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tir from Escherichia coli (strain: D, other: UK epidemic CTX-M-producing strain (PFGE-defined); MLST-defined ST131 linea

Victor ID 3689
Gene Name tir from Escherichia coli (strain: D, other: UK epidemic CTX-M-producing strain (PFGE-defined); MLST-defined ST131 linea
Sequence Strain (Species/Organism) Escherichia coli (strain: D, other: UK epidemic CTX-M-producing strain (PFGE-defined); MLST-defined
NCBI Gene ID 8319157
NCBI Protein GI 256367694
Locus Tag pEK516_p77
Protein Accession YP_003108263.1
Other Database IDs UniProtKB-ID: C7S9J7_ECOLX
UniRef100: UniRef100_C7S9J7
UniRef90: UniRef90_C7S9J7
UniRef50: UniRef50_C7S9J7
UniParc: UPI0001B22ED5
EMBL: EU935738
EMBL-CDS: ACQ41959.1
RefSeq_NT: NC_013121.1
ProtClustDB: CLSK687309
Taxonomy ID 562
Plasmid No pEK516
Gene Starting Position 63132
Gene Ending Position 63683
Gene Strand (Orientation) +
Protein Name Tir
DNA Sequence 
>gi|256367628:63132-63683 Escherichia coli plasmid pEK516, complete sequence
TTTGCAACAGTGCCGAAAAAACTATTTGTTCTTCAGTCATGGTACTGTTCTGATGTACCTGCTGTGTGTT
TTCCTGGTATACCGCCGTTGGATAGCTCCGCTACCGGTCGTTGGTCAGCTGCGCAACGTTGGCGTACCGT
GGCTGGTCGGTGCGATGGCCGTGGTGTATGTCGGTGTATTTCTGCTCGGTAAGGCGCTGGCTCTGCCTGC
TGAGCCATTTATGACGAAACTTTTTGCCGATAAGTCCATACCTGACGTGATCCTGACGTTGCTGACCATC
TTTATCCTTGCCCCGTTGAATGAGGAAACGCTGTTCCGGGGGATTATGCTGAACGTCTTCCGTTCACGGT
ACTGCTGGACGATGTGGCTGGGGGCGCTGATAACGTCGTTGTTGTTCGTCGCCGCGCACAGCCAGTATCA
GAACCTGCTGACACTGGCAGAACTGTTCCTGGTGGGGTTGATTACATCAGTGGCCAGGATCAGAAGTGGT
GGCCTGCTGCTGCCGGTATTGCTGCATATGGAAGCAACCACGCTGGGTTTACTGTTTGGTTG
Protein Sequence 
>gi|256367694|ref|YP_003108263.1| Tir [Escherichia coli] MQQCRKNYLFFSHGTVLMYLLCVFLVYRRWIAPLPVVGQLRNVGVPWLVGAMAVVYVGVFLLGKALALPAEPFMTKLFADKSIPDVILTLLTIFILAPLNEETLFRGIMLNVFRSRYCWTMWLGALITSLLFVAAHSQYQNLLTLAELFLVGLITSVARIRSGGLLLPVLLHMEATTLGLLFG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture (Schüller et al., 2007).
References
Schüller et al., 2007: Schüller S, Chong Y, Lewin J, Kenny B, Frankel G, Phillips AD. Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture models. Cellular microbiology. 2007; 9(5); 1352-1364. [PubMed: 17474908].