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ompA from Escherichia coli SMS-3-5

Victor ID 2250
Gene Name ompA from Escherichia coli SMS-3-5
Sequence Strain (Species/Organism) Escherichia coli SMS-3-5
NCBI Gene ID 6146246
NCBI Protein GI 170681860
Locus Tag EcSMS35_2163
Protein Accession YP_001744213.1
Other Database IDs UniProtKB-ID: B1LJ42_ECOSM
UniRef100: UniRef100_B1LJ42
UniRef90: UniRef90_B7LNW7
UniRef50: UniRef50_B7LNW7
UniParc: UPI000170F047
EMBL: CP000970
EMBL-CDS: ACB17756.1
RefSeq_NT: NC_010498.1
EnsemblGenome: EBESCG00000061513.
EnsemblGenome_TRS: EBESCT00000062466
EnsemblGenome_PRO: EBESCP00000060108
GenomeReviews: CP000970_GR
KEGG: ecm:EcSMS35_2163
HOGENOM: HBG741096
OMA: DDNEAQK
ProtClustDB: PRK10808
BioCyc: ECOL439855:ECSMS35_2163-MONOMER
Taxonomy ID 439855
Gene Starting Position 2167504
Gene Ending Position 2168580
Gene Strand (Orientation) +
Protein Name outer membrane protein A
DNA Sequence 
>gi|170679574:2167504-2168580 Escherichia coli SMS-3-5, complete genome
TTTGGATGATAACGAGGCGCAAAAAATGAAAAAGACAGCTATCGCGATTGCAGTGGCACTGGCTGGTTTC
GCTACCGTAGCGCAGGCCGCTCCGAAAGATAACACCTGGTACACTGGTGCTAAACTGGGCTGGTCCCAGT
ACCATGACACTGGTTTTATTCCTAACAATGGTCCGACCCACGAAAACCAACTGGGTGCAGGTGCTTTTGG
TGGTTACCAGGTTAACCCGTATGTTGGCTTTGAAATGGGTTACGACTGGTTAGGTCGTATGCCGTACAAA
GGCGACAACATCAACGGCGCATACAAAGCTCAGGGCGTTCAGCTGACCGCTAAACTGGGTTACCCAATCA
CTGACGATCTGGACGTTTACACTCGTCTGGGTGGTATGGTATGGCGTGCAGACACCAAGTCTAACGTACC
TGGTGGCGCATCCACTAAAGACCACGACACCGGCGTTTCTCCGGTCTTCGCTGGCGGTGTTGAGTACGCG
ATCACTCCTGAAATCGCTACCCGTCTGGAATACCAGTGGACCAACAACATCGGTGACGCACACACCATCG
GTACTCGTCCGGACAACGGCATGCTGAGCCTGGGTGTTTCCTACCGTTTCGGTCAGGGCGAAGCAGCTCC
AGTAGTTGCTCCGGCTCCAGCTCCGGCACCGGAAGTACAGACCAAGCACTTCACTCTGAAGTCTGACGTT
CTGTTCAACTTCAACAAAGCAACCCTGAAACCGGAAGGTCAGGCTGCTCTGGATCAGCTGTACAGCCAGC
TGAGCAACCTGGATCCGAAAGACGGTTCCGTAGTTGTTCTGGGTTACACCGACCGCATCGGTTCTGACGC
TTACAACCAGGCTCTGTCCGAGCGTCGTGCTCAGTCTGTTGTTGATTACCTGATCTCTAAAGGTATCCCG
GCAGACAAAATCTCCGCACGTGGTATGGGCGAATCCAACCCGGTTACTGGCAACACCTGTGACAACGTGA
AACAGCGTGCTGCACTGATCGACTGCCTGGCTCCGGATCGTCGCGTAGAGATCGAAGTTAAAGGTATCAA
AGACGTTGTAACTCAGCCGCAGGCTTA
Protein Sequence 
>gi|170681860|ref|YP_001744213.1| outer membrane protein A [Escherichia coli SMS-3-5] MDDNEAQKMKKTAIAIAVALAGFATVAQAAPKDNTWYTGAKLGWSQYHDTGFIPNNGPTHENQLGAGAFGGYQVNPYVGFEMGYDWLGRMPYKGDNINGAYKAQGVQLTAKLGYPITDDLDVYTRLGGMVWRADTKSNVPGGASTKDHDTGVSPVFAGGVEYAITPEIATRLEYQWTNNIGDAHTIGTRPDNGMLSLGVSYRFGQGEAAPVVAPAPAPAPEVQTKHFTLKSDVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQALSERRAQSVVDYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEVKGIKDVVTQPQA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: OmpA− strains are unable to cause actin condensation needed for invasion of brain epithelial cells (Prasadarao et al., 1999).
COG COG2885M, under M: Cell wall/membrane/envelope biogenesis
References
Prasadarao et al., 1999: Prasadarao NV, Wass CA, Stins MF, Shimada H, Kim KS. Outer membrane protein A-promoted actin condensation of brain microvascular endothelial cells is required for Escherichia coli invasion. Infection and immunity. 1999; 67(11); 5775-5783. [PubMed: 10531228].