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pgaA

Victor ID 2160
Gene Name pgaA
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. EDL933
NCBI Gene ID 959162
NCBI Protein GI 15801015
Locus Tag Z1526
Genbank Accession AE005174
Protein Accession NP_287031
Other Database IDs UniProtKB-ID: PGAA_ECO57
UniRef100: UniRef100_P69435
UniRef90: UniRef90_P69435
UniRef50: UniRef50_P69435
UniParc: UPI000013A5EB
EMBL: AE005174
EMBL: BA000007
EMBL-CDS: AAG55642.1
EMBL-CDS: BAB34693.1
RefSeq_NT: NC_002655.2
RefSeq_NT: NC_002695.1
EnsemblGenome: EBESCG00000024206
EnsemblGenome_TRS: EBESCT00000025152
EnsemblGenome_PRO: EBESCP00000024045
EnsemblGenome: EBESCG00000059003
EnsemblGenome_TRS: EBESCT00000059956
EnsemblGenome_PRO: EBESCP00000057784
GenomeReviews: AE005174_GR
GenomeReviews
Taxonomy ID 155864
Gene Starting Position 1416588
Gene Ending Position 1419011
Gene Strand (Orientation) -
Protein Name outer membrane protein PgaA
Protein pI 6.56
Protein Weight 88237.742
Protein Length 807
Protein Note outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia
DNA Sequence 
>gi|16445223:1416588-1419011 Escherichia coli O157:H7 str. EDL933 chromosome, complete genome
CTTAAAATCTGAATGTCATATCGAATTCAACGTATAAGTTGTGTTCTCTGTCACCGTCATAAGGTCGTTT
TTCCCAGCGTAGCGTTGCGCCAGCATCAATCACGTCATTCCAGCTAATGCGTTGCCCGTAGCCGAGTTGG
GTGACGACATCCGTGCCATAATGTTTTTGCCAGGAGGCACCAACACCTGCGCTGAATATTTGCTCCCAGC
TATTTTCATAGCTTCGCCATAACAAATGGCTTGCCTCAAATGCCGGAACAATATCGAACGTTTTTATAGG
GTTGTAGTATGGGGTATCGTGTTCTGTATTTTGTTCGTAATACAGACTGGGTAGGAAATCGACAATCAAA
TATGGTGAAGACCAGATGCGTTCCTGACCCTCAAGTGAGACTTCATGACGCTGGTTACTGTCGGAAAAAT
CAGTGAAAGCCCAGGAGACACCGTACTTACGCCGCTCATTTTGATACCAGCGAACATAAGCCTGAGCACT
GTTGCCTGTAACACCATTTTTCATTGCCCGTAATGGAACGCGGTGAGAGAGGCGTTCCAGTTGCGAACCA
ATACGCCAGTTATCATTAAAATCATACCAGCCAGACAGGCGCGCGCCGGGTTTATGCTCATGATTGAAAA
CGCGTTCAGCGTACTCTGCCTCGAGCCAGATATTACGTGACCGCCACTCAACACCCGCAAGCCAGTCGCG
AACAATCCCTTTTCCTTCGCTAAATTGTCCATCGGCATAACCGAATCCAGCAAAACCGCGCCAGTTATCC
TTCAGCGGTGGTGAATAAACGATGGTGGTTAAGTCGACATCATGTTTACCACTATCCGGGCCTTCGGCAT
CAATTCCTGTTGAGCCAGCGATACGAAGCTCTGCAAGATTATGTACATCAACCGCACGTTTTAATCGTAC
AACGCCGGGATCTTGCGGTTCACGTTCGACAACATCGTGCGTTAAGACAGCTGCCTGCTGCCATTCTTGT
AACGTTAATGCTGTCCAGGCTTGTTCAACCTCCAGATTAATATTACGTGGCTCGATCACTTCTGCTTTTT
TTAATTCATTTTCTGCTGCACGAGGCCAACCGCGGGCTTGTAACACACTCGCGTAATCAATGCGCAGTCC
CTGATTTCCTGGTGCGTTATAAGCAAGCTCTCTGGCTGTCATTTCAGCCTGAGGAAGATCATTACTATAT
TTTGCTACGGTTGAGAGAAACGAATGCCCCTGTAACCAGGTATCATTCGGGATGCTCGTAGGCGTGCCCA
TTAACCGAAGGAAAGGCGGCGAAGTATTAATGGTATGTTGGGTGACAGTTAGCGCGCCCGGATAATTTTC
