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hlyC from Escherichia coli UTI89

Victor ID 2072
Gene Name hlyC from Escherichia coli UTI89
Sequence Strain (Species/Organism) Escherichia coli UTI89
NCBI Gene ID 3990776
NCBI Protein GI 91213875
Locus Tag UTI89_C4927
Protein Accession YP_543861.1
Other Database IDs UniProtKB-ID: Q1R2T4_ECOUT
UniRef100: UniRef100_Q1R2T4
UniRef90: UniRef90_P09985
UniRef50: UniRef50_P09985
UniParc: UPI0000D50EDB
EMBL: CP000243
EMBL-CDS: ABE10330.1
RefSeq_NT: NC_007946.1
EnsemblGenome: EBESCG00000069101.
EnsemblGenome_TRS: EBESCT00000070054
EnsemblGenome_PRO: EBESCP00000067532
GenomeReviews: CP000243_GR
KEGG: eci:UTI89_C4927
eggNOG: COG2994
HOGENOM: HBG296557
OMA: WALMDAD
ProtClustDB: CLSK862057
BioCyc: ECOL364106:UTI89_C4927-MONOMER
Taxonomy ID 364106
Gene Starting Position 4828107
Gene Ending Position 4828751
Gene Strand (Orientation) -
Protein Name hemolysin C
DNA Sequence 
>gi|91209055:4828107-4828751 Escherichia coli UTI89, complete genome
CTTAACCTGTTAATGAAAAATTGAAATCTGTCTTGTTTTTTACTTCAGTTATTAACTCGTGGTGATATTG
TTTAAAAATTTTATTCGCTAACTGTTTATCAATTTTACCTCCGTGAAATTCTGATACTTTACCAACATGA
GTTTTGGGATCCACCCTGATGGCTCGGAATAGTTCATCAGGGAATTTTTTTCGCATATATTTGTACAGGG
CACCGTTATCCCCGAAAGGAGCAATCCAGTCAATGAACCATTTACGATCACCTGAAGTCCAGTCTTCTGC
GACTAATGAGGTAACATCATTAAGATATTTAATTTCATTTTCTAAACTTAAATTAGCCCAACTACAATAT
GCAACAGGGTAATTATCCCGGGTTAATAAAGCATATTGGTTAGCCCGTATTGCAGGTAATACATTTATTG
CAAACAAAGAAACTGGCCAGTTTCTGTGTAATGGGGAACTGGCCCAGAGCCAGGATACATGCCCAAGAAC
CTCTAATGGATTGTTCATATTCATAATAAGCTCACTATAAATTAAATTATATTCTTGAATAAGTAAACGG
AGTCTGTGAGAGAACGATATTAATCCTTTAAATATGTTTCTTGCATTTAGTTTCATAACGCACATTAACA
TAAAAAAAGCATTCA
Protein Sequence 
>gi|91213875|ref|YP_543861.1| hemolysin C [Escherichia coli UTI89] MNAFFMLMCVMKLNARNIFKGLISFSHRLRLLIQEYNLIYSELIMNMNNPLEVLGHVSWLWASSPLHRNWPVSLFAINVLPAIRANQYALLTRDNYPVAYCSWANLSLENEIKYLNDVTSLVAEDWTSGDRKWFIDWIAPFGDNGALYKYMRKKFPDELFRAIRVDPKTHVGKVSEFHGGKIDKQLANKIFKQYHHELITEVKNKTDFNFSLTG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hlyC is required for the acylation and therefore activation of the toxin hemolysin which has the ability to lyse several different types of cells (Stanley et al., 1996).
COG COG2994O, under O: Posttranslational modification, protein turnover, chaperones
References
Stanley et al., 1996: Stanley P, Koronakis V, Hardie K, Hughes C. Independent interaction of the acyltransferase HlyC with two maturation domains of the Escherichia coli toxin HlyA. Molecular microbiology. 1996; 20(4); 813-822. [PubMed: 8793877].