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espF from Escherichia coli O111:H- str. 11128

Victor ID 3717
Gene Name espF from Escherichia coli O111:H- str. 11128
Sequence Strain (Species/Organism) Escherichia coli O111:H- str. 11128
NCBI Gene ID 8485564
NCBI Protein GI 260869668
Locus Tag ECO111_3734
Protein Accession YP_003236070.1
Other Database IDs UniProtKB-ID: C8UFJ7_ECO1A
UniRef100: UniRef100_B8ZY82
UniRef90: UniRef90_B8ZY82
UniRef50: UniRef50_Q5K5R0
UniParc: UPI00019234CD
EMBL: AP010960
EMBL-CDS: BAI37519.1
RefSeq_NT: NC_013364.1
EnsemblGenome: EBESCG00000185724.
EnsemblGenome_TRS: EBESCT00000185670
EnsemblGenome_PRO: EBESCP00000172888
GenomeReviews: AP010960_GR
KEGG: eoi:ECO111_3734
ProtClustDB: CLSK2393223
Taxonomy ID 585396
Gene Starting Position 3720610
Gene Ending Position 3721398
Gene Strand (Orientation) -
Protein Name T3SS secreted effector EspF
DNA Sequence 
>gi|260866153:3720610-3721398 Escherichia coli O111:H- str. 11128, complete genome
ATTATACTTTTTTCGATTGCTCATAGGCAGCTAAATGATCTTTTAATGCCTGTGCAATGGGCGGTAGTCC
ACCAGACTCGGATGCCTGTCCACTTGTTGGTGGCGGGGGTGCCTGACGGGTTGGCTTAAAGCTTACAGTC
TCAGACGCTTTCGATAGTTCATAGGCAGCTAAATGATCTTTTAATGCCTGTGCAATGGGCGGTAGTCCAC
CAGACTCGGATGCCTGTCCACTTGTTGGTGGCGGGGGTGCCTGACGGGTTGGCTTAAAGCTTACAGTCTC
AGACGCTTTCGATAGTTCATAGGCAGCTAAATGATCTTTTAATGCCTGTGCAATGGGCGGTAGTCCACCA
GACTCGGATGCCTGTCCACTTGTTGGTGGCGGGGGTGCCTGACGGGTTGGCTTAAAGCTTACAGTCTCAG
ACGCTTTCGATAGTTCATAGGCAGCTAAATGATCTTTTAATGCCTGTGCAATGGGCGGTAGCCCGGCAGA
CCCGGATGCCTGTCCACTTGTCGGTGGCGGTGGTGCCGGGCGAGTAGGAGTAAATGAAGTCGCCATCTGA
CTCATACGACTCATCTGACTCATCTGACTCATATGACTCATATTAAAAGTCGTTCTCGCATTAATATTCG
ACGAACCTGGAGAAAAAGGGGAATGAAATCTCACCGGAGTAAGACGCACAGTCTGAGGGGCTACAGAAAA
TCCAGATACCCCCGCAGAGCCCACTCGACTTGCGACACCTCTAAGATGCAGCCCTATTGTAGAAACAGCG
TTACTAATTCCATTAAGCA
Protein Sequence 
>gi|260869668|ref|YP_003236070.1| T3SS secreted effector EspF [Escherichia coli O111:H- str. 11128] MLNGISNAVSTIGLHLRGVASRVGSAGVSGFSVAPQTVRLTPVRFHSPFSPGSSNINARTTFNMSHMSQMSQMSRMSQMATSFTPTRPAPPPPTSGQASGSAGLPPIAQALKDHLAAYELSKASETVSFKPTRQAPPPPTSGQASESGGLPPIAQALKDHLAAYELSKASETVSFKPTRQAPPPPTSGQASESGGLPPIAQALKDHLAAYELSKASETVSFKPTRQAPPPPTSGQASESGGLPPIAQALKDHLAAYEQSKKV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: espF mutant of EPEC is deficient in its ability to disrupt electrical resistance across a polarized monolayer of intestinal epithelial cells, suggesting that EspF is an effector molecule required for disrupting intestinal epithelial barrier function (McNamara et al., 2001).
References
McNamara et al., 2001: McNamara BP, Koutsouris A, O'Connell CB, Nougayréde JP, Donnenberg MS, Hecht G. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. The Journal of clinical investigation. 2001; 107(5); 621-629. [PubMed: 11238563].