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espP from Escherichia coli O157:H7 str. EDL933

Victor ID 2292
Gene Name espP from Escherichia coli O157:H7 str. EDL933
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. EDL933
NCBI Gene ID 3683719
NCBI Protein GI 75994466
Locus Tag L7020
Protein Accession YP_325580.1
Other Database IDs UniProtKB-ID: ESPP_ECO57
UniRef100: UniRef100_Q7BSW5
UniRef90: UniRef90_O32591
UniRef50: UniRef50_O32591
UniParc: UPI00000B5B8A
EMBL: X97542
EMBL: AF074613
EMBL: AB011549
EMBL: AJ010390
EMBL-CDS: CAA66144.1
EMBL-CDS: AAC70088.1
EMBL-CDS: BAA31836.1
EMBL-CDS: CAB42538.1
RefSeq_NT: NC_002128.1
RefSeq_NT: NC_012487.1
RefSeq_NT: NC_007414.1
PDB: 2QOM
TCDB: 1.B.12.4.3
EnsemblGenome: EBESCG00000028451
EnsemblGenome_TRS: EBESCT00000029401
EnsemblGenome_PRO: EBESCP00000028106
EnsemblGenome: EBESCG000000
Taxonomy ID 155864
Plasmid No pO157
Gene Starting Position 11241
Gene Ending Position 15143
Gene Strand (Orientation) +
Protein Name putative exoprotein-precursor
DNA Sequence 
>gi|75994447:11241-15143 Escherichia coli O157:H7 EDL933 plasmid pO157, complete sequence
TATGAATAAAATATACTCTCTTAAATACAGCCATATTACAGGAGGGTTAATCGCTGTTTCTGAATTATCC
GGCAGAGTATCATCAAGAGCAACTGGTAAGAAAAAACACAAACGCATACTTGCATTATGTTTTTTAGGCT
TATTACAATCCTCATATTCTTTTGCGTCACAGATGGATATTTCAAATTTCTACATCCGTGACTATATGGA
TTTTGCACAGAACAAGGGCATATTTCAGGCTGGCGCAACAAATATTGAAATAGTGAAGAAAGATGGCTCC
ACCCTGAAACTACCGGAAGTACCATTTCCTGACTTCTCACCGGTTGCAAACAAAGGGTCAACCACATCTA
TTGGTGGTGCATACAGTATCACAGCCACACACAATACGAAAAACCACCACTCAGTTGCGACGCAAAACTG
GGGGAACAGCACGTACAAACAAACTGACTGGAATACTTCACATCCTGATTTTGCAGTATCCCGACTTGAC
AAGTTTGTTGTTGAGACCCGAGGTGCGACTGAAGGCGCAGATATTTCGTTATCAAAACAGCAGGCACTTG
AACGTTACGGGGTTAATTATAAAGGAGAAAAGAAACTTATCGCATTCAGAGCCGGCTCTGGTGTGGTATC
CGTTAAAAAAAATGGACGCATAACTCCATTTAATGAGGTTTCTTATAAGCCAGAAATGTTAAATGGCTCT
TTCGTTCACATTGATGACTGGAGTGGATGGCTGATATTAACCAACAACCAGTTTGATGAGTTTAATAACA
TTGCCTCTCAGGGTGACAGCGGTTCAGCACTGTTCGTCTATGATAACCAAAAGAAAAAGTGGGTTGTCGC
TGGAACTGTCTGGGGGATTTATAATTACGCCAATGGCAAAAACCACGCAGCATACAGTAAATGGAACCAG
ACAACCATTGACAACCTGAAGAACAAGTATTCTTACAACGTGGATATGTCAGGGGCTCAGGTTGCAACCA
TTGAAAATGGAAAACTGACAGGCACTGGCTCAGACACCACCGATATAAAAAATAAGGACTTAATATTTAC
TGGCGGTGGAGATATCCTCCTGAAATCCTCTTTTGATAATGGTGCTGGCGGTCTTGTCTTTAATGATAAA
AAGACCTATCGAGTAAACGGGGATGATTTCACCTTTAAAGGTGCCGGTGTTGATACAAGAAACGGCAGCA