ACTCTCCAGGTGGCTGTAAAAGAGATCCGCAAGTTCTTCATCGGATAAATCCGGGGCAATGGTCTCCTTG
TGATAAAAGAGCTCGGTCATTATTGACTGTGCTTTTTTCGGCTGATGATCTTTGAGATAAGCCGATGCAA
CCCAATATTGCCCCCAGGGCGGAATAATTTGCCCCGTCTTTTTTAATCGCTGATAGTGAGAAATAACGTC
TTTATAACGATCGCGAGTTAATAACGCGCCAAGATGATCAACCTGAATACGCTGGTACTGGGCAGTACGG
TCTGGGTTATCGTGCCACAGAATTTCTAATGCAGCGTATTGGGCGAGGGCGCGATCGGCAATGGCATAAC
GTTCACTTTCACTGCGCGTAGGCATAAACGACAGTCTGACCAGTTCGGCATGAATATCAGCGCGAATATC
TGGCGTTAAATTGGCATCGTCAATCGCGGCAGCAAGTTGATTATTACGTAATGCCTGCACGTATTCTGTG
GGATATTGTTGCGTAGATGCATTTTCAGGTAATGACTCTGTCATCGCCCGTAATTCATCCTGATGACGCC
CCGCCAGTTTATAGATATAGGCTTCTGCGAGTAAATTGGCTTTGTCCGGTGCTCCAGAGTTAAGCTGCTT
AAGTTTAACCAGCGCAGTATCATAGTGACCAGCATCTGCCAGGGTTAAAATTTGTCCCCGTTGATAATCC
TTATTTTGCGGCTCCAGAGAGAGCGCCTTTTGCCACAGTGTAAGCGAGTTTTGCCATTGTTGCAGGTTAC
GATAAGCGACGGCGACAGCTGCATAACCACGCGCTGGTAATTGCTGATGACGGTAGCGGTTGTAAACGGT
AATAACCTGTTTATCTTGCCCGGCCCATAAGGCAATCTGTAACCAGTCAGCAATTTGGTTATTGCTGART
GCTGATTTTARTGCAAACCATGACAAAGCTGGCTGAGTATTACCCTTGCGAGCTTCAATAATCAATGCAT
CATAGGCGTTATTAACAGCACTCTTCGCCGCGGGACTCGCTGCTAAAAATGCGGCAGTAAGAAGTTTCAA
AGCCCATTTGGTTTTCGGGCACCTTTTTCTGCTACTTGAATACA
Protein Sequence 
>gi|15801015|ref|NP_287031.1| outer membrane protein PgaA [Escherichia coli O157:H7 str. EDL933]
MYSSSRKRCPKTKWALKLLTAAFLAASPAAKSAVNNAYDALIIEARKGNTQPALSWFALKSAXSNNQIAD
WLQIALWAGQDKQVITVYNRYRHQQLPARGYAAVAVAYRNLQQWQNSLTLWQKALSLEPQNKDYQRGQIL
TLADAGHYDTALVKLKQLNSGAPDKANLLAEAYIYKLAGRHQDELRAMTESLPENASTQQYPTEYVQALR
NNQLAAAIDDANLTPDIRADIHAELVRLSFMPTRSESERYAIADRALAQYAALEILWHDNPDRTAQYQRI
QVDHLGALLTRDRYKDVISHYQRLKKTGQIIPPWGQYWVASAYLKDHQPKKAQSIMTELFYHKETIAPDL
SDEELADLFYSHLESENYPGALTVTQHTINTSPPFLRLMGTPTSIPNDTWLQGHSFLSTVAKYSNDLPQA
EMTARELAYNAPGNQGLRIDYASVLQARGWPRAAENELKKAEVIEPRNINLEVEQAWTALTLQEWQQAAV
LTHDVVEREPQDPGVVRLKRAVDVHNLAELRIAGSTGIDAEGPDSGKHDVDLTTIVYSPPLKDNWRGFAG
FGYADGQFSEGKGIVRDWLAGVEWRSRNIWLEAEYAERVFNHEHKPGARLSGWYDFNDNWRIGSQLERLS
HRVPLRAMKNGVTGNSAQAYVRWYQNERRKYGVSWAFTDFSDSNQRHEVSLEGQERIWSSPYLIVDFLPS
LYYEQNTEHDTPYYNPIKTFDIVPAFEASHLLWRSYENSWEQIFSAGVGASWQKHYGTDVVTQLGYGQRI
SWNDVIDAGATLRWEKRPYDGDREHNLYVEFDMTFRF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ycdS mutant is attenuated in calves (Dziva et al., 2004).
References
Dziva et al., 2004: Dziva F, van Diemen PM, Stevens MP, Smith AJ, Wallis TS. Identification of Escherichia coli O157 : H7 genes influencing colonization of the bovine gastrointestinal tract using signature-tagged mutagenesis. Microbiology (Reading, England). 2004; 150(Pt 11); 3631-3645. [PubMed: 15528651].