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espF from Escherichia coli O127:H6 str. E2348/69

Victor ID 3480
Gene Name espF from Escherichia coli O127:H6 str. E2348/69
Sequence Strain (Species/Organism) Escherichia coli O127:H6 str. E2348/69
NCBI Gene ID 7061130
NCBI Protein GI 215488961
Locus Tag E2348C_3930
Protein Accession YP_002331392.1
Other Database IDs UniProtKB-ID: B7UM88_ECO27
UniRef100: UniRef100_O52152
UniRef90: UniRef90_O52152
UniRef50: UniRef50_Q5K5R0
UniParc: UPI00000B7593
EMBL: FM180568
EMBL-CDS: CAS11478.1
RefSeq_NT: NC_011601.1
EnsemblGenome: EBESCG00000114946.
EnsemblGenome_TRS: EBESCT00000114252
EnsemblGenome_PRO: EBESCP00000107220
GenomeReviews: FM180568_GR
KEGG: ecg:E2348C_3930
HOGENOM: HBG468004
OMA: VNARTIF
ProtClustDB: CLSK2393223
Taxonomy ID 574521
Gene Starting Position 4103270
Gene Ending Position 4103890
Gene Strand (Orientation) -
Protein Name LEE-encoded effector EspF
DNA Sequence 
>gi|215485161:4103270-4103890 Escherichia coli O127:H6 str. E2348/69, complete genome
GTTACCCTTTCTTCGATTGCTCATAGGCAGCTAAATGATCTTTTAGTGCCTGTGCAAGGGGCGGTAGTCC
ACCAGGCCCGGATGCCTGTCCACTTGTCGGTGGCGGTGGTGCCTGACGGGTTGGCTTAAAGCTTACAGTC
TCAGACGCTTTCGATAGTTCATAGGCAGCTAAATGATCTTTTAATGCCTGTGCAATGGGCGGTAAAGGTC
GGGATGCCCCGGATGCCTGTCCACTTGTCGGTGGCGGCGGTGCCGGACGGGTTGGCTTAAAGTTTACAGT
CTCAGACGCTTTCGATAGTTCATAGGCAGCTAAATGATCTTTTAATGCCTGTGCAATGGGCGGTAAAGGT
CGGGATGCCCCGGATGCCTGTCCACTTGTCGGTGGCGGCGGTGCCGGACGAGAGGGAGTAAATGAAGTCA
CCTGGCTGCTCACATTAAAAATCGTCCTCGCATTAACATTCGACGAACCTGGAGAAAAGGGGGAATGAAC
TCTCACCGGAGTAAGACGAACAGCCTGAGGGGCTACAGAAAATCCAGTTCCCCCCGCAGAGCTCACTCGA
CTTGCGATACCTACAAGCTGCCGCCCTAGTGTAGAAGCAGCGTTACTAATTCCATTAAGCA
Protein Sequence 
>gi|215488961|ref|YP_002331392.1| LEE-encoded effector EspF [Escherichia coli O127:H6 str. E2348/69] MLNGISNAASTLGRQLVGIASRVSSAGGTGFSVAPQAVRLTPVRVHSPFSPGSSNVNARTIFNVSSQVTSFTPSRPAPPPPTSGQASGASRPLPPIAQALKDHLAAYELSKASETVNFKPTRPAPPPPTSGQASGASRPLPPIAQALKDHLAAYELSKASETVSFKPTRQAPPPPTSGQASGPGGLPPLAQALKDHLAAYEQSKKG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: espF mutant of EPEC is deficient in its ability to disrupt electrical resistance across a polarized monolayer of intestinal epithelial cells, suggesting that EspF is an effector molecule required for disrupting intestinal epithelial barrier function (McNamara et al., 2001).
References
McNamara et al., 2001: McNamara BP, Koutsouris A, O'Connell CB, Nougayréde JP, Donnenberg MS, Hecht G. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. The Journal of clinical investigation. 2001; 107(5); 621-629. [PubMed: 11238563].