CCGTTGAGTGGAATATCCGGTATGATAATAAAGACAACCTTCACAAAATTGGTGATGGCACATTAGATGT
CCGAAAAACCCAGAACACCAACCTGAAAACAGGTGAGGGTCTTGTCATTCTTGGAGCTGAAAAAACATTC
AATAATATCTACATAACCAGTGGTGATGGAACTGTCCGACTGAATGCAGAAAATGCACTGTCTGGCGGTG
AATACAACGGTATTTTCTTTGCGAAAAATGGCGGAACTCTTGACCTGAACGGATATAATCAGTCTTTCAA
TAAAATTGCTGCAACTGATTCAGGTGCTGTAATAACCAATACGTCAACCAAAAAATCCATTTTATCCCTG
AATAATACTGCTGACTATATCTATCACGGTAACATAAACGGGAATCTGGACGTACTTCAGCATCATGAGA
CGAAAAAAGAGAACCGTCGTCTTATTCTTGATGGGGGCGTGGACACAACAAATGATATAAGCCTGCGTAA
TACACAACTGTCCATGCAGGGACATGCCACTGAACATGCCATTTATCGGGATGGAGCTTTCTCTTGTTCA
CTACCAGCTCCTATGCGCTTTTTGTGTGGCAGTGATTATGTTGCAGGAATGCAAAATACAGAAGCTGATG
CTGTAAAACAAAACGGAAATGCCTATAAAACCAACAATGCTGTCTCTGATTTATCGCAGCCAGACTGGGA
AACCGGAACATTCAGATTTGGAACGCTACATCTTGAAAATTCCGATTTTTCTGTTGGTCGTAATGCAAAT
GTAATCGGGGACATTCAGGCCAGTAAATCAAACATTACTATTGGTGACACTACAGCATATATTGATTTGC
ATGCTGGTAAAAATATTACCGGTGATGGTTTTGGCTTCCGCCAGAATATTGTGCGTGGAAACTCACAAGG
AGAAACGCTGTTTACAGGAGGGATCACAGCAGAAGACAGCACTATCGTTATTAAAGATAAAGCAAAAGCA
TTATTTTCAAATTATGTATACCTGCTGAACACAAAAGCAACCATAGAGAACGGTGCTGATGTGACAACTC
AAAGTGGTATGTTCTCCACGAGCGATATCAGCATCTCTGGTAATCTGTCCATGACAGGCAATCCCGACAA
AGACAATAAATTCGAGCCCTCAATATATCTGAATGATGCTTCTTATCTACTGACTGACGACTCCGCCAGA
CTCGTTGCCAAAAATAAAGCATCTGTGGTGGGAGATATACACTCCACTAAAAGTGCATCCATCATGTTTG
GTCATGATGAAAGCGACCTCTCGCAGTTGTCTGACAGAACCTCAAAAGGGCTTGCACTTGGTCTTTTAGG
TGGCTTTGATGTCTCATATCGCGGTTCAGTCAATGCCCCGTCAGCATCTGCCACTATGAACAACACCTGG
TGGCAACTAACCGGAGATTCTGCGCTGAAAACACTGAAAAGTACAAACAGCATGGTCTATTTCACTGACA
GCGCAAACAATAAGAAATTCCATACGCTGACGGTCGATGAGCTGGCAACCAGCAACAGCGCCTATGCGAT
GCGTACAAACCTTTCTGAATCAGACAAACTGGAGGTCAAAAAACACTTGTCTGGTGAGAACAATATTTTA
CTCGTTGATTTCCTTCAGAAACCAACGCCTGAAAAACAACTGAATATTGAACTGGTAAGCGCGCCAAAAG
ACACCAATGAAAATGTCTTTAAAGCCAGTAAACAAACCATTGGTTTCAGTGATGTAACGCCGGTCATTAC
AACCAGGGAAACCGATGACAAAATAACATGGTCACTGACAGGCTATAACACGGTAGCAAACAAGGAAGCA
ACCCGGAATGCCGCCGCCCTGTTCTCTGTTGACTATAAAGCGTTTCTGAACGAGGTCAACAACCTGAACA
AACGTATGGGTGACCTGCGTGATATCAACGGCGAAGCCGGTGCATGGGCACGCATCATGAGCGGTACCGG
CTCTGCCAGTGGTGGTTTCAGTGACAACTACACGCACGTTCAGGTCGGGGTCGACAAAAAACACGAGCTG
GACGGACTGGATTTGTTTACCGGTTTCACTGTCACACACACTGACAGCAGTGCCTCCGCCGATGTTTTCA
GTGGTAAAACGAAGTCTGTGGGGGCTGGCCTGTATGCTTCCGCCATGTTTGATTCCGGTGCCTATATCGA
CCTGATTGGCAAGTATGTTCACCATGATAATGAGTACACTGCAACCTTTGCCGGACTCGGAACCCGTGAT
TACAGCACGCATTCATGGTATGCCGGTGCAGAAGCGGGCTACCGCTATCATGTCACTGAGGATGCCTGGA
