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fimD

Victor ID 2102
Gene Name fimD
Sequence Strain (Species/Organism) Escherichia coli CFT073
NCBI Gene ID 1037242
NCBI Protein GI 26251204
Locus Tag c5396
Genbank Accession AE014075
Protein Accession NP_757244
Other Database IDs UniProtKB-ID: Q8CVG1_ECOL6
UniRef100: UniRef100_D7YWJ4
UniRef90: UniRef90_P30130
UniRef50: UniRef50_P30130
UniParc: UPI00000E4ABE
EMBL: AE014075
EMBL-CDS: AAN83818.1
RefSeq_NT: NC_004431.1
EnsemblGenome: EBESCG00000041501.
EnsemblGenome_TRS: EBESCT00000042451
EnsemblGenome_PRO: EBESCP00000040800
GenomeReviews: AE014075_GR
KEGG: ecc:c5396
NMPDR: fig|199310.1.peg.5287
HOGENOM: HBG511492
OMA: YNSSDRS
ProtClustDB: CLSK879695
Taxonomy ID 199310
Gene Starting Position 5139825
Gene Ending Position 5142461
Gene Strand (Orientation) +
Protein Name Outer membrane usher protein fimD precursor
Protein pI 7.02
Protein Weight 91731.41
Protein Length 878
Protein Note Escherichia coli K-12 ortholog: b4317; Escherichia coli O157:H7 ortholog: z5915
DNA Sequence 
>gi|26245917:5139825-5142461 Escherichia coli CFT073, complete genome
AATGTCATATCTGAATTTAAGACTTTACCAGCGAAACACACAGTGCTTGCATATTCGTAAGCATCGTTTG
GCTGGTTTTTTTGTCCGGCTCTTTGTTGCCTGTGCTTTTGCCGCACAGGCACCTTTGTCATCTGCCGAAC
TCTATTTTAACCCGCGTTTTTTAGCGGATGATCCCCAGGCTGTGGCTGATTTATCGCGTTTTGAGAATGG
GCAAGAATTACCGCCAGGGACGTATCGTGTCGATATCTATTTGAATAATGGTTATATGGCAACGCGTGAT
GTCACATTTAATACGGGCGACAGCGAACAAGGGATTGTTCCCTGCCTGACACGCGCGCAACTTGCCAGTA
TGGGGCTGAATACGGCTTCTGTCTCCGGTATGAATCTGCTGGCGGATGATGCCTGCGTGCCATTAACCTC
AATGATCCATGACGCTACTGCGCATTTAGATGTTGGTCAGCAGCGACTCAACCTGACGATCCCTCAGGCA
TTTATGAGTAATCGCGCGCGTGGTTATATTCCTCCTGAGTTATGGGATCCCGGTATTAATGCCGGATTGC
TCAATTATAATTTCAGCGGAAATAGTGTACAGAATCGAATTGGGGGTAACAGCCATTATGCATATTTAAA
CCTACAGAGTGGGTTAAATATTGGTGCGTGGCGTTTACGCGACAATACCACCTGGAGTTATAACAGTAGC
GACAGTTCATCAGGTAGCAAAAATAAATGGCAGCATATCAATACCTGGCTTGAGCGAGACATAATTCCGT
TACGTTCCCGGCTGACGTTGGGTGATGGTTATACTCAGGGCGATATTTTCGATGGTATTAACTTTCGCGG
CGCACAATTGGCCTCAGATGACAATATGTTACCCGATAGCCAAAGAGGATTTGCCCCGGTGATCCACGGT
ATTGCTCGTGGTACTGCACAGGTCACTATTAAACAAAATGGGTATGACATTTATAATAGTACGGTGCCAC
CGGGGCCTTTTACCATCAACGATATCTATGCCGCAGGTAATAGTGGTGACTTGCAGGTAACGATTAAAGA
GGCTGACGGCAGTACGCAGATTTTTACCGTACCCTATTCGTCAGTCCCGCTTTTGCAGCGTGAAGGGCAT
ACACGTTATTCCATTACGGCAGGAGAATACCGTAGTGGAAATGCGCAACAGGAAAAACCTCGCTTTTTCC
AGAGTACATTACTCCACGGCCTTCCGGCTGGCTGGACAATATATGGTGGAACGCAACTGGCGGATCGTTA
TCGTGCTTTTAATTTCGGTATCGGGAAAAACATGGGGGCACTGGGCGCTCTGTCTGTGGATATGACGCAG
GCTAATTCCACACTTCCCGATGACAGTCAGCATGACGGACAATCGGTGCGTTTTCTCTATAACAAATCGC
TCAATGAGTCAGGCACGAATATTCAGTTAGTGGGTTACCGTTATTCGACCAGTGGGTATTTTAATTTCGC
