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ehxA

Victor ID 4
Gene Name ehxA
Sequence Strain (Species/Organism) Escherichia coli
NCBI Gene ID 3654480
NCBI Protein GI 73853298
Locus Tag LH0144
Genbank Accession AY258503
Protein Accession YP_308794
Other Database IDs UniProtKB-ID: Q3ZU04_ECOLX
UniRef100: UniRef100_Q3ZU04
UniRef90: UniRef90_A1EAA3
UniRef50: UniRef50_P55129
UniParc: UPI000059921F
EMBL: AY258503
EMBL-CDS: AAZ76497.1
RefSeq_NT: NC_007365.1
ProtClustDB: CLSK862058
Taxonomy ID 562
Plasmid No pO113
Gene Starting Position 114135
Gene Ending Position 117131
Gene Strand (Orientation) -
Protein Name hemolysin A
Protein pI 4.77
Protein Weight 101308.83
Protein Length 998
Protein Note predicted subcellular location is inner membrane
DNA Sequence 
>gi|73853177:114135-117131 Escherichia coli EH41 plasmid pO113, complete sequence
CTCAGACAGTTGTCGTTAAAGTTGTTGAGTGTGTGTTATTTTGATGTAAGGATAAATTATATAAAGATGC
TAATCGTTCATCACCTGAATCGAACCCTGAAACTGAAGAAATAATCTTGTTAATATCATTGGCAACACTA
GTGATATTAACCATGTTTTTTTCAGATGCTATATTACTGGCTTTTATATAACCTGACTGTTCATTATTAT
TATGAGATATCTTATCAGCTTTTATCTCACGACCATCTTTATCTGTTATAACCTCAACAAGATGATTATC
TTCACCTGAGGCATCTTTCGCAAACCAGTTTTTAAATGTTATCCCATTGACATCATTTGACTCATTAAAT
GAAAGTGCACCATTAATGGCTTTATTCATGATAAGATCATTTCCAACTTTCTTAAATGCGATATCATCAA
AGCTAATATCAGATAAGTGCAGACGATCTCCTTTACCTCCTTCATCTGCAATTGTATGATGACCATAGTT
TTGCCTATAAACATAAATATCATTACCAAAACCACCATTCAGATAGTCATTACCTTCCCCTCCATCCAGA
AGGTCAATACCACCACCACCATAAAGTTTATCATCACCAGTACCACCTGACAGAATATTATAAGCTCCGT
GTGCCTGAAGCTCATCATTACCGCGTCCTCCTGTCAGATAATTATTACCATCCCCTCCACTCAATTTATC
GTTTCCACTACCACCAAATAACTGGTCGTCTCCCTGTCCACCGGATATATAATCATCCCCATCATCGCCG
TATAGTCGATCATTACCATAATTACCTTCGATATAATCGTTCCCATCTGCACCATGGAATATATCATTAA
ACTTACCGCCTTTGAATTCATCATCATGTTTTCCGCCAATGAGTTCTTCAACAGAATGAAGATTATCTAT
CACATCATAAGGAATTCCACCGGTTCTGAATTCAAAATCACGATATTGTATTTTCTCTGTTCTCTTCCCT
ACTGACACCTCCTGTTCCTTAACGACTTCCTGCAATACCTTCACGTCACCATACATATTTTTTGAAACTA
TATATTCACCAGGTTTTGATGCTCCTGTTGCATCAATTGTTAGTTTACCAACATCCGTCTTATTATAAGA
TACGGTATCATGACCTTCACCAGCAAATACTTCTGATGAGCCTGCCCCAGAATAAACTATATCGTCTTTA
TCTCCGAGCTCAGAAATTATTCTCGCCTGATAGTGTTTGTTATCCTTTTCAACAAACTGAATCAAATTTG
AATAATCATATACACCTTTATGATTTTTTATGCCTTTTACAGACCATGTATCCTTACCATTTACAATAAG
AGATGTCATATATTCATATTTACCACTCTGTTTTCTTTCTCTGACTTCTTCTCCTGGGGTAAATGTTGGT
GTTACAAATGTCAAAACACTTGATACATTACCTGTTGAAAGGTCTATAGTCCCTTTTTGAGGATCAAAAA
CTTGTTGTGTAAACTCCTTCGGTTGAGCCTCTAAAAGCCCTCCATTCTCCAGATAATTAATATATGCCTT
ACCACTCTGACTGCGATCAGCATTACGGGTTATACCTGCAAGTTCACCGATCTTCTCATCCCAATGTTGC
TGGGTTATTGCGACAGCTCTTTCTACTGCATGCTGACGAGAAAAATCAGCAAGCAAAGACAGAGAGTCTT
CTAAAAACGCAGCATGTCTTGCGTCATAGCCATTCTCAAAATAATTTTTGCCATGCTCCTTTTCCCATTC
ATTGATCCGAGCAGCGAATTTATCTGCAACGTGCTCAAACATAGCCTGTTTTGATGCTTCCAGAATGCCA
