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tir from Escherichia coli O26:H11 str. 11368

Victor ID 3757
Gene Name tir from Escherichia coli O26:H11 str. 11368
Sequence Strain (Species/Organism) Escherichia coli O26:H11 str. 11368
NCBI Gene ID 8481750
NCBI Protein GI 260858269
Locus Tag ECO26_5278
Protein Accession YP_003232160.1
Other Database IDs UniProtKB-ID: C8TNT7_ECO26
UniRef100: UniRef100_Q47014
UniRef90: UniRef90_O85508
UniRef50: UniRef50_Q47016
UniParc: UPI00000BCD23
EMBL: AP010953
EMBL-CDS: BAI28420.1
RefSeq_NT: NC_013361.1
EnsemblGenome: EBESCG00000172716.
EnsemblGenome_TRS: EBESCT00000173215
EnsemblGenome_PRO: EBESCP00000160259
GenomeReviews: AP010953_GR
KEGG: eoj:ECO26_5278
ProtClustDB: CLSK334862
Taxonomy ID 573235
Gene Starting Position 5352384
Gene Ending Position 5354000
Gene Strand (Orientation) +
Protein Name translocated intimin receptor Tir
DNA Sequence 
>gi|260853213:5352384-5354000 Escherichia coli O26:H11 str. 11368, complete genome
TATGCCTATTGGTAATCTTGGCCACAATCCCAATGTGAGAGCTTTAATTCCACCTGCACCGCCATTACCT
TCACAAACCGACGGTGCAGGAGGTGCCCGTAATCAGCTCATTAACTCAAATGGCCCGATGGGGTCTCGTT
TGCTATTTACGCCTATAAGGAATTCTGTTGCTGATGCTGCTGATTCTCGTGCCAGTGATATTCCCGGACT
TCCTACAAATCCACTGCGCTTTGCTGCGTCCGAGGTATCTTTGCATGGTGCGCTTGAAGTTCTTCATGAT
AAAGGGGGGCTTGATACTCTTAACTCTGCTATTGGATCTTCGTTATTCCGTGTTGAAACTCGGGATGATG
GCAGCCATGTTGCTATCGGGCAAAAAAATGGCCTCGAGACCACTGTTGTTTTAAGTGAGCAAGAGTTTTC
TAGCTTACAGTCCCTTGATCCTGAAGGTAAAAACAAATTTGTATTTACTGGAGGCCGCGGTGGCGCAGGG
CATGCTATGGTCACGGTTGCTTCAGATATCGCCGAAGCCCGTCAGAGGATAATAGATAAATTAGAACCAA
AGGATACAAAGGAGACGAAGGAGCCAGGGGATCCAAATAGTGGCGAGGGAAAAATCATTGAAATTCATAC
CTCAACCTCAACTTCTAGCCTCCGTGCAGATCCTAAACTTTGGTTGTCATTGGGGACTATTGCTGCAGGT
CTGATAGGGATGGCTGCGACGGGGATTGCACAGGCTGTTGCGTTGACTCCAGAGCCGGATGACCCAATCA
CTACCGACCCTGATGCTGCAGCAAACACAGCTGAAGCAGCGGCAAAAGATCAGTTAACGAAAGAAGCATT
CCAGAACCCAGATAACCAGAAAGTTAATATCGATGAGAACGGAAATGCAATTCCGTCCGGGGAACTAAAA
GATGATGTTGTTGCGCAAATAGCAGAACAAGCTAAAGCGGCGGGTGAACAGGCCAGACAGGAAGCTATTG
AAAGTAATTCTCAGGCGCAGCAAAAATATGATGAACAGCATGCTAAACGCGAACAGGAAATGTCTCTTTC
ATCGGGGGTTGGCTACGGTATTAGTGGTGCGCTGATTCTTGGCGGGGGAATTGGTGCCGGTGTTACTGCT
GCTCTTCATCGGAAAAACCAACCGGCAGAACAAACAATCACTACACGTACGGTAGTCGATAATCAGCCTA
CGAATAACGCATCTGCGCAGGGCAATACTGACACAAGTGGGCCAGAAGAGTCCCCGGCGAGCAGACGTAA
TTCGAATGCCAGCCTCGCATCGAACGGGTCTGACACCTCCAGCACGGGCACGGTAGAGAATCCGTATGCT
GACGTTGGAATGCCCAGAAATGATTCACTGGCTCGCATTTCAGAGGAACCTATTTATGATGAGGTCGCTG
CAGATCCTAATTATAGCGTCATTCAACATTTTTCAGGGAACAGCCCAGTTACCGGAAGGTTAGTGGGAAC
CCCAGGGCAAGGTATCCAAAGTACTTATGCGCTTCTGGCAAGCAGCGGCGGATTGCGTTTAGGTATGGGA
GGATTAACGGGGGGGGGCGAGAGCGCAGTAAGTACTGCCAATGCCGCACCAACGCCGGGACCCGCACGTT
TCGTTTA
Protein Sequence 
>gi|260858269|ref|YP_003232160.1| translocated intimin receptor Tir [Escherichia coli O26:H11 str. 11368] MPIGNLGHNPNVRALIPPAPPLPSQTDGAGGARNQLINSNGPMGSRLLFTPIRNSVADAADSRASDIPGLPTNPLRFAASEVSLHGALEVLHDKGGLDTLNSAIGSSLFRVETRDDGSHVAIGQKNGLETTVVLSEQEFSSLQSLDPEGKNKFVFTGGRGGAGHAMVTVASDIAEARQRIIDKLEPKDTKETKEPGDPNSGEGKIIEIHTSTSTSSLRADPKLWLSLGTIAAGLIGMAATGIAQAVALTPEPDDPITTDPDAAANTAEAAAKDQLTKEAFQNPDNQKVNIDENGNAIPSGELKDDVVAQIAEQAKAAGEQARQEAIESNSQAQQKYDEQHAKREQEMSLSSGVGYGISGALILGGGIGAGVTAALHRKNQPAEQTITTRTVVDNQPTNNASAQGNTDTSGPEESPASRRNSNASLASNGSDTSSTGTVENPYADVGMPRNDSLARISEEPIYDEVAADPNYSVIQHFSGNSPVTGRLVGTPGQGIQSTYALLASSGGLRLGMGGLTGGGESAVSTANAAPTPGPARFV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture (Schüller et al., 2007).
References
Schüller et al., 2007: Schüller S, Chong Y, Lewin J, Kenny B, Frankel G, Phillips AD. Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture models. Cellular microbiology. 2007; 9(5); 1352-1364. [PubMed: 17474908].