTACTCCCCCC
CGTTAATCCTCCCATGTCATGGCGTAATCCACCACTTAGCGCCAGACGCGCATAAGTGCTTTGAATCCCC
GCACTTGGATTTCCTAATAACCGTGCGCCGTTATCAGTAGTATCCCGGGGAGGATGTTGAATGGTGCTAT
ATACAACAGAATCTGTATTCCCCATATTCTGAACAGACGTATTAGAATTAGAAGTCGGCACCTGCGAATC
ATGCAGCGATGTTTTAACATCAGCATACGGATTCTGCACGGTCCCTATGCTGGAAGTGTCAAAGAAAGTC
GACGAGGTGCTAGCCATCGAGCTACGTCTGCTCTCCATGGTATCTTCTGACCCAGGGGTATCTACATTGC
CCTGTGCAGGTGTATTATTTGCAGGCTTATTCTCTACCGTACGTGCGCTTGTAGTTGTAGTTGTAGTAGT
TGTTGTTGTTGTTTGTTCTACCGGCTGATTTTTTCGATGAAGCGCAGCGGTGACGGCAACACCAATTCCC
CCACCAAGAATCAATGCGCCACTAAGACCGTAGCCAGCCCCCGATGAAACTTTCAGCTCCTCCTGGCGTT
TAGCTTGTTGTTCATCATATTTTTTTTGCGCCTGAGCATTATTTTCAATGGCTTGCTGTTTGGCCTCTTC
GCCTGCTGCTTTAGCCTGCTCTTCTATATTCGCAACAACATCATCTTTCAATACCCCTGACGGAATCGCA
TTTCCGAGCTCATCGATATTAACTTTTTGATTATCTGGGTTCTGGAACGCTTCTTTCGTTAACTGATCTC
TTGTCGCAGTTTCAGTTGCACTTGCAGCTGCATCAGGGTCGGTCGTGGTTGGGCTATCCGGCTCCGGCGT
CAATGCAAGCGCCTGTACAATACCCGTCGCCGCCAACCCTATCAGACCTGTAGCAACAGTCCCCAACGCC
AACCAAAGTTTAGGATCTGAACGAAGGCTGGAAGTTGAGGTTGAGGTCTGAGTTTCTGTGGTGTTTTCCG
CACCGCTATTTGACTCCCTCAACTCCCCAACGCCTTTTGACTCCCCAGCACCTTTGGACTCCCCGGTCCC
TTTGGGCTCTAACAGCTCCAGTATCCTTTGGCGGGCTTCCGTGATATCTGAAGCAACGGTGACCATAGCA
TGCCCAGCACCACCACGGCCTCCAGTAAATACAAATTTGTCTTTACCTTCAGGATCAATGGACTGCAAGC
GAGCGTACTCTTGATCACTTAAAACAACAGAGGTCTCAACACCATTCCTCTGACCGACAGCAATATGTTT
ACCATCTTCCTGAGTTTCAACTCGAAATACCGAAGAGCCAATCTGCCTGTTAAGAGTATCGAGCGGACCA
TGATCATGAAGAACTTCAAATCCATCATTCAGTGTTATCTCAGACGCCGCCAGGCGCATCGGATTTACAG
GAAGTCCAGGAACATCACTGGCACGATTGTCGCCAGAATCAGCCATAGAATTCCTTACAGGCGTAAATAG
CGCACGAGATCCCAACGGCCCCGTAGAGTTAATGAGCTGACCACGCCCCCCTGCACCGTCGGTTTGTGAA
GGTAATGGAGGTGCAGGAGGAATTGAATTATTCACATTGGGATTATGACCAAGATTACCAATAGGCA
Protein Sequence 
>gi|15804222|ref|NP_290261.1| translocated intimin receptor protein [Escherichia coli O157:H7 str. EDL933] MPIGNLGHNPNVNNSIPPAPPLPSQTDGAGGRGQLINSTGPLGSRALFTPVRNSMADSGDNRASDVPGLPVNPMRLAASEITLNDGFEVLHDHGPLDTLNRQIGSSVFRVETQEDGKHIAVGQRNGVETSVVLSDQEYARLQSIDPEGKDKFVFTGGRGGAGHAMVTVASDITEARQRILELLEPKGTGESKGAGESKGVGELRESNSGAENTTETQTSTSTSSLRSDPKLWLALGTVATGLIGLAATGIVQALALTPEPDSPTTTDPDAAASATETATRDQLTKEAFQNPDNQKVNIDELGNAIPSGVLKDDVVANIEEQAKAAGEEAKQQAIENNAQAQKKYDEQQAKRQEELKVSSGAGYGLSGALILGGGIGVAVTAALHRKNQPVEQTTTTTTTTTTTSARTVENKPANNTPAQGNVDTPGSEDTMESRRSSMASTSSTFFDTSSIGTVQNPYADVKTSLHDSQVPTSNSNTSVQNMGNTDSVVYSTIQHPPRDTTDNGARLLGNPSAGIQSTYARLALSGGLRHDMGGLTGGSNSAVNTSNNPPAPGSHRFV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture (Schüller et al., 2007).
References
Schüller et al., 2007: Schüller S, Chong Y, Lewin J, Kenny B, Frankel G, Phillips AD. Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture models. Cellular microbiology. 2007; 9(5); 1352-1364. [PubMed: 17474908].