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escN from Escherichia coli O127:H6 str. E2348/69

Victor ID 3486
Gene Name escN from Escherichia coli O127:H6 str. E2348/69
Sequence Strain (Species/Organism) Escherichia coli O127:H6 str. E2348/69
NCBI Gene ID 7062686
NCBI Protein GI 215488979
Locus Tag E2348C_3948
Protein Accession YP_002331410.1
Other Database IDs UniProtKB-ID: B7UMA6_ECO27
UniRef100: UniRef100_O52140
UniRef90: UniRef90_O85632
UniRef50: UniRef50_O85632
UniParc: UPI00000B796B
EMBL: FM180568
EMBL-CDS: CAS11496.1
RefSeq_NT: NC_011601.1
PDB: 2OBL
PDB: 2OBM
EnsemblGenome: EBESCG00000111082.
EnsemblGenome_TRS: EBESCT00000111417
EnsemblGenome_PRO: EBESCP00000105635
GenomeReviews: FM180568_GR
KEGG: ecg:E2348C_3948
HOGENOM: HBG565875
OMA: KLANDHV
ProtClustDB: CLSK334788
Taxonomy ID 574521
Gene Starting Position 4119464
Gene Ending Position 4120804
Gene Strand (Orientation) -
Protein Name translocator EscN
DNA Sequence 
>gi|215485161:4119464-4120804 Escherichia coli O127:H6 str. E2348/69, complete genome
CTCAGGCAACCACTTTGAATAGGCTTTCAATCGTTTTTTCGTAACTACTGATATCTTTGGTGCTTTGTTG
TATAAAGTTCTGAATTAATTTCCTATTTTTTATTGCCTTATCTGCTTCAGGATCTTGCCCCATCGTGTAC
TCACCAATACGAATAAGCAGCTCAACATTTTTATAAGTTGCAATAAGCTTTTTGCATTCTGCCGCCGCAC
GCAAATGCTCCGATGTAACAACGTTATGCATAACACGACTGGCACTTAAACCAATATCAATTGCAGGGAA
ATGGTTTTCCTCTGCAAGTTCTCGGGTAAGTACGATGTGCCCATCAAGAATAGAGCGGACTTCATCGCCA
ATAGGATCATTAACATTATCGCTTTCTAACAACACCGTATAAATCGCGGTTATTGAACCTTTTGGCGCAG
GCCCCGCTCGCTCTAATAATTTGGGTAACGAAGAAAAAACACTCGGAGGGAATCCCCCCCTTACATCAGG
CTCTCCCGATGCAAGCCCAACATCACGCGCGGCTCGGGCATAACGAGTTACAGAATCCATCATTAATAAT
ACATTTTTACCTTGATCGCGGAAGTACTCTGCAATAGTCGTCGCCGTAAATGCGGCTTTCATCCTTTCCA
GCGCGGGGCGGTCTGACGTTGTGACGACCAGCACACATTTAGAAAGCGTGGATTGAGGTAAAAGCGCGAG
GAATTCATTTACTTCGCGACCACGTTCGCCGATAAGAGCAAGGACAATAATATCTGCGGATGCGCCATTA
CAAATCATCCCCAAAAGCGTACTTTTACCAACGCCTGAACCAGCAAAAATACCGATACGCTGCCCAATAC
CGCAAGTTAGTAGCCCATCAATTGCCCTGACGCCAAGTATAAATGGCTGATCAATAACCTGCCTTAATAA
AGGATCTGGTGGTTCAGCATACAAGCTGCGTTCAAACGGAAGATAGGGGGCAACAATATTACTCTCCATT
GGTCTGCCTATGCCATCAATAAGCCGCCCAAGTAGTGCGTCTCCAACACGAATCTTGAACTCATCCCCCT
GATAACTTAACCACTGACCACAGTACATGCCGGAAACATGCTCAAAAGGCAACAAGAAAACCTCATCTTC
ATCAATAGCGATCACCTCGGCTAAACGTTGACTGGGTTCTATCTTGTAAAAGGCGCCAATACGCGCTTTT
GGTAAACGCGCCTTAATAATCGTCCCGCCGATATTGATAATCTTGCCTTCATATCTGGTAGACGAATTTA
ATGATAATGCCGGCACAGTGCTATTGAGCACTTTCTGAATACGTGGGTATTTTTCCAATACAGAATCATG
CTCTGAAATCA
Protein Sequence 
>gi|215488979|ref|YP_002331410.1| translocator EscN [Escherichia coli O127:H6 str. E2348/69] MISEHDSVLEKYPRIQKVLNSTVPALSLNSSTRYEGKIINIGGTIIKARLPKARIGAFYKIEPSQRLAEVIAIDEDEVFLLPFEHVSGMYCGQWLSYQGDEFKIRVGDALLGRLIDGIGRPMESNIVAPYLPFERSLYAEPPDPLLRQVIDQPFILGVRAIDGLLTCGIGQRIGIFAGSGVGKSTLLGMICNGASADIIVLALIGERGREVNEFLALLPQSTLSKCVLVVTTSDRPALERMKAAFTATTIAEYFRDQGKNVLLMMDSVTRYARAARDVGLASGEPDVRGGFPPSVFSSLPKLLERAGPAPKGSITAIYTVLLESDNVNDPIGDEVRSILDGHIVLTRELAEENHFPAIDIGLSASRVMHNVVTSEHLRAAAECKKLIATYKNVELLIRIGEYTMGQDPEADKAIKNRKLIQNFIQQSTKDISSYEKTIESLFKVVA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: deletion of escN abolished pathogenicity in infant rabbits compared to wild-type EHEC (Ritchie and Waldor, 2005).
COG COG1157NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport
References
Ritchie and Waldor, 2005: Ritchie JM, Waldor MK. The locus of enterocyte effacement-encoded effector proteins all promote enterohemorrhagic Escherichia coli pathogenicity in infant rabbits. Infection and immunity. 2005; 73(3); 1466-1474. [PubMed: 15731044].