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pyrD

Victor ID 2120
Gene Name pyrD
Sequence Strain (Species/Organism) Escherichia coli CFT073
NCBI Gene ID 1039998
NCBI Protein GI 26246966
Locus Tag c1081
Genbank Accession AE014075
Protein Accession NP_753006
Other Database IDs UniProtKB-ID: PYRD_ECOL6
UniRef100: UniRef100_B7UN24
UniRef90: UniRef90_B7UN24
UniRef50: UniRef50_Q2Y5H8
UniParc: UPI0000191E6D
EMBL: AE014075
EMBL-CDS: AAN79549.1
RefSeq_NT: NC_004431.1
EnsemblGenome: EBESCG00000039697
EnsemblGenome_TRS: EBESCT00000040647
EnsemblGenome_PRO: EBESCP00000038996
GenomeReviews: AE014075_GR
KEGG: ecc:c1081
HOGENOM: HBG351027
OMA: SYVTVNI
ProtClustDB: PRK05286
Taxonomy ID 199310
Gene Starting Position 1048662
Gene Ending Position 1049699
Gene Strand (Orientation) +
Protein Name dihydroorotate dehydrogenase 2
Protein pI 7.58
Protein Weight 35605.21
Protein Length 345
Protein Note catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
DNA Sequence 
>gi|26245917:1048662-1049699 Escherichia coli CFT073, complete genome
TTTGCACACCGGGAATCCAGGAGAGTTCATGTACTACCCCTTCGTTCGTAAAGCCCTTTTCCAGCTCGAT
CCAGAGCGCGCTCATGAGTTTACTTTTCAGCAATTACGCCGTATTACAGGAACGCCGTTTGAAGCACTGG
TGCGGCAGAAAGTGCCTGCGAAACCTGTTAACTGCATGGGCCTGACGTTTAAAAATCCGCTTGGTCTGGC
AGCCGGTCTTGATAAAGACGGGGAGTGCATTGACGCGTTAGGCGCGATGGGATTTGGATCCATCGAGATC
GGTACCGTCACGCCACGTCCCCAGCCAGGTAATGACAAGCCGCGTCTCTTTCGTCTGGTAGATGCCGAAG
GTTTGATCAACCGTATGGGCTTTAATAATCTTGGCGTTGATAACCTCGTAGAGAACGTAAAAAAAGCCCA
TTATGACGGCGTTCTGGGTATTAACATCGGCAAAAATAAAGATACGCCGGTGGAGCAGGGTAAAGATGAC
TATCTGATTTGTATGGAAAAAATCTATGCCTATGCGGGATATATCGCCATCAATATTTCATCGCCAAATA
CCCCAGGATTACGCACACTGCAATATGGTGAAGCGCTGGATGATCTCTTAACTGCGATTAAAAATAAACA
AAATGATTTGCAAGTGATGCACCATAAATATGTGCCGATCGCAGTGAAGATCGCGCCGGATCTTTCTGAA
GAAGAATTGATCCAGGTTGCCGATAGTTTAGTTCGCCATAATATTGATGGCGTTATTGCAACCAATACCA
CACTCGATCGTTCTCTGGTTCAGGGAATGAAAAATTGTGATCAAACCGGTGGCTTAAGTGGTCGTCCGCT
TCAGTTAAAAAGCACCGAAATTATTCGCCGCTTGTCACAGGAATTAAACGGACGCTTGCCGATTATTGGT
GTTGGCGGCATTGACTCGGTTATCGCTGCGCGTGAAAAGATTGCTGCGGGTGCCTCACTGGTGCAAATTT
ATTCTGGTTTTATTTTTAAAGGTCCGCCGCTGATTAAAGAAATCGTTACCCATATCTA
Protein Sequence 
>gi|26246966|ref|NP_753006.1| dihydroorotate dehydrogenase 2 [Escherichia coli CFT073]
MHTGNPGEFMYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA
AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAH
YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQ
NDLQVMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPL
QLKSTEIIRRLSQELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pyrD mutant is attenuated in mice (Bahrani-Mougeot et al., 2002).
COG COG0167F, under F: Nucleotide transport and metabolism
References
Bahrani-Mougeot et al., 2002: Bahrani-Mougeot FK, Buckles EL, Lockatell CV, Hebel JR, Johnson DE, Tang CM, Donnenberg MS. Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract. Molecular microbiology. 2002; 45(4); 1079-1093. [PubMed: 12180926].