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espG from Escherichia coli O26:H11 str. 11368

Victor ID 3740
Gene Name espG from Escherichia coli O26:H11 str. 11368
Sequence Strain (Species/Organism) Escherichia coli O26:H11 str. 11368
NCBI Gene ID 8480236
NCBI Protein GI 260858241
Locus Tag ECO26_5250
Protein Accession YP_003232132.1
Other Database IDs UniProtKB-ID: C8TNQ9_ECO26
UniRef100: UniRef100_Q9AJ34
UniRef90: UniRef90_C7BUR4
UniRef50: UniRef50_Q8VNS6
UniParc: UPI000005D12D
EMBL: AP010953
EMBL-CDS: BAI28392.1
RefSeq_NT: NC_013361.1
EnsemblGenome: EBESCG00000170748.
EnsemblGenome_TRS: EBESCT00000171002
EnsemblGenome_PRO: EBESCP00000164909
GenomeReviews: AP010953_GR
KEGG: eoj:ECO26_5250
ProtClustDB: CLSK2393224
Taxonomy ID 573235
Gene Starting Position 5331457
Gene Ending Position 5332653
Gene Strand (Orientation) -
Protein Name T3SS secreted effector EspG
DNA Sequence 
>gi|260853213:5331457-5332653 Escherichia coli O26:H11 str. 11368, complete genome
TTTAAATGTTTTTCAGGTATGTTTCAGATGCGCCATACCTTGGTTGTAGCGTTCTTACCATCTCATCGAT
TTCACATTTCACACCTTGTGGCACTTCATAGGAGGTCCTGTTCGTCAACATTCCTAACTCGTTGGGGCGG
TCTTCTGGCGCCATTATCAGAATCCCGGTATGGCTGGCAACGTGAATGCTTCCATCTGGTGATTGAGAGA
TACTTATGTTAATGCACGCGTTAGGTACATCTAACGATCTTTCCACATTGTATTCTCTGGCTTGAGAGAT
CCTTGTATGTGTCAACATTAAGGCTGGCACATTGAAAGATTGATAGAAAGCCGAGCATATGGCTGTTGCC
GCTTCGGGGTGGCATAAAAACTCCACAACTTCAGCTTTCTGTTTATCGCTGCCGCTGCTTTCCCTTGCTA
TTTGCTTTGCATGATGACGAGAAATACCATTATTTATAACATTCCGGGCAAGTGATGAATGTGTGTCTTT
AAGTCCTAGTGCATCGCGAAGCAATTTTTGTGCATCTACAGGTATATCAACACCATTGAGTGAAAGCTTT
GCATTGCCGAGTCCTCGAAATGTATCCATAAACATAGAGCTGAATGGTGTAGGCCCGGAAAGCGGATCTG
TTTGAGTATTATGAGGAATCAAGGTTGCTGATAGTTTTGACGTAAAACTAAGTAGATTGTGCATTGACTT
ATGATCAGTCAGGTCCATCTTAGATAAGGCACGATGAACCTGAATGTATGGCATGTGGAGATTGATGGGT
AAAGATTGTAATAACCTATTTTGTTCGTTTGACTCCAGGAGCATAAGAATCTTTTCATTATCTGGTGTGC
GAATCTCGGCTTCAACAAGTTCGCTGTTAGTGACGGAAATTCTTAAGGATGAGCCATCTGCAAAATTAGC
ATATATTCTGCCCAATTCATTAGGCGCGGGAGATACAGGTTCTAAAACGGTTAACAACTCTTGAAATGTT
TGCCTTTCACTACGAGTATACGTTGGATTCCATAAACCAAAACTAAGAACTTTTAGTAATTTTTCAGCGC
ATGACATATCATTCCACTGCTTTTTAAAATCAGAATTAATTCTAATTGCAGCATCTAAAACTAAAGATGC
GGAATTATTATTAAGTCCGTTTATCATGAGAGATTCCCCTGTCTCATTTATTATGAATGATTCGACAACA
GATATCA
Protein Sequence 
>gi|260858241|ref|YP_003232132.1| T3SS effector EspG [Escherichia coli O26:H11 str. 11368] MISVVESFIINETGESLMINGLNNNSASLVLDAAIRINSDFKKQWNDMSCAEKLLKVLSFGLWNPTYTRSERQTFQELLTVLEPVSPAPNELGRIYANFADGSSLRISVTNSELVEAEIRTPDNEKILMLLESNEQNRLLQSLPINLHMPYIQVHRALSKMDLTDHKSMHNLLSFTSKLSATLIPHNTQTDPLSGPTPFSSMFMDTFRGLGNAKLSLNGVDIPVDAQKLLRDALGLKDTHSSLARNVINNGISRHHAKQIARESSGSDKQKAEVVEFLCHPEAATAICSAFYQSFNVPALMLTHTRISQAREYNVERSLDVPNACINISISQSPDGSIHVASHTGILIMAPEDRPNELGMLTNRTSYEVPQGVKCEIDEMVRTLQPRYGASETYLKNI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: the inhibitory effect of the espG mutant on Cl– uptake in Caco-2 monolayers was significantly attenuated as compared with wild-type EPEC (Gill et al., 2007).
References
Gill et al., 2007: Gill RK, Borthakur A, Hodges K, Turner JR, Clayburgh DR, Saksena S, Zaheer A, Ramaswamy K, Hecht G, Dudeja PK. Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli. The Journal of clinical investigation. 2007; 117(2); 428-437. [PubMed: 17256057].