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tir from Escherichia coli O111:H- str. 11128

Victor ID 3723
Gene Name tir from Escherichia coli O111:H- str. 11128
Sequence Strain (Species/Organism) Escherichia coli O111:H- str. 11128
NCBI Gene ID 8486118
NCBI Protein GI 260869679
Locus Tag ECO111_3745
Protein Accession YP_003236081.1
Other Database IDs UniProtKB-ID: C8UFK8_ECO1A
UniRef100: UniRef100_O68258
UniRef90: UniRef90_O68258
UniRef50: UniRef50_Q58I88
UniParc: UPI00000B7B57
EMBL: AP010960
EMBL-CDS: BAI37530.1
RefSeq_NT: NC_013364.1
EnsemblGenome: EBESCG00000185697.
EnsemblGenome_TRS: EBESCT00000183149
EnsemblGenome_PRO: EBESCP00000173406
GenomeReviews: AP010960_GR
KEGG: eoi:ECO111_3745
ProtClustDB: CLSK334862
Taxonomy ID 585396
Gene Starting Position 3731499
Gene Ending Position 3733154
Gene Strand (Orientation) -
Protein Name putative translocated intimin receptor Tir
DNA Sequence 
>gi|260866153:3731499-3733154 Escherichia coli O111:H- str. 11128, complete genome
TTTAAACGAAACGTCCTGGTCCCGGCGTTGGTGCGGCATTTGCAGTATTTACTGCGCTCCCGCCACTCCC
CGTTAATCCACCCATACCTAAACGCAATCCAGCGCTGTTGTTTGTCAGAATCGCATAAGTACTTTGGATA
CCTTGCCCTGGAGTTCCCATTAACCTTCCGGTAACTTGGTTATTCCCTGAGAAATTTTGAATGACGCTAT
AATTAGGATCTGCAGCGACCTCATCGTAAATATGCTCTTCTGCCTGACGAGCCGGTGAACTATTCCGAGC
CTCCCCAACTTCAGCATATGGATTAACCACTGCGCTAGAAGTATCTGACCAGTGTGTCGATGCCGTACTC
CTCTGCGAATCACGTCTATTCAGAGATGTGTCTTCCGCTCTTATGGCATCAGTGCCACCTTGTGCTGGGG
TATTCCCTCCGGTCTGCTGCTGCACTACCGTATGTGTTGTTGTTGTCGTTGTTTGTTCTGCCGGCTGATT
TCGTCTATGAAGCGCAGTCGTTACACCAGCACCAATTCCCCCACCAACAATCAATGCACTGCTGAGGCTG
TAACCAATACCCGATGAAAGCTCTAATTCCTCCTGACGTCTGGCATACTGAGTATCATATCGCTGCTGCG
CCTGTGCATTGCTTTCAACAGCCTGCTGTCTGGCCGCCTCACCCGCCTCTTTAGCTTGTTCTTCTATTTT
AGCAACAACATCATCTTTTAATTCCCCAGACGGAATAGAATTTCCGATCTCATCAATGCTAACTTTCTGG
TTCTCAGGATTCTTGAATGCTTCTTGCGTTAACTGATCTCTTGTCGCACTTTCTGCAGCACTTGCAGCCT
GCTCAGGATCGGTGGTTGTAGGATCATCCGGTTCCGGTGTCAAAGCCAACGCCTGTGTAATACCAGTAGC
CGCCAGCCCCGCTAAACCAGCAGCAATTGCGCCGATAGAAACCCAGAATTTAGGATCTGAACGAACGCTG
GAAGCTGTTGATGAAGTACGAGTTTCGCTAACAACGCTATCATCCATTCCCGAAGCACTTCCAACACCAA
CAGAACGCGTATCAACGTTCCTGGCTTGACTTCCCCCATGATTGTTTGGGTCTAATTTGGCCAGTATTTT
CGCACGAGCTTCTGCGATATCTGATGCAGGAGTGACCATGGAATGCCCACCACCACCACGTCCCCCGGTA
AAAACAAATCGGCCTTTATCCTCAATATCGATAGCTTGCAAGCTTTGCAATTCTTGAGAATTTAATATAA
CGCTAACCTCTACACCATTTTTTTCTCCAATAGCGGCATAAGAACCATCTGACTGCTGTTCAATACGAAA
TGCAGAGGCTCCAATTTGCTTATTGAGAGTATCAAGTGGTCCCTTATCATGGAGAACTTCAAATCCTCCA
AGCAAGCATATCTCTGATGTAGCAGTAGCAAGCCTCGATGGGTGTACAGGAAGTCCTGGAATATCTCTGG
AATCGACAGAATCAGCTATAGAATTTCTCAGGGGAGAAAACAATAAACGAGATCCTAATGCTCCTGTAGA
GTTAATTAGTTGACCCGCTCCTCCCCGTGACGCGCCGTCTGTTTGTGAAGGTAGTGGCGGCGCAGGCGGA
ATTAAATTATTGCTATTTACATTATTACCAAGGTTACCAATAGGCA
Protein Sequence 
>gi|260869679|ref|YP_003236081.1| putative translocated intimin receptor Tir [Escherichia coli O111:H- str. 11128] MPIGNLGNNVNSNNLIPPAPPLPSQTDGASRGGAGQLINSTGALGSRLLFSPLRNSIADSVDSRDIPGLPVHPSRLATATSEICLLGGFEVLHDKGPLDTLNKQIGASAFRIEQQSDGSYAAIGEKNGVEVSVILNSQELQSLQAIDIEDKGRFVFTGGRGGGGHSMVTPASDIAEARAKILAKLDPNNHGGSQARNVDTRSVGVGSASGMDDSVVSETRTSSTASSVRSDPKFWVSIGAIAAGLAGLAATGITQALALTPEPDDPTTTDPEQAASAAESATRDQLTQEAFKNPENQKVSIDEIGNSIPSGELKDDVVAKIEEQAKEAGEAARQQAVESNAQAQQRYDTQYARRQEELELSSGIGYSLSSALIVGGGIGAGVTTALHRRNQPAEQTTTTTTHTVVQQQTGGNTPAQGGTDAIRAEDTSLNRRDSQRSTASTHWSDTSSAVVNPYAEVGEARNSSPARQAEEHIYDEVAADPNYSVIQNFSGNNQVTGRLMGTPGQGIQSTYAILTNNSAGLRLGMGGLTGSGGSAVNTANAAPTPGPGRFV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tir deletion strains are unable to adhere to tissue in an in vitro organ culture (Schüller et al., 2007).
References
Schüller et al., 2007: Schüller S, Chong Y, Lewin J, Kenny B, Frankel G, Phillips AD. Tir phosphorylation and Nck/N-WASP recruitment by enteropathogenic and enterohaemorrhagic Escherichia coli during ex vivo colonization of human intestinal mucosa is different to cell culture models. Cellular microbiology. 2007; 9(5); 1352-1364. [PubMed: 17474908].