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espG from Escherichia coli O103:H2 str. 12009

Victor ID 3778
Gene Name espG from Escherichia coli O103:H2 str. 12009
Sequence Strain (Species/Organism) Escherichia coli O103:H2 str. 12009
NCBI Gene ID 8475820
NCBI Protein GI 260845718
Locus Tag ECO103_3639
Protein Accession YP_003223496.1
Other Database IDs UniProtKB-ID: C8TWQ0_ECO10
UniRef100: UniRef100_Q5K5M1
UniRef90: UniRef90_C7BUR4
UniRef50: UniRef50_Q8VNS6
UniParc: UPI00004B4E3F
EMBL: AP010958
EMBL-CDS: BAI32362.1
RefSeq_NT: NC_013353.1
EnsemblGenome: EBESCG00000176717.
EnsemblGenome_TRS: EBESCT00000179871
EnsemblGenome_PRO: EBESCP00000169013
GenomeReviews: AP010958_GR
KEGG: eoh:ECO103_3639
ProtClustDB: CLSK2393224
Taxonomy ID 585395
Gene Starting Position 3711227
Gene Ending Position 3712423
Gene Strand (Orientation) +
Protein Name T3SS secreted effector EspG
DNA Sequence 
>gi|260842239:3711227-3712423 Escherichia coli O103:H2 str. 12009, complete genome
TATGATATCTGTTGTCGAATCATTCATAATAAATGAGATAGGGGAATCTCTCATGATAAACGGACTTAAT
AATAATTCCGCATCTTTAGTTTTAGATGCTGCAATTAGAATTAATTCTGATTTTAAAAAGCAGTGGAATG
ATATGTCATGCGCTGAAAAATTACTAAAAGTTCTTAGTTTTGGTTTATGGAATCCAACGTATACTCGTAG
TGAAAGGCAAACATTTCAAGAGTTGTTAACCGTTTTAGAACCTGTATCTCCCGCGCCTAATGAATTGGGC
AGAATATATGCTAATTTTGCAGATGGCTCATCCTTAAGAATTTCCGTCACTAACAGCGAACTTGTTGAAG
CCGAGATTCGCACACCAGATAATGAAAAGATTCTTATGCTCCTGGAGTCAAACGAACAAAATAGGTTATT
ACAATCTTTACCCATCAATCTCCACATGCCATACATTCAGGTTCATCGTGCCTTATCTAAGATGGACCTG
ACTGATCATAAGTCAATGCACAATCTACTTAGTTTTACGTCAAAACTATCAGCAACCTTGATTCCTCATA
ATACTCAAACAGATCCGTTTTCCGGGCCTACACCATTCAGCTCTATGTTTATGGATACATTTCGAGGACT
CGGCAATGCAAAGCTTTCACTCAATGGTGTTGATATACCTGTAGATGCACAAAAATTGCTTCGCGATGCA
CTAGGACTTAAAGACACACATTCATCACTTGCCCGGAATGTTATAAATAATGGTATTTCTCGTCATCATG
CAGAGCAAATAGCAAGGGAAAGCAGCGGCAGCGATAAACAGAAAGCTGAAGTTGTGGAGTTTTTATGCCA
CCCCGAAGCGGCAACAGCCATATGCTCGGCTTTCTATCAATCTTTCAATGTGCCAGCCTTAATGTTGACA
CATACAAGGATCTCTCAAGCCAGAGAATACAATGTGGAAAGATCGTTAGATGTACCTAACGCGTGCATTA
ACATAAGTATCTCTCAATCACCAGATGGAAGCATTCACGTTGCCAGCCATACCGGGATTCTGATAATGGC
GCCAGAAGACCGCCCCAACGAGTTAGGAATGTTGACGAACAGGACCTCCTATGAAGTGCCACAAGGTGTG
AAATGTGAAATCGATGAGATGGTAAGAACGCTACAACCAAGGTATGGCGCATCTGAAACATACCTGAAAA
ACATTTA
Protein Sequence 
>gi|260845718|ref|YP_003223496.1| T3SS effector EspG [Escherichia coli O103:H2 str. 12009] MISVVESFIINEIGESLMINGLNNNSASLVLDAAIRINSDFKKQWNDMSCAEKLLKVLSFGLWNPTYTRSERQTFQELLTVLEPVSPAPNELGRIYANFADGSSLRISVTNSELVEAEIRTPDNEKILMLLESNEQNRLLQSLPINLHMPYIQVHRALSKMDLTDHKSMHNLLSFTSKLSATLIPHNTQTDPFSGPTPFSSMFMDTFRGLGNAKLSLNGVDIPVDAQKLLRDALGLKDTHSSLARNVINNGISRHHAEQIARESSGSDKQKAEVVEFLCHPEAATAICSAFYQSFNVPALMLTHTRISQAREYNVERSLDVPNACINISISQSPDGSIHVASHTGILIMAPEDRPNELGMLTNRTSYEVPQGVKCEIDEMVRTLQPRYGASETYLKNI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: the inhibitory effect of the espG mutant on Cl– uptake in Caco-2 monolayers was significantly attenuated as compared with wild-type EPEC (Gill et al., 2007).
References
Gill et al., 2007: Gill RK, Borthakur A, Hodges K, Turner JR, Clayburgh DR, Saksena S, Zaheer A, Ramaswamy K, Hecht G, Dudeja PK. Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli. The Journal of clinical investigation. 2007; 117(2); 428-437. [PubMed: 17256057].