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hylC

Victor ID 3788
Gene Name hylC
Sequence Strain (Species/Organism) Escherichia coli O103:H2 str. 12009
NCBI Gene ID 8470589
NCBI Protein GI 260718958
Locus Tag ECO103_p32
Genbank Accession AP010959
Protein Accession YP_003225099
Other Database IDs UniProtKB-ID: C8UB13_ECO10
UniRef100: UniRef100_Q5K5Z5
UniRef90: UniRef90_Q5K5Z5
UniRef50: UniRef50_P09985
UniParc: UPI00000B3039
EMBL: AP010959
EMBL-CDS: BAI33965.1
RefSeq_NT: NC_013354.1
EnsemblGenome: EBESCG00000195409.
EnsemblGenome_TRS: EBESCT00000196388
EnsemblGenome_PRO: EBESCP00000183662
GenomeReviews: AP010959_GR
KEGG: eoh:ECO103_p32
ProtClustDB: CLSK862057
Taxonomy ID 585395
Plasmid No pO103
Gene Starting Position 32093
Gene Ending Position 32608
Gene Strand (Orientation) -
Protein Name hemolysin C
Protein pI 8.77
Protein Weight 19341.93
Protein Length 171
DNA Sequence 
>gi|260718930:32093-32608 Escherichia coli O103:H2 str. 12009 plasmid pO103, complete sequence
ATTAGTTTTCTTTCTCAATATTAAAATTAAAATCTTGTCTGTTTTTTACTTCAGACATAAGTTCATGATG
GTATTGCCTGAATATTTTTGATGCCAGTTTTTTATCTATCCCCCCTCCATGAAATTCAGCTATTTTTCCT
GTTTTACTGCTCTCATCTAACCTTATTGCTCTGAATAACTCATAAGGATACTTTTTCCTCATGTATTTAT
ATAACTCCATGTTGTGTCCAAATGGAGCTATCCAGTCAATAAACCACTTTCTTTCTCCCGACATCCAGTC
TTTTGCATACAAAGATGTTACATCATTTATATATTTTACCTCACATTCCAGATCTAAACTGGCCCAGCTA
CAAAAAGCTACAGGAAGCTCATCCTTTATTAAGAGAGCAAATTGATTTGTCTGAATAGCAGGTATGACAT
TAATAGCAAAAACAGATAATGGCCATTTTTTATGCAGAGGAGAACAGGCCCATAGCCATGCAACCTTCCC
CATGACGTCAAAAGCATTAGATTTCA
Protein Sequence 
>gi|260718958|ref|YP_003225099.1| hemolysin C [Escherichia coli O103:H2 str. 12009]
MKSNAFDVMGKVAWLWACSPLHKKWPLSVFAINVIPAIQTNQFALLIKDELPVAFCSWASLDLECEVKYI
NDVTSLYAKDWMSGERKWFIDWIAPFGHNMELYKYMRKKYPYELFRAIRLDESSKTGKIAEFHGGGIDKK
LASKIFRQYHHELMSEVKNRQDFNFNIEKEN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells (Stanley et al., 1996).
COG COG2994O, under O: Posttranslational modification, protein turnover, chaperones
References
Stanley et al., 1996: Stanley P, Koronakis V, Hardie K, Hughes C. Independent interaction of the acyltransferase HlyC with two maturation domains of the Escherichia coli toxin HlyA. Molecular microbiology. 1996; 20(4); 813-822. [PubMed: 8793877].