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espF from Escherichia coli O103:H2 str. 12009

Victor ID 3765
Gene Name espF from Escherichia coli O103:H2 str. 12009
Sequence Strain (Species/Organism) Escherichia coli O103:H2 str. 12009
NCBI Gene ID 8474190
NCBI Protein GI 260845679
Locus Tag ECO103_3600
Protein Accession YP_003223457.1
Other Database IDs UniProtKB-ID: C8TWL1_ECO10
UniRef100: UniRef100_Q5K5R0
UniRef90: UniRef90_Q5K5R0
UniRef50: UniRef50_Q5K5R0
UniParc: UPI00004B4E2E
EMBL: AP010958
EMBL-CDS: BAI32323.1
RefSeq_NT: NC_013353.1
EnsemblGenome: EBESCG00000180662.
EnsemblGenome_TRS: EBESCT00000181660
EnsemblGenome_PRO: EBESCP00000165442
GenomeReviews: AP010958_GR
KEGG: eoh:ECO103_3600
ProtClustDB: CLSK2393223
Taxonomy ID 585395
Gene Starting Position 3678870
Gene Ending Position 3679754
Gene Strand (Orientation) -
Protein Name T3SS secreted effector EspF
DNA Sequence 
>gi|260842239:3678870-3679754 Escherichia coli O103:H2 str. 12009, complete genome
CTTAATATCGGTTTTTATCTTTTAATGCCTGAGCAATAGGCGGTAATGGCCGGGATGCCTCGGATGCCTG
TCCACTTGTCGGTGGCGGCGGTGCCGGGCGGCTTGGCTTAAGACCTGAAGTATCAAGACTTTTCGATTTT
TCATAGGCAGCCAAATGATCTTTTAGCGCCTGAGCAATGGGCGGTAAAGACCGGGATGACCCAGATACCA
ACCCGCTTGTCGGCGGCGGCGGTGCCGGGCGGCTTGGCTTAAGGCTTGAAGTATCAAGACTTTTCGACTT
TTCATAGGCAGCTAAATGATCTTTTAATGCCTGAGCAATGGGCGGTAAAGACCGGGATGATCCAGATACC
TGCCCACTTGTCGGCGGCGGTGGAGCCGGGCGGGCCGGCTTAAGGCCTGAAGCCTCAAGGCTTTTCGATT
TTTCATAGGCAGCCAAATGATCTTTTAATGCCTGCGCAATGGGCGGTAAAGGGCGGGATGCCCCGGAAGC
CTGTCCACTTGTCGGCGGCGGTGGGGCCGGGCGGCTTGGCTTAAGACCTGAAGCCTCAAGGCTTTTCGAC
TTTTCATAGGCAGCCAAATGATCTTTTAGTGCCTGAGCAATGGGCGGTAAAGGGCGGGATGCCCCGGAAG
CCTGTCCACTTGTCGGCGGCGGTGGGGCCGGACGAGAGGGAGTAAATGAAGTCGCCGGGCTACTCACATT
AAAAGTCGTTCTCGCATTGATATTCGACGTACCGGGAGAAAAAGGAGATTGAGCCCTAATCGGATTCAGA
CGAACAGCCTGAGGGGACACTGAAAAGCCAGATAACCCCGCAGAGCTTACCCGGCTTGCCGCACTAGTAA
TATGCCGTCCTAGTGTAGAAACAGCTTGACTAATTCCATTAAGCA
Protein Sequence 
>gi|260845679|ref|YP_003223457.1| T3SS effector EspF [Escherichia coli O103:H2 str. 12009] MLNGISQAVSTLGRHITSAASRVSSAGLSGFSVSPQAVRLNPIRAQSPFSPGTSNINARTTFNVSSPATSFTPSRPAPPPPTSGQASGASRPLPPIAQALKDHLAAYEKSKSLEASGLKPSRPAPPPPTSGQASGASRPLPPIAQALKDHLAAYEKSKSLEASGLKPARPAPPPPTSGQVSGSSRSLPPIAQALKDHLAAYEKSKSLDTSSLKPSRPAPPPPTSGLVSGSSRSLPPIAQALKDHLAAYEKSKSLDTSGLKPSRPAPPPPTSGQASEASRPLPPIAQALKDKNRY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: espF mutant of EPEC is deficient in its ability to disrupt electrical resistance across a polarized monolayer of intestinal epithelial cells, suggesting that EspF is an effector molecule required for disrupting intestinal epithelial barrier function (McNamara et al., 2001).
References
McNamara et al., 2001: McNamara BP, Koutsouris A, O'Connell CB, Nougayréde JP, Donnenberg MS, Hecht G. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. The Journal of clinical investigation. 2001; 107(5); 621-629. [PubMed: 11238563].