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EHEC-hlyA

Victor ID 2294
Gene Name EHEC-hlyA
Sequence Strain (Species/Organism) Escherichia coli O157:H7 str. EDL933
NCBI Gene ID 3683747
NCBI Protein GI 75994494
Locus Tag L7048
Genbank Accession AF074613
Protein Accession YP_325608
Other Database IDs UniProtKB-ID: Q46716_ECO57
UniRef100: UniRef100_Q0E868
UniRef90: UniRef90_A1EAA3
UniRef50: UniRef50_P55129
UniParc: UPI00000B51F9
EMBL: AF074613
EMBL: AB011549
EMBL-CDS: AAC70116.1
EMBL-CDS: BAA31774.1
RefSeq_NT: NC_002128.1
RefSeq_NT: NC_007414.1
EnsemblGenome: EBESCG00000028457.
EnsemblGenome_TRS: EBESCT00000029407
EnsemblGenome_PRO: EBESCP00000028112
EnsemblGenome: EBESCG00000059797.
EnsemblGenome_TRS: EBESCT00000060750
EnsemblGenome_PRO: EBESCP00000058394
GenomeReviews: AB011549_GR
GenomeRev
Taxonomy ID 155864
Plasmid No pO157
Gene Starting Position 39821
Gene Ending Position 42817
Gene Strand (Orientation) +
Protein Name hemolysin toxin protein
Protein pI 4.79
Protein Weight 100993.64
Protein Length 998
Protein Note 99 pct identical (0 gaps) and equal length to a protein EHEC-hlyA TRSW: Q47461
DNA Sequence 
>gi|75994447:39821-42817 Escherichia coli O157:H7 EDL933 plasmid pO157, complete sequence
TATGACAGTAAATAAAATAAAGAACATTTTCAATAATGCGACATTGACTACAAAATCAGCATTTAATACA
GCATCATCAAGCGTACGTTCCGCTGGAAAAAAACTCATATTATTAATACCTGATAATTATGAAGCTCAGG
GCGTGGGTATTAATGAGTTGGTCAAAGCTGCTGATGAGCTTGGAATAGAAATACACCGTACTGAACGAGA
TGATACAGCGATTGCAAACCAGTTTTTTGGTGCAGCAGAAAAAGTTGTAGGATTAACTGAACGTGGTGTT
GCAATATTCGCACCACAACTTGACAAACTTCTGCAGAAGTATCAGAAAGTTGGGAGTAAAATAGGAGGAA
CCGCTGAAAATGTAGGTAATAATCTGGGAAAAGCCGGAACAGTTCTCTCAGCACTACAGAATTTTACGGG
GATTGCTTTATCAGGCATGGCTCTTGATGAATTGCTGAGAAAACAACGGGAAGGAGAGGATATAAGTCAG
AATGATATTGCCAAAAGTAGTATTGAACTTATTAATCAGCTTGTAGATACAGTATCAAGTATAAACAGTA
CCGTTGATTCATTTTCTGAGCAGCTTAACCAGCTTGGCTCATTTTTATCCAGTAAACCTCGATTAAGTTC
TGTTGGTGGGAAATTACAAAATTTACCAGACCTGGGCCCCCTGGGGGATGGGCTGGATGTTGTCTCCGGA
ATTCTTTCTGCTGTATCAGCAAGCTTTATTCTGGGAAACAGTGACGCACATACAGGAACAAAAGCTGCAG
CGGGTATCGAACTGACAACTCAGGTTCTTGGAAATGTTGGTAAAGCTGTTTCGCAATATATTCTGGCTCA
GAGAATGGCACAGGGGTTATCGACAACAGCTGCAAGTGCGGGTCTGATCACATCGGCTGTTATGCTGGCT
ATCAGTCCTCTTTCTTTCCTGGCTGCTGCAGATAAATTTGAGCGAGCTAAGCAGCTTGAATCATATTCTG
AACGATTTAAAAAATTGAATTATGAAGGGGATGCTTTACTCGCAGCCTTTCATAAAGAAACCGGAGCTAT
AGATGCAGCCCTGACAACAATAAATACTGTCCTGAGTTCTGTATCTGCGGGAGTTAGTGCAGCCTCCAGT
GCATCCCTCATAGGGGCCCCGATAAGCATGCTGGTGAGTGCATTAACCGGTACGATATCTGGCATTCTGG
AAGCATCAAAACAGGCTATGTTTGAGCACGTTGCAGAGAAATTCGCTGCTCGGATCAATGAATGGGAAAA
GGAGCATGGCAAAAATTATTTTGAGAATGGATATGACGCAAGACATGCTGCGTTTTTAGAAGACTCTCTG
TCTTTGCTTGCTGATTTTTCTCGTCAGCATGCAGTAGAAAGAGCAGTCGCAATAACCCAGCAACATTGGG
ATGAGAAGATCGGTGAACTTGCAGGCATAACCCGTAATGCTGATCGCAGTCAGAGTGGTAAGGCATATAT
TAATTATCTGGAAAATGGAGGGCTTTTAGAGGCTCAACCGAAGGAGTTTACACAACAAGTGTTTGATCCT
CAAAAAGGGACCATAGACCTTTCAACAGGTAATGTATCAAGTGTTTTGACATTTATAACACCAACATTTA