GATATCGTACCGGTTAATGCACTCACCAGCATGCTTATCGGGGCCCCTATGAGGGATGCACTGGAGGCTG
CACTAACTCCCGCAGATACAGAACTCAGGACAGTATTTATTGTTGTCAGGGCTGCATCTATAGCTCCGCT
TTCTTTATGAAAGGCTGCGAGTAAAGCATCTCCTTCATAATTGAATTTTTTAAATCGTTCAGAATATGAT
TCAAGCTGCTTAGCTCGCTCAAATTTATCTGCAATAGCCAGGAAAGAAAGAGGACTGATAGCCAGCATAA
CAGCCGATGTGATCAGACCCGCACTTGCAGCTGTTGTCGATAATCCCTGTGCCATTCTCTGAGCCAGAAT
ATATTGCGAAACAGCTTTACCAACATTTCCAAGAACCTGAGTTGTCAGTTCGATACCCGCTGCAGCTTTT
GTTCCTGTATGTGCGTCACTGTTTCCCAGAATAAAACTTGCTGATACAGCAGAAAGAATTCCGGAGACAA
CATCCAGCCCATCCCCCAGGGGGCCCAGGTCTGGTAAATTTTGTAATTTTCCACCAACAGAACTTAAGCG
AGGTTTACTGGATAAAAATGAGCCAAGCTGGTTAAGCTGCTCAGAAAATGAATCAACGGTACTGTTTATA
CTTGATACTGTATCTACAAGCTGATTAATAAGTTCAATACTACTTTTGGCAATATCATTCTGACTTATAT
CCTCTCCTTCCCGTTGTTTTCTCAGCAATTCATCAAGAGCCATGCCTGATAAAGCAATCCCCGTAAAATT
CTGTAGTGCTGAGAGAACTGTTCCGGCTTTTCCCAGATTATTACCTACATTTTCAGCAGTTCCGCCTATT
TTACTCCCAACTTTCTGATACTTCTGCAGAAGTTTGTCAAGTTGTGGTGCGAATATTGCAACACCACGTT
CAGTTAATCCTACAACTTTTTCTGCTGTACCAAAAAACTGGTTTGCAATCGCTGTATCATCTCGTTCAGT
ACGGTGTATTTCTATTCCAAGCTCATCAGCAGCTTTGACCAACTCATTAATACCCACGCCCTGAGCTTCA
TAATTATCAGGTATTAATAATATGAGTTTTTTTCCAGCGGAACGTACGCTTGATGATGCTGTATTAAATG
CTGATTTTGTAGTCGATGTCGCATTGTTGAAAATGTTCTTTATTTTATTTACTGTCA
Protein Sequence 
>gi|73853298|ref|YP_308794.1| hemolysin A [Escherichia coli]
MTVNKIKNIFNNATSTTKSAFNTASSSVRSAGKKLILLIPDNYEAQGVGINELVKAADELGIEIHRTERD
DTAIANQFFGTAEKVVGLTERGVAIFAPQLDKLLQKYQKVGSKIGGTAENVGNNLGKAGTVLSALQNFTG
IALSGMALDELLRKQREGEDISQNDIAKSSIELINQLVDTVSSINSTVDSFSEQLNQLGSFLSSKPRLSS
VGGKLQNLPDLGPLGDGLDVVSGILSAVSASFILGNSDAHTGTKAAAGIELTTQVLGNVGKAVSQYILAQ
RMAQGLSTTAASAGLITSAVMLAISPLSFLAIADKFERAKQLESYSERFKKFNYEGDALLAAFHKESGAI
DAALTTINTVLSSVSAGVSAASSASLIGAPISMLVSALTGTISGILEASKQAMFEHVADKFAARINEWEK
EHGKNYFENGYDARHAAFLEDSLSLLADFSRQHAVERAVAITQQHWDEKIGELAGITRNADRSQSGKAYI
NYLENGGLLEAQPKEFTQQVFDPQKGTIDLSTGNVSSVLTFVTPTFTPGEEVRERKQSGKYEYMTSLIVN
GKDTWSVKGIKNHKGVYDYSNLIQFVEKDNKHYQARIISELGDKDDIVYSGAGSSEVFAGEGHDTVSYNK
TDVGKLTIDATGASKPGEYIVSKNMYGDVKVLQEVVKEQEVSVGKRTEKIQYRDFEFRTGGIPYDVIDNL
HSVEELIGGKHDDEFKGGKFNDIFHGADGNDYIEGNYGNDRLYGDDGDDYISGGQGDDQLFGGSGNDKLS
GGDGNNYLTGGRGNDELQAHGAYNILSGGTGDDKLYGGGGIDLLDGGEGNDYLNGGFGNDIYVYRQNYGH
HTIADEGGKGDRLHLSDISFDDIAFKKVGNDLIMNKAINGALSFNESNDVNGITFKNWFAKDASGEDNHL
VEVITDKDGREIKADKISHNNNEQSGYIKASNIASEKNMVNITSVANDINKIISSVSGFDSGDERLASLY
NLSLHQNNTHSTTLTTTV
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: Ehx demonstrated lysis of BL-3 cells (cells from a bovine lymphoma cell line), sheep and human erythrocytes (Bauer and Welch, 1996).
References
Bauer and Welch, 1996: Bauer ME, Welch RA. Characterization of an RTX toxin from enterohemorrhagic Escherichia coli O157:H7. Infection and immunity. 1996; 64(1); 167-175. [PubMed: 8557336].