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recD

Victor ID 2141
Gene Name recD
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. EDL933
NCBI Gene ID 958288
NCBI Protein GI 15803338
Locus Tag Z4136
Genbank Accession AE005174
Protein Accession NP_289371
Other Database IDs UniProtKB-ID: Q8X6N0_ECO57
UniRef100: UniRef100_Q8X6N0
UniRef90: UniRef90_P04993
UniRef50: UniRef50_P04993
UniParc: UPI00001658FF
EMBL: AE005174
EMBL-CDS: AAG57930.1
RefSeq_NT: NC_002655.2
EnsemblGenome: EBESCG00000024588.
EnsemblGenome_TRS: EBESCT00000025535
EnsemblGenome_PRO: EBESCP00000024428
GenomeReviews: AE005174_GR
KEGG: ece:Z4136
HOGENOM: HBG482408
OMA: KIHRNPH
ProtClustDB: PRK10875
Taxonomy ID 155864
Gene Starting Position 3740332
Gene Ending Position 3742158
Gene Strand (Orientation) -
Protein Name exonuclease V subunit alpha
Protein pI 6.76
Protein Weight 63661.372
Protein Length 608
Protein Note helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
DNA Sequence 
>gi|16445223:3740332-3742158 Escherichia coli O157:H7 str. EDL933 chromosome, complete genome
TTTATTCCCGTGAAYTAAACAACGCCGCCAGACCACTGCGCCGCTCAGTACGAGTGGCGATTGCCGCACT
TAATATGCGCTCATCGGCATACAGCGACAGACGGCGACGCGCGCGGGTCACCGCGGTATAAACCAGCTCT
CGCGTTACTACCGGCGTGCGTTGGCTCGGTAAAATCAACGCCGCATGGTCGAACTCCGATCCCTGCGATT
TATGTACCGTCATCGCCCACGTAGTTTCGTGCTCTGGCAAGCGACTCGGTTGCACAGACTTAATATTGCC
GTCCGGCATCGCAAACCAGACGCGCGTCCCCTGCCCGCGATCCAGCGCAATACCGATATCGCCATTAAAC
AACCCAAGCGCGCTGTCATTACGGGCAATCATCACCGGTCGGCCTTCGTACCAACGAGAGTGCGGATTAC
GATGAATTTTGCGCTTCTGTTGCATAAACTGCTCAATTCGCTCATTCAGTCCAGCCACGCCAAATGGCCC
TTCCCGCAGGGCGCACAAAAGTTGGTACTCATTGAACGCCTGAATGATTAAATCCGGCTCGGCACGCGCT
TGCAGCAGATCCAGATAACGTCCATAACCCGCAAGAGCTTCCTCAAGCATCGCAATATAATCTTCGCCGC
TCTGTAAAAGCCGTTTTTCAATATCAGTAAAATCCTGCTGAAAAACGGTTTTCACTGCCGTTTTATCACC
ACGGTTGATCGCCGCAGCTAACTGACCAATGCCAGAATCGCTGCCGAAACGATAGCTTTTTTGCAGCAGG
CAGAGACTGTCGCGCAAAGATGCCGCTTCTGTGCCAGTTCCTGCCGGAACGTGAGTTCCCGTCAGGCGGC
TTAGCTGCCCGGCACGCTCGGCGGTAAAGCCGGCATTGGCATAAGCGCAGATATCGCCCAGCACAGCCCC
AGCCTCAACCGAGGCCAGTTGATCACGATCGCCGAGAAAGATCACTCGCGCATGATCGGGCAAGGCGTCG
ATCAGTCTCGACATCATAGGCAGATCGATCATTGACGCTTCATCTACCACCAGCACATCAAGATGCAGCG
GGTTACCGGCATGATGACGTAAACGCTGGCTACCCGGCTGCGCACCCAGCAATCGGTGCAAAGTACTGGC
ATCTTCCGGAATACGTTTCTTTTGTTCATCGGTCAGCGGTAACTGTCGCAAAGCCTTGCCGAGAGATTCG
GTTAAGCGCGCGGCAGCTTTACCCGTTGGTGCAGCCAGACGGATACGGCAGCGTTCGCCGTCGGCCATTT
GAATTAACGCTGCCAGCAACTTCGCTACGGTGGTCGTTTTACCGGTGCCAGGGCCGCCGGAAATCACCGA
GATCCGCCGCGTCAGCGCCACTGCTGCCGCCACTTTTTGCCAGTTAATTTCATCACCAGTCGGAAAGAGT
TTATCCAGGGTTTGCGCCAACAAGGCTTCATCCACCTCGATGGCATGATTCACCTCATTGAAGAAGCGCG
CTACCGTCCGCTCGTTACACCACATGCGATTCAAATAAAGACGATCGCCACAGAGGATCATCGGCGTGGG
TTCATCTCCCCGGCTGACCGCTTGTGAAGCCAGCAAGCATTCTTCCCAATTTTGTAGCTCACCGATTTCA
CTGACACAGGTCGCCAACAGCGGATGCGACTCCTCATTATTTTCCAGTCGTGAAAGCGGCAAACAAACGT
GCCCCTCTCCGGCATCATGACTTAACAGTGCCGCCGCGAGGGTGACGGCAGGATGTTCATCTCCCGCCAC
GGTCAGGGCAAACTGCACGTCCAGCGGGCGTAGCTGTTTGTGCTCCACAGCTTCCAGTAATTGCTTTTGC
AATTTCA
Protein Sequence 
>gi|15803338|ref|NP_289371.1| exonuclease V subunit alpha [Escherichia coli O157:H7 str. EDL933]
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEESHPLLAT
CVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQT
LDKLFPTGDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAA
RLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMS
RLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERAGQLSRLTGTHVPAGTGTEAASLRD
SLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLD
LLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRNPHSRWYEGRPVMIARNDSA
LGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPV
VTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFXSRE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: recD mutant is attenuated in calves (van et al., 2005).
COG COG0507L, under L: Replication, recombination and repair
References
van et al., 2005: van Diemen PM, Dziva F, Stevens MP, Wallis TS. Identification of enterohemorrhagic Escherichia coli O26:H- genes required for intestinal colonization in calves. Infection and immunity. 2005; 73(3); 1735-1743. [PubMed: 15731074].