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espK

Victor ID 3695
Gene Name espK
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. TW14359
NCBI Gene ID 8216050
NCBI Protein GI 254792564
Locus Tag ECSP_1484
Genbank Accession CP001368
Protein Accession YP_003077401
Other Database IDs UniProtKB-ID: C6URD0_ECO5T
UniRef100: UniRef100_C6URD0
UniRef90: UniRef90_C6URD0
UniRef50: UniRef50_C8TWK8
UniParc: UPI00000D0AA7
EMBL: CP001368
EMBL-CDS: ACT71325.1
RefSeq_NT: NC_013008.1
EnsemblGenome: EBESCG00000168915.
EnsemblGenome_TRS: EBESCT00000170502
EnsemblGenome_PRO: EBESCP00000154382
GenomeReviews: CP001368_GR
KEGG: etw:ECSP_1484
ProtClustDB: CLSK879968
Taxonomy ID 544404
Gene Starting Position 1529363
Gene Ending Position 1530724
Gene Strand (Orientation) -
Protein Name non-LEE-encoded type III secreted effector
Protein pI 7.21
Protein Weight 48722.26
Protein Length 453
DNA Sequence 
>gi|254791136:1529363-1530724 Escherichia coli O157:H7 str. TW14359 chromosome, complete genome
ATTAAGAATATTTATATGTGGAACCAGAGTATTTTGGACGATAGTCTTTCCATTCTGGTGTATCTAATAT
TCTTTCTGCTGGTATCTCTTTGCCATGTAGATAAAATTTTATGTTTTTCATTATTTGGTTGTTGTCTTTA
TTACGGTAAATCCATCGTAATTCGCTGGCGGTAATACTCTGGCCATAGCCCTCTGACTTGTTAGCTATGA
GTTTGAGTGAGTTGACAAGCTCATCCGCACAAAAAATAACCGTTTTATTGCGTGTTAATGTCTGAAACTC
TAGGCCGGCCTTGCTTGTTTTTGCCCATAATTTGTCGCGATTGTATACGGAAAGGTCGGCCATGGTAACA
TTATAATTATTGTGATTCTTTAAGTGTTGTTTAAATTTTATTCCTCTTTCGTGTTCATTTAATGCTCTTT
TGATAAGTGGATCTTGCTTATATTTGCGAGGTGTTCTGGGGTCCCATACTGCGTTTGTTAACGTATTCTG
AGTTATAATATCTTTTTTGGAAAAGTCGTTAACTAGTTTAATGCTGTTGACAAGTTTTTCTCTGGGTGAA
GATAGTCCATAGACAATGTCTCCCTCGCGAAAGTGTAAGGCCACATCCAGAGCGTTGCCCTGAAAGGTGA
TGTTTTTTGCTTTAACTACATCTGGAGAGAGTAGTACATTTTGTAAATCAAGATCCAGCCCATCAGGCAT
CCCTTCAACACCGATGTTCCACGTGGTTTTCTGCTCCGCATGAATGGTTACCGATGTCACACTCTCCGGA
AGTTTCTCCGGCAGTATAATATTGCTACATCCAGTCAGCGATAGCGTCTTCAGTGACGGTGATATCAGGT
TGTCAATTCTGGCCTGATTCTCCGGGTTATAGCTATTGATGCTGAGAGATGATAACCCGTTTGGAACATT
TTTTATGCTGTCTGTGGCGCTACCTTTTATTTCAAGGTAGCGGACACTCTCTGGCACTCCAGATATATAG
CAGTGGCAAACCGTCAGGCACTCGATGCCTTCAGATATGAAATGTATAAATGGTGAATCAGTTAATTCAA
TATGTAGATTTTTTACGGTTGATGGCATGTCTGTGATTTGTAATTTTTCACAGTTAATGACGGAGAGGTT
TTGTGTATTAACCGGCAATCCTGTAAGGGTTGTCAGGTTGTTGCAGTTTTCGATTGTAACTGATGTTATT
TCGTTTGGTAACTGTGGCAGATACTCAATATCACAATCTTTGATATATAAACGACCACTGGCCCGCGCTT
CTTCTATCTGAATTGGTGTGATTTCGCTTTTGATGTCTGCTGATGTTTCAGCGGAATAGGAGCAGAATGT
CCCGGTCGGTCGTAATTGCGATGTAGGAAGCA
Protein Sequence 
>gi|254792564|ref|YP_003077401.1| non-LEE-encoded type III secreted effector [Escherichia coli O157:H7 str. TW14359]
MLPTSQLRPTGTFCSYSAETSADIKSEITPIQIEEARASGRLYIKDCDIEYLPQLPNEITSVTIENCNNL
TTLTGLPVNTQNLSVINCEKLQITDMPSTVKNLHIELTDSPFIHFISEGIECLTVCHCYISGVPESVRYL
EIKGSATDSIKNVPNGLSSLSINSYNPENQARIDNLISPSLKTLSLTGCSNIILPEKLPESVTSVTIHAE
QKTTWNIGVEGMPDGLDLDLQNVLLSPDVVKAKNITFQGNALDVALHFREGDIVYGLSSPREKLVNSIKL
VNDFSKKDIITQNTLTNAVWDPRTPRKYKQDPLIKRALNEHERGIKFKQHLKNHNNYNVTMADLSVYNRD
KLWAKTSKAGLEFQTLTRNKTVIFCADELVNSLKLIANKSEGYGQSITASELRWIYRNKDNNQIMKNIKF
YLHGKEIPAERILDTPEWKDYRPKYSGSTYKYS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: espK mutant attenuated in calves (Vlisidou et al., 2006).
References
Vlisidou et al., 2006: Vlisidou I, Marchés O, Dziva F, Mundy R, Frankel G, Stevens MP. Identification and characterization of EspK, a type III secreted effector protein of enterohaemorrhagic Escherichia coli O157:H7. FEMS microbiology letters. 2006; 263(1); 32-40. [PubMed: 16958848].