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tir from Escherichia coli O103:H2 str. 12009

Victor ID 3770
Gene Name tir from Escherichia coli O103:H2 str. 12009
Sequence Strain (Species/Organism) Escherichia coli O103:H2 str. 12009
NCBI Gene ID 8474874
NCBI Protein GI 260845690
Locus Tag ECO103_3611
Protein Accession YP_003223468.1
Other Database IDs UniProtKB-ID: C8TWM2_ECO10
UniRef100: UniRef100_Q5K5P9
UniRef90: UniRef90_O85508
UniRef50: UniRef50_Q47016
UniParc: UPI00004B4E33
EMBL: AP010958
EMBL-CDS: BAI32334.1
RefSeq_NT: NC_013353.1
EnsemblGenome: EBESCG00000180293.
EnsemblGenome_TRS: EBESCT00000177474
EnsemblGenome_PRO: EBESCP00000167498
GenomeReviews: AP010958_GR
KEGG: eoh:ECO103_3611
ProtClustDB: CLSK334862
Taxonomy ID 585395
Gene Starting Position 3689884
Gene Ending Position 3691500
Gene Strand (Orientation) -
Protein Name translocated intimin receptor Tir
DNA Sequence 
>gi|260842239:3689884-3691500 Escherichia coli O103:H2 str. 12009, complete genome
TTTAAACGAAACGTGCGGGTCCCGGCGTTGGTGAGGCATTGGCAGTACTTACTGCGCTCTCGCCCCCCCC
CGTTAATCCTCCCATACCTAAACGCAATCCGCCGCTGCTTGCCAGAAGCGCATAAGTACTTTGGATGCCT
TGCCCTGGGGTTCCCACTAACCTTCCGGTAACTGGGCTGTTCCCTGAAAAATGTTGAATGACGCTATAAT
TAGGATCTGCAGCGACCTCATCATAAATAGGTTCCTCTGGAATACGAGCCAGTGAATCATTTCTGGGCAT
TCCAACGTCAGCATACGGATTCTCTACCGTGCCCGTACTGGAGGTATCAGACCCGTTCGATGCAAGGCTG
GCATTCGAATTGCGCCTGCTCGCCGGGGACTCTTCTGGCCCACTTGTGTCAGTATTGCCCTGTGCAGATG
CGTTATTCGTAGGCTGATTATCGACTACTGTACGTGTAGTGATTGTTTGTTCTGCCGGTTGGTTTTTCCG
ATGAAGAGCAGCAGTAACACCGGCACCAATTCCCCCGCCAAGAATCAGCGCCCCACTAATACCGTAGCCA
ACCCCCGATGAAAGAGACATTTCCTGTTCGCGTTTAGCATGCTGCTCATCATATTTTTTCTGCGCCTGAG
AATTACTTTCAATAGCTTCCTGTCTGGCCTGTTCCCCCGCCGCTTTAGCTTGTTCTGCTATTTGCGCAAC
AACATCATCTATTAATTCCCCTGACGGAATTGCATTTCCGTTCTCATCGATATTAACTTTTTGTTTATCT
GGATCCTGGAATGCCTCCTGCGTTAACCGATCTTTTGTCGCAGCTTCAGCTGTGCTTGCTGCAGTATCAG
GATCGGTAGTAGTTGGATCATCCGGCTCTGGAGTCAACGCAACAGCCTGTGCAATACCCGTCGCAGCCAT
CCCTATCAGACCTGCAGCAATAGTCCCCAATGACAACCAAAGTTTAGGATCTGCACGGAGGCTAGAAGTT
GAGGTTGAGGTATGAATTTCAATGATTTTTCCCTCGCCACTATTTGGATCCCCTGGCTCCTTCGTCTCCT
TTGTATCCTTTGGTTCTAATTTATCTATTATCCTCTGACGGGCTTCGGCGATATCTGAAGCAACCGTGAC
CATAGCATGCCCTGCGCCACCGCGGCCTCCAGTAAATACAAATTTGTTTTTACCTTCAGGATCAAGGGAC
TGTAAGCTAGAAAACTCTTGATCACTTAAAACAACAGTGGTCTCGAGGCCATTTTTTTGCCCGATAGCAA
CATGGCTGCCATCATCCCGAGTTTCAACACGGAATAACGAAGATCCAATAGCAGAGTTAAGAGTATCAAG
CCCCCCTTTATCATGAAGAACTTCAAGCGCACCATGCAAAGATACCTCGGACGCAGCAAAGCGCAGTGGA
TTTGTAGGAAGTCCGGGAATATCACTGGCACGAGAATCAGCAGCATCAGCAACAGAATTCCTTATAGGCG
TAAATAGCAAACGAGACCCCATCGGGCCATTTGAGTTAATGAGCTGATTACGGGCACCTCCTGCACCGTC
GGTTTGTGAAGGTAATGGCGGTGCAGGTGGAATTAAAGCTCTCACATTGGGATTGTGGCCAAGATTACCA
ATAGGCA
Protein Sequence 
>gi|260845690|ref|YP_003223468.1| translocated intimin receptor Tir [Escherichia coli O103:H2 str. 12009] MPIGNLGHNPNVRALIPPAPPLPSQTDGAGGARNQLINSNGPMGSRLLFTPIRNSVADAADSRASDIPGLPTNPLRFAASEVSLHGALEVLHDKGGLDTLNSAIGSSLFRVETRDDGSHVAIGQKNGLETTVVLSDQEFSSLQSLDPEGKNKFVFTGGRGGAGHAMVTVASDIAEARQRIIDKLEPKDTKETKEPGDPNSGEGKIIEIHTSTSTSSLRADPKLWLSLGTIAAGLIGMAATGIAQAVALTPEPDDPTTTDPDTAASTAEAATKDRLTQEAFQDPDKQKVNIDENGNAIPSGELIDDVVAQIAEQAKAAGEQARQEAIESNSQAQKKYDEQHAKREQEMSLSSGVGYGISGALILGGGIGAGVTAALHRKNQPAEQTITTRTVVDNQPTNNASAQGNTDTSGPEESPASRRNSNASLASNGSDTSSTGTVENPYADVGMPRNDSLARIPEEPIYDEVAADPNYSVIQHFSGNSPVTGRLVGTPGQGIQSTYALLASSGGLRLGMGGLTGGGESAVSTANASPTPGPARFV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture (Schüller et al., 2007).
References
Schüller et al., 2007: Schüller S, Chong Y, Lewin J, Kenny B, Frankel G, Phillips AD. Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture models. Cellular microbiology. 2007; 9(5); 1352-1364. [PubMed: 17474908].