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espA from Escherichia coli O127:H6 str. E2348/69

Victor ID 3494
Gene Name espA from Escherichia coli O127:H6 str. E2348/69
Sequence Strain (Species/Organism) Escherichia coli O127:H6 str. E2348/69
NCBI Gene ID 7063880
NCBI Protein GI 215488967
Locus Tag E2348C_3936
Protein Accession YP_002331398.1
Other Database IDs UniProtKB-ID: B7UM94_ECO27
UniRef100: UniRef100_Q47184
UniRef90: UniRef90_Q47184
UniRef50: UniRef50_O87743
UniParc: UPI0000033222
EMBL: FM180568
EMBL-CDS: CAS11484.1
RefSeq_NT: NC_011601.1
EnsemblGenome: EBESCG00000114022.
EnsemblGenome_TRS: EBESCT00000112683
EnsemblGenome_PRO: EBESCP00000108568
GenomeReviews: FM180568_GR
KEGG: ecg:E2348C_3936
HOGENOM: HBG468009
OMA: AISAKAN
ProtClustDB: CLSK701598
Taxonomy ID 574521
Gene Starting Position 4107072
Gene Ending Position 4107650
Gene Strand (Orientation) -
Protein Name translocon EspA
DNA Sequence 
>gi|215485161:4107072-4107650 Escherichia coli O127:H6 str. E2348/69, complete genome
GTTATTTACCAAGGGATATTCCTGAAATAGTTCTATATTGCAGTGACTGCATATCAGAACGTGCACTCGT
TAATAGGTTTAACGTATTTGACATTTGCTGTATTTCAAGCTGGCTATTATTGACCGTCGTTGTCAAATTA
TTCGCTTTAGCTGAAATAGCTGCTTTCACCGTTTGCAAATCACCAGCGCCTAATTGAGCATTTATATTGT
CAATACCACTTATTGTAATGTCATTGCGAGGATCATTTATATATGAAATCACTTCATCAGGAAGTTGAGC
TTTCGCATTCTTGTCAGAGCTACTCTGAACGTCAGCAATTTTAGCATCTACAAGATTAGCCATTTTTTGG
GCAGTGGTTGACTCCTTAGATGCCTCATTCATATCAGCAAACTTTGCAATCGACAGATCGCTTTGTGCCT
GATACATATAGGCAAACATGAGAATTGCAGCCTGAAAAACACCGAGTTTATTAAATAGATCAATAACGTC
ATCTTTCGACATGCTCCCTAAATCATAGGCCATTGATGTCGAAGTACTCGCATTCGCACTAGCAACTGAT
GCTGTAGTTGATGTATCCA
Protein Sequence 
>gi|215488967|ref|YP_002331398.1| translocon EspA [Escherichia coli O127:H6 str. E2348/69] MDTSTTASVASANASTSTSMAYDLGSMSKDDVIDLFNKLGVFQAAILMFAYMYQAQSDLSIAKFADMNEASKESTTAQKMANLVDAKIADVQSSSDKNAKAQLPDEVISYINDPRNDITISGIDNINAQLGAGDLQTVKAAISAKANNLTTTVNNSQLEIQQMSNTLNLLTSARSDMQSLQYRTISGISLGK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: deletion of espA in STEC abolished ability to attach to HeLa cells and induce actin rearrangements (Ebel et al., 1998).
References
Ebel et al., 1998: Ebel F, Podzadel T, Rohde M, Kresse AU, Krämer S, Deibel C, Guzmán CA, Chakraborty T. Initial binding of Shiga toxin-producing Escherichia coli to host cells and subsequent induction of actin rearrangements depend on filamentous EspA-containing surface appendages. Molecular microbiology. 1998; 30(1); 147-161. [PubMed: 9786192].