TGATACAACATACAGTCGAATGAATGGCTACAACATCGAAACACAGGATGGAGTTATTCAGGTTAAGCCG
AAATTCACCGACTATTACAATCTCGCTTATAACAAACGCGGGAAATTACAACTCACCGTTACTCAGCAAC
TCGGGCGCACATCAACACTGTATTTGAGTGGTAGCCATCAAACTTATTGGGGAACGAGTAATGTCGATGA
GCAATTCCAGGCTGGATTAAATACTGCGTTCGAAGATATTAACTGGACGCTCAGCTATAGCCTGACGAAA
AACGCCTGGCAAAAAGGACGGGATCAGATGTTAGCGCTTAACGTCAATATTCCTTTCAGCCACTGGCTGC
GTTCTGACAGTAAATCTCAGTGGCGACATGCCAGTGCCAGTTACAGCATGTCACACGATCTCAACGGTCG
GATGACCAATCTGGCTGGTGTATACGGTACGTTGCTGGAAGACAACAACCTCAGCTATAGCGTGCAAACC
GGCTATGCCGGGGGAGGCGATGGTAATAGCGGAAGTACAGGCTACGCCACGCTGAATTATCGCGGTGGTT
ACGGCAATGCCAATATCGGTTACAGCCATAGCGATGATATTAAGCAGCTCTATTACGGAGTCAGCGGTGG
GGTACTGGCTCATGCCAATGGCGTAACGCTGGGGCAGCCGTTAAACGATACGGTGGTGCTTGTTAAAGCG
CCTGGCGCAAAAGATGCAAAAGTCGAAAACCAGACGGGGGTGCGTACCGACTGGCGCGGTTATGCCGTGC
TGCCTTATGCCACTGAATATCGGGAAAACAGAGTAGCGCTGGATACCAATACCCTGGCTGATAACGTCGA
TTTAGATAACGCGGTCGCTAACGTTGTTCCCACCCGTGGGGCGATCGTGCGAGCAGAGTTTAAAGCGCGC
GTTGGGATAAAACTGCTCATGACGCTAACCCACAATAATAAGCCGCTGCCGTTTGGGGCGATGGTGACAT
CAGAGAGTAGCCAGAGTAGCGGCATTGTTGCGGATAATGGTCAGGTTTACCTCAGCGGAATGCCTTTAGC
GGGAAAAGTGCAGGTGAAATGGGGAGAAGAGGAAAATGCTCACTGTGTCGCCAATTATCAACTGCCACCA
GAGAGTCAGCAGCAGTTATTAACCCAGCTATCAGCTGAATGTCGTTA
Protein Sequence 
>gi|26251204|ref|NP_757244.1| Outer membrane usher protein fimD precursor [Escherichia coli CFT073]
MSYLNLRLYQRNTQCLHIRKHRLAGFFVRLFVACAFAAQAPLSSAELYFNPRFLADDPQAVADLSRFENG
QELPPGTYRVDIYLNNGYMATRDVTFNTGDSEQGIVPCLTRAQLASMGLNTASVSGMNLLADDACVPLTS
MIHDATAHLDVGQQRLNLTIPQAFMSNRARGYIPPELWDPGINAGLLNYNFSGNSVQNRIGGNSHYAYLN
LQSGLNIGAWRLRDNTTWSYNSSDSSSGSKNKWQHINTWLERDIIPLRSRLTLGDGYTQGDIFDGINFRG
AQLASDDNMLPDSQRGFAPVIHGIARGTAQVTIKQNGYDIYNSTVPPGPFTINDIYAAGNSGDLQVTIKE
ADGSTQIFTVPYSSVPLLQREGHTRYSITAGEYRSGNAQQEKPRFFQSTLLHGLPAGWTIYGGTQLADRY
RAFNFGIGKNMGALGALSVDMTQANSTLPDDSQHDGQSVRFLYNKSLNESGTNIQLVGYRYSTSGYFNFA
DTTYSRMNGYNIETQDGVIQVKPKFTDYYNLAYNKRGKLQLTVTQQLGRTSTLYLSGSHQTYWGTSNVDE
QFQAGLNTAFEDINWTLSYSLTKNAWQKGRDQMLALNVNIPFSHWLRSDSKSQWRHASASYSMSHDLNGR
MTNLAGVYGTLLEDNNLSYSVQTGYAGGGDGNSGSTGYATLNYRGGYGNANIGYSHSDDIKQLYYGVSGG
VLAHANGVTLGQPLNDTVVLVKAPGAKDAKVENQTGVRTDWRGYAVLPYATEYRENRVALDTNTLADNVD
LDNAVANVVPTRGAIVRAEFKARVGIKLLMTLTHNNKPLPFGAMVTSESSQSSGIVADNGQVYLSGMPLA
GKVQVKWGEEENAHCVANYQLPPESQQQLLTQLSAECR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: fimD mutant is attenuated in mice (Bahrani-Mougeot et al., 2002).
COG COG3188NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport
References
Bahrani-Mougeot et al., 2002: Bahrani-Mougeot FK, Buckles EL, Lockatell CV, Hebel JR, Johnson DE, Tang CM, Donnenberg MS. Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract. Molecular microbiology. 2002; 45(4); 1079-1093. [PubMed: 12180926].