CCCCAGGAGAAGAAGTTAGAGAAAGAAAACAGAGTGGTAAATATGAATATATGACATCTCTTATTGTAAA
TGGTAAGGATACATGGTCTGTAAAAGGCATAAAAAATCATAAAGGTGTATATGATTATTCAAAATTGATT
CAGTTTGTTGAAAAGAATAACAAACACTATCAGGCGAGAATAATTTCTGAGCTCGGAGATAAAGACGATG
TGGTTTATTCTGGAGCAGGCTCATCAGAAGTATTTGCTGGTGAAGGTTATGATACCGTATCTTATAATAA
GACGGATGTTGGTAAACTAACAATTGATGCAACAGGAGCATCAAAACCTGGTGAGTATATAGTTTCAAAA
AATATGTATGGTGACGTGAAGGTATTGCAGGAAGTCGTTAAGGAACAGGAGGTGTCAGTAGGGAAGCGAA
CAGAGAAAATACAATATCGTGATTTTGAATTCAGAACCGGTGGAATTCCTTATGATGTAATAGATAATCT
TCATTCTGTTGAAGAGCTCATTGGCGGAAAACATGATGATGAATTCAAAGGCGGTAAGTTTAATGATATA
TTCCATGGCGCAGATGGGAACGATTATATCGAAGGTAATTATGGTAATGATCGACTATACGGCGATGATG
GGGATGATTATATATCCGGAGGACAGGGAGACGACCAGTTATTTGGTGGTAGTGGAAACGATAAATTGAG
TGGAGGGGATGGTAATAATTATCTGACAGGAGGAAGCGGTAATGATGAGCTTCAGGCACACGGAGCTTAT
AATATTCTGTCAGGTGGTACTGGTGATGATAAACTTTATGGTGGTGGTGGTATTGATCTTCTGGATGGAG
GGGAAGGTAATGACTATCTGAATGGTGGTTTTGGTAATGATATTTATGTTTATGGGCAAAACTATGGTCA
TCATACAATTGCAGATGAAGGAGGTAAAGGAGATCGTTTGCACTTATCTGATATTAGCTTTGATGATATC
GCATTTAAGAGAGTTGGAAATGATCTTATCATGAATAAAGCCATTAATGGTGTACTTTCATTTAATGAGT
CAAATGATGTCAATGGGATAACATTTAAAAACTGGTTTGCGAAAGATGCCTCAGGAGCAGATAATCATCT
TGTTGAGGTTATAACAGATAAAGATGGTCGAGAGATAAAAGTTGATAAGATACCTCATAATAATAATGAA
CGGTCAGGTTATATAAAAGCCAGTAATATAGCATCTGAAAAAAACATGGTTAATATCACCAGTGTTGCCA
ATGATATTAATAAGATTATTTCTTCAGTTTCAGGGTTCGATTCAGGTGATGAACGATTAGCATCTTTATA
TAATTTATCCTTACATCAAAACAACACACACTCAACAACTTTAACGACAACTGTCTG
Protein Sequence 
>gi|75994494|ref|YP_325608.1| hemolysin toxin protein [Escherichia coli O157:H7 EDL933]
MTVNKIKNIFNNATLTTKSAFNTASSSVRSAGKKLILLIPDNYEAQGVGINELVKAADELGIEIHRTERD
DTAIANQFFGAAEKVVGLTERGVAIFAPQLDKLLQKYQKVGSKIGGTAENVGNNLGKAGTVLSALQNFTG
IALSGMALDELLRKQREGEDISQNDIAKSSIELINQLVDTVSSINSTVDSFSEQLNQLGSFLSSKPRLSS
VGGKLQNLPDLGPLGDGLDVVSGILSAVSASFILGNSDAHTGTKAAAGIELTTQVLGNVGKAVSQYILAQ
RMAQGLSTTAASAGLITSAVMLAISPLSFLAAADKFERAKQLESYSERFKKLNYEGDALLAAFHKETGAI
DAALTTINTVLSSVSAGVSAASSASLIGAPISMLVSALTGTISGILEASKQAMFEHVAEKFAARINEWEK
EHGKNYFENGYDARHAAFLEDSLSLLADFSRQHAVERAVAITQQHWDEKIGELAGITRNADRSQSGKAYI
NYLENGGLLEAQPKEFTQQVFDPQKGTIDLSTGNVSSVLTFITPTFTPGEEVRERKQSGKYEYMTSLIVN
GKDTWSVKGIKNHKGVYDYSKLIQFVEKNNKHYQARIISELGDKDDVVYSGAGSSEVFAGEGYDTVSYNK
TDVGKLTIDATGASKPGEYIVSKNMYGDVKVLQEVVKEQEVSVGKRTEKIQYRDFEFRTGGIPYDVIDNL
HSVEELIGGKHDDEFKGGKFNDIFHGADGNDYIEGNYGNDRLYGDDGDDYISGGQGDDQLFGGSGNDKLS
GGDGNNYLTGGSGNDELQAHGAYNILSGGTGDDKLYGGGGIDLLDGGEGNDYLNGGFGNDIYVYGQNYGH
HTIADEGGKGDRLHLSDISFDDIAFKRVGNDLIMNKAINGVLSFNESNDVNGITFKNWFAKDASGADNHL
VEVITDKDGREIKVDKIPHNNNERSGYIKASNIASEKNMVNITSVANDINKIISSVSGFDSGDERLASLY
NLSLHQNNTHSTTLTTTV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: hlyA mutant is attenuated in calves (van et al., 2005).
References
van et al., 2005: van Diemen PM, Dziva F, Stevens MP, Wallis TS. Identification of enterohemorrhagic Escherichia coli O26:H- genes required for intestinal colonization in calves. Infection and immunity. 2005; 73(3); 1735-1743. [PubMed: 15731074].