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espA from Escherichia coli O111:H- str. 11128

Victor ID 3727
Gene Name espA from Escherichia coli O111:H- str. 11128
Sequence Strain (Species/Organism) Escherichia coli O111:H- str. 11128
NCBI Gene ID 8486432
NCBI Protein GI 260869674
Locus Tag ECO111_3740
Protein Accession YP_003236076.1
Other Database IDs UniProtKB-ID: C8UFK3_ECO1A
UniRef100: UniRef100_B8ZY88
UniRef90: UniRef90_B8ZY88
UniRef50: UniRef50_O87743
UniParc: UPI00019234D1
EMBL: AP010960
EMBL-CDS: BAI37525.1
RefSeq_NT: NC_013364.1
EnsemblGenome: EBESCG00000181034.
EnsemblGenome_TRS: EBESCT00000187007
EnsemblGenome_PRO: EBESCP00000170846
GenomeReviews: AP010960_GR
KEGG: eoi:ECO111_3740
ProtClustDB: CLSK701598
Taxonomy ID 585396
Gene Starting Position 3724686
Gene Ending Position 3725264
Gene Strand (Orientation) -
Protein Name translocon EspA
DNA Sequence 
>gi|260866153:3724686-3725264 Escherichia coli O111:H- str. 11128, complete genome
GTTATTTACCAAGGGATATTGATGATATAGTTCTGAATTGCAGTGACTGCATATCAGAACGTGCACTCGT
TAATAGGTTTAACGTATTTGACATTTGCTGTATTTCAAGCTGGCTATTATTCACCGTCGTTGTCAAATTA
TTCGCTTGAGCTGAAATAGCTGCTTTCACCGTTTGCAAATCACCAGCGCCTAATGCAGCATTTAGATCGG
TAATACCACTTATTGTAACGTCATTGCGAGGATCATTTATATAGTCAAGCACTTCTTTAGGAAGTTGAGC
CTTCGCATTCTTGTCGGAGCTACTCTGAACCTCAGCAATTTTAGCATCCACAAGATTCGCCATTTTTTGG
GCAGTGGTTGACGCCTTAGATGCCTCATTCATATCAGCAAACTTTGCAATCGACAGATCGCTTTGTGCCT
GATACATATAGGAAAACATGAGAAGCGCAGCCTGAAAAACACCGAGTTTATTGAATAGTTCAACAACCTG
ATCTTTCGACATGCTCCCTAAATCATAGGTCAGCGATGTCGAAGTACTCGCATTCGTACTAGCAACTGAT
GCTGTATTTAATGTATCCA
Protein Sequence 
>gi|260869674|ref|YP_003236076.1| translocon EspA [Escherichia coli O111:H- str. 11128] MDTLNTASVASTNASTSTSLTYDLGSMSKDQVVELFNKLGVFQAALLMFSYMYQAQSDLSIAKFADMNEASKASTTAQKMANLVDAKIAEVQSSSDKNAKAQLPKEVLDYINDPRNDVTISGITDLNAALGAGDLQTVKAAISAQANNLTTTVNNSQLEIQQMSNTLNLLTSARSDMQSLQFRTISSISLGK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: deletion of espA in STEC abolished ability to attach to HeLa cells and induce actin rearrangements (Ebel et al., 1998).
References
Ebel et al., 1998: Ebel F, Podzadel T, Rohde M, Kresse AU, Krämer S, Deibel C, Guzmán CA, Chakraborty T. Initial binding of Shiga toxin-producing Escherichia coli to host cells and subsequent induction of actin rearrangements depend on filamentous EspA-containing surface appendages. Molecular microbiology. 1998; 30(1); 147-161. [PubMed: 9786192].