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serA

Victor ID 2164
Gene Name serA
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. EDL933
NCBI Gene ID 959584
NCBI Protein GI 15803448
Locus Tag Z4251
Genbank Accession AE005174
Protein Accession NP_289481
Other Database IDs UniProtKB-ID: SERA_ECO57
UniRef100: UniRef100_P0A9T2
UniRef90: UniRef90_P0A9T2
UniRef50: UniRef50_P43885
UniParc: UPI000002D3AC
EMBL: AE005174
EMBL: BA000007
EMBL-CDS: AAG58040.1
EMBL-CDS: BAB37207.1
RefSeq_NT: NC_002655.2
RefSeq_NT: NC_002695.1
EnsemblGenome: EBESCG00000027875
EnsemblGenome_TRS: EBESCT00000028824
EnsemblGenome_PRO: EBESCP00000027717
EnsemblGenome: EBESCG00000058765
EnsemblGenome_TRS: EBESCT00000059718
EnsemblGenome_PRO: EBESCP00000057546
GenomeReviews: AE005174_GR
GenomeReviews
Taxonomy ID 155864
Gene Starting Position 3862007
Gene Ending Position 3863239
Gene Strand (Orientation) -
Protein Name D-3-phosphoglycerate dehydrogenase
Protein pI 6.32
Protein Weight 41397.11
Protein Length 410
Protein Note catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
DNA Sequence 
>gi|16445223:3862007-3863239 Escherichia coli O157:H7 str. EDL933 chromosome, complete genome
ATTAGTACAGCAGACGGGCGCGAATGGTACCCGGAATAGCTTTCATTGCCTGCAGCGCTTTTTCGGCAAC
GTCTTCGTCAGCTTCAATATCAATAACTACATAACCCATCTGGGCGGAAGTTTGTAGATATTGCGCGGCG
ATGTTGACGCCCTGCTCGGCGAAGATTTTGTTCAGCGCAGTTAGCACGCCCGGACGGTTTTCGTGGATGT
GCATCAGACGACGACCACCATGCAGTGGCAGCGAGACTTCCGGGAAGTTCACCGCAGAGAGCGTTGAGCC
ATTGTCAGAATACTTGATCAATTTACCCGCAACTTCCAGGCCGATATTCTCCTGCGCTTCCTGAGTCGAA
CCGCCAATGTGTGGCGTCAGAAGGACGTTGTCGAATTCACACAGTGGAGAGGTAAATGGATCGCTATTGG
TCGCCGGTTCCGTCGGGAATACGTCGATTGCCGCCCCCGCCAGATGTTTGCTCGCCAGCGCATCACACAG
CGCCGGAATATCCACCACAGTACCGCGCGAGGCATTAATCAGCAGCGAGCCGGGCTTCATTAGCGAAATC
TCTTTCGCGCCCATCATATTTTTGGTGGACGGATTCTCTGGTACATGCAGACTCACCACATCGCTCATAT
TCAGCAGGTCAGAAAGATGCTGTACCTGAGTGGCGTTGCCCAGCGGCAGTTTGTTTTCAATATCATAAAA
GTAAACATACATTCCCAGCGATTCAGCCAGAATGCCCAATTGCGTACCAATATGACCGTAGCCGATGATA
CCCAGCTTTTTGCCGCGCGCTTCAAAAGAACCCGCCGCCAGTTTGTTCCACACGCCACGGTGCGCTTTAG
CATTGGCTTCCGGCACGCCGCGCAATAGCAGCAGCAGTTCGCCAATCACCAGCTCCGCAACAGAGCGCGT
ATTTGAGAACGGTGCGTTAAATACCGGGATCCCGCGCTTTGCCGCCGCATCCAGATCAACCTGGTTTGTT
CCTATACAGAAACAGCCAATAGCGACCAGCTTTTCTGCGGCGTTGATCACGTCTTCAGTCAGATGGGTAC
GGGATCGCAGGCCGATGAAGTGGGCATCGCGGATGGATTCTTTTAATTGTTCATCATCCAGCGCGCCTTT
GTGAAATTCGATGTTGGTGTAACCAGCTGCACGAAGGCTTTCCAGCGCCTTTTGGTGCACGCCTTCTACC
AGCAGAAACTTAATCTTGTCTTTCTCCAGCGATACCTTTGCCA
Protein Sequence 
>gi|15803448|ref|NP_289481.1| D-3-phosphoglycerate dehydrogenase [Escherichia coli O157:H7 str. EDL933]
MAKVSLEKDKIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVI
NAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWN
KLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQHLSDLLNMSDVVSLH
VPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSP
LCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLIKYSDNGSTLSAVNFPEVSLPLHGGRRLMHIHENRPGV
LTALNKIFAEQGVNIAAQYLQTSAQMGYVVIDIEADEDVAEKALQAMKAIPGTIRARLLY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: serA mutant is attenuated in calves (van et al., 2005).
COG COG0111HE, under H: Coenzyme transport and metabolism; E: Amino acid transport and metabolism
References
van et al., 2005: van Diemen PM, Dziva F, Stevens MP, Wallis TS. Identification of enterohemorrhagic Escherichia coli O26:H- genes required for intestinal colonization in calves. Infection and immunity. 2005; 73(3); 1735-1743. [PubMed: 15731074].