TTGAGCCACAGGCTGAGCTGGTTTACGGTTCTGTATCCGGTAAACAGTTTGCATGGAAGGACCAGGGAAT
GCATCTGTCCATGAAGGACAAGGACTACAATCCGCTGATTGGCCGAACGGGTGTGGATGTGGGTAAATCC
TTCTCTGGTAAGGACTGGAAAGTGACAGCCCGTGCCGGTCTGGGCTACCAGTTCGACCTGCTGGCTAACG
GCGAAACCGTATTGCGGGATGCATCTGGTGAAAAACGCATCAAAGGTGAAAAGGACAGCCGTATGCTGAT
GTCCGTTGGCCTGAATGCAGAAATCAGGGATAACGTCCGCTTTGGACTGGAGTTTGAGAAATCCGCCTTT
GGTAAGTACAACGTTGATAATGCTGTCAACGCTAATTTCCGTTACTCGTTCTG
Protein Sequence 
>gi|75994466|ref|YP_325580.1| putative exoprotein-precursor [Escherichia coli O157:H7 str. EDL933] MNKIYSLKYSHITGGLIAVSELSGRVSSRATGKKKHKRILALCFLGLLQSSYSFASQMDISNFYIRDYMDFAQNKGIFQAGATNIEIVKKDGSTLKLPEVPFPDFSPVANKGSTTSIGGAYSITATHNTKNHHSVATQNWGNSTYKQTDWNTSHPDFAVSRLDKFVVETRGATEGADISLSKQQALERYGVNYKGEKKLIAFRAGSGVVSVKKNGRITPFNEVSYKPEMLNGSFVHIDDWSGWLILTNNQFDEFNNIASQGDSGSALFVYDNQKKKWVVAGTVWGIYNYANGKNHAAYSKWNQTTIDNLKNKYSYNVDMSGAQVATIENGKLTGTGSDTTDIKNKDLIFTGGGDILLKSSFDNGAGGLVFNDKKTYRVNGDDFTFKGAGVDTRNGSTVEWNIRYDNKDNLHKIGDGTLDVRKTQNTNLKTGEGLVILGAEKTFNNIYITSGDGTVRLNAENALSGGEYNGIFFAKNGGTLDLNGYNQSFNKIAATDSGAVITNTSTKKSILSLNNTADYIYHGNINGNLDVLQHHETKKENRRLILDGGVDTTNDISLRNTQLSMQGHATEHAIYRDGAFSCSLPAPMRFLCGSDYVAGMQNTEADAVKQNGNAYKTNNAVSDLSQPDWETGTFRFGTLHLENSDFSVGRNANVIGDIQASKSNITIGDTTAYIDLHAGKNITGDGFGFRQNIVRGNSQGETLFTGGITAEDSTIVIKDKAKALFSNYVYLLNTKATIENGADVTTQSGMFSTSDISISGNLSMTGNPDKDNKFEPSIYLNDASYLLTDDSARLVAKNKASVVGDIHSTKSASIMFGHDESDLSQLSDRTSKGLALGLLGGFDVSYRGSVNAPSASATMNNTWWQLTGDSALKTLKSTNSMVYFTDSANNKKFHTLTVDELATSNSAYAMRTNLSESDKLEVKKHLSGENNILLVDFLQKPTPEKQLNIELVSAPKDTNENVFKASKQTIGFSDVTPVITTRETDDKITWSLTGYNTVANKEATRNAAALFSVDYKAFLNEVNNLNKRMGDLRDINGEAGAWARIMSGTGSASGGFSDNYTHVQVGVDKKHELDGLDLFTGFTVTHTDSSASADVFSGKTKSVGAGLYASAMFDSGAYIDLIGKYVHHDNEYTATFAGLGTRDYSTHSWYAGAEAGYRYHVTEDAWIEPQAELVYGSVSGKQFAWKDQGMHLSMKDKDYNPLIGRTGVDVGKSFSGKDWKVTARAGLGYQFDLLANGETVLRDASGEKRIKGEKDSRMLMSVGLNAEIRDNVRFGLEFEKSAFGKYNVDNAVNANFRYSF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: espP mutant is attenuated in calves (Dziva et al., 2007).
COG COG4625S, under S: Function unknown
References
Dziva et al., 2007: Dziva F, Mahajan A, Cameron P, Currie C, McKendrick IJ, Wallis TS, Smith DG, Stevens MP. EspP, a Type V-secreted serine protease of enterohaemorrhagic Escherichia coli O157:H7, influences intestinal colonization of calves and adherence to bovine primary intestinal epithelial cells. FEMS microbiology letters. 2007; 271(2); 258-264. [PubMed: 17451446].