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ler from Escherichia coli O127:H6 str. E2348/69

Victor ID 3487
Gene Name ler from Escherichia coli O127:H6 str. E2348/69
Sequence Strain (Species/Organism) Escherichia coli O127:H6 str. E2348/69
NCBI Gene ID 7062691
NCBI Protein GI 215488999
Locus Tag E2348C_3968
Protein Accession YP_002331430.1
Other Database IDs UniProtKB-ID: B7UMC6_ECO27
UniRef100: UniRef100_O52122
UniRef90: UniRef90_C7BUR5
UniRef50: UniRef50_Q8VTF2
UniParc: UPI00000B3377
EMBL: FM180568
EMBL-CDS: CAS11516.1
RefSeq_NT: NC_011601.1
EnsemblGenome: EBESCG00000115163.
EnsemblGenome_TRS: EBESCT00000114918
EnsemblGenome_PRO: EBESCP00000108414
GenomeReviews: FM180568_GR
KEGG: ecg:E2348C_3968
HOGENOM: HBG740436
OMA: ITYYNIT
ProtClustDB: CLSK334877
Taxonomy ID 574521
Gene Starting Position 4133551
Gene Ending Position 4133940
Gene Strand (Orientation) -
Protein Name transcription regulator Ler
DNA Sequence 
>gi|215485161:4133551-4133940 Escherichia coli O127:H6 str. E2348/69, complete genome
GTTAAATATTTTTCAGCGGTATTATTTCTTCTTCAGTGTCCTTCACAAGAAAATCTTCTTTCTTCATTCC
ATTCAACAGTGCTTCTTTAAGCCAGCGTGGCTGTCGGCCTACGCCCGACCAGGTCTGCCCTTCTTCATTG
CGGTAGTAAACACCTTTCGATGAGTTCCGGCGAGCGAGTCCATCATCAGGCACATTAGTATATCCCAGCT
CTTGTAAGGTTATATTGTAATAAGTAATCTGCTTCTGAATCGACTCAATTACACTTTGAACTTCCTGCTC
TCGCAGTCGCTTTGCTTCCTGCTGTAGAACTGCAATTTGCTCTATAAGCTGAATGTATGGACTTGTTGTA
TGTGAATTAGTTTCCATATTCATAATAAATAATCTCCGCA
Protein Sequence 
>gi|215488999|ref|YP_002331430.1| transcriptional regulator Ler [Escherichia coli O127:H6 str. E2348/69] MRRLFIMNMETNSHTTSPYIQLIEQIAVLQQEAKRLREQEVQSVIESIQKQITYYNITLQELGYTNVPDDGLARRNSSKGVYYRNEEGQTWSGVGRQPRWLKEALLNGMKKEDFLVKDTEEEIIPLKNI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ler mutants had less adhesion to HeLa cells, ler is a regulator of many virulence genes in the LEE PAI which are needed for adherence (Torres et al., 2008).
COG COG2916R, under R: General function prediction only
References
Torres et al., 2008: Torres AG, Slater TM, Patel SD, Popov VL, Arenas-Hernández MM. Contribution of the Ler- and H-NS-regulated long polar fimbriae of Escherichia coli O157:H7 during binding to tissue-cultured cells. Infection and immunity. 2008; 76(11); 5062-5071. [PubMed: 18794291].