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EHEC-hlyC

Victor ID 2293
Gene Name EHEC-hlyC
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. EDL933
NCBI Gene ID 3683746
NCBI Protein GI 75994493
Locus Tag L7047
Genbank Accession AF074613
Protein Accession YP_325607
Other Database IDs UniProtKB-ID: Q9ZGT5_ECO57
UniRef100: UniRef100_Q5K5Z5
UniRef90: UniRef90_Q5K5Z5
UniRef50: UniRef50_P09985
UniParc: UPI00000B3039
EMBL: AF074613
EMBL-CDS: AAC70115.1
RefSeq_NT: NC_007414.1
EnsemblGenome: EBESCG00000028524.
EnsemblGenome_TRS: EBESCT00000029474
EnsemblGenome_PRO: EBESCP00000028179
GenomeReviews: AF074613_GR
KEGG: ece:L7047
HOGENOM: HBG296557
OMA: WALMDAD
ProtClustDB: CLSK862057
Taxonomy ID 155864
Plasmid No pO157
Gene Starting Position 39304
Gene Ending Position 39819
Gene Strand (Orientation) +
Protein Name hemolysin transport protein
Protein pI 8.77
Protein Weight 19341.93
Protein Length 171
Protein Note 99 pct identical (0 gaps) to 168 residues of an 168 aa protein EHEC-hlyC TRSW: Q47460, alternate start in Q47460
DNA Sequence 
>gi|75994447:39304-39819 Escherichia coli O157:H7 EDL933 plasmid pO157, complete sequence
TATGAAATCTAATGCTTTTGACGTCATGGGGAAGGTTGCATGGCTATGGGCCTGTTCTCCTCTGCATAAA
AAATGGCCATTATCTGTTTTTGCTATTAATGTCATACCTGCTATTCAGACAAATCAATTTGCTCTCTTAA
TAAAGGATGAGCTTCCTGTAGCTTTTTGTAGCTGGGCCAGTTTAGATCTGGAATGTGAGGTAAAATATAT
AAATGATGTAACATCTTTGTATGCAAAAGACTGGATGTCGGGAGAAAGAAAGTGGTTTATTGACTGGATA
GCTCCATTTGGACACAACATGGAGTTATATAAATACATGAGGAAAAAGTATCCTTATGAGTTATTCAGAG
CAATAAGGTTAGATGAGAGCAGTAAAACAGGAAAAATAGCTGAATTTCATGGAGGGGGGATAGATAAAAA
ACTGGCATCAAAAATATTCAGGCAATACCATCATGAACTTATGTCTGAAGTAAAAAACAGACAAGATTTT
AATTTTAATATTGAGAAAGAAAACTA
Protein Sequence 
>gi|75994493|ref|YP_325607.1| hemolysin transport protein [Escherichia coli O157:H7 EDL933]
MKSNAFDVMGKVAWLWACSPLHKKWPLSVFAINVIPAIQTNQFALLIKDELPVAFCSWASLDLECEVKYI
NDVTSLYAKDWMSGERKWFIDWIAPFGHNMELYKYMRKKYPYELFRAIRLDESSKTGKIAEFHGGGIDKK
LASKIFRQYHHELMSEVKNRQDFNFNIEKEN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells (Stanley et al., 1996).
COG COG2994O, under O: Posttranslational modification, protein turnover, chaperones
References
Stanley et al., 1996: Stanley P, Koronakis V, Hardie K, Hughes C. Independent interaction of the acyltransferase HlyC with two maturation domains of the Escherichia coli toxin HlyA. Molecular microbiology. 1996; 20(4); 813-822. [PubMed: 8793877].